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2024-03-29 01:50:01, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001270427            3375 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 5 (PSMD5), transcript variant 2, mRNA.
ACCESSION   NM_001270427
VERSION     NM_001270427.1  GI:394025671
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Shim,S.M., Lee,W.J., Kim,Y., Chang,J.W., Song,S. and Jung,Y.K.
  TITLE     Role of S5b/PSMD5 in proteasome inhibition caused by
            TNF-alpha/NFkappaB in higher eukaryotes
  JOURNAL   Cell Rep 2 (3), 603-615 (2012)
   PUBMED   22921402
  REMARK    GeneRIF: the critical role of S5b/PSMD5 in negative regulation of
            proteasome by TNF-alpha/NFkappaB and provide insights into
            proteasome inhibition in human disease.
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Roelofs,J., Park,S., Haas,W., Tian,G., McAllister,F.E., Huo,Y.,
            Lee,B.H., Zhang,F., Shi,Y., Gygi,S.P. and Finley,D.
  TITLE     Chaperone-mediated pathway of proteasome regulatory particle
            assembly
  JOURNAL   Nature 459 (7248), 861-865 (2009)
   PUBMED   19412159
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Kaneko,T., Hamazaki,J., Iemura,S., Sasaki,K., Furuyama,K.,
            Natsume,T., Tanaka,K. and Murata,S.
  TITLE     Assembly pathway of the Mammalian proteasome base subcomplex is
            mediated by multiple specific chaperones
  JOURNAL   Cell 137 (5), 914-925 (2009)
   PUBMED   19490896
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm. Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
            Lebendiker,M. and Brandeis,M.
  TITLE     Mammalian Cdh1/Fzr mediates its own degradation
  JOURNAL   EMBO J. 23 (7), 1619-1626 (2004)
   PUBMED   15029244
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu. Rev. Biochem. 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Deveraux,Q., Jensen,C. and Rechsteiner,M.
  TITLE     Molecular cloning and expression of a 26 S protease subunit
            enriched in dileucine repeats
  JOURNAL   J. Biol. Chem. 270 (40), 23726-23729 (1995)
   PUBMED   7559544
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Deveraux,Q., Ustrell,V., Pickart,C. and Rechsteiner,M.
  TITLE     A 26 S protease subunit that binds ubiquitin conjugates
  JOURNAL   J. Biol. Chem. 269 (10), 7059-7061 (1994)
   PUBMED   8125911
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur. J. Biochem. 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023459.1, AK303007.1,
            D31889.1 and BC014478.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a non-ATPase subunit of the 19S regulator base that
            functions as a chaperone protein during 26S proteasome assembly.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303007.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                HY023459.1         2-71
            71-1164             AK303007.1         1-1094
            1165-3304           D31889.1           1181-3320
            3305-3375           BC014478.1         3325-3395
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..3375
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 5"
                     /db_xref="GeneID:5711"
                     /db_xref="HGNC:9563"
                     /db_xref="MIM:604452"
     exon            1..285
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    11..13
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="upstream in-frame stop codon"
     CDS             113..1498
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="isoform 2 is encoded by transcript variant 2; 26S
                     protease subunit S5 basic; 26S proteasome subunit S5B; 26S
                     proteasome non-ATPase regulatory subunit 5"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 5
                     isoform 2"
                     /protein_id="NP_001257356.1"
                     /db_xref="GI:394025672"
                     /db_xref="CCDS:CCDS59143.1"
                     /db_xref="GeneID:5711"
                     /db_xref="HGNC:9563"
                     /db_xref="MIM:604452"
                     /translation="
MAAQALALLREVARLEAPLEELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKALIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSNVEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPVSTTAVEGAE
"
     misc_feature    188..1495
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="Proteasome non-ATPase 26S subunit; Region:
                     Proteasom_PSMB; pfam10508"
                     /db_xref="CDD:192608"
     exon            286..430
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            431..544
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            545..654
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            655..797
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            798..989
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            990..1099
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1100..1240
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     variation       1165
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060817"
     exon            1241..3351
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:1.39.8"
     STS             1575..1792
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /standard_name="SHGC-31585"
                     /db_xref="UniSTS:6895"
     STS             1595..1727
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /standard_name="STS-D31889"
                     /db_xref="UniSTS:29367"
     STS             2402..2582
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /standard_name="RH25302"
                     /db_xref="UniSTS:19105"
     STS             2402..2582
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /standard_name="RH35526"
                     /db_xref="UniSTS:85782"
     variation       2718
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6602"
     variation       2949
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10384"
     polyA_signal    3032..3037
                     /gene="PSMD5"
                     /gene_synonym="S5B"
     polyA_site      3051
                     /gene="PSMD5"
                     /gene_synonym="S5B"
     polyA_signal    3312..3317
                     /gene="PSMD5"
                     /gene_synonym="S5B"
     polyA_site      3351
                     /gene="PSMD5"
                     /gene_synonym="S5B"
ORIGIN      
ggcagccccatagccatctcagggacaaggaggctgtgatcagatctcgcgaggttcaggaaagcgccccgggaactgggccgctgggccagcccctgcgtcggggggcaagatggcagcccaggctttggcgctgctgagagaggtagcgaggctggaagcgccgctggaggagctacgcgcgcttcactccgtgctgcaggcagtgccgctcaacgagcttcgccagcaagcggcggagctgcgcctcggcccgctcttctccctgcttaacgagaaccatagggaaaagactactttgtgtgtatccattctggagagattgctccaagctatggaaccggttcacgtggcccggaacctcagggttgacctgcagaggggactaattcaccctgatgattctgtaaaaatcctcactctttcccagattggaagaattgttgaaaattctgatgctgttactgagattctaaataatgctgaattactaaaacaaattgtttattgcattggtggagagaatctatctgtagcaaaagcgctaattatagagatttcttccgtgtcaccagaatctttaaactactgtaccacaagtggattggtaacccagctcctgagagagctgactggtgaggatgtgttggtcagagccacctgtatagaaatggtgacatcactggcatatactcatcatgggcgacaatatcttgctcaagaaggagtaattgaccaaatttctaatataattgttggggcagattcagaccctttctctagcttctatctgccaggattcgtgaagttttttggaaacctggctgtcatggatagtcctcaacagatctgtgagcgttatcctatctttgtggaaaaagtctttgaaatgatagaaagtcaggaccccactatgattggtgtagctgtagacacagttggaatcttgggatccaatgttgaaggaaaacaggttttacagaaaacaggaactcgctttgaacgcttgcttatgagaataggacatcaatcaaagaatgccccagtggagctaaaaattagatgtttggatgcaatttcatctcttctgtacttaccacctgagcagcagactgatgaccttctgaggatgacagaatcctggttttcttctttatctcgggatccactggagctcttccgtggcattagtagtcagcccttccctgaactacactgtgctgccttaaaagtgtttacggccattgcaaaccaaccctgggctcagaaacttatgtttaacagtccaggttttgtagaatatgtggtggaccggtctgtggagcatgacaaagcttcaaaggatgccaaatatgaactagtgaaagcacttgccaattccaagacaattgcagaaatctttgggaacccaaattatttgaggctcagaacttacctgagtgaagggccatactatgtgaaacctgtttccacgacagcagtagaaggagccgaatgatttcttctagagctcatgtagaggaccacgttttgaccaaaacttctcctaaggcatttgactccatctatatttcacaaaagagacttcctttccccaagaattatcatggaatgtcagatgttactttgttaccaacactgttatatttctacattgaaatgcaaagtggaactaggagtttggaatgcattaagagcagacaagcttggtcataatagatccagtgtttttcagattcctttcactgccttaatctttgcaacagggtggaagtttttttcttccctcaaaattttcatggacatgcaatcttatctaaaagcctgcttcagggctgggcgcggtggctaacacctataattcccagcactttgggaggccaagatgggcaaatcacttgagtctaggagttcaagaccagcctggccaatatggcaaaaccctgtctctactaaaaatataaaatcagccaggcatggtggcgcacacctataatctcagctactcaggaggctgaggcacgagaatcgcttgagcctgggaggcagaggttgcagtgagctgagatcttgccactgcacaccagcctgggcaacacagcaagactctgtctcaaaaataaatgaataaaataaaaacctgccaccaaattatttctggattctcttcactatctttttttttctttttggtcctttttccatttctgattccactttcaaagtcttggatatattctttgaaaaatgagtagtatggaatattaagattatgttccttatactcagaatactttttatgagctctcttgtttttttgttactattattcctttgaaaaaaagacaaaatatctaaaaaatgtttatagtgttcatgtaattttttttgctgtttaccaatgaactttgccctgttgtggttttgggggatcagaaggattcctaaactgtcatttcatttattggtaggtcatgattgctgagggttttgctttggatttttcatacctataaagtcaatcttgagttgatcagagaaagggaaacttactcctaataaacagactcagaacagaagggacatatgcataaatcaggataccatctcattaatttacaaaggataatctttcttttcattgacaacacctacacccacctgttttccagtgttcttctctctaaacagcaaagccaaagcactctgcacaccaaatcacctgttcagaggtttatgcatgagcatatttcttttaggccgtggtgaagttgataaaccacccctgctttgtaacaaaattattttaaagtgactggaattatctagtccccagattgatcatctcccctggcaacgtgactctgttttttgtgtgtgtttccatgctgactagtcccctactgttaatatcactactaattaggctataaccaggtctttcctggcctgagaaatattctcttaaaatgacctttgttttaatctcattcatgatgttgattttttttcaatgtggtgcaatatatacaataaaatttgtcataactattttaagtgtacagttcagtatattacatatgttcataagttgtacaaccatcaccaccatccatcttcagaattattttcatcttatacaattgaaactgtattcattaaacaataactgtctattccctcttttccccagcctctggcaaccaccattctgcttcatgacattgattttattcacttaacatcagattttggggggatgccctctctcctatgtatggtctacacattctgattttttttttagattgaataaaatttgtaaatcattattttcatttcataagtaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5711 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5711 -> Molecular function: GO:0044183 [protein binding involved in protein folding] evidence: IEA
            GeneID:5711 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5711 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5711 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5711 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5711 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5711 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5711 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5711 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5711 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5711 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5711 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5711 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5711 -> Biological process: GO:0070682 [proteasome regulatory particle assembly] evidence: TAS
            GeneID:5711 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5711 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5711 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5711 -> Cellular component: GO:0008540 [proteasome regulatory particle, base subcomplex] evidence: IDA
            GeneID:5711 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS

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