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2024-04-26 17:43:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001258005 1510 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens chitinase, acidic (CHIA), transcript variant 9, mRNA.
ACCESSION NM_001258005
VERSION NM_001258005.1 GI:384367987
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1510)
AUTHORS Di Rosa,M., De Gregorio,C., Malaguarnera,G., Tuttobene,M.,
Biazzo,F. and Malaguarnera,L.
TITLE Evaluation of AMCase and CHIT-1 expression in monocyte macrophages
lineage
JOURNAL Mol. Cell. Biochem. 374 (1-2), 73-80 (2013)
PUBMED 23129258
REMARK GeneRIF: results showed that the expression of AMCase and CHIT-1
were differently modulated in monocyte macrophages at different
stage of maturation. The behavior of these two active chitinase
suggests that in the immune response their role is complementary.
REFERENCE 2 (bases 1 to 1510)
AUTHORS Aminuddin,F., Akhabir,L., Stefanowicz,D., Pare,P.D., Connett,J.E.,
Anthonisen,N.R., Fahy,J.V., Seibold,M.A., Burchard,E.G., Eng,C.,
Gulsvik,A., Bakke,P., Cho,M.H., Litonjua,A., Lomas,D.A.,
Anderson,W.H., Beaty,T.H., Crapo,J.D., Silverman,E.K. and
Sandford,A.J.
TITLE Genetic association between human chitinases and lung function in
COPD
JOURNAL Hum. Genet. 131 (7), 1105-1114 (2012)
PUBMED 22200767
REMARK GeneRIF: study demonstrated genetic associations between chitinase
gene variants and lung function level and rate of decline in
chronic obstructive pulmonary disease patients from the Lung Health
Study; also functional effect of the rs3818822 polymorphism on
AMCase levels and activity was demonstrated
REFERENCE 3 (bases 1 to 1510)
AUTHORS Birben,E., Sackesen,C., Kazani,S., Tincer,G., Karaaslan,C.,
Durgunsu,B., Gursel,I., Wechsler,M.E., Israel,E. and Kalayci,O.
TITLE The effects of an insertion in the 5'UTR of the AMCase on gene
expression and pulmonary functions
JOURNAL Respir Med 105 (8), 1160-1169 (2011)
PUBMED 21511453
REMARK GeneRIF: A ten base pair insertion in the second exon in the 5'UTR
region of the AMCase gene may modify the gene expression and thus
may affect the severity of asthma.
REFERENCE 4 (bases 1 to 1510)
AUTHORS Gu,Z., Cao,Z. and Jin,M.
TITLE Expression and role of acidic mammalian chitinase and eotaxin-3 in
chronic rhinosinusitis with nasal polyps
JOURNAL J Otolaryngol Head Neck Surg 40 (1), 64-69 (2011)
PUBMED 21303604
REMARK GeneRIF: AMCase and eotaxin-3 may be important mediators in the
pathogenesis of nasal polyps. The increased AMCase and eotaxin-3
might lead to nasal polyp formation and growth.
REFERENCE 5 (bases 1 to 1510)
AUTHORS Park,S.K., Heo,K.W., Hur,D.Y. and Yang,Y.I.
TITLE Chitinolytic activity in nasal polyps
JOURNAL Am J Rhinol Allergy 25 (1), 12-14 (2011)
PUBMED 21711963
REMARK GeneRIF: increased chitinolytic activity in nasal polyps
REFERENCE 6 (bases 1 to 1510)
AUTHORS Chou,Y.T., Yao,S., Czerwinski,R., Fleming,M., Krykbaev,R., Xuan,D.,
Zhou,H., Brooks,J., Fitz,L., Strand,J., Presman,E., Lin,L.,
Aulabaugh,A. and Huang,X.
TITLE Kinetic characterization of recombinant human acidic mammalian
chitinase
JOURNAL Biochemistry 45 (14), 4444-4454 (2006)
PUBMED 16584180
REMARK GeneRIF: human AMCase has only one pH optimum for k(cat)/K(m)
between pH 4 and 5. Steady state kinetics shows that human AMCase
has 'low' intrinsic transglycosidase activity, which leads to the
observation of apparent substrate inhibition.
REFERENCE 7 (bases 1 to 1510)
AUTHORS Zhu,Z., Zheng,T., Homer,R.J., Kim,Y.K., Chen,N.Y., Cohn,L.,
Hamid,Q. and Elias,J.A.
TITLE Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13
pathway activation
JOURNAL Science 304 (5677), 1678-1682 (2004)
PUBMED 15192232
REMARK GeneRIF: expressed in exaggerated quantities in human asthma
REFERENCE 8 (bases 1 to 1510)
AUTHORS Goto,M., Fujimoto,W., Nio,J., Iwanaga,T. and Kawasaki,T.
TITLE Immunohistochemical demonstration of acidic mammalian chitinase in
the mouse salivary gland and gastric mucosa
JOURNAL Arch. Oral Biol. 48 (10), 701-707 (2003)
PUBMED 12971947
REFERENCE 9 (bases 1 to 1510)
AUTHORS Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
Bijl,N., Moe,C., Place,A. and Aerts,J.M.
TITLE Identification of a novel acidic mammalian chitinase distinct from
chitotriosidase
JOURNAL J. Biol. Chem. 276 (9), 6770-6778 (2001)
PUBMED 11085997
REFERENCE 10 (bases 1 to 1510)
AUTHORS Saito,A., Ozaki,K., Fujiwara,T., Nakamura,Y. and Tanigami,A.
TITLE Isolation and mapping of a human lung-specific gene, TSA1902,
encoding a novel chitinase family member
JOURNAL Gene 239 (2), 325-331 (1999)
PUBMED 10548734
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290702.1, AB025008.1,
AF290004.1, AY911311.1, AL356387.16 and BC036339.1.
Summary: The protein encoded by this gene degrades chitin, which is
found in the cell wall of most fungi as well as in arthropods and
some nematodes. The encoded protein can also stimulate interleukin
13 expression, and variations in this gene can lead to asthma
susceptibility. Several transcript variants encoding a few
different isoforms have been found for this gene. [provided by
RefSeq, Apr 2012].
Transcript Variant: This variant (9) lacks exons and contains
another exon in the 5' coding region, initiating translation at a
downstream AUG compared to variant 4. The encoded isoform (b, also
known as TSA1902-S) has a shorter N-terminus and lacks a signal
peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode
the same isoform (b).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AY911311.1, AY911310.1 [ECO:0000331]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 AK290702.1 1-10
11-64 AB025008.1 1-54
65-164 AF290004.1 1-100
165-367 AY911311.1 1-203
368-368 AL356387.16 4433-4433
369-952 AY911311.1 205-788
953-1510 BC036339.1 795-1352
FEATURES Location/Qualifiers
source 1..1510
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.2"
gene 1..1510
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="chitinase, acidic"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
exon 1..99
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 16..18
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:34698010"
variation 16..17
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:374234404"
variation 22
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:116488064"
variation 44
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:12026825"
variation 72
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149411814"
variation 75
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:146385552"
variation 88
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139768111"
variation 97
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:142723581"
exon 100..192
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 103
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:193167990"
variation 123
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:376415475"
variation 126
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:367796033"
variation 131
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:371120238"
variation 134
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200693541"
variation 136..137
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="aagcc"
/db_xref="dbSNP:201649523"
variation 137..138
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="agccaatct"
/db_xref="dbSNP:200345479"
variation 138..139
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="gccaatctag"
/db_xref="dbSNP:143789088"
variation 140..141
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="caatctaggc"
/db_xref="dbSNP:375930070"
variation 146
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:374220212"
variation 151
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:201988572"
variation 155
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:17027394"
variation 163
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:376159900"
variation 165
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200929969"
variation 166
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373861430"
variation 170
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:368020028"
variation 178
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:371398270"
variation 182
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:200053948"
variation 185
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:375003916"
exon 193..222
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
exon 223..279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 226
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368828123"
variation 233
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:143910053"
variation 262
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147282128"
variation 269
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:3818822"
variation 279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201556508"
exon 280..418
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 368
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2786156"
variation 407
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:72693264"
misc_feature 416..418
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="upstream in-frame stop codon"
exon 419..543
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
CDS 422..1369
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/EC_number="3.2.1.14"
/note="isoform b is encoded by transcript variant 9;
acidic mammalian chitinase; lung-specific protein TSA1902"
/codon_start=1
/product="acidic mammalian chitinase isoform b"
/protein_id="NP_001244934.1"
/db_xref="GI:384367988"
/db_xref="CCDS:CCDS58017.1"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
/translation="
MREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
"
misc_feature <422..1099
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="The GH18 (glycosyl hydrolase, family 18) type II
chitinases hydrolyze chitin, an abundant polymer of
beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
major component of the cell wall of fungi and the
exoskeleton of arthropods. Chitinases have...; Region:
GH18_chitinase-like; cl10447"
/db_xref="CDD:209141"
misc_feature <422..1033
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Glyco_18 domain; Region: Glyco_18; smart00636"
/db_xref="CDD:197811"
misc_feature 1223..1366
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Chitin-binding domain type 2; Region: ChtBD2;
smart00494"
/db_xref="CDD:197759"
variation 425
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139158262"
variation 440
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:199860140"
variation 443
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:143586120"
variation 453
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144679403"
variation 455
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:116430435"
variation 460
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:200617710"
variation 480
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377181497"
variation 503
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:369860168"
variation 518
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199874052"
variation 533
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="c"
/db_xref="dbSNP:150563512"
exon 544..667
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 550
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:140904700"
variation 562
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368843945"
variation 574
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:148384495"
variation 575
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200134913"
variation 631
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369614927"
variation 633
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:376497990"
variation 638
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147103194"
variation 643
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:143960572"
variation 652
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139759326"
variation 653
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142137716"
variation 659
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:151297358"
exon 668..853
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 691
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:114510939"
variation 695
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:181434663"
variation 722
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:367730751"
variation 749
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:78293817"
variation 754
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:139093708"
variation 763
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:143107428"
variation 765
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:371506503"
variation 770
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143732960"
variation 786
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150309903"
variation 801
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:61748620"
variation 811
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:61748619"
variation 821
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:79500525"
variation 827
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139420194"
variation 829
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201390788"
variation 840
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:150840174"
variation 851
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201266629"
exon 854..973
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 861
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:142736771"
variation 888
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139812869"
variation 894..895
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="tgcccctcaggaag"
/db_xref="dbSNP:151326722"
variation 896
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200566957"
variation 898..899
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:375881947"
variation 912
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:74706064"
variation 931
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:144546962"
variation 932
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:375947945"
variation 934
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:17027410"
variation 935
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:190772785"
variation 937
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:144182515"
variation 946
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:370020615"
variation 952
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:182916944"
variation 953
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:2275253"
variation 960
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:189146821"
variation 964
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:200092579"
variation 968
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:374270214"
exon 974..1115
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 999
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2275254"
variation 1006
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:151038298"
variation 1007
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201691527"
variation 1008
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:374315938"
variation 1010
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142800191"
variation 1020
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373985805"
variation 1035
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:141843885"
variation 1051
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:76395847"
variation 1067
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:36011905"
variation 1081
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368203516"
variation 1089
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143969273"
variation 1094
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:147768976"
variation 1099
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2820092"
variation 1100
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:371701062"
variation 1103
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:12094378"
exon 1116..1469
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 1123
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:372590829"
variation 1130
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:140459744"
variation 1144
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199879175"
variation 1153
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377085074"
variation 1156
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150421495"
variation 1158
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:145023911"
variation 1159
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:187769579"
variation 1170
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623576"
variation 1178
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199811046"
variation 1179
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:141747675"
variation 1184
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138227985"
variation 1204
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:376164222"
variation 1210
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:35242709"
variation 1214
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149869566"
variation 1233
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:2256721"
variation 1246
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:369442393"
variation 1253
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:368010768"
variation 1254
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:143551303"
variation 1256
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138073907"
variation 1275
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201456008"
variation 1279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368211379"
variation 1315
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:145057685"
variation 1324
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:140461957"
variation 1325
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142653250"
variation 1364
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:146040153"
variation 1386
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:373720681"
variation 1391
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139802202"
variation 1403
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:372826781"
variation 1408
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:141163072"
polyA_signal 1445..1450
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
polyA_site 1469
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
ORIGIN
aaagcttcatgaaacctcctcgtctgtgcacgaacaggtggccgactctggagcccaggctgttgctttccagtctggtggtgaatcctccatagtctgaagcctttgtgataaccacagaatcagaacatataaaaagctctgcgggactggtgctgactgcaaccatgacaaagcttattctcctcacaggtcttgtccttatactgaatttgcagctcggaacagccagctgaaaactctcctggccattggaggctggaacttcgggactgccccatgaggaaactaaagtacagagaggatttaagcaacttgcccaagatcacacaactagtaggaatcataacttcctctgcagtttggccacagagtccattgcttctaagcattacactaggctgcccgttattactgagaaatgcgtgaagcttttgagcaggaggccaagcagatcaacaagcccaggctgatggtcactgctgcagtagctgctggcatctccaatatccagtctggctatgagatcccccaactgtcacagtacctggactacatccatgtcatgacctacgacctccatggctcctgggagggctacactggagagaacagccccctctacaaatacccgactgacaccggcagcaacgcctacctcaatgtggattatgtcatgaactactggaaggacaatggagcaccagctgagaagctcatcgttggattccctacctatggacacaacttcatcctgagcaacccctccaacactggaattggtgcccccacctctggtgctggtcctgctgggccctatgccaaggagtctgggatctgggcttactacgagatctgtaccttcctgaaaaatggagccactcagggatgggatgcccctcaggaagtgccttatgcctatcagggcaatgtgtgggttggctatgacaacatcaagagcttcgatattaaggctcaatggcttaagcacaacaaatttggaggcgccatggtctgggccattgatctggatgacttcactggcactttctgcaaccagggcaagtttcccctaatctccaccctgaagaaggccctcggcctgcagagtgcaagttgcacggctccagctcagcccattgagccaataactgctgctcccagtggcagcgggaacgggagcgggagtagcagctctggaggcagctcgggaggcagtggattctgtgctgtcagagccaacggcctctaccccgtggcaaataacagaaatgccttctggcactgcgtgaatggagtcacgtaccagcagaactgccaggccgggcttgtcttcgacaccagctgtgattgctgcaactgggcataaacctgacctggtctatattccctagagttccagtctcttttgcttaggacatgttgcccctacctaaagtcctgcaataaaatcagcagtcaaaacatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27159 -> Molecular function: GO:0003796 [lysozyme activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: IDA
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0008061 [chitin binding] evidence: TAS
GeneID:27159 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
GeneID:27159 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: NAS
GeneID:27159 -> Biological process: GO:0000272 [polysaccharide catabolic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0001101 [response to acid] evidence: TAS
GeneID:27159 -> Biological process: GO:0002532 [production of molecular mediator involved in inflammatory response] evidence: IDA
GeneID:27159 -> Biological process: GO:0006030 [chitin metabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: IDA
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006037 [cell wall chitin metabolic process] evidence: TAS
GeneID:27159 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0006955 [immune response] evidence: NAS
GeneID:27159 -> Biological process: GO:0007586 [digestion] evidence: NAS
GeneID:27159 -> Biological process: GO:0009620 [response to fungus] evidence: TAS
GeneID:27159 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IC
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001244934 -> EC 3.2.1.14
by
@meso_cacase at
DBCLS
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