2024-03-28 18:18:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256690 2283 bp mRNA linear PRI 15-APR-2013 DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 6, mRNA. ACCESSION NM_001256690 VERSION NM_001256690.1 GI:375493539 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2283) AUTHORS Choi,S. and Ku,J.L. TITLE Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011) PUBMED 21806965 REMARK GeneRIF: MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU. REFERENCE 2 (bases 1 to 2283) AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D., Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S., Viapiano,M. and Kornblum,H.I. TITLE Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway JOURNAL Neuro-oncology 13 (6), 622-634 (2011) PUBMED 21558073 REMARK GeneRIF: High MELK is associated with brain tumor. REFERENCE 3 (bases 1 to 2283) AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L., Mourtada-Maarabouni,M. and Williams,G.T. TITLE Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JOURNAL Breast Cancer Res. 11 (4), R60 (2009) PUBMED 19671159 REMARK GeneRIF: MELK expression is increased in breast cancer tissue and this is associated with poor survival. The most important factors controlling Bcl-G activity are post-translational modification by Fau & MELK. REFERENCE 4 (bases 1 to 2283) AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M., Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S., Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L. TITLE Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JOURNAL Int. J. Cancer 122 (4), 807-815 (2008) PUBMED 17960622 REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas REFERENCE 5 (bases 1 to 2283) AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S., Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A., Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M., Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F., Mischel,P.S., Terskikh,A.V. and Kornblum,H.I. TITLE Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008) PUBMED 17722061 REMARK GeneRIF: a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. REFERENCE 6 (bases 1 to 2283) AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A., Rider,M.H., Stalmans,W. and Bollen,M. TITLE Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004) PUBMED 14699119 REFERENCE 7 (bases 1 to 2283) AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P. TITLE Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation JOURNAL Oncogene 21 (50), 7630-7641 (2002) PUBMED 12400006 REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 REFERENCE 8 (bases 1 to 2283) AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H. TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002) PUBMED 11802789 REFERENCE 9 (bases 1 to 2283) AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H. TITLE Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JOURNAL Gene 195 (2), 295-301 (1997) PUBMED 9305775 REFERENCE 10 (bases 1 to 2283) AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L. TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997) PUBMED 9136115 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP365611.1, AB183428.1, AI590871.1 and DB368226.1. Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293447.1, AB183428.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 BP365611.1 3-49 48-1666 AB183428.1 1-1619 1667-1667 AI590871.1 619-619 c 1668-2282 AB183428.1 1621-2235 2283-2283 DB368226.1 1-1 c FEATURES Location/Qualifiers source 1..2283 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..2283 /gene="MELK" /gene_synonym="HPK38" /note="maternal embryonic leucine zipper kinase" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" exon 1..146 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 30 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:368403180" variation 35 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:188647479" variation 63 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:73436949" variation 68 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:139108274" variation 84 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:192249789" variation 106..108 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="ctt" /db_xref="dbSNP:143350018" variation 108..110 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="tct" /db_xref="dbSNP:371278776" exon 147..242 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:182440001" misc_feature 186..188 /gene="MELK" /gene_synonym="HPK38" /note="upstream in-frame stop codon" CDS 195..1937 /gene="MELK" /gene_synonym="HPK38" /EC_number="2.7.11.1" /EC_number="2.7.10.2" /note="isoform 6 is encoded by transcript variant 6; pEg3 kinase; protein kinase PK38; protein kinase Eg3; tyrosine-protein kinase MELK" /codon_start=1 /product="maternal embryonic leucine zipper kinase isoform 6" /protein_id="NP_001243619.1" /db_xref="GI:375493540" /db_xref="CCDS:CCDS59127.1" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" /translation="
MMNFSNIMNYMKLLGQYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
" misc_feature <219..770 /gene="MELK" /gene_synonym="HPK38" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature <240..767 /gene="MELK" /gene_synonym="HPK38" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:213116" misc_feature order(240..248,258..260,264..266,375..377,381..383, 387..392,396..398,429..431,438..440,489..500) /gene="MELK" /gene_synonym="HPK38" /note="active site" /db_xref="CDD:173623" misc_feature order(240..248,258..260,375..377,381..383,387..392, 396..398,429..431) /gene="MELK" /gene_synonym="HPK38" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(258..260,264..266,375..377,381..383,387..389, 438..440,489..500) /gene="MELK" /gene_synonym="HPK38" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(426..443,447..449,489..500) /gene="MELK" /gene_synonym="HPK38" /note="activation loop (A-loop); other site" /db_xref="CDD:173623" misc_feature 1797..1934 /gene="MELK" /gene_synonym="HPK38" /note="Kinase associated domain 1; Region: KA1; pfam02149" /db_xref="CDD:190228" variation 220 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:371313222" variation 235 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:202138204" exon 243..386 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 245 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142987107" variation 272 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377591615" variation 275 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370732572" variation 309 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:150500682" variation 322 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370963407" variation 347 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375693491" exon 387..455 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 422 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146379072" variation 428 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374766454" variation 452 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:139481227" exon 456..548 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 458 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:374077047" variation 459 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199834356" variation 513 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:149686898" variation 522 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:115586289" exon 549..647 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 552 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199880240" variation 560 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:374075415" variation 566 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146709588" variation 589 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:369063583" variation 637 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:35142210" variation 638 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144075335" exon 648..716 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 680 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:111341110" variation 688 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:376164595" variation 709 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:112003774" exon 717..815 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 739 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201211316" variation 741 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146486300" exon 816..902 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 827 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:56115025" variation 839 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374946247" variation 840 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374744271" variation 848 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:190200350" exon 903..1034 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 922 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:116620621" variation 929 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:368444354" variation 957 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:148081976" variation 958 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146185715" variation 972 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:140963190" variation 973 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146537035" variation 979 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:34655121" variation 980 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372595506" variation 989 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:1137377" variation 1024 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55845414" variation 1033 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369940373" exon 1035..1157 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1042 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147502395" variation 1043 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:138281295" variation 1064 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55637735" variation 1065 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:377133091" variation 1087 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:370552987" variation 1090 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144405877" variation 1100 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148610937" variation 1147 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:147684393" variation 1151 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:200203253" exon 1158..1389 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1199 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56223064" variation 1238 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369328430" variation 1247 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:371627417" variation 1259 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:201838679" variation 1287 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374730094" variation 1291 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:139147189" variation 1360 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:144052967" variation 1361 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369059064" exon 1390..1486 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1391 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377540320" variation 1402 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:150974354" variation 1424 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56176668" variation 1439 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:149745317" variation 1457 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:145670187" variation 1469 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200256801" variation 1485 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148905986" exon 1487..1655 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1491 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200746617" variation 1500 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:2068826" variation 1514 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:376763778" variation 1525 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375073240" variation 1529 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370585219" variation 1549 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:202227041" variation 1559 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375455193" variation 1600 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:62637654" variation 1615 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147882939" variation 1629 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141614983" variation 1637 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115242044" variation 1638 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370307671" exon 1656..1759 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1667 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:2274473" variation 1676 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375021615" variation 1700 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372375679" variation 1722 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:117713820" variation 1729 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:141986091" variation 1753 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199547857" variation 1757 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:150268458" exon 1760..2283 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1829 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:200440363" variation 1926 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:113044021" variation 1932 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138922465" variation 1938 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142248586" variation 1951 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201409152" variation 1960 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201509530" STS 1961..2133 /gene="MELK" /gene_synonym="HPK38" /standard_name="RH25391" /db_xref="UniSTS:52302" variation 1961 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374341087" variation 1983 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:368962453" variation 2024 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:12685407" variation 2065 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375359642" variation 2092 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138890476" variation 2211 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:12347708" variation 2248 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:189562435" variation 2278 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141466859" ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001243619 -> EC 2.7.10.2 NP_001243619 -> EC 2.7.11.1
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