2024-04-26 09:00:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001258310 2826 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens NOP2 nucleolar protein (NOP2), transcript variant 5, mRNA. ACCESSION NM_001258310 VERSION NM_001258310.1 GI:385198062 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2826) AUTHORS Holsinger,L.J., Ward,K., Duffield,B., Zachwieja,J. and Jallal,B. TITLE The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn) JOURNAL Oncogene 21 (46), 7067-7076 (2002) PUBMED 12370829 REFERENCE 2 (bases 1 to 2826) AUTHORS Colombo,E., Marine,J.C., Danovi,D., Falini,B. and Pelicci,P.G. TITLE Nucleophosmin regulates the stability and transcriptional activity of p53 JOURNAL Nat. Cell Biol. 4 (7), 529-533 (2002) PUBMED 12080348 REFERENCE 3 (bases 1 to 2826) AUTHORS Ren,Y., Busch,R.K., Perlaky,L. and Busch,H. TITLE The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120 JOURNAL Eur. J. Biochem. 253 (3), 734-742 (1998) PUBMED 9654073 REFERENCE 4 (bases 1 to 2826) AUTHORS Jallal,B., Mossie,K., Vasiloudis,G., Knyazev,P., Zachwieja,J., Clairvoyant,F., Schilling,J. and Ullrich,A. TITLE The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase JOURNAL J. Biol. Chem. 272 (18), 12158-12163 (1997) PUBMED 9115287 REFERENCE 5 (bases 1 to 2826) AUTHORS Valdez,B.C., Perlaky,L., Henning,D., Saijo,Y., Chan,P.K. and Busch,H. TITLE Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23 JOURNAL J. Biol. Chem. 269 (38), 23776-23783 (1994) PUBMED 8089149 REFERENCE 6 (bases 1 to 2826) AUTHORS Valdez,B.C., Perlaky,L., Saijo,Y., Henning,D., Zhu,C., Busch,R.K., Zhang,W.W. and Busch,H. TITLE A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation JOURNAL Cancer Res. 52 (20), 5681-5686 (1992) PUBMED 1394192 REFERENCE 7 (bases 1 to 2826) AUTHORS Busch,H. TITLE The final common pathway of cancer JOURNAL Cancer Res. 50 (16), 4830-4838 (1990) PUBMED 2199030 REMARK Review article REFERENCE 8 (bases 1 to 2826) AUTHORS Larson,R.G., Henning,D., Haidar,M.A., Jhiang,S., Lin,W.L., Zhang,W.W. and Busch,H. TITLE Genomic structure of the human proliferating cell nucleolar protein P120 JOURNAL Cancer Commun. 2 (2), 63-71 (1990) PUBMED 2372471 REFERENCE 9 (bases 1 to 2826) AUTHORS Fonagy,A., Henning,D., Jhiang,S., Haidar,M., Busch,R.K., Larson,R., Valdez,B. and Busch,H. TITLE Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120 JOURNAL Cancer Commun. 1 (4), 243-251 (1989) PUBMED 2576976 REFERENCE 10 (bases 1 to 2826) AUTHORS Freeman,J.W., Busch,R.K., Gyorkey,F., Gyorkey,P., Ross,B.E. and Busch,H. TITLE Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase JOURNAL Cancer Res. 48 (5), 1244-1251 (1988) PUBMED 3422591 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC316656.1, BC082985.1 and CX868076.1. Transcript Variant: This variant (5) contains an alternate internal exon in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC082985.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-50 DC316656.1 1-50 51-2801 BC082985.1 1-2751 2802-2826 CX868076.1 1-25 c FEATURES Location/Qualifiers source 1..2826 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12p13" gene 1..2826 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="NOP2 nucleolar protein" /db_xref="GeneID:4839" /db_xref="HGNC:7867" /db_xref="MIM:164031" exon 1..126 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" misc_feature 113..115 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="upstream in-frame stop codon" exon 127..233 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" CDS 131..2017 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="isoform 4 is encoded by transcript variant 5; nucleolar protein 2 homolog; nucleolar protein 1, 120kDa; NOP2 nucleolar protein homolog; NOL1/NOP2/Sun domain family, member 1; putative ribosomal RNA methyltransferase NOP2; proliferating-cell nucleolar antigen p120; proliferation-associated nucleolar protein p120" /codon_start=1 /product="putative ribosomal RNA methyltransferase NOP2 isoform 4" /protein_id="NP_001245239.1" /db_xref="GI:385198063" /db_xref="CCDS:CCDS58202.1" /db_xref="GeneID:4839" /db_xref="HGNC:7867" /db_xref="MIM:164031" /translation="
MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTDGVLLCRSGWTAVVQSQLIATSTFQVQAILVPQTPK
" misc_feature 236..238 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 302..304 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 329..331 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 659..661 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 671..673 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 701..703 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P46087.2); phosphorylation site" misc_feature 1016..1873 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189" /db_xref="CDD:201649" misc_feature 1277..1663 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440" /db_xref="CDD:100107" misc_feature order(1289..1309,1364..1369,1442..1450,1496..1498) /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /note="S-adenosylmethionine binding site [chemical binding]; other site" /db_xref="CDD:100107" misc_feature 1292..1312 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P46087.2); Region: S-adenosyl-L-methionine binding (Potential)" exon 234..279 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 280..368 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" variation 348 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /replace="c" /replace="t" /db_xref="dbSNP:1128164" exon 369..592 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" variation 448 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /replace="c" /replace="t" /db_xref="dbSNP:35415744" variation 537 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /replace="c" /replace="t" /db_xref="dbSNP:35556146" exon 593..648 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 649..806 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 807..1006 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1007..1096 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1097..1184 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1185..1325 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1326..1465 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1466..1555 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1556..1678 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1679..1907 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 1908..2029 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" exon 2030..2802 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /inference="alignment:Splign:1.39.8" STS 2420..2569 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /standard_name="D12S1466" /db_xref="UniSTS:24641" STS 2657..2787 /gene="NOP2" /gene_synonym="NOL1; NOP120; NSUN1; p120" /standard_name="WI-15438" /db_xref="UniSTS:75552" ORIGIN
gcgaggctagcgctacccgtgcgcctgcgtggaacgattctgtggcgagtgccggccgaaagctaggtccggattgcacgtggagggccgcccgaagggcactctcggacattaacccgcattctgtaccatggggcgcaagttggaccctacgaaggagaagcgggggccaggccgaaaggcccggaagcagaagggtgccgagacagaactcgtcagattcttgcctgcagtaagtgacgaaaattccaagaggctgtctagtcgtgctcgaaagagggcagccaagaggagattgggctctgttgaagcccctaagacaaataagtctcctgaggccaaaccattgcctggaaagctaccaaaaggagctgtccagacagctggtaagaagggaccccagtccctatttaatgctcctcgaggcaagaagcgcccagcacctggcagtgatgaggaagaggaggaggaagactctgaagaagatggtatggtgaaccacggggacctctggggctccgaggacgatgctgatacggtagatgactatggagctgactccaactctgaggatgaggaggaaggtgaagcgttgctgcccattgaaagagctgctcggaagcagaaggcccgggaagctgctgctgggatccagtggagtgaagaggagaccgaggacgaggaggaagagaaagaagtgacccctgagtcaggccccccaaaggtggaagaggcagatgggggcctgcagatcaatgtggatgaggaaccatttgtgctgccccctgctggggagatggagcaggatgcccaggctccagacctgcaacgagttcacaagcggatccaggatattgtgggaattctgcgtgattttggggctcagcgggaggaagggcggtctcgttctgaatacctgaaccggctcaagaaggatctggccatttactactcctatggagacttcctgcttggcaagctcatggacctcttccctctgtctgagctggtggagttcttagaagctaatgaggtgcctcggcccgtcaccctccggaccaataccttgaaaacccgacgccgagaccttgcacaggctctaatcaatcgtggggttaacctggatcccctgggcaagtggtcaaagactggactagtggtgtatgattcttctgtgcccattggtgctacccccgagtacctggctgggcactacatgctgcagggagcctccagcatgttgcccgtcatggccttggcaccccaggaacatgagcggatcctggacatgtgttgtgcccctggaggaaagaccagctacatggcccagctgatgaagaacacgggtgtgatccttgccaatgacgccaatgctgagcggctcaagagtgttgtgggcaacttgcatcggctgggagtcaccaacaccattatcagccactatgatgggcgccagttccccaaggtggtggggggctttgaccgagtactgctggatgctccctgcagtggcactggggtcatctccaaggatccagccgtgaagactaacaaggatgagaaggacatcctgcgctgtgctcacctccagaaggagttgctcctgagtgctattgactctgtcaatgcgacctccaagacaggaggctacctggtttactgcacctgttctatcacagtagaagagaatgagtgggtggtagactatgctctgaaaaagaggaatgtgcgactggtgcccacgggcctagactttggccaggaaggttttacccgctttcgagaaaggcgcttccaccccagtctgcgttctacccgacgcttctaccctcatacccacaatatggatgggttcttcattgccaagttcaagaaattttccaattctatccctcagtcccagacagacggtgtcttgctttgtcgctcaggctggactgcagtggtgcaatctcagctcattgcaacctccaccttccaggttcaagcgattcttgtgcctcagactcccaagtagctaggattacaggaaattctgaaacagccacacctacaaatgtagacttgcctcaggtcatccccaagtctgagaacagcagccagccagccaagaaagccaagggggctgcaaagacaaagcagcagctgcagaaacagcaacatcccaagaaggcctccttccagaagctgaatggcatctccaaaggggcagactcagaattgtccactgtaccttctgtcacaaagacccaagcttcctccagcttccaggatagcagtcagccagctggaaaagccgaagggatcagggagccaaaggtgactgggaagctaaagcaacgatcacctaaattacagtcctccaagaaagttgctttcctcaggcagaatgcccctcccaagggcacagacacacaaacaccggctgtgttatccccatccaagactcaggccaccctgaaacctaaggaccatcatcagccccttggaagggccaagggggttgagaagcagcagttgccagagcagccttttgagaaagctgccttccagaaacagaatgatacccccaaggggcctcagcctcccactgtgtctcccatccgttccagccgccccccaccagcaaagaggaagaaatctcagtccaggggcaacagccagctgctgctatcttagatggttgaaaactagacgggtggctcactgccattgtcaccaggttggaactcttgcctctgtgaggatgccttctctactgtgcatacccatgaaatttaatacacattttaaaacctctggaaaaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4839 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA GeneID:4839 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4839 -> Molecular function: GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] evidence: IEA GeneID:4839 -> Biological process: GO:0006364 [rRNA processing] evidence: IEA GeneID:4839 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: TAS GeneID:4839 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:4839 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
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