2024-04-24 14:39:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001267057 2638 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant f, mRNA. ACCESSION NM_001267057 VERSION NM_001267057.1 GI:388596699 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2638) AUTHORS Park,C., Han,S., Lee,K.M., Choi,J.Y., Song,N., Jeon,S., Park,S.K., Ahn,H.S., Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E. and Kang,D. TITLE Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia JOURNAL Hum. Immunol. 73 (7), 736-739 (2012) PUBMED 22548721 REMARK GeneRIF: genetic polynorphism is associated with the risk of childhood leukemia REFERENCE 2 (bases 1 to 2638) AUTHORS Nagano,T., Hashimoto,T., Nakashima,A., Kikkawa,U. and Kamada,S. TITLE X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7 JOURNAL FEBS Lett. 586 (11), 1612-1616 (2012) PUBMED 22584050 REMARK GeneRIF: XIAP does not function as a NEDD8-E3 ligase for caspase-7 in vivo REFERENCE 3 (bases 1 to 2638) AUTHORS Jin,Y., Birlea,S.A., Fain,P.R., Ferrara,T.M., Ben,S., Riccardi,S.L., Cole,J.B., Gowan,K., Holland,P.J., Bennett,D.C., Luiten,R.M., Wolkerstorfer,A., van der Veen,J.P., Hartmann,A., Eichner,S., Schuler,G., van Geel,N., Lambert,J., Kemp,E.H., Gawkrodger,D.J., Weetman,A.P., Taieb,A., Jouary,T., Ezzedine,K., Wallace,M.R., McCormack,W.T., Picardo,M., Leone,G., Overbeck,A., Silverberg,N.B. and Spritz,R.A. TITLE Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo JOURNAL Nat. Genet. 44 (6), 676-680 (2012) PUBMED 22561518 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 2638) AUTHORS Boucher,D., Blais,V. and Denault,J.B. TITLE Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (15), 5669-5674 (2012) PUBMED 22451931 REMARK GeneRIF: Cellular expression of caspase-7 lacking the critical lysine residues resulted in less-efficient PARP and p23 cleavage compared with cells expressing the wild-type peptidase. REFERENCE 5 (bases 1 to 2638) AUTHORS Riedl,S.J., Fuentes-Prior,P., Renatus,M., Kairies,N., Krapp,S., Huber,R., Salvesen,G.S. and Bode,W. TITLE Structural basis for the activation of human procaspase-7 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (26), 14790-14795 (2001) PUBMED 11752425 REFERENCE 6 (bases 1 to 2638) AUTHORS Tiso,N., Pallavicini,A., Muraro,T., Zimbello,R., Apolloni,E., Valle,G., Lanfranchi,G. and Danieli,G.A. TITLE Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis JOURNAL Biochem. Biophys. Res. Commun. 225 (3), 983-989 (1996) PUBMED 8780721 REFERENCE 7 (bases 1 to 2638) AUTHORS Lippke,J.A., Gu,Y., Sarnecki,C., Caron,P.R. and Su,M.S. TITLE Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32 JOURNAL J. Biol. Chem. 271 (4), 1825-1828 (1996) PUBMED 8567622 REFERENCE 8 (bases 1 to 2638) AUTHORS Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J., Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G. et al. TITLE Mch3, a novel human apoptotic cysteine protease highly related to CPP32 JOURNAL Cancer Res. 55 (24), 6045-6052 (1995) PUBMED 8521391 REFERENCE 9 (bases 1 to 2638) AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. TITLE CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994) PUBMED 7983002 REFERENCE 10 (bases 1 to 2638) AUTHORS Olson,R.E., Morello,J.A. and Kieff,E.D. TITLE Antibiotic treatment of oral anaerobic infections JOURNAL J Oral Surg 33 (8), 619-621 (1975) PUBMED 1056466 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U67206.1, AL627395.14, AK301437.1, BC015799.1, BM976488.1 and BQ006259.1. Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. Transcript Variant: This variant (f) lacks an internal exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant d. The encoded isoform (e) is longer and has a distinct N-terminus, compared to isoform delta. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025094 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-141 U67206.1 3-143 142-217 AL627395.14 7738-7813 218-321 AK301437.1 1-104 322-322 AL627395.14 25433-25433 323-612 AK301437.1 106-395 613-2062 BC015799.1 350-1799 2063-2618 BM976488.1 17-572 c 2619-2638 BQ006259.1 1-20 c FEATURES Location/Qualifiers source 1..2638 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q25" gene 1..2638 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="caspase 7, apoptosis-related cysteine peptidase" /db_xref="GeneID:840" /db_xref="HGNC:1508" /db_xref="MIM:601761" exon 1..310 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 17 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="" /replace="a" /db_xref="dbSNP:56204896" CDS 87..1253 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /EC_number="3.4.22.60" /note="isoform e is encoded by transcript variant f; caspase 7, apoptosis-related cysteine protease; ICE-like apoptotic protease 3; apoptotic protease MCH-3" /codon_start=1 /product="caspase-7 isoform e" /protein_id="NP_001253986.1" /db_xref="GI:388596700" /db_xref="GeneID:840" /db_xref="HGNC:1508" /db_xref="MIM:601761" /translation="
MRAGTRVALGSSTPAERTTPSQGRCKPRPALPRAAPPSAAPRLLVSLSLKGPQTLAAERRRETVPVPAALPPWERWQMIRAVLKSRGLRIQQMKIQWMLSQTGPRLYRPSSAPDSGTLYFTSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
" misc_feature 519..1244 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cd00032" /db_xref="CDD:28914" misc_feature order(600..602,774..776,891..893,912..914,1029..1046, 1056..1061) /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="substrate pocket [chemical binding]; other site" /db_xref="CDD:28914" misc_feature order(771..773,897..899) /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="active site" /db_xref="CDD:28914" misc_feature order(915..917,984..989,1008..1010,1017..1019,1026..1028, 1095..1097,1119..1121,1137..1139,1197..1199,1212..1217, 1221..1223,1230..1235) /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:28914" misc_feature order(918..920,981..983) /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /note="proteolytic cleavage site; other site" /db_xref="CDD:28914" variation 103 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:28411397" variation 142 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:7921977" variation 214..215 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="" /replace="tt" /db_xref="dbSNP:10553596" variation 262 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:140427264" exon 311..420 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 322 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="g" /replace="t" /db_xref="dbSNP:11555408" variation 345 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:147218371" variation 354 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="t" /db_xref="dbSNP:367975864" variation 392 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:372133111" variation 393 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:115389257" variation 411 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="c" /db_xref="dbSNP:372587822" exon 421..588 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 449 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:78946854" variation 478 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:148675407" variation 501 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:112348087" variation 509 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:141263741" variation 542 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:150759529" exon 589..717 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 597 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:115183028" variation 605 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:181777209" variation 623 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:199874997" variation 629 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:114786731" variation 635 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:143659216" variation 645 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:202060178" variation 646 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:146796754" variation 650 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:2229998" variation 677 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:144555540" variation 704 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="g" /replace="t" /db_xref="dbSNP:368309877" variation 707 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:115421189" variation 711 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="" /replace="a" /db_xref="dbSNP:72431166" exon 718..893 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 742 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:372396520" variation 764 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:374718188" variation 827 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:193124738" variation 832 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:369067741" variation 836 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:116709623" variation 842 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:143354631" variation 853 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:201040237" variation 875 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:75516871" variation 882 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:141266925" exon 894..1023 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 900 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:373690332" variation 901 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:376348175" variation 909 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:187106799" variation 929 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:370774542" variation 937 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:375409071" variation 938 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:146952079" variation 945 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:367682197" variation 970 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:370400085" variation 1009 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:116560793" variation 1015 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:200665202" variation 1021 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:137956734" exon 1024..2622 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /inference="alignment:Splign:1.39.8" variation 1034 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:1127684" variation 1041 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="c" /db_xref="dbSNP:200326742" variation 1052 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="c" /db_xref="dbSNP:112264603" variation 1082 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:191429899" variation 1106 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="g" /db_xref="dbSNP:2227310" variation 1121 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:2227309" variation 1131 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:116437863" variation 1141 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="c" /db_xref="dbSNP:61755278" variation 1169 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:373028643" variation 1181 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:377322540" variation 1189 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:373624501" variation 1208..1209 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="" /replace="c" /db_xref="dbSNP:35322299" variation 1208 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:61755279" variation 1248 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="c" /db_xref="dbSNP:78202169" variation 1250 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:61757658" variation 1287 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:143800552" variation 1311 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="" /replace="t" /db_xref="dbSNP:372361034" variation 1324 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:76579192" variation 1368 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:112631326" variation 1438 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:148146424" variation 1543 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:4353229" variation 1584 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:1127685" variation 1593 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:1127686" variation 1604 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="g" /replace="t" /db_xref="dbSNP:10787498" variation 1609 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:183912507" variation 1626 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:77191867" variation 1721 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:188652831" variation 1815 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:141018894" variation 1941 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:79838074" variation 2014 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:12247479" variation 2019 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:181350515" variation 2027 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:116185385" variation 2063 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:1127687" STS 2113..2210 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /standard_name="D10S1306E" /db_xref="UniSTS:151338" STS 2140..2375 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /standard_name="RH18047" /db_xref="UniSTS:8837" variation 2144 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:12247588" variation 2253 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:150326299" variation 2377 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="g" /replace="t" /db_xref="dbSNP:186832916" variation 2419 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="c" /replace="t" /db_xref="dbSNP:137932518" STS 2461..2610 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /standard_name="SHGC-33054" /db_xref="UniSTS:60686" variation 2563 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" /replace="a" /replace="g" /db_xref="dbSNP:190021522" polyA_signal 2591..2596 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" polyA_site 2618 /gene="CASP7" /gene_synonym="CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3" ORIGIN
cccgcgcgcgggctcaactttgtagagcgaggggccaacttggcagagcgcgcggccagctttgcagagagcgccctccagggactatgcgtgcggggacacgggtcgctttgggctcttccacccctgcggagcgcactaccccgagccaggggcggtgcaagccccgcccggccctacccagggcggctcctccctccgcagcgccgagacttttagtttcgctttcgctaaaggggccccagacccttgctgcggagcgacggagagagactgtgccagtcccagccgccctaccgccgtgggaacgatggcagatgatcagggctgtattgaagagcagggggttgaggattcagcaaatgaagattcagtggatgctaagccagaccggtcctcgtttgtaccgtccctcttcagcccctgactctggaactttatatttcaccagtaagaagaagaaaaatgtcaccatgcgatccatcaagaccacccgggaccgagtgcctacatatcagtacaacatgaattttgaaaagctgggcaaatgcatcataataaacaacaagaactttgataaagtgacaggtatgggcgttcgaaacggaacagacaaagatgccgaggcgctcttcaagtgcttccgaagcctgggttttgacgtgattgtctataatgactgctcttgtgccaagatgcaagatctgcttaaaaaagcttctgaagaggaccatacaaatgccgcctgcttcgcctgcatcctcttaagccatggagaagaaaatgtaatttatgggaaagatggtgtcacaccaataaaggatttgacagcccactttaggggggatagatgcaaaacccttttagagaaacccaaactcttcttcattcaggcttgccgagggaccgagcttgatgatggcatccaggccgactcggggcccatcaatgacacagatgctaatcctcgatacaagatcccagtggaagctgacttcctcttcgcctattccacggttccaggctattactcgtggaggagcccaggaagaggctcctggtttgtgcaagccctctgctccatcctggaggagcacggaaaagacctggaaatcatgcagatcctcaccagggtgaatgacagagttgccaggcactttgagtctcagtctgatgacccacacttccatgagaagaagcagatcccctgtgtggtctccatgctcaccaaggaactctacttcagtcaatagccatatcaggggtacattctagctgagaagcaatgggtcactcattaatgaatcacatttttttatgctcttgaaatattcagaaattctccaggattttaatttcaggaaaatgtattgattcaacagggaagaaactttctggtgctgtcttttgttctctgaattttcagagactttttttataatgttattcatttggtgactgtgtaactttctcttaagattaattttctctttgtatgtctgttaccttgttaatagacttaatacatgcaacagaagtgacttctggagaaagctcatggctgtgtccactgcaattggtggtaacagtggtagagtcatgtttgcacttggcaaaaagaatcccaatgtttgacaaaacacagccaaggggatatttactgctctttattgcagaatgtgggtattgagtgtgatttgaatgatttttcattggcttagggcagattttcatgcaaaagttctcatatgagttagaggagaaaaagcttaatgattctgatatgtatccatcaggatccagtctggaaaacagaaaccattctaggtgtttcaacagagggagtttaatacaggaaattgacttacatagatgataaaagagaagccaaacagcaagaagctgttaccacacccagggctatgaggataatgggaagaggtttggtttcctgtgtccagtagtgggatcatccagaggagctggaaccatggtgggggctgcctagtgggagttaggaccaccaatggattgtggaaaatggagccatgacaagaacaaagccactgactgagatggagtgagctgagacagataagagaataccttggtctcacctatcctgccctcacatcttccaccagcaccttactgcccaggcctatctggaagccacctcaccaaggaccttggaagagcaagggacagtgaggcaggagaagaacaagaaatggatgtaagcctggcccataatgtgaacataagtaatcactaatgctcaacaatttatccattcaatcatttattcattgggttgtcagatagtctatgtatgtgtaaaacaatctgttttggctttatgtgcaaaatctgttatagctttaaaatatatctggaactttttagattattccaagccttattttgagtaaatatttgttacttttagttctataagtgaggaagagtttatggcaaagatttttggcactttgttttcaagatggtgttatcttttgaattcttgataaatgactgtttttttctgcctaatagtaactggttaaaaaacaaatgttcatatttattgattaaaaatgtggttgcttaattcctaaccagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:840 -> Molecular function: GO:0004190 [aspartic-type endopeptidase activity] evidence: IEA GeneID:840 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: TAS GeneID:840 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:840 -> Molecular function: GO:0008234 [cysteine-type peptidase activity] evidence: TAS GeneID:840 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IEA GeneID:840 -> Biological process: GO:0006508 [proteolysis] evidence: IDA GeneID:840 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:840 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA GeneID:840 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:840 -> Biological process: GO:0007507 [heart development] evidence: IEA GeneID:840 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: TAS GeneID:840 -> Biological process: GO:0009411 [response to UV] evidence: IEA GeneID:840 -> Biological process: GO:0016485 [protein processing] evidence: IEA GeneID:840 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA GeneID:840 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:840 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:840 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:840 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS GeneID:840 -> Cellular component: GO:0005829 [cytosol] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001253986 -> EC 3.4.22.60
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