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2024-03-29 16:30:11, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001258309            2815 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens NOP2 nucleolar protein (NOP2), transcript variant 4,
            mRNA.
ACCESSION   NM_001258309
VERSION     NM_001258309.1  GI:385198060
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Holsinger,L.J., Ward,K., Duffield,B., Zachwieja,J. and Jallal,B.
  TITLE     The transmembrane receptor protein tyrosine phosphatase DEP1
            interacts with p120(ctn)
  JOURNAL   Oncogene 21 (46), 7067-7076 (2002)
   PUBMED   12370829
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Colombo,E., Marine,J.C., Danovi,D., Falini,B. and Pelicci,P.G.
  TITLE     Nucleophosmin regulates the stability and transcriptional activity
            of p53
  JOURNAL   Nat. Cell Biol. 4 (7), 529-533 (2002)
   PUBMED   12080348
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Ren,Y., Busch,R.K., Perlaky,L. and Busch,H.
  TITLE     The 58-kDa microspherule protein (MSP58), a nucleolar protein,
            interacts with nucleolar protein p120
  JOURNAL   Eur. J. Biochem. 253 (3), 734-742 (1998)
   PUBMED   9654073
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Jallal,B., Mossie,K., Vasiloudis,G., Knyazev,P., Zachwieja,J.,
            Clairvoyant,F., Schilling,J. and Ullrich,A.
  TITLE     The receptor-like protein-tyrosine phosphatase DEP-1 is
            constitutively associated with a 64-kDa protein serine/threonine
            kinase
  JOURNAL   J. Biol. Chem. 272 (18), 12158-12163 (1997)
   PUBMED   9115287
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Valdez,B.C., Perlaky,L., Henning,D., Saijo,Y., Chan,P.K. and
            Busch,H.
  TITLE     Identification of the nuclear and nucleolar localization signals of
            the protein p120. Interaction with translocation protein B23
  JOURNAL   J. Biol. Chem. 269 (38), 23776-23783 (1994)
   PUBMED   8089149
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Valdez,B.C., Perlaky,L., Saijo,Y., Henning,D., Zhu,C., Busch,R.K.,
            Zhang,W.W. and Busch,H.
  TITLE     A region of antisense RNA from human p120 cDNA with high homology
            to mouse p120 cDNA inhibits NIH 3T3 proliferation
  JOURNAL   Cancer Res. 52 (20), 5681-5686 (1992)
   PUBMED   1394192
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   Busch,H.
  TITLE     The final common pathway of cancer
  JOURNAL   Cancer Res. 50 (16), 4830-4838 (1990)
   PUBMED   2199030
  REMARK    Review article
REFERENCE   8  (bases 1 to 2815)
  AUTHORS   Larson,R.G., Henning,D., Haidar,M.A., Jhiang,S., Lin,W.L.,
            Zhang,W.W. and Busch,H.
  TITLE     Genomic structure of the human proliferating cell nucleolar protein
            P120
  JOURNAL   Cancer Commun. 2 (2), 63-71 (1990)
   PUBMED   2372471
REFERENCE   9  (bases 1 to 2815)
  AUTHORS   Fonagy,A., Henning,D., Jhiang,S., Haidar,M., Busch,R.K., Larson,R.,
            Valdez,B. and Busch,H.
  TITLE     Cloning of the cDNA and sequence of the human proliferating-cell
            nucleolar protein P120
  JOURNAL   Cancer Commun. 1 (4), 243-251 (1989)
   PUBMED   2576976
REFERENCE   10 (bases 1 to 2815)
  AUTHORS   Freeman,J.W., Busch,R.K., Gyorkey,F., Gyorkey,P., Ross,B.E. and
            Busch,H.
  TITLE     Identification and characterization of a human
            proliferation-associated nucleolar antigen with a molecular weight
            of 120,000 expressed in early G1 phase
  JOURNAL   Cancer Res. 48 (5), 1244-1251 (1988)
   PUBMED   3422591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC316656.1, BC106072.1 and CX868076.1.
            
            Transcript Variant: This variant (4) contains an alternate exon and
            uses an alternate splice site in the coding region, but maintians
            the reading frame, compared to variant 1. The encoded isoform (3)
            is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106072.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025095 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DC316656.1         1-54
            55-2790             BC106072.1         1-2736
            2791-2815           CX868076.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13"
     gene            1..2815
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="NOP2 nucleolar protein"
                     /db_xref="GeneID:4839"
                     /db_xref="HGNC:7867"
                     /db_xref="MIM:164031"
     exon            1..126
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    113..115
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="upstream in-frame stop codon"
     exon            127..233
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     CDS             131..2668
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="isoform 3 is encoded by transcript variant 4;
                     nucleolar protein 2 homolog; nucleolar protein 1, 120kDa;
                     NOP2 nucleolar protein homolog; NOL1/NOP2/Sun domain
                     family, member 1; putative ribosomal RNA methyltransferase
                     NOP2; proliferating-cell nucleolar antigen p120;
                     proliferation-associated nucleolar protein p120"
                     /codon_start=1
                     /product="putative ribosomal RNA methyltransferase NOP2
                     isoform 3"
                     /protein_id="NP_001245238.1"
                     /db_xref="GI:385198061"
                     /db_xref="CCDS:CCDS58204.1"
                     /db_xref="GeneID:4839"
                     /db_xref="HGNC:7867"
                     /db_xref="MIM:164031"
                     /translation="
MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEAAGVQWLGLGSLQPPPPGFKQFSCLSFPSSWDLQLLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS
"
     misc_feature    605..>697
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="Putative binding domain; Region: GVQW; pfam13900"
                     /db_xref="CDD:206071"
     misc_feature    1127..1984
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu;
                     pfam01189"
                     /db_xref="CDD:201649"
     misc_feature    1388..1774
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
                     cd02440"
                     /db_xref="CDD:100107"
     misc_feature    order(1400..1420,1475..1480,1553..1561,1607..1609)
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     exon            234..279
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            280..368
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     variation       348
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1128164"
     exon            369..604
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     variation       460
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35415744"
     variation       549
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35556146"
     exon            605..703
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            704..759
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            760..917
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            918..1117
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1118..1207
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1208..1295
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1296..1436
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1437..1576
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1577..1666
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1667..1789
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            1790..2018
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     exon            2019..2791
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /inference="alignment:Splign:1.39.8"
     STS             2409..2558
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /standard_name="D12S1466"
                     /db_xref="UniSTS:24641"
     STS             2646..2776
                     /gene="NOP2"
                     /gene_synonym="NOL1; NOP120; NSUN1; p120"
                     /standard_name="WI-15438"
                     /db_xref="UniSTS:75552"
ORIGIN      
gcgaggctagcgctacccgtgcgcctgcgtggaacgattctgtggcgagtgccggccgaaagctaggtccggattgcacgtggagggccgcccgaagggcactctcggacattaacccgcattctgtaccatggggcgcaagttggaccctacgaaggagaagcgggggccaggccgaaaggcccggaagcagaagggtgccgagacagaactcgtcagattcttgcctgcagtaagtgacgaaaattccaagaggctgtctagtcgtgctcgaaagagggcagccaagaggagattgggctctgttgaagcccctaagacaaataagtctcctgaggccaaaccattgcctggaaagctaccaaaagggatctctgcaggagctgtccagacagctggtaagaagggaccccagtccctatttaatgctcctcgaggcaagaagcgcccagcacctggcagtgatgaggaagaggaggaggaagactctgaagaagatggtatggtgaaccacggggacctctggggctccgaggacgatgctgatacggtagatgactatggagctgactccaactctgaggatgaggaggaaggtgaagcggctggagtgcagtggctcggtcttggctcactgcaacctccacctcccgggttcaagcaattctcctgcctcagcttcccaagtagctgggatttacagttgctgcccattgaaagagctgctcggaagcagaaggcccgggaagctgctgctgggatccagtggagtgaagaggagaccgaggacgaggaggaagagaaagaagtgacccctgagtcaggccccccaaaggtggaagaggcagatgggggcctgcagatcaatgtggatgaggaaccatttgtgctgccccctgctggggagatggagcaggatgcccaggctccagacctgcaacgagttcacaagcggatccaggatattgtgggaattctgcgtgattttggggctcagcgggaggaagggcggtctcgttctgaatacctgaaccggctcaagaaggatctggccatttactactcctatggagacttcctgcttggcaagctcatggacctcttccctctgtctgagctggtggagttcttagaagctaatgaggtgcctcggcccgtcaccctccggaccaataccttgaaaacccgacgccgagaccttgcacaggctctaatcaatcgtggggttaacctggatcccctgggcaagtggtcaaagactggactagtggtgtatgattcttctgtgcccattggtgctacccccgagtacctggctgggcactacatgctgcagggagcctccagcatgttgcccgtcatggccttggcaccccaggaacatgagcggatcctggacatgtgttgtgcccctggaggaaagaccagctacatggcccagctgatgaagaacacgggtgtgatccttgccaatgacgccaatgctgagcggctcaagagtgttgtgggcaacttgcatcggctgggagtcaccaacaccattatcagccactatgatgggcgccagttccccaaggtggtggggggctttgaccgagtactgctggatgctccctgcagtggcactggggtcatctccaaggatccagccgtgaagactaacaaggatgagaaggacatcctgcgctgtgctcacctccagaaggagttgctcctgagtgctattgactctgtcaatgcgacctccaagacaggaggctacctggtttactgcacctgttctatcacagtagaagagaatgagtgggtggtagactatgctctgaaaaagaggaatgtgcgactggtgcccacgggcctagactttggccaggaaggttttacccgctttcgagaaaggcgcttccaccccagtctgcgttctacccgacgcttctaccctcatacccacaatatggatgggttcttcattgccaagttcaagaaattttccaattctatccctcagtcccagacaggaaattctgaaacagccacacctacaaatgtagacttgcctcaggtcatccccaagtctgagaacagcagccagccagccaagaaagccaagggggctgcaaagacaaagcagcagctgcagaaacagcaacatcccaagaaggcctccttccagaagctgaatggcatctccaaaggggcagactcagaattgtccactgtaccttctgtcacaaagacccaagcttcctccagcttccaggatagcagtcagccagctggaaaagccgaagggatcagggagccaaaggtgactgggaagctaaagcaacgatcacctaaattacagtcctccaagaaagttgctttcctcaggcagaatgcccctcccaagggcacagacacacaaacaccggctgtgttatccccatccaagactcaggccaccctgaaacctaaggaccatcatcagccccttggaagggccaagggggttgagaagcagcagttgccagagcagccttttgagaaagctgccttccagaaacagaatgatacccccaaggggcctcagcctcccactgtgtctcccatccgttccagccgccccccaccagcaaagaggaagaaatctcagtccaggggcaacagccagctgctgctatcttagatggttgaaaactagacgggtggctcactgccattgtcaccaggttggaactcttgcctctgtgaggatgccttctctactgtgcatacccatgaaatttaatacacattttaaaacctctggaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4839 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:4839 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4839 -> Molecular function: GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] evidence: IEA
            GeneID:4839 -> Biological process: GO:0006364 [rRNA processing] evidence: IEA
            GeneID:4839 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: TAS
            GeneID:4839 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:4839 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA

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