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2024-04-19 04:27:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001270940 4640 bp mRNA linear PRI 01-MAY-2013
DEFINITION Homo sapiens exportin 6 (XPO6), transcript variant 1, mRNA.
ACCESSION NM_001270940
VERSION NM_001270940.1 GI:401461770
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4640)
AUTHORS Dopie,J., Skarp,K.P., Rajakyla,E.K., Tanhuanpaa,K. and
Vartiainen,M.K.
TITLE Active maintenance of nuclear actin by importin 9 supports
transcription
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (9), E544-E552 (2012)
PUBMED 22323606
REFERENCE 2 (bases 1 to 4640)
AUTHORS Park,S.H., Park,T.J. and Lim,I.K.
TITLE Reduction of exportin 6 activity leads to actin accumulation via
failure of RanGTP restoration and NTF2 sequestration in the nuclei
of senescent cells
JOURNAL Exp. Cell Res. 317 (7), 941-954 (2011)
PUBMED 21195711
REMARK GeneRIF: Data suggest actin accumulation in senescent cells is due
to the failure of RanGTP restoration with ATP deficiency and NTF2
accumulation, resulting in decreased actin export via Exp6
inactivation.
REFERENCE 3 (bases 1 to 4640)
AUTHORS O'Reilly,A.J., Dacks,J.B. and Field,M.C.
TITLE Evolution of the karyopherin-beta family of nucleocytoplasmic
transport factors; ancient origins and continued specialization
JOURNAL PLoS ONE 6 (4), E19308 (2011)
PUBMED 21556326
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4640)
AUTHORS Ambs,S., Prueitt,R.L., Yi,M., Hudson,R.S., Howe,T.M., Petrocca,F.,
Wallace,T.A., Liu,C.G., Volinia,S., Calin,G.A., Yfantis,H.G.,
Stephens,R.M. and Croce,C.M.
TITLE Genomic profiling of microRNA and messenger RNA reveals deregulated
microRNA expression in prostate cancer
JOURNAL Cancer Res. 68 (15), 6162-6170 (2008)
PUBMED 18676839
REFERENCE 5 (bases 1 to 4640)
AUTHORS Suzuki,T., Ishigami,Y., Okada,N., Kaneko,A., Fukutomi,R. and
Isemura,M.
TITLE Differentiation-associated alteration in gene expression of
importins and exportins in human leukemia HL-60 cells
JOURNAL Biomed. Res. 29 (3), 141-145 (2008)
PUBMED 18614847
REFERENCE 6 (bases 1 to 4640)
AUTHORS Suzuki,T., Tazoe,H., Taguchi,K., Koyama,Y., Ichikawa,H.,
Hayakawa,S., Munakata,H. and Isemura,M.
TITLE DNA microarray analysis of changes in gene expression induced by
1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60
cells
JOURNAL Biomed. Res. 27 (3), 99-109 (2006)
PUBMED 16847355
REFERENCE 7 (bases 1 to 4640)
AUTHORS Stuven,T., Hartmann,E. and Gorlich,D.
TITLE Exportin 6: a novel nuclear export receptor that is specific for
profilin.actin complexes
JOURNAL EMBO J. 22 (21), 5928-5940 (2003)
PUBMED 14592989
REMARK GeneRIF: identify exportin 6 (Exp6) as a novel family member from
higher eukaryotes and show that it mediates nuclear export of
profilin.actin complexes
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI465054.1, BX346769.2,
AB002368.3, AK123846.1, AY026388.1 and AK026172.1.
Summary: The protein encoded by this gene is a member of the
importin-beta family. Members of this family are regulated by the
GTPase Ran to mediate transport of cargo across the nuclear
envelope. This protein has been shown to mediate nuclear export of
profilin-actin complexes. A pseudogene of this gene is located on
the long arm of chromosome 14. Alternative splicing results in
multiple transcript variants that encode different protein
isoforms. [provided by RefSeq, Aug 2012].
Transcript Variant: This variant (1) represents the longer
transcript and encodes isoform (1).
##Evidence-Data-START##
Transcript exon combination :: AK123846.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-5 BI465054.1 5-9
6-49 BX346769.2 1-44
50-368 AB002368.3 1-319
369-1136 AK123846.1 1-768
1137-2938 AB002368.3 952-2753
2939-4607 AY026388.1 2276-3944
4608-4640 AK026172.1 3616-3648
FEATURES Location/Qualifiers
source 1..4640
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p11.2"
gene 1..4640
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/note="exportin 6"
/db_xref="GeneID:23214"
/db_xref="HGNC:19733"
/db_xref="MIM:608411"
exon 1..553
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 554..689
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
misc_feature 672..674
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/note="upstream in-frame stop codon"
exon 690..780
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
CDS 729..4064
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/note="isoform 1 is encoded by transcript variant 1;
exportin-6; ran-binding protein 20"
/codon_start=1
/product="exportin-6 isoform 1"
/protein_id="NP_001257869.1"
/db_xref="GI:401461771"
/db_xref="CCDS:CCDS59266.1"
/db_xref="GeneID:23214"
/db_xref="HGNC:19733"
/db_xref="MIM:608411"
/translation="
MTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL
"
misc_feature 777..974
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/note="Importin-beta N-terminal domain; Region: IBN_N;
smart00913"
/db_xref="CDD:197981"
misc_feature 993..1445
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/note="Exportin 1-like protein; Region: Xpo1; pfam08389"
/db_xref="CDD:203927"
exon 781..893
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 894..1091
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 1092..1251
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 1252..1329
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
variation 1290
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="c"
/replace="g"
/db_xref="dbSNP:199701357"
exon 1330..1783
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 1784..1910
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 1911..2020
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2021..2129
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2130..2222
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
variation 2219
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="a"
/replace="t"
/db_xref="dbSNP:181760"
exon 2223..2292
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2293..2452
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
STS 2343..2443
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/standard_name="RH125206"
/db_xref="UniSTS:162028"
exon 2453..2545
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2546..2690
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2691..2837
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 2838..3027
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 3028..3183
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
variation 3057
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="c"
/replace="g"
/db_xref="dbSNP:11557749"
variation 3125
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:11557750"
exon 3184..3298
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 3299..3470
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
variation 3347
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="a"
/replace="g"
/db_xref="dbSNP:35178107"
exon 3471..3632
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 3633..3731
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
exon 3732..3962
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
variation 3771
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="g"
/replace="t"
/db_xref="dbSNP:14672"
exon 3963..4626
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/inference="alignment:Splign:1.39.8"
STS 4012..4616
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/standard_name="XPO6__4913"
/db_xref="UniSTS:462949"
STS 4368..4504
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/standard_name="RH11596"
/db_xref="UniSTS:86526"
variation 4408
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
/replace="c"
/replace="t"
/db_xref="dbSNP:11291"
polyA_signal 4597..4602
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
polyA_site 4626
/gene="XPO6"
/gene_synonym="EXP6; RANBP20"
ORIGIN
agcgggcggctccagggcgggcgcgcgcaaggatgctctagggggcggcggcagtggccgtgtgggttgaggctgcgaggacagcgcgggcccccgggcctctcccctgagccggccgcctgggccgcgcggtcgaggcctgtcagcctccgcccgttcagcctcggggccggggccgccgccacctctgcccgcggaggccggggagcccctgcctgggcccgcagcctcccccgcgggggtcgggcccgggcgggggtcccgagcagctgccctcctcgccggcatccgagcctcatttcctgctttttcagtttccttggggaggggcgggtgggtctggatgaattgtctcggggtcccccgatgaggcgacccgggcggccctgccctttttagagggtcccctcggggcccggtggggaaggggttgtctttgcatgggtgggggacttcccgagtctgccgggaccatgacctgaactgtgcgagcgggacgtgtccgaagcccaagaaccagctcatctgagccgccccctccccggccagcatggtagctcatgtaagtggagtcatgaagtatttggcctgttgtgactgccttatttcacatggcacagtgttctcaagcttcatccgtgtggtggcgtgtgtcagagcttccttccttttgaaagctgaattccattgcatctgaagaagcctctctcagggcattggaaagtctgatgacagaattttttcacgattgtacaaccaatgaaagaaaacgtgagatagaggagcttcttaataactttgcccagcaaataggagcctggagattctgcctgtactttctctccagcactaggaatgactatgtaatgatgtacagtttaacagtttttgagaatctgatcaataaaatgtggcttggggtcccatctcaggataagatggaaatccgtagctgtctgcccaaactccttttggctcaccataaaaccttaccttactttatccggaacaagctctgcaaagttattgttgatattggacgtcaggattggcccatgttctaccacgacttttttactaacattttacagttgatccagtcccctgtgacaaccccccttgggctgatcatgttgaagacaacttcagaagagctggcttgtccccgtgaggacctcagtgtggctcggaaggaggagttgcggaagctgctactggaccaggtgcagacagtgcttgggctactgacaggtatcttggagactgtctgggacaaacacagtgttactgctgccactccaccaccatccccgacctcaggagaaagtggtgacttactgagtaacctgttgcagagtcccagttcagccaaactgttgaatcagccaattcccatccttgatgtggagagtgagtatatctgttccctggctttggagtgcctggcccatctcttcagttggattcctctgtctgccagcatcaccccatccctccttaccaccatcttccactttgcacgatttggctgtgacatccgggccagaaagatggcgtcagttaacggcagcagccagaactgtgtctcgggtcaggagcgcggccggctgggggtcctggccatgtcctgcatcaatgaactcatgtccaagaactgtgtgcctatggaatttgaggagtatttactgcgtatgttccagcagactttctacctcctgcagaaaatcaccaaggataacaatgcccacacagtgaagagcaggctagaagagctcgatgagagctatatcgagaagtttactgactttcttcggctctttgtgagtgttcacctaagaagaatcgagtcttactcccagttccctgtggtggagtttttgacacttttgttcaagtacacatttcatcagcctactcatgaaggttacttctcttgtttggatatctggacgctgtttttggactatctgacaagtaaaattaaaagtcgtcttggagacaaggaagcagttctcaacaggtacgaagatgccctggtgctcctgctcacagaggtgttgaatcgaatccagttcagatacaaccaagcccagctggaggagttggatgatgagactctggatgacgatcagcagacggagtggcagcggtacttacggcagagcttggaggtggtggccaaagtgatggagctcctgcccacgcacgccttctccacactgttccctgttcttcaggacaatttagaagtttatttgggattacaacagtttatagtcacttcagggtcaggacacaggttgaacatcacggcggagaacgactgccggcggctgcactgctccctgagagacttgagctccctgctgcaggccgtgggccgcctggccgagtactttatcggggatgtgtttgctgcacggttcaatgatgccctcacagtcgtggaaaggttggtcaaagtcactctgtacggatctcagataaaattgtacaacattgaaactgctgtgccatcagtattgaaacctgacctcattgatgtgcatgctcagtccctggctgcgctgcaggcttactctcactggttagcacagtattgcagtgaagttcaccggcagaacacgcagcagttcgtgacactcatctctactaccatggatgcaatcacacctctaatcagcaccaaggtccaagacaagctgctgctatctgcgtgccacttactggtctcactggccaccaccgtgcggcccgtctttctgatcagcatccctgcagtgcagaaagtattcaacagaatcactgatgcctctgccctgcgacttgtcgataaggcccaggtgttggtgtgccgagccctctctaacatcttgctgcttccgtggccaaaccttccagagaatgagcagcagtggcccgtgcgctccatcaaccacgccagcctcatctctgcactctcccgggactatcgcaacctgaagcccagtgctgttgccccacagagaaagatgccactggatgacaccaaactgattatccaccagacactcagcgtcttagaagatattgtggagaatatctcgggggagtccaccaagtctcgacagatttgctaccagtcgctgcaggaatctgttcaggtctccctggccctctttccagcttttatccatcagtcagatgtgactgatgagatgctgagcttcttcctcactctgtttcgaggccttagagtacagatgggtgtgcctttcactgagcaaatcatacagactttcctcaacatgtttaccagagagcagttagccgagagcatcctccacgagggcagcacaggctgccgggtggtggagaagtttctgaagatcctgcaggtggtggtccaggagccaggccaggtgttcaagcccttcctccccagcatcatcgccctgtgcatggagcaagtgtatcccatcattgccgagcgtccctcccctgatgtgaaggccgagctgtttgagctccttttccggacgctccatcacaactggaggtacttcttcaagtccaccgtgctggccagtgtccagagggggatcgctgaggagcagatggagaatgagccccagttcagtgccatcatgcaggctttcggacagtcctttctccagcccgacatccacctttttaaacaaaatctcttctacttggagactctcaacaccaagcagaagctgtaccacaagaagatcttccggactgccatgctgttccagtttgtgaacgtgctgctccaggtcctggtccacaagtcccatgatcttctgcaggaggagattggcatcgccatctacaacatggcctcagtcgactttgatggcttctttgccgccttcctcccagagttcctgaccagctgtgatggtgtggatgccaaccagaaaagtgtgctggggcggaatttcaagatggatcgggacctgccctcattcacccagaatgtgcacaggctggtcaacgacctgcgctactacagactctgcaacgacagcctgccccctggcactgtgaagctctaggcctgctactgcctggggacacggacttctgctgctgccacctgcgccagccctaccttccaccacagatgtctcccagatgggccttggtcacactccttggcttctcccaccgcaagcaacgctgcctgcctctgccgctcctccacatcttgccgctgcccagcagagctggcttctgggtccacctgagcactggacggtgctcccagggcgttggagcaggcggaggggtgtgtggccaggtactaggaggcaccaggaaatcccgcggggtggcccatgcagaccaggcgcacgtggctcatggggcagaattgccaaggacagctcacgacagtgccaccttctcaccattccagccaaggagagatgtgacgttggaactgctctggcacttctgtcaagcctcccccgccccaattgccttgagatctctgctctttgtcagagatttgcaaagactcacgtttttgttgttttctcatcattccattgtgatactaagaaactaagaagcttaatgaaaagaaataaaatgcctatgttgttgttctagaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23214 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23214 -> Molecular function: GO:0008536 [Ran GTPase binding] evidence: IEA
GeneID:23214 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IDA
GeneID:23214 -> Biological process: GO:0006611 [protein export from nucleus] evidence: IDA
GeneID:23214 -> Cellular component: GO:0005634 [nucleus] evidence: IC
GeneID:23214 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:23214 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:23214 -> Cellular component: GO:0005737 [cytoplasm] evidence: IC
GeneID:23214 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:23214 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
by
@meso_cacase at
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