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2024-04-24 06:27:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256693 2300 bp mRNA linear PRI 18-APR-2013
DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK),
transcript variant 9, mRNA.
ACCESSION NM_001256693
VERSION NM_001256693.1 GI:375493545
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2300)
AUTHORS Choi,S. and Ku,J.L.
TITLE Resistance of colorectal cancer cells to radiation and 5-FU is
associated with MELK expression
JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
PUBMED 21806965
REMARK GeneRIF: MELK could be associated with increased resistance of
colorectal cancer cells against radiation and 5-FU.
REFERENCE 2 (bases 1 to 2300)
AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
Viapiano,M. and Kornblum,H.I.
TITLE Siomycin A targets brain tumor stem cells partially through a
MELK-mediated pathway
JOURNAL Neuro-oncology 13 (6), 622-634 (2011)
PUBMED 21558073
REMARK GeneRIF: High MELK is associated with brain tumor.
REFERENCE 3 (bases 1 to 2300)
AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
Mourtada-Maarabouni,M. and Williams,G.T.
TITLE Dysregulated expression of Fau and MELK is associated with poor
prognosis in breast cancer
JOURNAL Breast Cancer Res. 11 (4), R60 (2009)
PUBMED 19671159
REMARK GeneRIF: MELK expression is increased in breast cancer tissue and
this is associated with poor survival. The most important factors
controlling Bcl-G activity are post-translational modification by
Fau & MELK.
REFERENCE 4 (bases 1 to 2300)
AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
TITLE Maternal embryonic leucine zipper kinase transcript abundance
correlates with malignancy grade in human astrocytomas
JOURNAL Int. J. Cancer 122 (4), 807-815 (2008)
PUBMED 17960622
REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript
abundance correlates with malignancy grade in astrocytomas
REFERENCE 5 (bases 1 to 2300)
AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
TITLE Maternal embryonic leucine zipper kinase is a key regulator of the
proliferation of malignant brain tumors, including brain tumor stem
cells
JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008)
PUBMED 17722061
REMARK GeneRIF: a critical role for MELK in the proliferation of brain
tumors, including their stem cells, and suggest that MELK may be a
compelling molecular target for treatment of high-grade brain
tumors.
REFERENCE 6 (bases 1 to 2300)
AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
Rider,M.H., Stalmans,W. and Bollen,M.
TITLE Inhibition of spliceosome assembly by the cell cycle-regulated
protein kinase MELK and involvement of splicing factor NIPP1
JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004)
PUBMED 14699119
REFERENCE 7 (bases 1 to 2300)
AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
TITLE Human pEg3 kinase associates with and phosphorylates CDC25B
phosphatase: a potential role for pEg3 in cell cycle regulation
JOURNAL Oncogene 21 (50), 7630-7641 (2002)
PUBMED 12400006
REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and
may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
able to specifically phosphorylate CDC25B in vitro. One
phosphorylation site was identified and corresponded to serine 323
REFERENCE 8 (bases 1 to 2300)
AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
murine protein serine/threonine kinase 38 (MPK38)
JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002)
PUBMED 11802789
REFERENCE 9 (bases 1 to 2300)
AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
TITLE Cloning and expression of a cDNA encoding a novel protein
serine/threonine kinase predominantly expressed in hematopoietic
cells
JOURNAL Gene 195 (2), 295-301 (1997)
PUBMED 9305775
REFERENCE 10 (bases 1 to 2300)
AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in
the mouse egg and preimplantation embryo
JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997)
PUBMED 9136115
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP365611.1, AK301131.1, AI590871.1, W01871.1 and DB368226.1.
Transcript Variant: This variant (9) lacks two consecutive exons in
the 5' region and initiates translation at a downstream, in-frame
start codon, compared to variant 1. The encoded isoform (9) has a
shorter N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK301131.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-68 BP365611.1 3-70
69-1683 AK301131.1 1-1615
1684-1684 AI590871.1 619-619 c
1685-2034 AK301131.1 1617-1966
2035-2299 W01871.1 16-280 c
2300-2300 DB368226.1 1-1 c
FEATURES Location/Qualifiers
source 1..2300
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p13.2"
gene 1..2300
/gene="MELK"
/gene_synonym="HPK38"
/note="maternal embryonic leucine zipper kinase"
/db_xref="GeneID:9833"
/db_xref="HGNC:16870"
/db_xref="MIM:607025"
exon 1..146
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:368403180"
variation 35
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:188647479"
variation 63
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:73436949"
variation 68
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:139108274"
variation 84
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:192249789"
variation 106..108
/gene="MELK"
/gene_synonym="HPK38"
/replace=""
/replace="ctt"
/db_xref="dbSNP:143350018"
variation 108..110
/gene="MELK"
/gene_synonym="HPK38"
/replace=""
/replace="tct"
/db_xref="dbSNP:371278776"
exon 147..263
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 169
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:35233455"
variation 191
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200697039"
variation 226
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:147513197"
variation 230
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:148574125"
variation 235
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:115531852"
exon 264..407
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 266
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:142987107"
variation 293
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:377591615"
variation 296
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370732572"
variation 330
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:150500682"
variation 343
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370963407"
variation 368
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375693491"
exon 408..476
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 443
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146379072"
variation 449
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:374766454"
variation 473
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:139481227"
exon 477..569
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 479
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:374077047"
variation 480
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:199834356"
misc_feature 533..535
/gene="MELK"
/gene_synonym="HPK38"
/note="upstream in-frame stop codon"
variation 534
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:149686898"
variation 543
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:115586289"
exon 570..664
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 577
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:374075415"
CDS 581..1954
/gene="MELK"
/gene_synonym="HPK38"
/EC_number="2.7.11.1"
/EC_number="2.7.10.2"
/note="isoform 9 is encoded by transcript variant 9; pEg3
kinase; protein kinase PK38; protein kinase Eg3;
tyrosine-protein kinase MELK"
/codon_start=1
/product="maternal embryonic leucine zipper kinase isoform
9"
/protein_id="NP_001243622.1"
/db_xref="GI:375493546"
/db_xref="CCDS:CCDS59129.1"
/db_xref="GeneID:9833"
/db_xref="HGNC:16870"
/db_xref="MIM:607025"
/translation="
MGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
misc_feature <584..784
/gene="MELK"
/gene_synonym="HPK38"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature 1814..1951
/gene="MELK"
/gene_synonym="HPK38"
/note="Kinase associated domain 1; Region: KA1; pfam02149"
/db_xref="CDD:190228"
variation 583
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146709588"
variation 606
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:369063583"
variation 654
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:35142210"
variation 655
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:144075335"
exon 665..733
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 697
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:111341110"
variation 705
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:376164595"
variation 726
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:112003774"
exon 734..832
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 756
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201211316"
variation 758
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146486300"
exon 833..919
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 844
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:56115025"
variation 856
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:374946247"
variation 857
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374744271"
variation 865
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:190200350"
exon 920..1051
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 939
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:116620621"
variation 946
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:368444354"
variation 974
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:148081976"
variation 975
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146185715"
variation 989
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:140963190"
variation 990
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146537035"
variation 996
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:34655121"
variation 997
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:372595506"
variation 1006
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:1137377"
variation 1041
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:55845414"
variation 1050
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369940373"
exon 1052..1174
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1059
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:147502395"
variation 1060
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:138281295"
variation 1081
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:55637735"
variation 1082
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:377133091"
variation 1104
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:370552987"
variation 1107
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:144405877"
variation 1117
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:148610937"
variation 1164
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:147684393"
variation 1168
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:200203253"
exon 1175..1406
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1216
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:56223064"
variation 1255
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369328430"
variation 1264
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:371627417"
variation 1276
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:201838679"
variation 1304
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374730094"
variation 1308
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:139147189"
variation 1377
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:144052967"
variation 1378
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369059064"
exon 1407..1503
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1408
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:377540320"
variation 1419
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:150974354"
variation 1441
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:56176668"
variation 1456
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:149745317"
variation 1474
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:145670187"
variation 1486
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200256801"
variation 1502
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:148905986"
exon 1504..1672
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1508
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200746617"
variation 1517
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:2068826"
variation 1531
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:376763778"
variation 1542
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375073240"
variation 1546
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370585219"
variation 1566
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:202227041"
variation 1576
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:375455193"
variation 1617
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:62637654"
variation 1632
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:147882939"
variation 1646
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:141614983"
variation 1654
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:115242044"
variation 1655
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370307671"
exon 1673..1776
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1684
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:2274473"
variation 1693
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:375021615"
variation 1717
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:372375679"
variation 1739
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:117713820"
variation 1746
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:141986091"
variation 1770
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:199547857"
variation 1774
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:150268458"
exon 1777..2300
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1846
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:200440363"
variation 1943
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:113044021"
variation 1949
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:138922465"
variation 1955
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:142248586"
variation 1968
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201409152"
variation 1977
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201509530"
STS 1978..2150
/gene="MELK"
/gene_synonym="HPK38"
/standard_name="RH25391"
/db_xref="UniSTS:52302"
variation 1978
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374341087"
variation 2000
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:368962453"
variation 2041
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:12685407"
variation 2082
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375359642"
variation 2109
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:138890476"
variation 2228
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:12347708"
variation 2265
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:189562435"
variation 2295
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:141466859"
ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcagagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001243622 -> EC 2.7.10.2
NP_001243622 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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