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2024-03-29 14:07:08, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001270482            4035 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 11 (PSMD11), transcript variant 1, mRNA.
ACCESSION   NM_001270482
VERSION     NM_001270482.1  GI:394953907
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Vilchez,D., Boyer,L., Morantte,I., Lutz,M., Merkwirth,C., Joyce,D.,
            Spencer,B., Page,L., Masliah,E., Berggren,W.T., Gage,F.H. and
            Dillin,A.
  TITLE     Increased proteasome activity in human embryonic stem cells is
            regulated by PSMD11
  JOURNAL   Nature 489 (7415), 304-308 (2012)
   PUBMED   22972301
  REMARK    GeneRIF: human embryonic stem cells (hESCs) exhibit high proteasome
            activity that is correlated with increased levels of the 19S
            proteasome subunit PSMD11 (known as RPN-6 in Caenorhabditis
            elegans) and a corresponding increased assembly of the 26S/30S
            proteasome
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Moreno,D., Viana,R. and Sanz,P.
  TITLE     Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the
            proteasome, as a novel interaction partner of AMP-activated protein
            kinase
  JOURNAL   Int. J. Biochem. Cell Biol. 41 (12), 2431-2439 (2009)
   PUBMED   19616115
  REMARK    GeneRIF: AMP-activated protein kinase is able to interact
            physically with this subunit and modify its phosphorylation status.
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
            Lebendiker,M. and Brandeis,M.
  TITLE     Mammalian Cdh1/Fzr mediates its own degradation
  JOURNAL   EMBO J. 23 (7), 1619-1626 (2004)
   PUBMED   15029244
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Conticello,S.G., Harris,R.S. and Neuberger,M.S.
  TITLE     The Vif protein of HIV triggers degradation of the human
            antiretroviral DNA deaminase APOBEC3G
  JOURNAL   Curr. Biol. 13 (22), 2009-2013 (2003)
   PUBMED   14614829
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J. Virol. 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Saito,A., Watanabe,T.K., Shimada,Y., Fujiwara,T., Slaughter,C.A.,
            DeMartino,G.N., Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of p44.5 and p55, two
            regulatory subunits of the 26S proteasome
  JOURNAL   Gene 203 (2), 241-250 (1997)
   PUBMED   9426256
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 4035)
  AUTHORS   Hoffman,L. and Rechsteiner,M.
  TITLE     Molecular cloning and expression of subunit 9 of the 26S proteasome
  JOURNAL   FEBS Lett. 404 (2-3), 179-184 (1997)
   PUBMED   9119060
REFERENCE   9  (bases 1 to 4035)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu. Rev. Biochem. 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 4035)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur. J. Biochem. 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP246240.1, AK290602.1,
            AC079336.5 and BQ006240.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a member of the proteasome subunit S9 family that
            functions as a non-ATPase subunit of the 19S regulator and is
            phosphorylated by AMP-activated protein kinase. Alternatively
            spliced transcript variants have been observed for this gene.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290602.1, BX334992.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BP246240.1         4-14
            12-1349             AK290602.1         1-1338
            1350-3364           AC079336.5         58676-60690
            3365-4035           BQ006240.1         1-671               c
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4035
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 11"
                     /db_xref="GeneID:5717"
                     /db_xref="HGNC:9556"
                     /db_xref="MIM:604449"
     exon            1..152
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       32
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368428306"
     CDS             62..1330
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="26S proteasome regulatory subunit 9; 26S proteasome
                     regulatory subunit S9; 26S proteasome regulatory subunit
                     p44.5; 26S proteasome regulatory subunit RPN6"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 11"
                     /protein_id="NP_001257411.1"
                     /db_xref="GI:394953908"
                     /db_xref="CCDS:CCDS11272.1"
                     /db_xref="GeneID:5717"
                     /db_xref="HGNC:9556"
                     /db_xref="MIM:604449"
                     /translation="
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
"
     misc_feature    65..67
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (O00231.3); acetylation site"
     misc_feature    101..103
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O00231.3); phosphorylation site"
     misc_feature    110..1324
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="26S proteasome regulatory complex component
                     [Posttranslational modification, protein turnover,
                     chaperones]; Region: RPN6; COG5159"
                     /db_xref="CDD:227488"
     misc_feature    920..1222
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="PCI domain; Region: PCI; pfam01399"
                     /db_xref="CDD:216479"
     variation       65..66
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:369131607"
     variation       76
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143871497"
     variation       106
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201788002"
     variation       109
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372127595"
     variation       111
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140202481"
     variation       120
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201397972"
     exon            153..254
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     exon            255..379
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       373
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373669061"
     exon            380..451
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       382
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143910284"
     variation       397
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146863808"
     variation       403
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140675261"
     variation       444
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377580898"
     exon            452..509
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       480
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142904428"
     exon            510..704
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       524
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200794922"
     variation       586
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151071670"
     variation       664
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192755593"
     variation       667
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34078182"
     variation       703
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150206106"
     exon            705..849
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       745
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35385209"
     variation       787
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141504283"
     variation       807
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376594311"
     variation       844
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146169141"
     exon            850..910
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       850
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138901273"
     variation       894
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199698435"
     exon            911..973
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       946
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34248115"
     exon            974..1099
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       988
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143543056"
     variation       1001
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148020019"
     variation       1027
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1803016"
     variation       1069
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201382857"
     variation       1071
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201116985"
     variation       1076
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376327399"
     variation       1080
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1803015"
     exon            1100..1135
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     exon            1136..1187
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       1138
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368347176"
     variation       1141
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200240721"
     variation       1168
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150525156"
     exon            1188..4018
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:1.39.8"
     variation       1225
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35729014"
     variation       1309
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78876518"
     variation       1330
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139814136"
     variation       1352
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148367648"
     variation       1378
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141587003"
     variation       1379
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150291345"
     variation       1488
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11539943"
     STS             1497..1616
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /standard_name="RH15931"
                     /db_xref="UniSTS:83710"
     variation       1535
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1801562"
     variation       1541
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11539944"
     variation       1671
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3209620"
     variation       1677
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1140706"
     variation       1681..1682
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:71859580"
     polyA_signal    1699..1704
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     variation       1704
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181680701"
     polyA_site      1723
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     variation       1761
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187088367"
     variation       1819..1821
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="ctc"
                     /db_xref="dbSNP:201362675"
     variation       1970
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191071137"
     variation       1980
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181305779"
     variation       2081
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185127088"
     variation       2205
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34280753"
     STS             2249..2495
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /standard_name="RH80424"
                     /db_xref="UniSTS:90263"
     variation       2295
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377368114"
     variation       2396
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11539942"
     variation       2510
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:71790599"
     variation       2519
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:9912777"
     variation       2550
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137942070"
     variation       2588
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143515603"
     variation       2764
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189830516"
     variation       2831
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73984544"
     polyA_signal    2832..2837
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     polyA_site      2856
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     variation       2988
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147178851"
     polyA_signal    3051..3056
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     variation       3062
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:11290468"
     variation       3073
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74917045"
     variation       3074..3075
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:139282160"
     variation       3075
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60871066"
     variation       3076
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:60979290"
     polyA_site      3079
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     variation       3136
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4523973"
     variation       3419
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72813041"
     variation       3441
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182443694"
     variation       3522
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188705695"
     variation       3582
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:140406244"
     variation       3660
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368795628"
     variation       3748
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:5819984"
     variation       3754
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371299240"
     variation       3768
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192408991"
     variation       3819
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142784276"
     STS             3852..3994
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /standard_name="WI-16331"
                     /db_xref="UniSTS:60493"
     variation       3876
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373431056"
     variation       3923..3927
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /replace=""
                     /replace="aaaag"
                     /db_xref="dbSNP:370748285"
     polyA_signal    3995..4000
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     polyA_site      4018
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
ORIGIN      
tttccgggtgtgtgtttccggcgtcggcggccgcggccggggacggtgtgagagcggtaagatggcggcggcggcggtggtggagttccagagagcccagtctctactcagcaccgaccgggaggcctccatcgacatcctccactccatcgtgaagcgtgacattcaggaaaacgatgaagaggcagtgcaagtcaaagagcagagcatcctggaactgggatctctcctggcaaagactggacaagctgcagagcttggaggactcctgaagtatgtacgacccttcttgaattccatcagcaaggctaaagcagctcgcctggtccgatctcttcttgatctgtttcttgatatggaagcagctacagggcaggaggtcgagctgtgtttagagtgcatcgaatgggccaagtcagagaaaagaactttcttacgccaagctttggaggcaagactggtgtctttgtactttgataccaagaggtaccaggaagcattgcatttgggttctcagctgctgcgggagttgaaaaagatggacgacaaagctcttttggtggaagtacagcttttagaaagcaaaacataccatgccctgagcaacctgccgaaagcccgagctgccttaacttctgctcgaaccacagcaaatgccatctactgcccccctaaattgcaggccaccttggacatgcagtcgggtattatccatgcagcagaagagaaggactggaaaactgcgtactcatacttctatgaggcatttgagggttatgactccatcgacagccccaaggccatcacatctctgaagtacatgttgctgtgcaaaatcatgctcaacaccccagaagatgtccaggctttggtgagcgggaagcttgcacttcggtatgcagggaggcagacagaagcattaaaatgcgtggctcaggctagcaagaacagatcactggcagattttgaaaaggctctgacagattaccgggcagagctccgggatgacccaatcatcagcacacacttggccaagttgtatgataacttactagaacagaatctgatccgagtcattgagcctttttccagagtacagattgaacacatatctagtctcatcaaactctccaaggccgacgtggaaaggaaattatcacagatgattcttgacaagaaatttcatgggattttggaccagggggagggtgtcctgattattttcgatgaacccccagtagataaaacttacgaagctgctctggaaacaattcagaacatgagcaaagtagtggattccctctacaacaaagccaagaaactgacataggtgagtgctggcttcaggaccccagggctgggcagctctgtcttctgcgtgtcgagactgaaaacctcctcctggtgtcctcatggcttcctgattgacactgctctgtcttctcttgcagagttggatctgtagcggtcctttggagagtgtgtgtggcgggagagtgaaaccttgggggaaaatgctaggagattcttttttctttttgttctacttttcgctcggaaagtttttaaatcctcatttggtgcatctgtattccagccaataggtgtgccagttttcatgtaatctttactggcccaacttgggagtggggaaattgcttaaaaaaaaagaaaaagaaaaaaaaaaagattattctaaataaaaggaaaaaggcttacactacctaaagctgtgctctctgcctcctgggagagggccgcaaagccaggcaccccgccaaccactgggggtcctaatccacctgctgggcatcacctctcctcctcctcagaattgggtgtttgctgaccatcaaaagcaatgactttttattctgtttgtactgaaccaaaacaaacaactgtgtatagactgctgttttcttttttatttgaaatgaggcattttggtgttctttcccctaccatacggcctgtctgcccttccctccccacattggctccagcagagtagccgaaggtcctgccgccgccgccaccaccaccaccactgcagcaacaacagcagcagcagcagcagcgcctgcatagctccactctgacctgtgaaggaatggggatgaggccaggagctagtgtctaccacggccacacagggagcagtgtgggcccttagcccccaaggggcctgctatgcatgtggctttttttttttttttaaacacagtaaactagattagtcgtcagtgttttaattgcccctcttctcctctcctgcattcctctcctctcttctttcctctctgtcccttctctttcccctctcaaccaggagaccatcatgtctctctgccttcctcctctcccctccaggggagtcaggctgtctgtgaaagccatgagcttctctccctctcccactcctcctctcctactttcagatggatttattccttttttaaacaatgaacatcggaaatgagactgtggggtgtggtttctctctctcttttttttttaattttctttgttgggtttttgagcaacctcatgtccccttcccagggagctttttaatttacctcttagaactcaagtggatgggaagtagagcactatgtgtcagtatgctttgttttctgacacgattacacagcgaggctttaatgccatttgggtaggtgagcttctgcacttctgttgtgctgaactgtattttcttctctcatctcctctttgtctttttctcttttcctctccttcctgccttcttctgctggcctccttttctctttctttaccttccttggattatccttccaggttttcataataaatttatattttgtaaaaggattttgttgtaccaggttttgcatcctcactgaatctgactggcttttattttcctctccaaaatcaggtttttgttctcaacatctttccccatcatgtctagtcactgttttggttttggcaccatcagtatcaaatgtacaaacggttcttgctaaccaacaccaggtatatctgatgttcagatgagttccaataaaaataatttttttttttttcaaaaggtgtctttttcttgagtgctggagggcttccaagcaagtccagacagctctgtgtggccccacactagtctagctctcatctggccaaagctgttatctcatttgtgtaatgggagtccttaaggtaaatttggggtccaaacttggagggctttgggggcaagaaagttggtgtgtgagttctgaggttggaaatgagttcaggtgtcttcttccagggcagcatggtccagtgagcacatgtaagtttgggcagtagatcctctgagcctactttctcttctactcagtgaggatgctgcttccttggcaggtgattgtgatgtgaagcttagtaagtcatagacgtgcaggtgtctggagagtcctgacatgcagttgtggtttcgtttccttttggaatcttcaaaggcagcgattttcatattgcctcacaccctggcgggggcggggggctctgggaccactgggggacctgctaaatcctcttcagtctgagcagttcagccattgtcagttttagtattgtgtctctgtatttcacttgcagaaagagctttgcttctataaaggactttaaaaagtactccaaagagatctagttttggagtagaggggagatgttttctcaaacttagggcagtcctgagatgctcaggcagtagcccttttctcagttccctttgcgggtcttggtcagatgatgccctctagacccgtgctgtccaatatgtagccgctagccatgtgcagctgtcaggcccttgcaacgtggctggttcgagctgtgatacactgcaagtgtaaacacaaaccagacttcgaaggcttagtatgataacaaaagaaaaggagtgtaaaatatgtcaataacttttttatatatgtgttgaaatattttgggtattgggttaaataaaatatattattaaaattcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5717 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5717 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5717 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5717 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5717 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5717 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: IMP
            GeneID:5717 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5717 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5717 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5717 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0043248 [proteasome assembly] evidence: IMP
            GeneID:5717 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5717 -> Biological process: GO:0048863 [stem cell differentiation] evidence: IMP
            GeneID:5717 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5717 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5717 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5717 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5717 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5717 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5717 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: IDA

by @meso_cacase at DBCLS
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