GGRNA Home | Help | Advanced search

2019-03-23 03:53:52, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001267586            3293 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens F-box and WD repeat domain containing 10 (FBXW10),
            transcript variant 2, mRNA.
ACCESSION   NM_001267586
VERSION     NM_001267586.1  GI:389885063
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Chaturvedi,P. and Parnaik,V.K.
  TITLE     Lamin A rod domain mutants target heterochromatin protein 1alpha
            and beta for proteasomal degradation by activation of F-box
            protein, FBXW10
  JOURNAL   PLoS ONE 5 (5), E10620 (2010)
   PUBMED   20498703
  REMARK    GeneRIF: Mislocalized lamins can induce ubiquitin-mediated
            proteasomal degradation of certain HP1 isoforms by activation of
            FBXW10, a member of the F-box family of proteins that is involved
            in E3 ubiquitin ligase activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev. 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB055860.1, AL136822.1 and AC107982.6.
            
            Summary: Members of the F-box protein family, such as FBXW10, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136822.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DB055860.1         1-300
            301-937             AL136822.1         239-875
            938-938             AC107982.6         123912-123912       c
            939-1469            AL136822.1         877-1407
            1470-1470           AC107982.6         115359-115359       c
            1471-2533           AL136822.1         1409-2471
            2534-2534           AC107982.6         95069-95069         c
            2535-3293           AL136822.1         2473-3231
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3293
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="F-box and WD repeat domain containing 10"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:1211"
                     /db_xref="MIM:611679"
     exon            1..737
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371194302"
     variation       25
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367810251"
     misc_feature    71..73
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="upstream in-frame stop codon"
     variation       138
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150230158"
     variation       183
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369742505"
     variation       198
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186119518"
     variation       214
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116483657"
     CDS             233..3232
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     and WD-40 domain protein 10; F-box/WD repeat-containing
                     protein 10; ubiquitin ligase specificity factor"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 10 isoform 2"
                     /protein_id="NP_001254515.1"
                     /db_xref="GI:389885064"
                     /db_xref="CCDS:CCDS58524.1"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:1211"
                     /db_xref="MIM:611679"
                     /translation="
MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRLFSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCNIQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDADDVEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGLPIDNFTKQGKTAAPELGQNVFI
"
     misc_feature    <1463..2110
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="FOG: WD40 repeat [General function prediction
                     only]; Region: COG2319"
                     /db_xref="CDD:32473"
     misc_feature    1484..>2035
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:29257"
     misc_feature    order(1511..1513,1523..1525,1541..1546,1583..1588,
                     1640..1642,1652..1654,1670..1675,1709..1714,1757..1759,
                     1772..1774,1790..1795,1829..1831,1874..1876,1889..1891,
                     1907..1912,1946..1951,1997..1999,2009..2011,2027..2032)
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="structural tetrad; other site"
                     /db_xref="CDD:29257"
     variation       300
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:74502778"
     variation       312
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200553727"
     variation       326
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143662391"
     variation       338
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138647311"
     variation       397
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200806553"
     variation       441
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149323817"
     variation       464
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143573197"
     variation       477
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201935353"
     variation       500
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148027955"
     variation       536
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377476079"
     variation       575
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142528410"
     variation       640
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145973790"
     exon            738..902
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       742
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376114266"
     variation       753
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370476175"
     variation       854
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376241364"
     variation       880
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370045217"
     variation       891
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370320215"
     exon            903..1103
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       926
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375699839"
     variation       936
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374206318"
     variation       938
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9895749"
     variation       1003
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139842854"
     variation       1013
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200535885"
     variation       1056
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139431164"
     variation       1067
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368213609"
     exon            1104..1231
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1175
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372345142"
     variation       1184
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150057313"
     variation       1199
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145368701"
     variation       1207
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200034399"
     exon            1232..1354
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1264
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372134223"
     variation       1306
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376056941"
     variation       1307
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140944543"
     variation       1332
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371774794"
     variation       1333
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376006877"
     variation       1343
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149924362"
     variation       1346
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7209610"
     exon            1355..1464
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1364
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201169182"
     variation       1376
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147905984"
     variation       1387
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200851525"
     variation       1392
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144179290"
     variation       1395
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373122324"
     variation       1464
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142047019"
     exon            1465..1665
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1470
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200464103"
     variation       1478
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201657571"
     variation       1479
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376791823"
     variation       1527
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199572430"
     variation       1564
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373654877"
     variation       1587
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376635428"
     variation       1601
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370583951"
     variation       1642
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151034607"
     variation       1643
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140412541"
     variation       1649
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150381644"
     variation       1651
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138093156"
     exon            1666..1787
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1720
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376019829"
     exon            1788..1936
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1789
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144567782"
     variation       1814
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368003711"
     variation       1821
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142568223"
     variation       1828
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182760245"
     variation       1840
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144724584"
     variation       1889
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138625739"
     variation       1890
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141626132"
     variation       1904
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144460161"
     variation       1930
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368262323"
     variation       1931
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372082761"
     exon            1937..2079
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1943
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148396663"
     variation       2005
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149882032"
     variation       2016
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375390149"
     variation       2022
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150697158"
     variation       2033
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140982768"
     variation       2048
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147930073"
     variation       2051
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79757327"
     variation       2051
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144931466"
     exon            2080..2351
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2098
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368827263"
     variation       2128
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372149006"
     variation       2131
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138657360"
     variation       2140
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369517876"
     variation       2147
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78640521"
     variation       2157
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150329747"
     variation       2166
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:137965030"
     variation       2195
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372209815"
     variation       2206
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200658685"
     variation       2218..2221
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace=""
                     /replace="tctc"
                     /db_xref="dbSNP:377314029"
     variation       2293
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139177136"
     variation       2302
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149546887"
     variation       2319
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376804860"
     variation       2320
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147138981"
     exon            2352..2408
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2399
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372890959"
     variation       2400
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375352795"
     exon            2409..3283
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2418
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:236812"
     variation       2440
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377326035"
     variation       2451
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372843756"
     variation       2479
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:201275430"
     variation       2491
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202063654"
     variation       2504
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377068064"
     variation       2533
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370119394"
     variation       2534
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1026259"
     variation       2534
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77288131"
     variation       2550
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1026260"
     variation       2561
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373000642"
     variation       2573
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200062063"
     variation       2577
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201057327"
     variation       2678
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371149617"
     variation       2687
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143308813"
     variation       2689
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375662938"
     variation       2697
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:62070362"
     variation       2714
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147519900"
     variation       2715
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377642870"
     variation       2727
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140063499"
     variation       2728
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373925015"
     variation       2784
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1026261"
     variation       2784
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199779085"
     variation       2796
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142904621"
     variation       2798
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150642944"
     variation       2801
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:236813"
     variation       2812
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147350518"
     variation       2816
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139724959"
     variation       2823
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149783676"
     variation       2863
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146784395"
     variation       2890
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371467039"
     variation       2985
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143459755"
     variation       3020
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1318979"
     variation       3020
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147994056"
     variation       3030
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77817142"
     variation       3111
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373632534"
     variation       3126
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1024657"
     variation       3126
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117160613"
     variation       3253
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2014354"
     variation       3253
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28690836"
ORIGIN      
acggtaaagccatgtttccaaggaggtctgtacaaaaagccagacttctgctggcagttactgagagagataggctttccatccatggcagccatttacttttgctctgggagacgtttgtaatagaaaaggcacaactggggtatttattcattccccccgttcctctagtgtttggtggcgttgccgttgcaagtgcgcagggctaaaatggactggttatcttaggatcatggaaaacctggaatcaaggctcaagaatgccccctattttcgttgtgagaagggaaccgattccatccctctatgccggaagtgtgagacgtgtgtcttagcctggaagatcttctctaccaaagagtggttctgcaggatcaatgacatatcacagaggaggtttctagttggcattctgaagcagttaaatagcttatatttgttacactatttccaaaatatccttcagaccacacagggaaaggatttcatctataacaggtcccggatcaacctcagcaagaaagaggggaaagttgtgaagtcctccttgaaccaaatgttggataaaacagtagaacagaagatgaaagagatcttgtactggtttgcgaacagcacccagtggaccaaggcgaattatactctcttactgctgcagatgtgcaaccccaaattactgctcactgctgccaatgtgatcagagtcctgtttctgagagaggagaacaatatctcagggctcaatcaagacatcacagatgtgtgtttttcccctgagaaagaccacagctccaagtctgcgacctcacaagtctattggacagccaaaactcagcacacatcccttcctttgtccaaagccccagaaaatgaacacttgcttggggcagcatctaaccctgaggaaccatggaggaattcactccggtgtatatccgaaatgaataggctgttttctggaaaaggagacataaccaagccagggtacgatccctgcaatctattggttgacctggatgacatcagagacctgtcttctgggttcagcaaataccgagacttcatccgttacctgcccatccacctctccaagtacattctaagaatgctggatagacacaccctgaacaagtgcgcctctgtgagccagcactgggccgccatggctcaacaggtcaagatggacttgtcagcgcacggcttcattcagaaccagattaccttcttgcaggggtcctacacaagaggaattgatcctaattatgccaataaggtttctatcccagttcctaaaatggtagatgacgggaagagcatgcgtgtgaaacatccgaagtggaagctgagaacgaagaatgagtacaacctgtggactgcataccagaacgaggaaacgcagcaggtcctgatagaggagagaaatgttttctgtgggacctacaatgttcgcattctctctgacacgtgggatcaaaaccgagtcatccactattccgggggagatctgatagctgtgtcatctaatcgaaagatccatcttctggacatcatacaagtgaaagcgatacccgttgaattccgaggccatgctgggagtgtccgggccctcttcctgtgtgaggaggaaaactttctcctaagcgggagctatgacctaagtatcagatactgggatctgaaaagtggggtttgcacacgaatcttcggtggtcaccaggggactatcacttgcatggacttgtgtaagaacaggctcgtatctggaggaagagattgccaggtaaaagtatgggatgtagacacagggaagtgcctgaagacgtttagacacaaagaccccatcttggccaccaggatcaatgatacctacattgtgagcagctgtgagcgagggctggtgaaagtgtggcacattgccatggcccagttggtaaagactctcagtggccatgagggagccgtgaaatgcctgttctttgaccagtggcatctcctctcaggaagtactgatggcctggtcatggcctggagcatggtggggaagtacgagcgctgcctgatggccttcaagcatcccaagatggtggtcaacacagagagcaatgttctcatgttccagtttgagcacataaagtggcagtatgccgtggaaaaaacgaaacaaaagaagaataaggagaaagaggaggaaaaagaagaaaatagtctcatggaaattctctctaagtgtaatattcaggttcacagcccaagagagtctgtatccagtaaacaaactgtgatccaagagctcctaccaggcaaacctcccaagtcccgagtactcctgaagccggccaagttctcttcagcagtgttaatagaggaacttcaaagtcaaggaaagtcaaaatcaccccgaagagatgcagatgatgtggagaaagcacaaaaacaaggacaattggaaactcctggaaaactgcccagtcacccaaagaaaaagtcttggaaaatccctatgtcacctgaccaattcctcctgactgttagcgccctgcagcacgcccataattccggggaatttgcctatccctgtaggccccaaacagaaattactgatgtctggggaccttcaatttcatacccaaggaaggtcttgaatttcaaaggaaaatcaatccaacgtgcagttgatcggttgagattgagcaatcctcctatagatgtgaaacgaaccagtattccccttgaaatccagaaactgcagcccaacttgaagatctctttgcacagtcctagagtccagtccaccataccccagcccatgattatccgctccaggttctctggcagcttaaagggtggagaccaagtgaccagttcaattgaaagggctgtgtgcagtacgggtcccctgaccagtatgcaggtcattaaaccaaaccgcatgctagctccacaagtgggcacagccaccctgtctcttaagaaagaacggcctcgcatctatacagcccttgatccttttagagtgaacactgagttcgtgctgttgaccgtgaaggaggagaaggagcaccaggaagccaagatgaaggaatatcaggccagggagtccactggagtggttgatccaggaaaagtcagcaaagctgcatggatcaggaagatcaaaggcctgcctattgataatttcacgaagcaagggaaaacagcggcccctgaacttggacaaaatgtatttatctaaaccagccttgggaaattacaatgttttacaataaacagaaagccaagcggaaaaaaaaaaa
//

Annotations:



by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.