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2024-03-28 20:41:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001258003            1444 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens chitinase, acidic (CHIA), transcript variant 7, mRNA.
ACCESSION   NM_001258003
VERSION     NM_001258003.1  GI:384367985
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1444)
  AUTHORS   Di Rosa,M., De Gregorio,C., Malaguarnera,G., Tuttobene,M.,
            Biazzo,F. and Malaguarnera,L.
  TITLE     Evaluation of AMCase and CHIT-1 expression in monocyte macrophages
            lineage
  JOURNAL   Mol. Cell. Biochem. 374 (1-2), 73-80 (2013)
   PUBMED   23129258
  REMARK    GeneRIF: results showed that the expression of AMCase and CHIT-1
            were differently modulated in monocyte macrophages at different
            stage of maturation. The behavior of these two active chitinase
            suggests that in the immune response their role is complementary.
REFERENCE   2  (bases 1 to 1444)
  AUTHORS   Aminuddin,F., Akhabir,L., Stefanowicz,D., Pare,P.D., Connett,J.E.,
            Anthonisen,N.R., Fahy,J.V., Seibold,M.A., Burchard,E.G., Eng,C.,
            Gulsvik,A., Bakke,P., Cho,M.H., Litonjua,A., Lomas,D.A.,
            Anderson,W.H., Beaty,T.H., Crapo,J.D., Silverman,E.K. and
            Sandford,A.J.
  TITLE     Genetic association between human chitinases and lung function in
            COPD
  JOURNAL   Hum. Genet. 131 (7), 1105-1114 (2012)
   PUBMED   22200767
  REMARK    GeneRIF: study demonstrated genetic associations between chitinase
            gene variants and lung function level and rate of decline in
            chronic obstructive pulmonary disease patients from the Lung Health
            Study; also functional effect of the rs3818822 polymorphism on
            AMCase levels and activity was demonstrated
REFERENCE   3  (bases 1 to 1444)
  AUTHORS   Birben,E., Sackesen,C., Kazani,S., Tincer,G., Karaaslan,C.,
            Durgunsu,B., Gursel,I., Wechsler,M.E., Israel,E. and Kalayci,O.
  TITLE     The effects of an insertion in the 5'UTR of the AMCase on gene
            expression and pulmonary functions
  JOURNAL   Respir Med 105 (8), 1160-1169 (2011)
   PUBMED   21511453
  REMARK    GeneRIF: A ten base pair insertion in the second exon in the 5'UTR
            region of the AMCase gene may modify the gene expression and thus
            may affect the severity of asthma.
REFERENCE   4  (bases 1 to 1444)
  AUTHORS   Gu,Z., Cao,Z. and Jin,M.
  TITLE     Expression and role of acidic mammalian chitinase and eotaxin-3 in
            chronic rhinosinusitis with nasal polyps
  JOURNAL   J Otolaryngol Head Neck Surg 40 (1), 64-69 (2011)
   PUBMED   21303604
  REMARK    GeneRIF: AMCase and eotaxin-3 may be important mediators in the
            pathogenesis of nasal polyps. The increased AMCase and eotaxin-3
            might lead to nasal polyp formation and growth.
REFERENCE   5  (bases 1 to 1444)
  AUTHORS   Park,S.K., Heo,K.W., Hur,D.Y. and Yang,Y.I.
  TITLE     Chitinolytic activity in nasal polyps
  JOURNAL   Am J Rhinol Allergy 25 (1), 12-14 (2011)
   PUBMED   21711963
  REMARK    GeneRIF: increased chitinolytic activity in nasal polyps
REFERENCE   6  (bases 1 to 1444)
  AUTHORS   Chou,Y.T., Yao,S., Czerwinski,R., Fleming,M., Krykbaev,R., Xuan,D.,
            Zhou,H., Brooks,J., Fitz,L., Strand,J., Presman,E., Lin,L.,
            Aulabaugh,A. and Huang,X.
  TITLE     Kinetic characterization of recombinant human acidic mammalian
            chitinase
  JOURNAL   Biochemistry 45 (14), 4444-4454 (2006)
   PUBMED   16584180
  REMARK    GeneRIF: human AMCase has only one pH optimum for k(cat)/K(m)
            between pH 4 and 5. Steady state kinetics shows that human AMCase
            has 'low' intrinsic transglycosidase activity, which leads to the
            observation of apparent substrate inhibition.
REFERENCE   7  (bases 1 to 1444)
  AUTHORS   Zhu,Z., Zheng,T., Homer,R.J., Kim,Y.K., Chen,N.Y., Cohn,L.,
            Hamid,Q. and Elias,J.A.
  TITLE     Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13
            pathway activation
  JOURNAL   Science 304 (5677), 1678-1682 (2004)
   PUBMED   15192232
  REMARK    GeneRIF: expressed in exaggerated quantities in human asthma
REFERENCE   8  (bases 1 to 1444)
  AUTHORS   Goto,M., Fujimoto,W., Nio,J., Iwanaga,T. and Kawasaki,T.
  TITLE     Immunohistochemical demonstration of acidic mammalian chitinase in
            the mouse salivary gland and gastric mucosa
  JOURNAL   Arch. Oral Biol. 48 (10), 701-707 (2003)
   PUBMED   12971947
REFERENCE   9  (bases 1 to 1444)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J. Biol. Chem. 276 (9), 6770-6778 (2001)
   PUBMED   11085997
REFERENCE   10 (bases 1 to 1444)
  AUTHORS   Saito,A., Ozaki,K., Fujiwara,T., Nakamura,Y. and Tanigami,A.
  TITLE     Isolation and mapping of a human lung-specific gene, TSA1902,
            encoding a novel chitinase family member
  JOURNAL   Gene 239 (2), 325-331 (1999)
   PUBMED   10548734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290702.1, AY825504.1 and
            BC036339.1.
            
            Summary: The protein encoded by this gene degrades chitin, which is
            found in the cell wall of most fungi as well as in arthropods and
            some nematodes. The encoded protein can also stimulate interleukin
            13 expression, and variations in this gene can lead to asthma
            susceptibility. Several transcript variants encoding a few
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Transcript Variant: This variant (7) lacks exons in the 5' coding
            region and initiates translation at a downstream AUG compared to
            variant 4. The encoded isoform (a, also known as TSA1902-L) has a
            shorter N-terminus and lacks a signal peptide compared to isoform
            c. Variants 2, 5, and 7 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY825504.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK290702.1         1-10
            11-245              AY825504.1         1-235
            246-1444            BC036339.1         154-1352
FEATURES             Location/Qualifiers
     source          1..1444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1444
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /note="chitinase, acidic"
                     /db_xref="GeneID:27159"
                     /db_xref="HGNC:17432"
                     /db_xref="MIM:606080"
     exon            1..99
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       16..18
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:34698010"
     variation       16..17
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:374234404"
     variation       22
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116488064"
     variation       44
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12026825"
     variation       72
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149411814"
     variation       75
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146385552"
     variation       88
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139768111"
     variation       97
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142723581"
     exon            100..129
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     exon            130..186
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       133
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368828123"
     variation       140
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143910053"
     variation       169
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147282128"
     variation       176
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3818822"
     variation       186
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201556508"
     exon            187..352
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     CDS             197..1303
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /EC_number="3.2.1.14"
                     /note="isoform a is encoded by transcript variant 7;
                     acidic mammalian chitinase; lung-specific protein TSA1902"
                     /codon_start=1
                     /product="acidic mammalian chitinase isoform a"
                     /protein_id="NP_001244932.1"
                     /db_xref="GI:384367986"
                     /db_xref="CCDS:CCDS832.1"
                     /db_xref="GeneID:27159"
                     /db_xref="HGNC:17432"
                     /db_xref="MIM:606080"
                     /translation="
MVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
"
     misc_feature    <197..1033
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /note="The GH18 (glycosyl hydrolase, family 18) type II
                     chitinases hydrolyze chitin, an abundant polymer of
                     beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
                     major component of the cell wall of fungi and the
                     exoskeleton of arthropods.  Chitinases have...; Region:
                     GH18_chitinase-like; cl10447"
                     /db_xref="CDD:209141"
     misc_feature    <197..967
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /note="Glyco_18 domain; Region: Glyco_18; smart00636"
                     /db_xref="CDD:197811"
     misc_feature    order(278..280,284..286,290..292,506..511,671..673,
                     950..952)
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /note="active site"
                     /db_xref="CDD:119349"
     misc_feature    1157..1300
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /note="Chitin-binding domain type 2; Region: ChtBD2;
                     smart00494"
                     /db_xref="CDD:197759"
     variation       219
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146209261"
     variation       223
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150698600"
     variation       240
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377228357"
     variation       246
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61756687"
     variation       250
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41282498"
     variation       251
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369223512"
     variation       255
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140031055"
     variation       259
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200273853"
     variation       271
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140252614"
     variation       290
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:144029730"
     variation       305
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188294966"
     variation       309
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142253415"
     variation       315
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373203725"
     variation       346
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146460083"
     variation       348
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199990081"
     exon            353..477
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       359
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139158262"
     variation       374
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199860140"
     variation       377
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143586120"
     variation       387
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144679403"
     variation       389
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:116430435"
     variation       394
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200617710"
     variation       414
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377181497"
     variation       437
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369860168"
     variation       452
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199874052"
     variation       467
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:150563512"
     exon            478..601
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       484
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:140904700"
     variation       496
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368843945"
     variation       508
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148384495"
     variation       509
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200134913"
     variation       565
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369614927"
     variation       567
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376497990"
     variation       572
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147103194"
     variation       577
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143960572"
     variation       586
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139759326"
     variation       587
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142137716"
     variation       593
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151297358"
     exon            602..787
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       625
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114510939"
     variation       629
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181434663"
     variation       656
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367730751"
     variation       683
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78293817"
     variation       688
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139093708"
     variation       697
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143107428"
     variation       699
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371506503"
     variation       704
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143732960"
     variation       720
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150309903"
     variation       735
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61748620"
     variation       745
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61748619"
     variation       755
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79500525"
     variation       761
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139420194"
     variation       763
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201390788"
     variation       774
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150840174"
     variation       785
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201266629"
     exon            788..907
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       795
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142736771"
     variation       822
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139812869"
     variation       828..829
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="tgcccctcaggaag"
                     /db_xref="dbSNP:151326722"
     variation       830
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200566957"
     variation       832..833
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="cctcaggaagtgcc"
                     /db_xref="dbSNP:375881947"
     variation       846
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace=""
                     /replace="cctcaggaagtgcc"
                     /db_xref="dbSNP:74706064"
     variation       865
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144546962"
     variation       866
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375947945"
     variation       868
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17027410"
     variation       869
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190772785"
     variation       871
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144182515"
     variation       880
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370020615"
     variation       886
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182916944"
     variation       887
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2275253"
     variation       894
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189146821"
     variation       898
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200092579"
     variation       902
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374270214"
     exon            908..1049
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       933
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2275254"
     variation       940
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151038298"
     variation       941
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201691527"
     variation       942
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374315938"
     variation       944
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142800191"
     variation       954
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373985805"
     variation       969
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141843885"
     variation       985
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76395847"
     variation       1001
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:36011905"
     variation       1015
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368203516"
     variation       1023
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143969273"
     variation       1028
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147768976"
     variation       1033
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2820092"
     variation       1034
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371701062"
     variation       1037
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12094378"
     exon            1050..1403
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /inference="alignment:Splign:1.39.8"
     variation       1057
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372590829"
     variation       1064
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140459744"
     variation       1078
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199879175"
     variation       1087
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377085074"
     variation       1090
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150421495"
     variation       1092
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145023911"
     variation       1093
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:187769579"
     variation       1104
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144623576"
     variation       1112
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199811046"
     variation       1113
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141747675"
     variation       1118
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138227985"
     variation       1138
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376164222"
     variation       1144
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35242709"
     variation       1148
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149869566"
     variation       1167
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2256721"
     variation       1180
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369442393"
     variation       1187
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368010768"
     variation       1188
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143551303"
     variation       1190
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138073907"
     variation       1209
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201456008"
     variation       1213
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368211379"
     variation       1249
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145057685"
     variation       1258
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140461957"
     variation       1259
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142653250"
     variation       1298
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146040153"
     variation       1320
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373720681"
     variation       1325
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139802202"
     variation       1337
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372826781"
     variation       1342
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141163072"
     polyA_signal    1379..1384
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
     polyA_site      1403
                     /gene="CHIA"
                     /gene_synonym="AMCASE; CHIT2; TSA1902"
ORIGIN      
aaagcttcatgaaacctcctcgtctgtgcacgaacaggtggccgactctggagcccaggctgttgctttccagtctggtggtgaatcctccatagtctggtcttgtccttatactgaatttgcagctcggaacagccagctgaaaactctcctggccattggaggctggaacttcgggactgcccctttcactgccatggtttctactcctgagaaccgccagactttcatcacctcagtcatcaaattcctgcgccagtatgagtttgacgggctggactttgactgggagtaccctggctctcgtgggagccctcctcaggacaagcatctcttcactgtcctggtgcaggaaatgcgtgaagcttttgagcaggaggccaagcagatcaacaagcccaggctgatggtcactgctgcagtagctgctggcatctccaatatccagtctggctatgagatcccccaactgtcacagtacctggactacatccatgtcatgacctacgacctccatggctcctgggagggctacactggagagaacagccccctctacaaatacccgactgacaccggcagcaacgcctacctcaatgtggattatgtcatgaactactggaaggacaatggagcaccagctgagaagctcatcgttggattccctacctatggacacaacttcatcctgagcaacccctccaacactggaattggtgcccccacctctggtgctggtcctgctgggccctatgccaaggagtctgggatctgggcttactacgagatctgtaccttcctgaaaaatggagccactcagggatgggatgcccctcaggaagtgccttatgcctatcagggcaatgtgtgggttggctatgacaacatcaagagcttcgatattaaggctcaatggcttaagcacaacaaatttggaggcgccatggtctgggccattgatctggatgacttcactggcactttctgcaaccagggcaagtttcccctaatctccaccctgaagaaggccctcggcctgcagagtgcaagttgcacggctccagctcagcccattgagccaataactgctgctcccagtggcagcgggaacgggagcgggagtagcagctctggaggcagctcgggaggcagtggattctgtgctgtcagagccaacggcctctaccccgtggcaaataacagaaatgccttctggcactgcgtgaatggagtcacgtaccagcagaactgccaggccgggcttgtcttcgacaccagctgtgattgctgcaactgggcataaacctgacctggtctatattccctagagttccagtctcttttgcttaggacatgttgcccctacctaaagtcctgcaataaaatcagcagtcaaaacatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:27159 -> Molecular function: GO:0003796 [lysozyme activity] evidence: NAS
            GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: IDA
            GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: NAS
            GeneID:27159 -> Molecular function: GO:0008061 [chitin binding] evidence: TAS
            GeneID:27159 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
            GeneID:27159 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: NAS
            GeneID:27159 -> Biological process: GO:0000272 [polysaccharide catabolic process] evidence: IEA
            GeneID:27159 -> Biological process: GO:0001101 [response to acid] evidence: TAS
            GeneID:27159 -> Biological process: GO:0002532 [production of molecular mediator involved in inflammatory response] evidence: IDA
            GeneID:27159 -> Biological process: GO:0006030 [chitin metabolic process] evidence: NAS
            GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: IDA
            GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: NAS
            GeneID:27159 -> Biological process: GO:0006037 [cell wall chitin metabolic process] evidence: TAS
            GeneID:27159 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:27159 -> Biological process: GO:0006955 [immune response] evidence: NAS
            GeneID:27159 -> Biological process: GO:0007586 [digestion] evidence: NAS
            GeneID:27159 -> Biological process: GO:0009620 [response to fungus] evidence: TAS
            GeneID:27159 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IDA
            GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IC
            GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
            GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
            GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001244932 -> EC 3.2.1.14

by @meso_cacase at DBCLS
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