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2024-03-28 18:18:38, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256690            2283 bp    mRNA    linear   PRI 15-APR-2013
DEFINITION  Homo sapiens maternal embryonic leucine zipper kinase (MELK),
            transcript variant 6, mRNA.
ACCESSION   NM_001256690
VERSION     NM_001256690.1  GI:375493539
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Choi,S. and Ku,J.L.
  TITLE     Resistance of colorectal cancer cells to radiation and 5-FU is
            associated with MELK expression
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
   PUBMED   21806965
  REMARK    GeneRIF: MELK could be associated with increased resistance of
            colorectal cancer cells against radiation and 5-FU.
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
            Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
            Viapiano,M. and Kornblum,H.I.
  TITLE     Siomycin A targets brain tumor stem cells partially through a
            MELK-mediated pathway
  JOURNAL   Neuro-oncology 13 (6), 622-634 (2011)
   PUBMED   21558073
  REMARK    GeneRIF: High MELK is associated with brain tumor.
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
            Mourtada-Maarabouni,M. and Williams,G.T.
  TITLE     Dysregulated expression of Fau and MELK is associated with poor
            prognosis in breast cancer
  JOURNAL   Breast Cancer Res. 11 (4), R60 (2009)
   PUBMED   19671159
  REMARK    GeneRIF: MELK expression is increased in breast cancer tissue and
            this is associated with poor survival. The most important factors
            controlling Bcl-G activity are post-translational modification by
            Fau & MELK.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
            Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
            Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
  TITLE     Maternal embryonic leucine zipper kinase transcript abundance
            correlates with malignancy grade in human astrocytomas
  JOURNAL   Int. J. Cancer 122 (4), 807-815 (2008)
   PUBMED   17960622
  REMARK    GeneRIF: Maternal embryonic leucine zipper kinase transcript
            abundance correlates with malignancy grade in astrocytomas
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
            Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
            Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
            Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
            Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
  TITLE     Maternal embryonic leucine zipper kinase is a key regulator of the
            proliferation of malignant brain tumors, including brain tumor stem
            cells
  JOURNAL   J. Neurosci. Res. 86 (1), 48-60 (2008)
   PUBMED   17722061
  REMARK    GeneRIF: a critical role for MELK in the proliferation of brain
            tumors, including their stem cells, and suggest that MELK may be a
            compelling molecular target for treatment of high-grade brain
            tumors.
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
            Rider,M.H., Stalmans,W. and Bollen,M.
  TITLE     Inhibition of spliceosome assembly by the cell cycle-regulated
            protein kinase MELK and involvement of splicing factor NIPP1
  JOURNAL   J. Biol. Chem. 279 (10), 8642-8647 (2004)
   PUBMED   14699119
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
  TITLE     Human pEg3 kinase associates with and phosphorylates CDC25B
            phosphatase: a potential role for pEg3 in cell cycle regulation
  JOURNAL   Oncogene 21 (50), 7630-7641 (2002)
   PUBMED   12400006
  REMARK    GeneRIF: pEg3 is a potential regulator of the G2/M progression and
            may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
            able to specifically phosphorylate CDC25B in vitro. One
            phosphorylation site was identified and corresponded to serine 323
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
  TITLE     Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
            murine protein serine/threonine kinase 38 (MPK38)
  JOURNAL   Biochem. J. 361 (PT 3), 597-604 (2002)
   PUBMED   11802789
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
  TITLE     Cloning and expression of a cDNA encoding a novel protein
            serine/threonine kinase predominantly expressed in hematopoietic
            cells
  JOURNAL   Gene 195 (2), 295-301 (1997)
   PUBMED   9305775
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
  TITLE     New member of the Snf1/AMPK kinase family, Melk, is expressed in
            the mouse egg and preimplantation embryo
  JOURNAL   Mol. Reprod. Dev. 47 (2), 148-156 (1997)
   PUBMED   9136115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP365611.1, AB183428.1, AI590871.1 and DB368226.1.
            
            Transcript Variant: This variant (6) initiates translation at an
            alternate start codon and lacks two consecutive exons in the 5'
            coding region, but maintains the reading frame, compared to variant
            1. The encoded isoform (6) is shorter and has a distinct
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293447.1, AB183428.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BP365611.1         3-49
            48-1666             AB183428.1         1-1619
            1667-1667           AI590871.1         619-619             c
            1668-2282           AB183428.1         1621-2235
            2283-2283           DB368226.1         1-1                 c
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..2283
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="maternal embryonic leucine zipper kinase"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
     exon            1..146
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368403180"
     variation       35
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188647479"
     variation       63
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73436949"
     variation       68
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139108274"
     variation       84
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192249789"
     variation       106..108
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="ctt"
                     /db_xref="dbSNP:143350018"
     variation       108..110
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="tct"
                     /db_xref="dbSNP:371278776"
     exon            147..242
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       172
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182440001"
     misc_feature    186..188
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="upstream in-frame stop codon"
     CDS             195..1937
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 6 is encoded by transcript variant 6; pEg3
                     kinase; protein kinase PK38; protein kinase Eg3;
                     tyrosine-protein kinase MELK"
                     /codon_start=1
                     /product="maternal embryonic leucine zipper kinase isoform
                     6"
                     /protein_id="NP_001243619.1"
                     /db_xref="GI:375493540"
                     /db_xref="CCDS:CCDS59127.1"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
                     /translation="
MMNFSNIMNYMKLLGQYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
     misc_feature    <219..770
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    <240..767
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:213116"
     misc_feature    order(240..248,258..260,264..266,375..377,381..383,
                     387..392,396..398,429..431,438..440,489..500)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(240..248,258..260,375..377,381..383,387..392,
                     396..398,429..431)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(258..260,264..266,375..377,381..383,387..389,
                     438..440,489..500)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    order(426..443,447..449,489..500)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    1797..1934
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Kinase associated domain 1; Region: KA1; pfam02149"
                     /db_xref="CDD:190228"
     variation       220
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371313222"
     variation       235
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138204"
     exon            243..386
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       245
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142987107"
     variation       272
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377591615"
     variation       275
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370732572"
     variation       309
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150500682"
     variation       322
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370963407"
     variation       347
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375693491"
     exon            387..455
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       422
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146379072"
     variation       428
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374766454"
     variation       452
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139481227"
     exon            456..548
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       458
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374077047"
     variation       459
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199834356"
     variation       513
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149686898"
     variation       522
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115586289"
     exon            549..647
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       552
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199880240"
     variation       560
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374075415"
     variation       566
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146709588"
     variation       589
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369063583"
     variation       637
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35142210"
     variation       638
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144075335"
     exon            648..716
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       680
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111341110"
     variation       688
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376164595"
     variation       709
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112003774"
     exon            717..815
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       739
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211316"
     variation       741
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146486300"
     exon            816..902
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       827
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56115025"
     variation       839
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374946247"
     variation       840
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374744271"
     variation       848
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190200350"
     exon            903..1034
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       922
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116620621"
     variation       929
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368444354"
     variation       957
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148081976"
     variation       958
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146185715"
     variation       972
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140963190"
     variation       973
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146537035"
     variation       979
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34655121"
     variation       980
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372595506"
     variation       989
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1137377"
     variation       1024
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55845414"
     variation       1033
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369940373"
     exon            1035..1157
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1042
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147502395"
     variation       1043
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138281295"
     variation       1064
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55637735"
     variation       1065
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377133091"
     variation       1087
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370552987"
     variation       1090
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144405877"
     variation       1100
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148610937"
     variation       1147
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147684393"
     variation       1151
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200203253"
     exon            1158..1389
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1199
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56223064"
     variation       1238
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369328430"
     variation       1247
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371627417"
     variation       1259
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201838679"
     variation       1287
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374730094"
     variation       1291
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139147189"
     variation       1360
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144052967"
     variation       1361
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369059064"
     exon            1390..1486
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1391
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377540320"
     variation       1402
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150974354"
     variation       1424
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56176668"
     variation       1439
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149745317"
     variation       1457
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145670187"
     variation       1469
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200256801"
     variation       1485
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148905986"
     exon            1487..1655
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1491
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200746617"
     variation       1500
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2068826"
     variation       1514
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376763778"
     variation       1525
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375073240"
     variation       1529
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370585219"
     variation       1549
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202227041"
     variation       1559
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375455193"
     variation       1600
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62637654"
     variation       1615
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147882939"
     variation       1629
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141614983"
     variation       1637
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115242044"
     variation       1638
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370307671"
     exon            1656..1759
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1667
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274473"
     variation       1676
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375021615"
     variation       1700
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372375679"
     variation       1722
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117713820"
     variation       1729
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141986091"
     variation       1753
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199547857"
     variation       1757
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150268458"
     exon            1760..2283
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1829
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200440363"
     variation       1926
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113044021"
     variation       1932
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138922465"
     variation       1938
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142248586"
     variation       1951
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201409152"
     variation       1960
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201509530"
     STS             1961..2133
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /standard_name="RH25391"
                     /db_xref="UniSTS:52302"
     variation       1961
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374341087"
     variation       1983
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368962453"
     variation       2024
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12685407"
     variation       2065
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375359642"
     variation       2092
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138890476"
     variation       2211
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12347708"
     variation       2248
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189562435"
     variation       2278
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141466859"
ORIGIN      
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
            GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
            GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
            GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
            GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
            GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
            GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001243619 -> EC 2.7.10.2
            NP_001243619 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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