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2024-04-19 15:12:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001270508 4753 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens tumor necrosis factor, alpha-induced protein 3
(TNFAIP3), transcript variant 1, mRNA.
ACCESSION NM_001270508
VERSION NM_001270508.1 GI:395393996
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4753)
AUTHORS Li,H., Liu,Q., Hou,S., Du,L., Zhou,Q., Zhou,Y., Kijlstra,A., Li,Z.
and Yang,P.
TITLE TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a
Chinese Han population
JOURNAL Hum. Genet. 132 (3), 293-300 (2013)
PUBMED 23161053
REMARK GeneRIF: This study identified one strong risk SNP rs9494885 and
two weak risk SNPs rs10499194 and rs7753873 of TNFAIP3 in Chinese
Han Behcet disease (BD) patients.
REFERENCE 2 (bases 1 to 4753)
AUTHORS Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen RC, Tang W, Mosley
TH, Rotter JI, deFilippi CR, O'Donnell CJ, Kathiresan S, Rice K,
Heckbert SR, Ballantyne CM, Psaty BM and Boerwinkle E.
CONSRTM CARDIoGRAM Consortium
TITLE Association of genome-wide variation with highly sensitive cardiac
troponin-T levels in European Americans and Blacks: a meta-analysis
from atherosclerosis risk in communities and cardiovascular health
studies
JOURNAL Circ Cardiovasc Genet 6 (1), 82-88 (2013)
PUBMED 23247143
REFERENCE 3 (bases 1 to 4753)
AUTHORS Yang,W., Tang,H., Zhang,Y., Tang,X., Zhang,J., Sun,L., Yang,J.,
Cui,Y., Zhang,L., Hirankarn,N., Cheng,H., Pan,H.F., Gao,J.,
Lee,T.L., Sheng,Y., Lau,C.S., Li,Y., Chan,T.M., Yin,X., Ying,D.,
Lu,Q., Leung,A.M., Zuo,X., Chen,X., Tong,K.L., Zhou,F., Diao,Q.,
Tse,N.K., Xie,H., Mok,C.C., Hao,F., Wong,S.N., Shi,B., Lee,K.W.,
Hui,Y., Ho,M.H., Liang,B., Lee,P.P., Cui,H., Guo,Q., Chung,B.H.,
Pu,X., Liu,Q., Zhang,X., Zhang,C., Chong,C.Y., Fang,H., Wong,R.W.,
Sun,Y., Mok,M.Y., Li,X.P., Avihingsanon,Y., Zhai,Z.,
Rianthavorn,P., Deekajorndej,T., Suphapeetiporn,K., Gao,F.,
Shotelersuk,V., Kang,X., Ying,S.K., Zhang,L., Wong,W.H., Zhu,D.,
Fung,S.K., Zeng,F., Lai,W.M., Wong,C.M., Ng,I.O.,
Garcia-Barcelo,M.M., Cherny,S.S., Shen,N., Tam,P.K., Sham,P.C.,
Ye,D.Q., Yang,S., Zhang,X. and Lau,Y.L.
TITLE Meta-analysis followed by replication identifies loci in or near
CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic
lupus erythematosus in Asians
JOURNAL Am. J. Hum. Genet. 92 (1), 41-51 (2013)
PUBMED 23273568
REFERENCE 4 (bases 1 to 4753)
AUTHORS Kulathu,Y., Garcia,F.J., Mevissen,T.E., Busch,M., Arnaudo,N.,
Carroll,K.S., Barford,D. and Komander,D.
TITLE Regulation of A20 and other OTU deubiquitinases by reversible
oxidation
JOURNAL Nat Commun 4, 1569 (2013)
PUBMED 23463012
REMARK GeneRIF: The reversible form of A20 oxidation is a cysteine
sulphenic acid intermediate, which is stabilised by the
architecture of the catalytic centre.
REFERENCE 5 (bases 1 to 4753)
AUTHORS Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
Cho JH.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 6 (bases 1 to 4753)
AUTHORS Vincenz,C. and Dixit,V.M.
TITLE 14-3-3 proteins associate with A20 in an isoform-specific manner
and function both as chaperone and adapter molecules
JOURNAL J. Biol. Chem. 271 (33), 20029-20034 (1996)
PUBMED 8702721
REFERENCE 7 (bases 1 to 4753)
AUTHORS Cooper,J.T., Stroka,D.M., Brostjan,C., Palmetshofer,A., Bach,F.H.
and Ferran,C.
TITLE A20 blocks endothelial cell activation through a
NF-kappaB-dependent mechanism
JOURNAL J. Biol. Chem. 271 (30), 18068-18073 (1996)
PUBMED 8663499
REFERENCE 8 (bases 1 to 4753)
AUTHORS Song,H.Y., Rothe,M. and Goeddel,D.V.
TITLE The tumor necrosis factor-inducible zinc finger protein A20
interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (13), 6721-6725 (1996)
PUBMED 8692885
REFERENCE 9 (bases 1 to 4753)
AUTHORS Opipari,A.W. Jr., Boguski,M.S. and Dixit,V.M.
TITLE The A20 cDNA induced by tumor necrosis factor alpha encodes a novel
type of zinc finger protein
JOURNAL J. Biol. Chem. 265 (25), 14705-14708 (1990)
PUBMED 2118515
REFERENCE 10 (bases 1 to 4753)
AUTHORS Dixit,V.M., Green,S., Sarma,V., Holzman,L.B., Wolf,F.W.,
O'Rourke,K., Ward,P.A., Prochownik,E.V. and Marks,R.M.
TITLE Tumor necrosis factor-alpha induction of novel gene products in
human endothelial cells including a macrophage-specific chemotaxin
JOURNAL J. Biol. Chem. 265 (5), 2973-2978 (1990)
PUBMED 2406243
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY009939.1, M59465.1 and
CB528739.1.
Summary: This gene was identified as a gene whose expression is
rapidly induced by the tumor necrosis factor (TNF). The protein
encoded by this gene is a zinc finger protein and ubiqitin-editing
enzyme, and has been shown to inhibit NF-kappa B activation as well
as TNF-mediated apoptosis. The encoded protein, which has both
ubiquitin ligase and deubiquitinase activities, is involved in the
cytokine-mediated immune and inflammatory responses. Several
transcript variants encoding the same protein have been found for
this gene. [provided by RefSeq, Jul 2012].
Transcript Variant: This variant (1) represents the longest
transcript. All three variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC041790.1, FJ434413.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-448 HY009939.1 59-506
449-4472 M59465.1 145-4168
4473-4753 CB528739.1 1-281 c
FEATURES Location/Qualifiers
source 1..4753
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q23"
gene 1..4753
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="tumor necrosis factor, alpha-induced protein 3"
/db_xref="GeneID:7128"
/db_xref="HGNC:11896"
/db_xref="MIM:191163"
exon 1..355
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
STS 30..115
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="PMC135646P2"
/db_xref="UniSTS:270766"
exon 356..665
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 357
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199763604"
variation 366
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369927129"
CDS 371..2743
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/EC_number="3.4.19.12"
/note="tumor necrosis factor inducible protein A20; zinc
finger protein A20; TNF alpha-induced protein 3; OTU
domain-containing protein 7C; putative DNA-binding protein
A20"
/codon_start=1
/product="tumor necrosis factor alpha-induced protein 3"
/protein_id="NP_001257437.1"
/db_xref="GI:395393997"
/db_xref="CCDS:CCDS5187.1"
/db_xref="GeneID:7128"
/db_xref="HGNC:11896"
/db_xref="MIM:191163"
/translation="
MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCFKRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGDRTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARASCKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFKQMYG
"
mat_peptide 371..1687
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/product="A20p50"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1)"
misc_feature 542..1270
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: TRAF-binding"
misc_feature 662..1141
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="OTU-like cysteine protease; Region: OTU; pfam02338"
/db_xref="CDD:202209"
misc_feature 839..847
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Interaction with ubiquitin (Probable)"
misc_feature 938..946
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Interaction with ubiquitin (Probable)"
misc_feature 1040..1051
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Interaction with ubiquitin (Probable)"
misc_feature 1226..1438
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: 2 X approximate repeats"
misc_feature 1475..2695
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Interaction with TNIP1 (By similarity)"
misc_feature 1520..1597
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc fingers; Region: ZnF_A20; smart00259"
/db_xref="CDD:128555"
misc_feature 1526..1729
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Interaction with RIPK1"
misc_feature 1685..1690
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by MALT1; propagated from
UniProtKB/Swiss-Prot (P21580.1); cleavage site"
mat_peptide 1688..2740
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/product="A20p37"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1)"
misc_feature 1745..1747
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P21580.1); phosphorylation site"
misc_feature 1793..1870
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc fingers; Region: ZnF_A20; smart00259"
/db_xref="CDD:128555"
misc_feature 2180..2257
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc fingers; Region: ZnF_A20; smart00259"
/db_xref="CDD:128555"
misc_feature 2183..2335
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Required for proteosomal degradation of UBE2N and
UBE2D3, TRAF6 deubiquitination, and TAX1BP1 interaction
with UBE2N (By similarity)"
misc_feature 2186..2740
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Sufficient for inhibitory activity of TNF-induced
NF-kappa-B activity (By similarity)"
misc_feature 2330..2407
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc fingers; Region: ZnF_A20; smart00259"
/db_xref="CDD:128555"
misc_feature 2459..2740
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21580.1);
Region: Required for lysosomal localization and for TRAF2
lysosomal degradation"
misc_feature 2507..2584
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc finger; Region: zf-A20; cl11604"
/db_xref="CDD:209366"
misc_feature 2645..2722
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/note="A20-like zinc fingers; Region: ZnF_A20; smart00259"
/db_xref="CDD:128555"
variation 404
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138988092"
variation 432
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149162594"
variation 433
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:183283680"
variation 435
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199876928"
variation 455
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:376163335"
variation 495
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370854824"
variation 578
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375335818"
variation 583
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143308022"
variation 607
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:148028402"
variation 618
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:112229105"
variation 652
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142122102"
variation 661
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376435384"
variation 664
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146004919"
exon 666..856
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368218194"
variation 675
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146534657"
variation 692
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376205580"
variation 713
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150717698"
variation 736
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:139060168"
variation 744
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:5029941"
variation 750
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2230926"
variation 756
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:183020993"
STS 759..839
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="PMC152246P3"
/db_xref="UniSTS:271205"
variation 760
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:202005030"
variation 776
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200740561"
variation 808
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065077"
variation 835
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140424499"
variation 855
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144788826"
exon 857..1004
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 879
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373331557"
variation 918
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375378882"
variation 921
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147932545"
variation 922
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370174617"
variation 928..929
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace=""
/replace="t"
/db_xref="dbSNP:34935799"
variation 989
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:141807543"
exon 1005..1175
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 1011
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:145706326"
variation 1026
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201505674"
variation 1042
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370381369"
variation 1047
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:151032703"
variation 1131
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61756235"
variation 1142
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140951984"
exon 1176..1356
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 1199
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200583935"
variation 1208
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150198888"
variation 1209
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200840068"
variation 1212
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201456101"
variation 1268
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201943285"
variation 1269
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200371583"
variation 1289
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:145745293"
variation 1309
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374243533"
exon 1357..2276
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 1403
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371548901"
variation 1432
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374987145"
variation 1459
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201483159"
variation 1474
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200595071"
variation 1499
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368146619"
variation 1512
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371258341"
variation 1563
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140616865"
variation 1584
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370736888"
variation 1645
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373211004"
variation 1650
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367828699"
variation 1671
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144728856"
variation 1672
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61748667"
variation 1675
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141837650"
variation 1698
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371312281"
variation 1714
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:143619694"
variation 1737
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:374721883"
variation 1738
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201600532"
variation 1740
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375007264"
variation 1747
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369402265"
variation 1768
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200878487"
variation 1828
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:377072679"
variation 1860
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201074555"
variation 1871
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141614391"
variation 1875
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150513567"
variation 1879
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375599053"
variation 1894
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368271377"
STS 1904..2169
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="PMC355833P3"
/db_xref="UniSTS:273255"
variation 1919
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140357085"
variation 1936
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202233466"
variation 2004
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142752989"
variation 2064
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370705859"
variation 2073
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374368025"
variation 2074
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147508242"
variation 2098
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140120540"
variation 2106
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:368025276"
variation 2109
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200132284"
variation 2123
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190199205"
variation 2130
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150056192"
variation 2141
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:145392420"
variation 2179
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201052251"
variation 2200
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199702896"
variation 2260
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148802108"
variation 2276
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200138929"
exon 2277..2458
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 2309
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:142253225"
variation 2338
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146788699"
variation 2406
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140610274"
exon 2459..4738
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/inference="alignment:Splign:1.39.8"
variation 2460
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201429571"
variation 2487
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3734553"
variation 2510
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:369155845"
variation 2524
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145731932"
variation 2537
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146720688"
variation 2545
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140354477"
variation 2552
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373799889"
variation 2583
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:199673474"
variation 2601
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150355046"
variation 2616
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201238112"
variation 2624
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138068339"
variation 2643
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:377038705"
variation 2652
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368859219"
variation 2658
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369621216"
variation 2665
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:5029956"
variation 2666
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:5029957"
variation 2734
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143002189"
variation 2763
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373379580"
variation 2823
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:146085256"
variation 2844
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:140042278"
STS 2863..2957
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="D6S1833"
/db_xref="UniSTS:51875"
variation 2895
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143551019"
variation 3071
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:146885399"
variation 3128
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77191406"
variation 3153
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:76710415"
variation 3240
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373372607"
STS 3255..4129
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="TNFAIP3_431"
/db_xref="UniSTS:277825"
variation 3385
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:73778206"
variation 3576
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="t"
/db_xref="dbSNP:5029966"
STS 3577..3819
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="G10608"
/db_xref="UniSTS:79322"
variation 3589
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:182842072"
variation 3599
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148995655"
variation 3642
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:187746434"
variation 3675
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:191520762"
variation 3708
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:184063064"
variation 3733
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:113524093"
variation 3803
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:187253173"
STS 3823..3964
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="D6S1858"
/db_xref="UniSTS:42178"
STS 3823..3940
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="D6S2077"
/db_xref="UniSTS:56662"
variation 3823
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:5029967"
STS 3853..3971
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="SHGC-132182"
/db_xref="UniSTS:170697"
variation 3933
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370877177"
variation 3950
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:5029968"
variation 3974
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="c"
/db_xref="dbSNP:368124900"
polyA_signal 3988..3993
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
polyA_site 4017
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
variation 4029
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73566247"
variation 4061
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151101149"
variation 4143
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="g"
/db_xref="dbSNP:192024473"
variation 4173
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73778207"
variation 4193
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201356190"
STS 4258..4451
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="STS-M59465"
/db_xref="UniSTS:50983"
variation 4258
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="g"
/replace="t"
/db_xref="dbSNP:12661"
variation 4288
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145896014"
variation 4303..4304
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace=""
/replace="a"
/db_xref="dbSNP:71691390"
polyA_signal 4488..4493
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
polyA_site 4512
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
STS 4552..4713
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/standard_name="STS-R70479"
/db_xref="UniSTS:6382"
variation 4595
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73778208"
variation 4596
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:5029958"
variation 4629
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200016426"
variation 4690
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
/replace="c"
/replace="t"
/db_xref="dbSNP:60589019"
polyA_signal 4718..4723
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
polyA_site 4738
/gene="TNFAIP3"
/gene_synonym="A20; OTUD7C; TNFA1P2"
ORIGIN
ctttggaaagtcccgtggaaatccccgggcctacaacccgcatacaactgaaacggggcaaagcagactgcgcagtctgcagtcttcgtggcgggccaagcgagcttggagcccgcgggggcggagcggtgagagcggccgccaagagagatcacacccccagccgaccctgccagcgagcgagcccgaccccaggcgtccatggagcgtcgcctccgcccggtccctgccccgacccccgcctgcggcgcgctcctgccttgaccaggacttgggactttgcgaaaggatcgcggggcccggagaggtaaccgccgcgcctcccggagaggtaaccgccgcgcctcccggagaggtgttggagagcacaatggctgaacaagtccttcctcaggctttgtatttgagcaatatgcggaaagctgtgaagatacgggagagaactccagaagacatttttaaacctactaatgggatcattcatcattttaaaaccatgcaccgatacacactggaaatgttcagaacttgccagttttgtcctcagtttcgggagatcatccacaaagccctcatcgacagaaacatccaggccaccctggaaagccagaagaaactcaactggtgtcgagaagtccggaagcttgtggcgctgaaaacgaacggtgacggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttggtactgaggaaggcgctgttcagcacgctcaaggaaacagacacacgcaactttaaattccgctggcaactggagtctctcaaatctcaggaatttgttgaaacggggctttgctatgatactcggaactggaatgatgaatgggacaatcttatcaaaatggcttccacagacacacccatggcccgaagtggacttcagtacaactcactggaagaaatacacatatttgtcctttgcaacatcctcagaaggccaatcattgtcatttcagacaaaatgctaagaagtttggaatcaggttccaatttcgcccctttgaaagtgggtggaatttacttgcctctccactggcctgcccaggaatgctacagataccccattgttctcggctatgacagccatcattttgtacccttggtgaccctgaaggacagtgggcctgaaatccgagctgttccacttgttaacagagaccggggaagatttgaagacttaaaagttcactttttgacagatcctgaaaatgagatgaaggagaagctcttaaaagagtacttaatggtgatagaaatccccgtccaaggctgggaccatggcacaactcatctcatcaatgccgcaaagttggatgaagctaacttaccaaaagaaatcaatctggtagatgattactttgaacttgttcagcatgagtacaagaaatggcaggaaaacagcgagcaggggaggagagaggggcacgcccagaatcccatggaaccttccgtgccccagctttctctcatggatgtaaaatgtgaaacgcccaactgccccttcttcatgtctgtgaacacccagcctttatgccatgagtgctcagagaggcggcaaaagaatcaaaacaaactcccaaagctgaactccaagccgggccctgaggggctccctggcatggcgctcggggcctctcggggagaagcctatgagcccttggcgtggaaccctgaggagtccactggggggcctcattcggccccaccgacagcacccagcccttttctgttcagtgagaccactgccatgaagtgcaggagccccggctgccccttcacactgaatgtgcagcacaacggattttgtgaacgttgccacaacgcccggcaacttcacgccagccacgccccagaccacacaaggcacttggatcccgggaagtgccaagcctgcctccaggatgttaccaggacatttaatgggatctgcagtacttgcttcaaaaggactacagcagaggcctcctccagcctcagcaccagcctccctccttcctgtcaccagcgttccaagtcagatccctcgcggctcgtccggagcccctccccgcattcttgccacagagctggaaacgacgcccctgctggctgcctgtctcaagctgcacggactcctggggacaggacggggacgagcaagtgcagaaaagccggctgcgtgtattttgggactccagaaaacaagggcttttgcacactgtgtttcatcgagtacagagaaaacaaacattttgctgctgcctcagggaaagtcagtcccacagcgtccaggttccagaacaccattccgtgcctggggagggaatgcggcacccttggaagcaccatgtttgaaggatactgccagaagtgtttcattgaagctcagaatcagagatttcatgaggccaaaaggacagaagagcaactgagatcgagccagcgcagagatgtgcctcgaaccacacaaagcacctcaaggcccaagtgcgcccgggcctcctgcaagaacatcctggcctgccgcagcgaggagctctgcatggagtgtcagcatcccaaccagaggatgggccctggggcccaccggggtgagcctgcccccgaagacccccccaagcagcgttgccgggcccccgcctgtgatcattttggcaatgccaagtgcaacggctactgcaacgaatgctttcagttcaagcagatgtatggctaaccggaaacaggtgggtcacctcctgcaagaagtggggcctcgagctgtcagtcatcatggtgctatcctctgaacccctcagctgccactgcaacagtgggcttaagggtgtctgagcaggagaggaaagataagctcttcgtggtgcccacgatgctcaggtttggtaacccgggagtgttcccaggtggccttagaaagcaaagcttgtaactggcaagggatgatgtcagattcagcccaaggttcctcctctcctaccaagcaggaggccaggaacttctttggacttggaaggtgtgcggggactggccgaggcccctgcaccctgcgcatcaggactgcttcatcgtcttggctgagaaagggaaaagacacacaagtcgcgtgggttggagaagccagagccattccacctcccctcccccagcatctctcagagatgtgaagccagatcctcatggcagcgaggccctctgcaagaagctcaaggaagctcagggaaaatggacgtattcagagagtgtttgtagttcatggtttttccctacctgcccggttcctttcctgaggacccggcagaaatgcagaaccatccatggactgtgattctgaggctgctgagactgaacatgttcacattgacagaaaaacaagctgctctttataatatgcaccttttaaaaaattagaatattttactgggaagacgtgtaactctttgggttattactgtctttacttctaaagaagttagcttgaactgaggagtaaaagtgtgtacatatataatatacccttacattatgtatgagggatttttttaaattatattgaaatgctgccctagaagtacaataggaaggctaaataataataacctgttttctggttgttgttggggcatgagcttgtgtatacactgcttgcataaactcaaccagctgcctttttaaagggagctctagtcctttttgtgtaattcactttatttattttattacaaacttcaagattatttaagtgaagatatttcttcagctctggggaaaatgccacagtgttctcctgagagaacatccttgctttgagtcaggctgtgggcaagttcctgaccacagggagtaaattggcctctttgatacacttttgcttgcctccccaggaaagaaggaattgcatccaaggtatacatacatattcatcgatgtttcgtgcttctccttatgaaactccagctatgtaataaaaaactatactctgtgttctgttaatgcctctgagtgtcctacctccttggagatgagatagggaaggagcagggatgagactggcaatggtcacagggaaagatgtggccttttgtgatggttttattttctgttaacactgtgtcctgggggggctgggaagtcccctgcatcccatggtaccctggtattgggacagcaaaagccagtaaccatgagtatgaggaaatctctttctgttgctggcttacagtttctctgtgtgctttgtggttgctgtcatatttgctctagaagaaaaaaaaaaaaggaggggaaatgcattttccccagagataaaggctgccattttgggggtctgtacttatggcctgaaaatatttgtgatccataactctacacagcctttactcatactattaggcacactttccccttagagccccctaagtttttcccagacgaatctttataatttctttccaaagataccaaataaacttcagtgttttcatctaattctcttaaagttgatatcttaatattttgtgttgatcattatttccattcttaatgtgaaaaaaagtaattatttatacttattataaaaagtatttgaaatttgcacatttaattgtccctaatagaaagccacctattctttgttggatttcttcaagtttttctaaataaatgtaacttttcacaagagtcaacattaaaaaataaattatttaagaacagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7128 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
GeneID:7128 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:7128 -> Molecular function: GO:0004221 [ubiquitin thiolesterase activity] evidence: IMP
GeneID:7128 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:7128 -> Molecular function: GO:0004843 [ubiquitin-specific protease activity] evidence: IDA
GeneID:7128 -> Molecular function: GO:0004843 [ubiquitin-specific protease activity] evidence: TAS
GeneID:7128 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7128 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7128 -> Molecular function: GO:0019900 [kinase binding] evidence: IEA
GeneID:7128 -> Molecular function: GO:0043130 [ubiquitin binding] evidence: IPI
GeneID:7128 -> Molecular function: GO:0043621 [protein self-association] evidence: IDA
GeneID:7128 -> Biological process: GO:0001922 [B-1 B cell homeostasis] evidence: ISS
GeneID:7128 -> Biological process: GO:0002237 [response to molecule of bacterial origin] evidence: IDA
GeneID:7128 -> Biological process: GO:0002634 [regulation of germinal center formation] evidence: ISS
GeneID:7128 -> Biological process: GO:0002677 [negative regulation of chronic inflammatory response] evidence: IEA
GeneID:7128 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:7128 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7128 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:7128 -> Biological process: GO:0016579 [protein deubiquitination] evidence: TAS
GeneID:7128 -> Biological process: GO:0031397 [negative regulation of protein ubiquitination] evidence: IDA
GeneID:7128 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:7128 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
GeneID:7128 -> Biological process: GO:0032495 [response to muramyl dipeptide] evidence: IEA
GeneID:7128 -> Biological process: GO:0032691 [negative regulation of interleukin-1 beta production] evidence: IEA
GeneID:7128 -> Biological process: GO:0032703 [negative regulation of interleukin-2 production] evidence: IMP
GeneID:7128 -> Biological process: GO:0032715 [negative regulation of interleukin-6 production] evidence: ISS
GeneID:7128 -> Biological process: GO:0032720 [negative regulation of tumor necrosis factor production] evidence: ISS
GeneID:7128 -> Biological process: GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] evidence: NAS
GeneID:7128 -> Biological process: GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway] evidence: IDA
GeneID:7128 -> Biological process: GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] evidence: NAS
GeneID:7128 -> Biological process: GO:0034148 [negative regulation of toll-like receptor 5 signaling pathway] evidence: IEA
GeneID:7128 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
GeneID:7128 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: NAS
GeneID:7128 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA
GeneID:7128 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:7128 -> Biological process: GO:0045732 [positive regulation of protein catabolic process] evidence: IDA
GeneID:7128 -> Biological process: GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
GeneID:7128 -> Biological process: GO:0045779 [negative regulation of bone resorption] evidence: NAS
GeneID:7128 -> Biological process: GO:0045824 [negative regulation of innate immune response] evidence: ISS
GeneID:7128 -> Biological process: GO:0048662 [negative regulation of smooth muscle cell proliferation] evidence: IDA
GeneID:7128 -> Biological process: GO:0050691 [regulation of defense response to virus by host] evidence: NAS
GeneID:7128 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: ISS
GeneID:7128 -> Biological process: GO:0050869 [negative regulation of B cell activation] evidence: ISS
GeneID:7128 -> Biological process: GO:0051259 [protein oligomerization] evidence: NAS
GeneID:7128 -> Biological process: GO:0061043 [regulation of vascular wound healing] evidence: NAS
GeneID:7128 -> Biological process: GO:0070301 [cellular response to hydrogen peroxide] evidence: ISS
GeneID:7128 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
GeneID:7128 -> Biological process: GO:0070429 [negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway] evidence: IEA
GeneID:7128 -> Biological process: GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] evidence: IEA
GeneID:7128 -> Biological process: GO:0070536 [protein K63-linked deubiquitination] evidence: IDA
GeneID:7128 -> Biological process: GO:0070936 [protein K48-linked ubiquitination] evidence: IDA
GeneID:7128 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: IDA
GeneID:7128 -> Biological process: GO:0072573 [tolerance induction to lipopolysaccharide] evidence: IMP
GeneID:7128 -> Biological process: GO:0090291 [negative regulation of osteoclast proliferation] evidence: NAS
GeneID:7128 -> Biological process: GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] evidence: IDA
GeneID:7128 -> Biological process: GO:2000347 [positive regulation of hepatocyte proliferation] evidence: IEA
GeneID:7128 -> Biological process: GO:2000349 [negative regulation of CD40 signaling pathway] evidence: IMP
GeneID:7128 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: IDA
GeneID:7128 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7128 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7128 -> Cellular component: GO:0005764 [lysosome] evidence: IEA
GeneID:7128 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:7128 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001257437 -> EC 3.4.19.12
by
@meso_cacase at
DBCLS
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