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2020-10-26 18:42:29, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001261829            4872 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens MYC induced nuclear antigen (MINA), transcript variant
            4, mRNA.
ACCESSION   NM_001261829
VERSION     NM_001261829.1  GI:387849374
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4872)
  AUTHORS   Chen,Y., Yang,X., Huang,Y., Liu,E. and Wang,L.
  TITLE     Associations of the single-nucleotide polymorphisms of the Mina
            gene with the development of asthma in Chinese Han children: a
            case-control study
  JOURNAL   Genet Test Mol Biomarkers 15 (7-8), 531-536 (2011)
   PUBMED   21631300
  REMARK    GeneRIF: The single nucleotide polymorphism of the Mina gene is
            associated with the development of asthma in Chinese Han children.
REFERENCE   2  (bases 1 to 4872)
  AUTHORS   Komiya,K., Sueoka-Aragane,N., Sato,A., Hisatomi,T., Sakuragi,T.,
            Mitsuoka,M., Sato,T., Hayashi,S., Izumi,H., Tsuneoka,M. and
            Sueoka,E.
  TITLE     Expression of Mina53, a novel c-Myc target gene, is a favorable
            prognostic marker in early stage lung cancer
  JOURNAL   Lung Cancer 69 (2), 232-238 (2010)
   PUBMED   19914733
  REMARK    GeneRIF: favorable prognostic marker in early stage lung cancer
REFERENCE   3  (bases 1 to 4872)
  AUTHORS   Komiya,K., Sueoka-Aragane,N., Sato,A., Hisatomi,T., Sakuragi,T.,
            Mitsuoka,M., Sato,T., Hayashi,S., Izumi,H., Tsuneoka,M. and
            Sueoka,E.
  TITLE     Mina53, a novel c-Myc target gene, is frequently expressed in lung
            cancers and exerts oncogenic property in NIH/3T3 cells
  JOURNAL   J. Cancer Res. Clin. Oncol. 136 (3), 465-473 (2010)
   PUBMED   19756735
  REMARK    GeneRIF: Mina53 plays an important role in carcinogenesis and may
            be a target for cancer prevention.
REFERENCE   4  (bases 1 to 4872)
  AUTHORS   Lu,Y., Chang,Q., Zhang,Y., Beezhold,K., Rojanasakul,Y., Zhao,H.,
            Castranova,V., Shi,X. and Chen,F.
  TITLE     Lung cancer-associated JmjC domain protein mdig suppresses
            formation of tri-methyl lysine 9 of histone H3
  JOURNAL   Cell Cycle 8 (13), 2101-2109 (2009)
   PUBMED   19502796
  REMARK    GeneRIF: The MINA protein alters histone H3 methylation contributes
            to the initiation or development of the human lung cancer.
REFERENCE   5  (bases 1 to 4872)
  AUTHORS   Zhang,Q., Hu,C.M., Yuan,Y.S., He,C.H., Zhao,Q. and Liu,N.Z.
  TITLE     Expression of Mina53 and its significance in gastric carcinoma
  JOURNAL   Int. J. Biol. Markers 23 (2), 83-88 (2008)
   PUBMED   18629780
  REMARK    GeneRIF: Mina53 was overexpressed in gastric carcinoma and
            associated with tumor proliferation and antioncogene inactivation.
REFERENCE   6  (bases 1 to 4872)
  AUTHORS   Eilbracht,J., Kneissel,S., Hofmann,A. and Schmidt-Zachmann,M.S.
  TITLE     Protein NO52--a constitutive nucleolar component sharing high
            sequence homologies to protein NO66
  JOURNAL   Eur. J. Cell Biol. 84 (2-3), 279-294 (2005)
   PUBMED   15819408
  REMARK    GeneRIF: Data suggests NO52 protein (MYC induced nuclear antigen)
            is directly involved in ribosome biogenesis, most likely during the
            assembly process of preribosomal particles.
REFERENCE   7  (bases 1 to 4872)
  AUTHORS   Tsuneoka,M., Fujita,H., Arima,N., Teye,K., Okamura,T., Inutsuka,H.,
            Koda,Y., Shirouzu,K. and Kimura,H.
  TITLE     Mina53 as a potential prognostic factor for esophageal squamous
            cell carcinoma
  JOURNAL   Clin. Cancer Res. 10 (21), 7347-7356 (2004)
   PUBMED   15534111
  REMARK    GeneRIF: Mina53 may have a role in progression of esophageal
            squamous cell carcinoma
REFERENCE   8  (bases 1 to 4872)
  AUTHORS   Eilbracht,J., Reichenzeller,M., Hergt,M., Schnolzer,M., Heid,H.,
            Stohr,M., Franke,W.W. and Schmidt-Zachmann,M.S.
  TITLE     NO66, a highly conserved dual location protein in the nucleolus and
            in a special type of synchronously replicating chromatin
  JOURNAL   Mol. Biol. Cell 15 (4), 1816-1832 (2004)
   PUBMED   14742713
REFERENCE   9  (bases 1 to 4872)
  AUTHORS   Teye,K., Tsuneoka,M., Arima,N., Koda,Y., Nakamura,Y., Ueta,Y.,
            Shirouzu,K. and Kimura,H.
  TITLE     Increased expression of a Myc target gene Mina53 in human colon
            cancer
  JOURNAL   Am. J. Pathol. 164 (1), 205-216 (2004)
   PUBMED   14695334
  REMARK    GeneRIF: the elevated expression of Mina53 is a characteristic
            feature in colon cancer
REFERENCE   10 (bases 1 to 4872)
  AUTHORS   Tsuneoka,M., Koda,Y., Soejima,M., Teye,K. and Kimura,H.
  TITLE     A novel myc target gene, mina53, that is involved in cell
            proliferation
  JOURNAL   J. Biol. Chem. 277 (38), 35450-35459 (2002)
   PUBMED   12091391
  REMARK    GeneRIF: role in cell division
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA310030.1, AK027299.1, AC026100.19 and AC110491.5.
            
            Summary: MINA is a c-Myc (MYC; MIM 190080) target gene that may
            play a role in cell proliferation or regulation of cell growth.
            (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005
            [PubMed 15897898]).[supplied by OMIM, May 2008].
            
            Transcript Variant: This variant (4) uses alternate splice sites in
            the 5' UTR and 3' coding region, compared to variant 1, and encodes
            a shorter protein (isoform B), compared to isoform A. Variants 3
            and 4 encode the same protein (isoform B).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA310030.1         7-56
            51-584              AK027299.1         1-534
            585-585             AC026100.19        95339-95339
            586-862             AK027299.1         536-812
            863-863             AC026100.19        102581-102581
            864-1262            AK027299.1         814-1212
            1263-1263           AC026100.19        111124-111124
            1264-1651           AK027299.1         1214-1601
            1652-4872           AC110491.5         67-3287
FEATURES             Location/Qualifiers
     source          1..4872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..4872
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /note="MYC induced nuclear antigen"
                     /db_xref="GeneID:84864"
                     /db_xref="HGNC:19441"
                     /db_xref="MIM:612049"
     exon            1..71
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            72..542
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     CDS             111..1505
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /note="isoform b is encoded by transcript variant 4;
                     myc-induced nuclear antigen, 53 kDa; mineral dust induced
                     gene protein; nucleolar protein 52; mineral dust-induced
                     gene protein; ribosomal oxygenase MINA; histone lysine
                     demethylase MINA; 60S ribosomal protein L27a histidine
                     hydroxylase; bifunctional lysine-specific demethylase and
                     histidyl-hydroxylase MINA"
                     /codon_start=1
                     /product="bifunctional lysine-specific demethylase and
                     histidyl-hydroxylase MINA isoform b"
                     /protein_id="NP_001248758.1"
                     /db_xref="GI:387849375"
                     /db_xref="CCDS:CCDS2929.1"
                     /db_xref="GeneID:84864"
                     /db_xref="HGNC:19441"
                     /db_xref="MIM:612049"
                     /translation="
MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV
"
     misc_feature    264..1199
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /note="Cupin superfamily protein; Region: Cupin_4;
                     pfam08007"
                     /db_xref="CDD:191926"
     misc_feature    <465..836
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /note="JmjC domain, hydroxylase; Region: JmjC; cl15814"
                     /db_xref="CDD:210214"
     misc_feature    1032..1034
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q8IUF8.1); phosphorylation site"
     STS             117..264
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /standard_name="D3S4225"
                     /db_xref="UniSTS:3610"
     variation       159
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35391656"
     STS             305..441
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /standard_name="SHGC-77141"
                     /db_xref="UniSTS:28655"
     variation       389
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34097037"
     exon            543..662
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            663..791
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            792..895
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            896..998
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            999..1167
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            1168..1256
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            1257..1346
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     exon            1347..4872
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /inference="alignment:Splign:1.39.8"
     STS             1805..1958
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /standard_name="D3S2782E"
                     /db_xref="UniSTS:33564"
     STS             4569..4721
                     /gene="MINA"
                     /gene_synonym="MDIG; MINA53; NO52; ROX"
                     /standard_name="SHGC-77136"
                     /db_xref="UniSTS:35373"
ORIGIN      
acgctgccccgcctccagccgctgcgccgcaacgcagtgggctcgcggccgcgagcaacaggccgtgccgggtttgcatttccttactgctttgtcttgaagacagaacgatgccaaagaaagcaaagcctacagggagtgggaaggaagaggggccggctccctgtaagcagatgaagttagaagcagctggggggccttcagctttaaactttgacagtcccagtagtctctttgaaagtttaatctcgcccatcaagacagagacttttttcaaggaattctgggagcagaagccccttctcattcagagagatgaccctgcactggccacatactatgggtccctgttcaagctaacagatctgaagagtctgtgcagccgggggatgtactatggaagagatgtgaatgtctgccggtgtgtcaatgggaagaagaaggttttaaataaagatggcaaagcacactttcttcagctgagaaaagattttgatcagaaaagggcaacgattcagtttcaccaacctcagagatttaaggatgagctttggaggatccaggagaagctggaatgttactttggctccttggttggctcgaatgtgtacataactcccgcaggatctcagggcctgccgccccattatgatgatgtcgaggttttcatcctgcagctggagggagagaaacactggcgcctctaccaccccactgtgcccctggcacgagagtacagcgtggaggccgaggaaaggatcggcaggccggtgcatgagtttatgctgaagccgggtgatttgttgtactttcccagaggaaccattcatcaagcggacactcctgcggggctggcccactctactcacgtgaccatcagcacctaccagaacaattcatggggagatttccttttggataccatctcggggcttgtatttgatactgcaaaggaagacgtggagttacggaccggcataccccggcagctgctcctggtggaatccacaactgttgctacaagacgattaagtggcttcctgaggacacttgcagaccggctggagggcaccaaagaactgctttcctcagacatgaagaaggattttattatgcacagactccccccttactctgcgggagatggggcagagctgtcaacaccaggtggaaagttaccgaggctggacagtgtagtgagactgcagtttaaagaccacattgtcctcacagtactgccggatcaagatcaatctgatgaagctcaagaaaagatggtgtacatctatcattccttaaagaatagtagagagacacacatgatgggaaatgaggaggaaacagagtttcatggacttcgcttccctttgtcacatttggatgcactgaagcaaatttggaatagtccagctatttctgtcaaggacctgaaacttactacagatgaggaaaaggaaagcctggtattatccctctggacagaatgtttaattcaagtagtctagtgcctttgcagaatcaaatgcctactattttatatgcatatattaaaagaaaagcaaagacctgagccgaggagaggatgaattcaagtttccttacctgcgtatctactaacaaacatgagacctccctgttacaggtggtcagttggccaaatgtactaacgggcacatgaaagaaagaacagcaaattaccaagtgtctcagaaaatgacaaaaccatattttgacaagtttatttaatccagtgtggtagaaaaggcacaattccaatgtatcatttagaattgaatgtcattaacctggctttgttctttggaagaaacaacttctttaaagagcttctttggctctagaaaaatttcaaacaattaaaataagaaaaaattttaaactggttttttataatgaaaatatacatacctttgtgtatagacaagcccatgcccattaaaataaagttatcctgtaacataaattttattaaataatacttccccacagatgagaggcacgcaacacctatggacaaaagggagttacagaggctgcttaaaagatggagaaaagcctgagattgaaggaggaaaaaaacccagtatttaaagtctataaaaaatactcaaaatagtgggtcttcgagtttaaaatagtcattgttattttacattctaaagtgcatgtaggttgatattttttaaaatatcattggagaatttaatctttctttataaaaatagagcatttttctgctttctggcaaaagttggggataaaaggaaaaaaagttgtcaaaatgtaattttcagtccaattcaccaggaaaacatgcttgtgaattgtgcagtaaaaggtggtaatgactactggaagctaagtcaaaggtgatttcctacctgattttacttacttaaataaaagttacttacaatgggagtgaaaaactgaggtttctgttatttagtagagaaatcaactccacgtttacttaaagagatggtaaggtcaaggttcaaatgctactgtgttttaatttggatatttgaaatttctcttgaggcaaaaaaaaaaaaaaattgatgcctctccttaaatctaggatgaagtgtcaacatggagacaggtaaccactgttatagagtcttgtcacctaaagggatgtcttggttaacacgtaacagtgcaagtttggccataggttatttatttgtacttttttagtttgaaggactgaggaaacaatagctacagaaaatacttcttgtgccttattcctaacaaagctgaggtccctgcctggggttagttacaagtataaatacttaacgaggtgcgttcattataaaagcctcagtatagaaaccttaaagtttatctaggaaagtttagtatattttcaggtgttgctaaaaaattactcatctgtttgcaaaagtatgacttgacctatagaaatctgtttctttatgctttgtactcatacaagcatctaggtaggatattaataaataatacaggataatagcatcaccagtgtccaataacgggccatcaggaacaggattcacgtttggtggatatgagagaaaataaacacttcaggaaacttgctcaccacagctggagatcaggaatagaacctttccaagatatcataatattttctttataggaacactgagtaatggcaagaatattttgagcttttccatggttaagagcgatagtctcagaggctggagaaaatgttcattctgctcagtgatccaggagtgtgaggacagtagcttcctttccacgtccacaagacaatgacagatgtgtttccttctttgctctttctagggatctttctagggatgttgattctctcacaatatttcaatgtcccatttctgtgtttcttctccctccaggggctgatttacaattacatgagtcttgtcacaataatttcctcctaaaatagaaattccaaaagaaaagattatttgttcaggcaggtgcttagcaatttcacaattttcacaagcttctgttcagctcaccatttcggtggatgaatgtgtcatttacaaagaagtctgaaatgggaagctgagtttgaacaggcttagccattattcacctcaaattggaccttattatgactcaaattgaaatactaaaaggtataatacatgattgtataagtggcgtgccttaatgtgattctttagaacaaagtgctcttgagagaactctggctgaatgtcaggtactgtgtttttgtttctacaccaacaaaactgtgactaacccaattaaagcaacagccatgaataatattggccctgaccttgctgaattcaaaaacaaggttaattgatacctaccataaattctacctgagggtttttaaggaccatggcaattcctggcaaaaagctagagatgtttctaagaaacagatgacattcatttcatggtttatggtgcttgaaatttagaactgttctgagttcacgtagcaaatgaaagttttacaactgtactaatgaacaaaaaccctaagctttgttgtttggctttttctgctaattgttttgtttgtaaaactgcctatcttaattttcttcaagcataattttaaatgacttaacatttctcttatacataaggatgtcctttacccaaaatgaggagatttggaactgaaactaatatccagggacacaacattgggtatcatcaaaggcccacctttaacatcaaggacaagttgatcactgagataagagctgatagttccatttttattcagtctccacttctgcctgaattgcccatgttcagtccatagagctactttagctccaggtgtgtcccggccaccaatcacatcaagacatgtatcactggcctaaaagggttaagaaatgattaattggcagtagtatgtttgctaaagtaagttgaattaggtcccttttatcttaggtaaacaagtcatagacatgaagtgtgtgtgtgtcttatctaaaaaaatactatatagtataatttcagtaagccttttttaatgtcttctttacggctgtgggtaggagatggtacagaaataaaccaactgaaatagaggtacttgtttttaataggatgtctacatctgacaacagatgttcaataaagatttggtgaattggaattaaatgttaaatccctgtttgcttaaaacgtattatgttgagcttggttttcttatgaaaacattgcatgatgggctaaagatatccagacaataattacttttaaaagtttttcatttttgaagcatgagaaaaagtagataatccattggtgatacaataaaacacagtttgaatgttt
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84864 -> Molecular function: GO:0001191 [RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription] evidence: IEA
            GeneID:84864 -> Molecular function: GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] evidence: IEA
            GeneID:84864 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:84864 -> Biological process: GO:0042254 [ribosome biogenesis] evidence: IEA
            GeneID:84864 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:84864 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:84864 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:84864 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:84864 -> Cellular component: GO:0005829 [cytosol] evidence: IEA

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