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2024-04-23 20:14:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001270987 2088 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3)
(LTBR), transcript variant 2, mRNA.
ACCESSION NM_001270987
VERSION NM_001270987.1 GI:402534564
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2088)
AUTHORS Upadhyay,V. and Fu,Y.X.
TITLE Lymphotoxin signalling in immune homeostasis and the control of
microorganisms
JOURNAL Nat. Rev. Immunol. 13 (4), 270-279 (2013)
PUBMED 23524463
REMARK GeneRIF: Studies indicate roles for Lymphotoxin-alpha (LTalpha) and
lymphotoxin-beta receptor (LTbetaR) pathway in innate and adaptive
immune responses to microorganisms.
Review article
REFERENCE 2 (bases 1 to 2088)
AUTHORS Kim,S.K., Lee,J.Y., Jeong Park,H., Chung,J.H., Suh,J.S., Hahn,W.H.,
Cho,B.S. and Kim,M.J.
TITLE Association between lymphotoxin beta receptor gene polymorphisms
and IgA nephropathy in Korean children
JOURNAL Immunol. Invest. 41 (5), 447-457 (2012)
PUBMED 22417320
REMARK GeneRIF: LTBR gene polymorphisms may be associated with risk of IgA
nephropathy in Korean children
REFERENCE 3 (bases 1 to 2088)
AUTHORS Remouchamps,C., Boutaffala,L., Ganeff,C. and Dejardin,E.
TITLE Biology and signal transduction pathways of the
Lymphotoxin-alphabeta/LTbetaR system
JOURNAL Cytokine Growth Factor Rev. 22 (5-6), 301-310 (2011)
PUBMED 22152226
REMARK Review article
REFERENCE 4 (bases 1 to 2088)
AUTHORS Summers deLuca,L., Ng,D., Gao,Y., Wortzman,M.E., Watts,T.H. and
Gommerman,J.L.
TITLE LTbetaR signaling in dendritic cells induces a type I IFN response
that is required for optimal clonal expansion of CD8+ T cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (5), 2046-2051 (2011)
PUBMED 21245292
REMARK GeneRIF: show that a cognate interaction between LTalphabeta on
CD4(+) helper T cells and LTbeta receptor on DCs results in unique
signals that are necessary for optimal CD8(+) T-cell expansion via
a type I IFN-dependent mechanism
REFERENCE 5 (bases 1 to 2088)
AUTHORS Fava,R.A., Kennedy,S.M., Wood,S.G., Bolstad,A.I., Bienkowska,J.,
Papandile,A., Kelly,J.A., Mavragani,C.P., Gatumu,M., Skarstein,K.
and Browning,J.L.
TITLE Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal
glands and improves corneal integrity in the NOD model of Sjogren's
syndrome
JOURNAL Arthritis Res. Ther. 13 (6), R182 (2011)
PUBMED 22044682
REMARK GeneRIF: Results suggest that blockade of lymphotoxin-beta receptor
(LTBR) pathways may have therapeutic potential for treatment of
Sjogren's syndrome.
REFERENCE 6 (bases 1 to 2088)
AUTHORS Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
Yagita,H. and Okumura,K.
TITLE TRAF5, an activator of NF-kappaB and putative signal transducer for
the lymphotoxin-beta receptor
JOURNAL J. Biol. Chem. 271 (25), 14661-14664 (1996)
PUBMED 8663299
REFERENCE 7 (bases 1 to 2088)
AUTHORS Browning,J.L., Miatkowski,K., Sizing,I., Griffiths,D., Zafari,M.,
Benjamin,C.D., Meier,W. and Mackay,F.
TITLE Signaling through the lymphotoxin beta receptor induces the death
of some adenocarcinoma tumor lines
JOURNAL J. Exp. Med. 183 (3), 867-878 (1996)
PUBMED 8642291
REFERENCE 8 (bases 1 to 2088)
AUTHORS Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
Marynen,P.
TITLE Isolation and regional assignment of human chromosome 12p cDNAs
JOURNAL Genomics 29 (1), 44-52 (1995)
PUBMED 8530100
REFERENCE 9 (bases 1 to 2088)
AUTHORS Crowe,P.D., VanArsdale,T.L., Walter,B.N., Ware,C.F., Hession,C.,
Ehrenfels,B., Browning,J.L., Din,W.S., Goodwin,R.G. and Smith,C.A.
TITLE A lymphotoxin-beta-specific receptor
JOURNAL Science 264 (5159), 707-710 (1994)
PUBMED 8171323
REFERENCE 10 (bases 1 to 2088)
AUTHORS Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
Marynen,P.
TITLE Construction and evaluation of a hncDNA library of human 12p
transcribed sequences derived from a somatic cell hybrid
JOURNAL Genomics 16 (1), 214-218 (1993)
PUBMED 8486360
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC424721.1, AK293187.1,
BC026262.1 and AK027080.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes a member of the tumor necrosis factor
receptor superfamily. The major ligands of this receptor include
lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily
member 14. The encoded protein plays a role in signalling during
the development of lymphoid and other organs, lipid metabolism,
immune response, and programmed cell death. Activity of this
receptor has also been linked to carcinogenesis. Alternatively
spliced transcript variants encoding multiple isoforms have been
observed. [provided by RefSeq, Aug 2012].
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
portion of the 5' coding region, and initiates translation at an
alternate start codon, compared to variant 1. The encoded isoform
(2) has a distinct N-terminus and is shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK293187.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-61 DC424721.1 325-385
62-356 AK293187.1 1-295
357-2065 BC026262.1 424-2132
2066-2088 AK027080.1 2126-2148
FEATURES Location/Qualifiers
source 1..2088
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13"
gene 1..2088
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="lymphotoxin beta receptor (TNFR superfamily, member
3)"
/db_xref="GeneID:4055"
/db_xref="HGNC:6718"
/db_xref="MIM:600979"
exon 1..227
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 85
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:72645134"
variation 133
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:13306617"
variation 142
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:72645135"
variation 174
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:112539501"
variation 175
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:111613196"
variation 176
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:10849447"
variation 186
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375596606"
CDS 189..1439
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="isoform 2 is encoded by transcript variant 2; tumor
necrosis factor C receptor; lymphotoxin B receptor; tumor
necrosis factor receptor type III; tumor necrosis factor
receptor 2-related protein"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 3 isoform 2"
/protein_id="NP_001257916.1"
/db_xref="GI:402534565"
/db_xref="CCDS:CCDS59233.1"
/db_xref="GeneID:4055"
/db_xref="HGNC:6718"
/db_xref="MIM:600979"
/translation="
MEATGISLASQLKVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
"
misc_feature 282..569
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(309..338,363..377,480..488)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(309..311,321..323,327..329,366..368,375..377,
405..407)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(393..395,426..428,459..461,525..527,555..557)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(402..407,423..431)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 525..>761
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cl12111"
/db_xref="CDD:209448"
misc_feature order(525..530,654..656,687..689,717..719)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(525..527,555..569)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature order(537..539,567..569,579..581,585..587,627..629,
636..638,666..668)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(567..593,597..599,624..638,738..746)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(663..668,684..692)
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
variation 196
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:72645136"
exon 228..324
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 247
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:113907340"
variation 287
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11555387"
variation 291
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:147291553"
exon 325..450
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 377
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:41480749"
variation 401
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144676461"
variation 407
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042318"
exon 451..603
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 461
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376062437"
variation 484
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200343421"
variation 504
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371101623"
variation 515
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:41489647"
variation 568
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41393248"
exon 604..700
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 619
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149981490"
variation 632
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199745608"
variation 633
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145130663"
variation 647
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:2364480"
variation 671
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41335846"
variation 675
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:113334413"
variation 677
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144218663"
variation 682
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199917609"
exon 701..798
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 749
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140294576"
variation 770
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="t"
/db_xref="dbSNP:374274216"
variation 775
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368496847"
variation 787
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:185897139"
exon 799..906
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 813
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:372316101"
variation 816
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:41332645"
variation 819
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:190288182"
variation 857
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369186345"
variation 858
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148007184"
variation 869
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372115715"
variation 898
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:141647006"
exon 907..932
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 910
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150503607"
exon 933..1161
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 951
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35681405"
variation 991
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:74400611"
variation 1017
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:11555386"
variation 1033
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144056108"
variation 1040
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147770937"
variation 1044
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140869621"
variation 1052
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201042007"
variation 1058
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:34407931"
variation 1063
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144755581"
variation 1088
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148530627"
variation 1090
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370657088"
variation 1126
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804534"
variation 1136
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374220510"
variation 1145
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:368425660"
exon 1162..2073
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/inference="alignment:Splign:1.39.8"
variation 1199
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375470015"
variation 1271
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:202215602"
variation 1312
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142824360"
variation 1323
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3764872"
variation 1418
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:376201696"
variation 1440
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369367670"
variation 1441
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:12354"
variation 1456
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:371743773"
variation 1481
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374817713"
variation 1524
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:367847000"
variation 1537
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:41355445"
variation 1538
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="g"
/db_xref="dbSNP:3203555"
variation 1552
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:184319376"
variation 1558
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:71584824"
variation 1565
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35986933"
variation 1624
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:12820636"
variation 1687
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149078929"
variation 1747
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="c"
/replace="t"
/db_xref="dbSNP:71584825"
variation 1785
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:3764870"
variation 1815
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="g"
/replace="t"
/db_xref="dbSNP:181205105"
STS 1851..1982
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/standard_name="D12S1911"
/db_xref="UniSTS:14505"
polyA_signal 2049..2054
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
variation 2064
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="c"
/db_xref="dbSNP:3176984"
variation 2069
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180974"
polyA_site 2073
/gene="LTBR"
/gene_synonym="CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR;
TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3"
ORIGIN
gattctgtctctgccccaggactgcagggctccaggaggtctgggctgcctccagcttcccactcccaggttgcggctggactgggactggttcctttccagttgaatctggcagccaaacctctcctccccctcacctgacaggtgcagcggcctggctggggagcccgcccgctggccggccagggatggaagcgacaggaatctcattagcatctcaattaaaggtgcctccatatgcgtcggagaaccagacctgcagggaccaggaaaaggaatactatgagccccagcaccgcatctgctgctcccgctgcccgccaggcacctatgtctcagctaaatgtagccgcatccgggacacagtttgtgccacatgtgccgagaattcctacaacgagcactggaactacctgaccatctgccagctgtgccgcccctgtgacccagtgatgggcctcgaggagattgccccctgcacaagcaaacggaagacccagtgccgctgccagccgggaatgttctgtgctgcctgggccctcgagtgtacacactgcgagctactttctgactgcccgcctggcactgaagccgagctcaaagatgaagttgggaagggtaacaaccactgcgtcccctgcaaggccgggcacttccagaatacctcctcccccagcgcccgctgccagccccacaccaggtgtgagaaccaaggtctggtggaggcagctccaggcactgcccagtccgacacaacctgcaaaaatccattagagccactgcccccagagatgtcaggaaccatgctgatgctggccgttctgctgccactggccttctttctgctccttgccaccgtcttctcctgcatctggaagagccacccttctctctgcaggaaactgggatcgctgctcaagaggcgtccgcagggagagggacccaatcctgtagctggaagctgggagcctccgaaggcccatccatacttccctgacttggtacagccactgctacccatttctggagatgtttccccagtatccactgggctccccgcagccccagttttggaggcaggggtgccgcaacagcagagtcctctggacctgaccagggagccgcagttggaacccggggagcagagccaggtggcccacggtaccaatggcattcatgtcaccggcgggtctatgactatcactggcaacatctacatctacaatggaccagtactggggggaccaccgggtcctggagacctcccagctacccccgaacctccataccccattcccgaagagggggaccctggccctcccgggctctctacaccccaccaggaagatggcaaggcttggcacctagcggagacagagcactgtggtgccacaccctctaacaggggcccaaggaaccaatttatcacccatgactgactgagtctgagaaaaggcagaagaaggggggcacaagggcaccttctcccttgaggctgccctgcccacgtgggattcacaggggcctgagtagggcccggggaagcagagccctaagggattaaggctcagacacctctgagagcaggtgggcactggctgggtacggtgccctccacaggactctccctactgcctgagcaaacctgaggcctcccggcagacccacccaccccctggggctgctcagcctcaggcacggacagggcacatgataccaactgctgcccactacggcacgccgcaccggagcacggcaccgagggagccgccacacggtcacctgcaaggacgtcacgggcccctctaaaggattcgtggtgctcatccccaagcttcagagaccctttggggttccacacttcacgtggactgaggtagaccctgcatgaagatgaaattatagggaggacgctccttccctcccctcctagaggagaggaaagggagtcattaacaactagggggttgggtaggattcctaggtatggggaagagttttggaaggggaggaaaatggcaagtgtatttatattgtaaccacatgcaaataaaaagaatgggacctagataaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4055 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4055 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:4055 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:4055 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4055 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:4055 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:4055 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:4055 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IMP
GeneID:4055 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:4055 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:4055 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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