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2024-04-20 17:37:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001267045 3782 bp mRNA linear PRI 01-MAY-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) activator subunit 3
(PA28 gamma; Ki) (PSME3), transcript variant 3, mRNA.
ACCESSION NM_001267045
VERSION NM_001267045.1 GI:388556515
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3782)
AUTHORS Ko,N.L., Taylor,J.M., Bellon,M., Bai,X.T., Shevtsov,S.P., Dundr,M.
and Nicot,C.
TITLE PA28gamma is a novel corepressor of HTLV-1 replication and controls
viral latency
JOURNAL Blood 121 (5), 791-800 (2013)
PUBMED 23104922
REMARK GeneRIF: PA28gamma acts as a co-repressor of HTLV-1 p30 to suppress
virus replication and is required for the maintenance of viral
latency.
REFERENCE 2 (bases 1 to 3782)
AUTHORS Li,L.P., Cheng,W.B., Li,H., Li,W., Yang,H., Wen,D.H. and Tang,Y.D.
TITLE Expression of proteasome activator REGgamma in human laryngeal
carcinoma and associations with tumor suppressor proteins
JOURNAL Asian Pac. J. Cancer Prev. 13 (6), 2699-2703 (2012)
PUBMED 22938444
REMARK GeneRIF: statistical analysisof laryngeal carcinomas revealed that
there was a positive relationship between the level of REGgamma and
the expression of p53 and p2; study suggests that REgamma
overexpression can facilitate the growth of laryngeal cancer cells
REFERENCE 3 (bases 1 to 3782)
AUTHORS Levy-Barda,A., Lerenthal,Y., Davis,A.J., Chung,Y.M., Essers,J.,
Shao,Z., van Vliet,N., Chen,D.J., Hu,M.C., Kanaar,R., Ziv,Y. and
Shiloh,Y.
TITLE Involvement of the nuclear proteasome activator PA28gamma in the
cellular response to DNA double-strand breaks
JOURNAL Cell Cycle 10 (24), 4300-4310 (2011)
PUBMED 22134242
REMARK GeneRIF: PA28gamma is an ATM target, being recruited to DNA damage
sites where it is required for rapid accumulation of proteasomes,
and the timely coordination of DNA double-strand break repair.
REFERENCE 4 (bases 1 to 3782)
AUTHORS Kohda,K., Ishibashi,T., Shimbara,N., Tanaka,K., Matsuda,Y. and
Kasahara,M.
TITLE Characterization of the mouse PA28 activator complex gene family:
complete organizations of the three member genes and a physical map
of the approximately 150-kb region containing the alpha- and
beta-subunit genes
JOURNAL J. Immunol. 160 (10), 4923-4935 (1998)
PUBMED 9590240
REFERENCE 5 (bases 1 to 3782)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 6 (bases 1 to 3782)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
REFERENCE 7 (bases 1 to 3782)
AUTHORS Jacob,A., Kandpal,G., Patanjali,S.R. and Kandpal,R.P.
TITLE Molecular cloning and expression pattern of genes from a 470 Kb
region near BRCA1 locus on chromosome 17q21
JOURNAL Oncogene 11 (5), 981-986 (1995)
PUBMED 7675458
REFERENCE 8 (bases 1 to 3782)
AUTHORS Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
TITLE A strong candidate for the breast and ovarian cancer susceptibility
gene BRCA1
JOURNAL Science 266 (5182), 66-71 (1994)
PUBMED 7545954
REFERENCE 9 (bases 1 to 3782)
AUTHORS Albertsen,H.M., Smith,S.A., Mazoyer,S., Fujimoto,E., Stevens,J.,
Williams,B., Rodriguez,P., Cropp,C.S., Slijepcevic,P., Carlson,M.
et al.
TITLE A physical map and candidate genes in the BRCA1 region on
chromosome 17q12-21
JOURNAL Nat. Genet. 7 (4), 472-479 (1994)
PUBMED 7951316
REFERENCE 10 (bases 1 to 3782)
AUTHORS Nikaido,T., Shimada,K., Shibata,M., Hata,M., Sakamoto,M.,
Takasaki,Y., Sato,C., Takahashi,T. and Nishida,Y.
TITLE Cloning and nucleotide sequence of cDNA for Ki antigen, a highly
conserved nuclear protein detected with sera from patients with
systemic lupus erythematosus
JOURNAL Clin. Exp. Immunol. 79 (2), 209-214 (1990)
PUBMED 1968796
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI464061.1, BX640801.1,
AC016889.28 and AI304773.1.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. The immunoproteasome
contains an alternate regulator, referred to as the 11S regulator
or PA28, that replaces the 19S regulator. Three subunits (alpha,
beta and gamma) of the 11S regulator have been identified. This
gene encodes the gamma subunit of the 11S regulator. Six gamma
subunits combine to form a homohexameric ring. Alternate splicing
results in multiple transcript variants. [provided by RefSeq, May
2012].
Transcript Variant: This variant (3) differs in the 5' UTR and 5'
coding region, and initiates translation at an alternate start
codon, compared to variant 1. The encoded isoform (3) has a
distinct N-terminus and is longer than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX640801.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-276 BI464061.1 4-279
277-918 BX640801.1 3-644
919-1067 BX640801.1 646-794
1068-1068 AC016889.28 103268-103268
1069-1229 BX640801.1 796-956
1230-1363 BX640801.1 958-1091
1364-1395 AC016889.28 104728-104759
1396-1619 BX640801.1 1125-1348
1620-3756 AC016889.28 107228-109364
3757-3782 AI304773.1 1-26 c
FEATURES Location/Qualifiers
source 1..3782
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
gene 1..3782
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/note="proteasome (prosome, macropain) activator subunit 3
(PA28 gamma; Ki)"
/db_xref="GeneID:10197"
/db_xref="HGNC:9570"
/db_xref="MIM:605129"
exon 1..532
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 10
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:375225506"
variation 38
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:185218030"
variation 60
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:118072016"
variation 169
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:7220766"
variation 267
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:144157969"
variation 322
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542144"
variation 347
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:189726007"
variation 421
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542143"
variation 471
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542142"
variation 490
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139945697"
variation 500
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="g"
/replace="t"
/db_xref="dbSNP:11542141"
variation 515
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:181426790"
exon 533..696
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 632
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376571315"
variation 686
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:113350146"
misc_feature 695..697
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/note="upstream in-frame stop codon"
exon 697..859
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 710
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:371475034"
CDS 785..1582
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/note="isoform 3 is encoded by transcript variant 3; Ki
nuclear autoantigen; PA28 gamma variant 5; Ki antigen;
proteasome activator 28-gamma; 11S regulator complex gamma
subunit; activator of multicatalytic protease subunit 3;
proteasome activator complex subunit 3; 11S regulator
complex subunit gamma; proteasome activator 28 subunit
gamma"
/codon_start=1
/product="proteasome activator complex subunit 3 isoform
3"
/protein_id="NP_001253974.1"
/db_xref="GI:388556516"
/db_xref="CCDS:CCDS59290.1"
/db_xref="GeneID:10197"
/db_xref="HGNC:9570"
/db_xref="MIM:605129"
/translation="
MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
"
misc_feature 857..1027
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/note="Proteasome activator pa28 alpha subunit; Region:
PA28_alpha; pfam02251"
/db_xref="CDD:145415"
misc_feature 1130..1579
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/note="Proteasome activator pa28 beta subunit; Region:
PA28_beta; pfam02252"
/db_xref="CDD:145416"
exon 860..892
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
exon 893..955
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
exon 956..1060
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 975
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:373928182"
variation 1043
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:111470609"
exon 1061..1109
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
exon 1110..1222
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1134
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377275510"
variation 1190
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:371137053"
variation 1199
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374111752"
exon 1223..1291
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1282
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:146329887"
exon 1292..1359
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1336
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376102848"
exon 1360..1414
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1363
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:376784465"
exon 1415..1501
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1432
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139649789"
variation 1474
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:144379026"
variation 1489
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:368656313"
exon 1502..3764
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/inference="alignment:Splign:1.39.8"
variation 1511
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200192436"
variation 1522
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:368470629"
variation 1534
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:202070240"
variation 1586
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:372417727"
variation 1631
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376013489"
variation 1654
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542140"
variation 1661
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:80340976"
variation 1813
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:111565009"
variation 1814
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:138778726"
variation 1883
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:376501511"
variation 1926
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:185308245"
variation 1932..1935
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace=""
/replace="taat"
/db_xref="dbSNP:10542459"
variation 1934..1937
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace=""
/replace="atta"
/db_xref="dbSNP:371175158"
variation 1934
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:199670623"
variation 2079
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:12185238"
variation 2137
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:16968036"
variation 2342
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:188953781"
variation 2371
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:181550421"
variation 2474..2475
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace=""
/replace="c"
/db_xref="dbSNP:34030346"
variation 2486
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:187634243"
variation 2516
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:144526875"
variation 2611..2616
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace=""
/replace="ctcttt"
/db_xref="dbSNP:374650825"
variation 2682
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376343613"
variation 2696
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="g"
/replace="t"
/db_xref="dbSNP:191910662"
variation 2942
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:115860809"
variation 2944
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:369381831"
STS 3023..3165
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/standard_name="RH16239"
/db_xref="UniSTS:2879"
variation 3064
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:1056730"
variation 3070
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:182960547"
variation 3108
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34878294"
variation 3204
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:186029887"
variation 3236
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="c"
/db_xref="dbSNP:34989919"
variation 3251
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373608001"
STS 3254..3422
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/standard_name="STS-U11292"
/db_xref="UniSTS:9169"
variation 3270
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35756762"
variation 3273
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35704777"
variation 3364..3365
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace=""
/replace="ag"
/db_xref="dbSNP:71825604"
variation 3461
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139296430"
variation 3523
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="g"
/db_xref="dbSNP:377471565"
STS 3564..3714
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/standard_name="RH47258"
/db_xref="UniSTS:72254"
variation 3568
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:111722913"
variation 3630
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="c"
/replace="t"
/db_xref="dbSNP:186987705"
variation 3635
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35759054"
variation 3671
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
/replace="a"
/replace="g"
/db_xref="dbSNP:192322990"
polyA_signal 3735..3740
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
polyA_site 3764
/gene="PSME3"
/gene_synonym="Ki; PA28-gamma; PA28G; PA28gamma;
REG-GAMMA"
ORIGIN
ggagtgcagcggctgagaaggtcccttcggtgaaggcgagttccgggacaacagagagggccgcaccgtttccgagtctctcggaggctcagttctcagcgcaccattccccacagctctcctttttactttacccctacccgacacttgaccccggcagtgtgaaccccgctgggagcgtccaaagccatgcctcatcgcggctgcgcagcgcacgtgcacagcctcgcaggagtctcggcgattggctgtgacgcagtttccggcgtgagcggcgaaagccgggagggcgagcgagagagcaagcaggcagcaggctgccggcgggcgggcggacggcacagagggagggagcgagcgagcagtgagtaagccagcaagggcggtcgggtcccgaggtcagccgagatttctcaggtccctccggccccctccctggagtccacagcgcctccggtgtccagaggatcggacacggcccggcccggccatggcctcgttgctgaaggtggatcaggaagtgaagctcaagctctgagcttccgctcggctcagcccagcccccaactcccggggtcggcttcgcgggagaggaaaatataggatggctttctgtaccgcgtctgatgatggagagtcccggggacacctccgcggacacgtgttggactcagggctttaggcccgtgacagctgacagcttcagacacaggaggaagggagggaagggggaggacagaggagacaggcaggtgctgtcctcaaagccctgcgttcttctgagatggaaaaatggatcctcaaaaaaataaagtatttgcagtctgggggcctctcagcttcttattacagttacaaggttgattctttcagggagcggatcacaagtgaggcagaagacttggtggcaaattttttcccaaagaagttattagaacttgatagttttctgaaggaaccaatcttaaacatccatgacctaactcagatccactctgacatgaatctcccagtccctgaccccattcttctcaccaatagccatgatggactggatggtcccacttataagaagcgaaggttggatgagtgtgaagaagccttccaaggaaccaaggtgtttgtgatgcccaatgggatgctgaaaagcaaccagcagctggtggacattattgagaaagtgaaacctgagatccggctgttgattgagaaatgtaacacggtcaaaatgtgggtacagctcctgattcccaggatagaagatggaaacaactttggggtgtccattcaggaggaaacagttgcagagctaagaactgttgagagtgaagctgcatcttatctggaccagatttctagatattatattacaagagccaaattggtttctaaaatagctaaatatccccatgtggaggactatcgccgcaccgtgacagagattgatgagaaagaatatatcagccttcggctcatcatatcagagctgaggaatcaatatgtcactctacatgacatgatcctgaaaaatatcgagaagatcaaacggccccggagcagcaatgcagagactctgtactgaggccagggccagggccaggggactctgtgagtctggctcaagaccgacattgccttggtttgttacatgactatcgtgatggggaaactggctggaaatagtaatcacacctctctgtttttagttagagtctaatgaaactctcatctagttctgtgatgtgtttacctcttttttcaggcctcaggaactcttctatttccttccctaataccccacacccaacctgtcgtaatttctggagaactccaggtttgtgtgtgcaggatgttggcacaaaaatacctgtgttttcattctccccctctctccctcctgtgtcttgcgctttatgttttcttccgtttgataattagttggttaaaagctgagggaaccggaaggaaagtgctaggtgttttttaggaactagggtggcggggggacgaacttctcttcctcacatgaggttactgtttctttcctctgtggggcattggatcctcccacagttgccctggtgatgacttagggcttcccatctgtgtacatcccactttgaatcttgatcgtgacaagaaataccttaggccttcagtcaattccgaagctccttcagttgtttttataatgggcgttttcacatgcacatatgtgtatgcatgtatacgcccatacagacatgcacacacagactcctactccattagctaacataccctccctctccacaacccctgtcacatacctttcaggaggtgacagttgtcttagttgtcatctacccagacaaacgtcctgggcccgtcctccctcctgatactgtagcctcttggtacccagggtgagttggtggagaacagagagatgagaagcagagggcttggggaaagcctgttcctctctgactcagccctttttggcattattgcaagagcttgactcctggttgccttttcccagccagttttcagttggggtgaaggtttctgcaagtgtgaggtccagatgctgctgctcatgttgggctttccttttgggaactatttctctttatttatagtgtcgggcttccggggaaagcaatcattggtgtgtatgtgtatgtgcatgcacacacgtgcatatacacatttgtgtatgtggaaatgtgctgggcaagtcaaaactatagaagagttgcctcctgtctctcgaatcttccagagatatcacttaattgttaacagcttttgtgttaatccccttcagcccctagctcttttattctaccacggctggagagttgatacctgcagtcagcctgccagtgactcttagtgtctgtttctgacttatttttcctgtctctgtcttccaacccccaataatatttccaccggggatgcatcatttttactcccaatattctgtagagagggagtcaggatgctgtcttcccacgaatagtactcagtaacaaaccaattgcattttagttgggcagtgctcccacccaccctccagatcccttccagctaaaacccttcccccttccctccatgtgtttctcagtttcccgtttcgtttgttggactgttccactgcccctcctcctcaccctatcacccatggatcgtaatgtaaaattcttttaccatgtcaagaaattattaaaaatacaggtactttgacctctttctaaagccgcagaccctggtgcaatgctctggtggctagggatgtactcatgctcatatgtgtgcacgcttggacacccacctccatggacacctagccaccctgttgtgtgtccttatgccagttgagctgaatcttttccccagtatagtggaaagactgaggcttctgcctactgagcaaggttgggtgcttcatttgtgttcagtctgaattatgggaaagttagctcttcccagacctaagctgccttctctccctactttcagaagatcctagttccttccttcccgagtgatacccatgaactgccagtagaggctgctatcgttccatgtgtaaggaatgaactggttcaaggcgcgtcctacccagtcattttctttaccttatactaattcttcctgaataatgtcttcagtttcttgaggagactcctagttttggttttcaaattacttggagggctgcctaggaatctatctccctctgaaataaagtttcctcatcttccaccttgcaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10197 -> Molecular function: GO:0002039 [p53 binding] evidence: IDA
GeneID:10197 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10197 -> Molecular function: GO:0061133 [endopeptidase activator activity] evidence: IDA
GeneID:10197 -> Molecular function: GO:0097371 [MDM2/MDM4 family protein binding] evidence: IDA
GeneID:10197 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:10197 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:10197 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:10197 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:10197 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:10197 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:10197 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:10197 -> Biological process: GO:0010950 [positive regulation of endopeptidase activity] evidence: IDA
GeneID:10197 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:10197 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:10197 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:10197 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:10197 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:10197 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:10197 -> Biological process: GO:0061136 [regulation of proteasomal protein catabolic process] evidence: IDA
GeneID:10197 -> Biological process: GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] evidence: IDA
GeneID:10197 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:10197 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:10197 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:10197 -> Cellular component: GO:0008537 [proteasome activator complex] evidence: IEA
by
@meso_cacase at
DBCLS
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