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2024-04-27 11:05:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001261840 1776 bp mRNA linear PRI 22-JUN-2013
DEFINITION Homo sapiens brain and reproductive organ-expressed (TNFRSF1A
modulator) (BRE), transcript variant 6, mRNA.
ACCESSION NM_001261840
VERSION NM_001261840.1 GI:387912572
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1776)
AUTHORS Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
Vermeire,S., Barrett,J.C. and Cho,J.H.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 2 (bases 1 to 1776)
AUTHORS Noordermeer,S.M., Monteferrario,D., Sanders,M.A., Bullinger,L.,
Jansen,J.H. and van der Reijden,B.A.
TITLE Improved classification of MLL-AF9-positive acute myeloid leukemia
patients based on BRE and EVI1 expression
JOURNAL Blood 119 (18), 4335-4337 (2012)
PUBMED 22555662
REMARK GeneRIF: High BRE and high EVI1 expression are mutually exclusive
in MLL-AF9-positive acute myeloid leukemia patients.
REFERENCE 3 (bases 1 to 1776)
AUTHORS Noordermeer,S.M., Sanders,M.A., Gilissen,C., Tonnissen,E., van der
Heijden,A., Dohner,K., Bullinger,L., Jansen,J.H., Valk,P.J. and van
der Reijden,B.A.
TITLE High BRE expression predicts favorable outcome in adult acute
myeloid leukemia, in particular among MLL-AF9-positive patients
JOURNAL Blood 118 (20), 5613-5621 (2011)
PUBMED 21937695
REMARK GeneRIF: High BRE expression defines a novel subtype of adult acute
myeloid leukemia characterized by a favorable prognosis.
REFERENCE 4 (bases 1 to 1776)
AUTHORS Hu,X., Kim,J.A., Castillo,A., Huang,M., Liu,J. and Wang,B.
TITLE NBA1/MERIT40 and BRE interaction is required for the integrity of
two distinct deubiquitinating enzyme BRCC36-containing complexes
JOURNAL J. Biol. Chem. 286 (13), 11734-11745 (2011)
PUBMED 21282113
REMARK GeneRIF: NBA1/MERIT40 and BRE interaction is required for the
integrity of two distinct deubiquitinating enzyme BRCC36-containing
complexes
REFERENCE 5 (bases 1 to 1776)
AUTHORS Balgobind,B.V., Zwaan,C.M., Reinhardt,D., Arentsen-Peters,T.J.,
Hollink,I.H., de Haas,V., Kaspers,G.J., de Bont,E.S., Baruchel,A.,
Stary,J., Meyer,C., Marschalek,R., Creutzig,U., den Boer,M.L.,
Pieters,R. and van den Heuvel-Eibrink,M.M.
TITLE High BRE expression in pediatric MLL-rearranged AML is associated
with favorable outcome
JOURNAL Leukemia 24 (12), 2048-2055 (2010)
PUBMED 20861917
REMARK GeneRIF: overexpression of the BRE gene is predominantly found in
MLL-rearranged AML with t(9;11)(p22;q23).
REFERENCE 6 (bases 1 to 1776)
AUTHORS Dong,Y., Hakimi,M.A., Chen,X., Kumaraswamy,E., Cooch,N.S.,
Godwin,A.K. and Shiekhattar,R.
TITLE Regulation of BRCC, a holoenzyme complex containing BRCA1 and
BRCA2, by a signalosome-like subunit and its role in DNA repair
JOURNAL Mol. Cell 12 (5), 1087-1099 (2003)
PUBMED 14636569
REFERENCE 7 (bases 1 to 1776)
AUTHORS Ching,A.K., Li,P.S., Li,Q., Chan,B.C., Chan,J.Y., Lim,P.L.,
Pang,J.C. and Chui,Y.L.
TITLE Expression of human BRE in multiple isoforms
JOURNAL Biochem. Biophys. Res. Commun. 288 (3), 535-545 (2001)
PUBMED 11676476
REFERENCE 8 (bases 1 to 1776)
AUTHORS Miao,J., Panesar,N.S., Chan,K.T., Lai,F.M., Xia,N., Wang,Y.,
Johnson,P.J. and Chan,J.Y.
TITLE Differential expression of a stress-modulating gene, BRE, in the
adrenal gland, in adrenal neoplasia, and in abnormal adrenal
tissues
JOURNAL J. Histochem. Cytochem. 49 (4), 491-500 (2001)
PUBMED 11259452
REFERENCE 9 (bases 1 to 1776)
AUTHORS Gu,C., Castellino,A., Chan,J.Y. and Chao,M.V.
TITLE BRE: a modulator of TNF-alpha action
JOURNAL FASEB J. 12 (12), 1101-1108 (1998)
PUBMED 9737713
REFERENCE 10 (bases 1 to 1776)
AUTHORS Li,L., Yoo,H., Becker,F.F., Ali-Osman,F. and Chan,J.Y.
TITLE Identification of a brain- and reproductive-organs-specific gene
responsive to DNA damage and retinoic acid
JOURNAL Biochem. Biophys. Res. Commun. 206 (2), 764-774 (1995)
PUBMED 7826398
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC021171.6, AF420605.1 and CR994399.1.
Transcript Variant: This variant (6) lacks an exon and uses an
alternate splice site in the 3' coding region, which results in a
frameshift, compared to variant 1. The encoded isoform (4) is
shorter and has a distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF420605.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-178 AC021171.6 30058-30235
179-1579 AF420605.1 1-1401
1580-1776 CR994399.1 524-720
FEATURES Location/Qualifiers
source 1..1776
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p23.2"
gene 1..1776
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/note="brain and reproductive organ-expressed (TNFRSF1A
modulator)"
/db_xref="GeneID:9577"
/db_xref="HGNC:1106"
/db_xref="MIM:610497"
exon 1..228
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
exon 229..380
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
misc_feature 232..234
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/note="upstream in-frame stop codon"
variation 240
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="c"
/db_xref="dbSNP:202093947"
variation 251
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:371787661"
CDS 253..1392
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/note="isoform 4 is encoded by transcript variant 6;
BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex
subunit BRE; BRCA1/BRCA2-containing complex subunit 45;
brain and reproductive organ-expressed protein"
/codon_start=1
/product="BRCA1-A complex subunit BRE isoform 4"
/protein_id="NP_001248769.1"
/db_xref="GI:387912573"
/db_xref="GeneID:9577"
/db_xref="HGNC:1106"
/db_xref="MIM:610497"
/translation="
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRANSRRQHLPMESSRKHQS
"
misc_feature 253..837
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/note="Brain and reproductive organ-expressed protein
(BRE); Region: BRE; pfam06113"
/db_xref="CDD:147983"
misc_feature 253..255
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (Q9NXR7.2); acetylation site"
misc_feature 256..258
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NXR7.2); phosphorylation site"
misc_feature 340..693
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NXR7.2);
Region: UEV-like 1"
misc_feature 1075..1344
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NXR7.2);
Region: UEV-like 2"
misc_feature <1108..1251
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/note="Brain and reproductive organ-expressed protein
(BRE); Region: BRE; pfam06113"
/db_xref="CDD:147983"
variation 282
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:147256639"
variation 284
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="g"
/db_xref="dbSNP:144572761"
variation 289
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:374065412"
variation 358
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="c"
/db_xref="dbSNP:200906690"
variation 365
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:201837586"
variation 371
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:200380663"
exon 381..457
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 415
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:145553462"
variation 417
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="t"
/db_xref="dbSNP:377112382"
exon 458..552
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 531
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:145549560"
variation 538
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="g"
/db_xref="dbSNP:140802379"
exon 553..747
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 600
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:191932782"
variation 636
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:182586969"
variation 643
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:373361156"
variation 649
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:200578948"
variation 650
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:138608273"
variation 715
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="c"
/db_xref="dbSNP:200034653"
variation 721
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:202064486"
variation 732..733
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace=""
/replace="a"
/db_xref="dbSNP:373964958"
variation 732
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:201904014"
exon 748..822
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 753
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:374750587"
variation 766
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:150887846"
variation 786
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:185398532"
variation 787
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:149653090"
variation 789
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:377461390"
variation 807
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:201716241"
exon 823..932
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 878
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:193920803"
variation 896
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="g"
/replace="t"
/db_xref="dbSNP:201050165"
variation 911
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:370306496"
exon 933..1032
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 933
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="g"
/replace="t"
/db_xref="dbSNP:367605362"
variation 973
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="g"
/db_xref="dbSNP:370651719"
variation 999
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:200441683"
variation 1000
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:146767400"
variation 1018
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:139141828"
exon 1033..1103
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 1035
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:147449945"
variation 1041
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:28997579"
variation 1056
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:144070701"
variation 1103
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:372205006"
exon 1104..1186
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 1186
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="t"
/db_xref="dbSNP:141089075"
exon 1187..1340
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 1200
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="g"
/db_xref="dbSNP:138374824"
variation 1210
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:140276316"
variation 1239
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:112441915"
variation 1279
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:373592489"
variation 1321
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:376668252"
exon 1341..1764
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/inference="alignment:Splign:1.39.8"
variation 1343
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:201259934"
variation 1398
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:375248335"
variation 1422
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:116114067"
variation 1457
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="g"
/replace="t"
/db_xref="dbSNP:145476479"
variation 1474
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="g"
/db_xref="dbSNP:148041909"
STS 1524..1680
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/standard_name="D2S2556"
/db_xref="UniSTS:38551"
variation 1598
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="c"
/db_xref="dbSNP:1802747"
variation 1616
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:140823168"
variation 1696
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="a"
/replace="c"
/db_xref="dbSNP:181212252"
variation 1753
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace=""
/replace="c"
/db_xref="dbSNP:199930737"
variation 1753
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:58720304"
variation 1754
/gene="BRE"
/gene_synonym="BRCC4; BRCC45"
/replace="c"
/replace="t"
/db_xref="dbSNP:55977836"
ORIGIN
ggaactgtcaggcaccgcggggacgcctttccgagcgcccggctcggcgcggcgcgggggcgcgcacgccgcccagcttcggggccgcagagggggcggggcgggacgtccggggagtgcgcacgcatcctgcccgcggcgcgcgcgcaggtcggtgcgtctgtcgggggcgcgctcgggtacctgtaccccacgtagtcgccggttaccgatcggactaagttccagtggtgatttacaagtcaagttaaaatgtccccagaagtggccttgaaccgaatatctccaatgctctcccctttcatatctagcgtggtccggaatggaaaagtgggactggatgctacaaactgtttgaggataactgacttaaaatctggctgcacatcattgactcctgggcccaactgtgaccgatttaaactgcacataccatatgctggagagacattaaagtgggatatcattttcaatgcccaatacccagaactgcctcccgattttatctttggagaagatgctgaattcctgccagacccctcagctttgcagaatcttgcctcctggaatccttcaaatcctgaatgtctcttacttgtggtgaaggaacttgtgcaacaatatcaccaattccaatgtagccgcctccgggagagctcccgcctcatgtttgaataccagacattactggaggagccacagtatggagagaacatggaaatttatgctgggaaaaaaaacaactggactggtgaattttcagctcgtttccttttgaagctgcccgtagatttcagcaatatccccacataccttctcaaggatgtaaatgaagaccctggagaagatgtggccctcctctctgttagttttgaggacactgaagccacccaggtgtaccccaagctgtacttgtcacctcgaattgagcatgcacttggaggctcctcagctcttcatatcccagcttttccaggaggaggatgtctcattgattacgttcctcaagtatgccacctgctcaccaacaaggtgcagtacgtgattcaagggtatcacaaaagaagagagtatattgctgcttttctcagtcactttggcacaggtgtcgtggaatatgatgcagaaggctttacaaaactcactctgctgctgatgtggaaagatttttgttttcttgtacacattgacctgcctctgtttttccctcgagaccagccaactctcacatttcagtccgtttatcactttaccaacagtggacagctttactcccaggcccaaaaaaattatccgtacagccccagatgggatggaaatgaaatggccaaaagagcaaattccaggaggcagcatttgccaatggaaagctctaggaaacaccagtcttgagaggtggccagccagactgcctgtccacatgcgtgtcagcacatacagccgcttcctggaagccgcctggaatgtcttcacggcagcgttttgctcacacagcagcttttgcacgccccaggcagccccgactgctgaaatccaacttgagctggctggtggtccctggatcctagagcccttcacttcgggttactccctctttcttgcctctatttcttagttggaagaaataaactcacaaattatggtgcagtaattttccggggaaagtaaagcctcaggaatgcccacgcctttcttccaaagcctttgtctctgagacctcttaagttctaagattaaatgcccctcgctgttcttcctctgaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9577 -> Molecular function: GO:0000268 [peroxisome targeting sequence binding] evidence: TAS
GeneID:9577 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IDA
GeneID:9577 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9577 -> Molecular function: GO:0031593 [polyubiquitin binding] evidence: IDA
GeneID:9577 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:9577 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:9577 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEP
GeneID:9577 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:9577 -> Biological process: GO:0010212 [response to ionizing radiation] evidence: IMP
GeneID:9577 -> Biological process: GO:0016568 [chromatin modification] evidence: IEA
GeneID:9577 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:9577 -> Biological process: GO:0045739 [positive regulation of DNA repair] evidence: IMP
GeneID:9577 -> Cellular component: GO:0000152 [nuclear ubiquitin ligase complex] evidence: IDA
GeneID:9577 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9577 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9577 -> Cellular component: GO:0070531 [BRCA1-A complex] evidence: IDA
GeneID:9577 -> Cellular component: GO:0070552 [BRISC complex] evidence: IDA
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DBCLS
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