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2024-04-19 18:40:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256689 2400 bp mRNA linear PRI 15-APR-2013
DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK),
transcript variant 5, mRNA.
ACCESSION NM_001256689
VERSION NM_001256689.1 GI:375340328
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2400)
AUTHORS Choi,S. and Ku,J.L.
TITLE Resistance of colorectal cancer cells to radiation and 5-FU is
associated with MELK expression
JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
PUBMED 21806965
REMARK GeneRIF: MELK could be associated with increased resistance of
colorectal cancer cells against radiation and 5-FU.
REFERENCE 2 (bases 1 to 2400)
AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
Viapiano,M. and Kornblum,H.I.
TITLE Siomycin A targets brain tumor stem cells partially through a
MELK-mediated pathway
JOURNAL Neuro-oncology 13 (6), 622-634 (2011)
PUBMED 21558073
REMARK GeneRIF: High MELK is associated with brain tumor.
REFERENCE 3 (bases 1 to 2400)
AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
Mourtada-Maarabouni,M. and Williams,G.T.
TITLE Dysregulated expression of Fau and MELK is associated with poor
prognosis in breast cancer
JOURNAL Breast Cancer Res. 11 (4), R60 (2009)
PUBMED 19671159
REMARK GeneRIF: MELK expression is increased in breast cancer tissue and
this is associated with poor survival. The most important factors
controlling Bcl-G activity are post-translational modification by
Fau & MELK.
REFERENCE 4 (bases 1 to 2400)
AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
TITLE Maternal embryonic leucine zipper kinase transcript abundance
correlates with malignancy grade in human astrocytomas
JOURNAL Int. J. Cancer 122 (4), 807-815 (2008)
PUBMED 17960622
REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript
abundance correlates with malignancy grade in astrocytomas
REFERENCE 5 (bases 1 to 2400)
AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
TITLE Maternal embryonic leucine zipper kinase is a key regulator of the
proliferation of malignant brain tumors, including brain tumor stem
cells
JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008)
PUBMED 17722061
REMARK GeneRIF: a critical role for MELK in the proliferation of brain
tumors, including their stem cells, and suggest that MELK may be a
compelling molecular target for treatment of high-grade brain
tumors.
REFERENCE 6 (bases 1 to 2400)
AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
Rider,M.H., Stalmans,W. and Bollen,M.
TITLE Inhibition of spliceosome assembly by the cell cycle-regulated
protein kinase MELK and involvement of splicing factor NIPP1
JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004)
PUBMED 14699119
REFERENCE 7 (bases 1 to 2400)
AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
TITLE Human pEg3 kinase associates with and phosphorylates CDC25B
phosphatase: a potential role for pEg3 in cell cycle regulation
JOURNAL Oncogene 21 (50), 7630-7641 (2002)
PUBMED 12400006
REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and
may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
able to specifically phosphorylate CDC25B in vitro. One
phosphorylation site was identified and corresponded to serine 323
REFERENCE 8 (bases 1 to 2400)
AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
murine protein serine/threonine kinase 38 (MPK38)
JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002)
PUBMED 11802789
REFERENCE 9 (bases 1 to 2400)
AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
TITLE Cloning and expression of a cDNA encoding a novel protein
serine/threonine kinase predominantly expressed in hematopoietic
cells
JOURNAL Gene 195 (2), 295-301 (1997)
PUBMED 9305775
REFERENCE 10 (bases 1 to 2400)
AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in
the mouse egg and preimplantation embryo
JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997)
PUBMED 9136115
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP365611.1, AB183427.1, AI590871.1 and DB368226.1.
Transcript Variant: This variant (5) initiates translation at an
alternate start codon and lacks an exon in the 5' coding region,
but maintains the reading frame, compared to variant 1. The encoded
isoform (5) is shorter and has a distinct N-terminus, compared to
isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB183427.1, AK300821.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-49 BP365611.1 3-51
50-1783 AB183427.1 1-1734
1784-1784 AI590871.1 619-619 c
1785-2399 AB183427.1 1736-2350
2400-2400 DB368226.1 1-1 c
FEATURES Location/Qualifiers
source 1..2400
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p13.2"
gene 1..2400
/gene="MELK"
/gene_synonym="HPK38"
/note="maternal embryonic leucine zipper kinase"
/db_xref="GeneID:9833"
/db_xref="HGNC:16870"
/db_xref="MIM:607025"
exon 1..146
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:368403180"
variation 35
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:188647479"
variation 63
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:73436949"
variation 68
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:139108274"
variation 84
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:192249789"
variation 106..108
/gene="MELK"
/gene_synonym="HPK38"
/replace=""
/replace="ctt"
/db_xref="dbSNP:143350018"
variation 108..110
/gene="MELK"
/gene_synonym="HPK38"
/replace=""
/replace="tct"
/db_xref="dbSNP:371278776"
exon 147..242
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 172
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:182440001"
misc_feature 186..188
/gene="MELK"
/gene_synonym="HPK38"
/note="upstream in-frame stop codon"
CDS 195..2054
/gene="MELK"
/gene_synonym="HPK38"
/EC_number="2.7.11.1"
/EC_number="2.7.10.2"
/note="isoform 5 is encoded by transcript variant 5; pEg3
kinase; protein kinase PK38; protein kinase Eg3;
tyrosine-protein kinase MELK"
/codon_start=1
/product="maternal embryonic leucine zipper kinase isoform
5"
/protein_id="NP_001243618.1"
/db_xref="GI:375340329"
/db_xref="CCDS:CCDS59126.1"
/db_xref="GeneID:9833"
/db_xref="HGNC:16870"
/db_xref="MIM:607025"
/translation="
MMNFSNIMNYMKLLGQSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
misc_feature 243..887
/gene="MELK"
/gene_synonym="HPK38"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 255..884
/gene="MELK"
/gene_synonym="HPK38"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(306..308,354..365,375..377,381..383,492..494,
498..500,504..509,513..515,546..548,555..557,606..617)
/gene="MELK"
/gene_synonym="HPK38"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(306..308,354..365,375..377,492..494,498..500,
504..509,513..515,546..548)
/gene="MELK"
/gene_synonym="HPK38"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(375..377,381..383,492..494,498..500,504..506,
555..557,606..617)
/gene="MELK"
/gene_synonym="HPK38"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(543..560,564..566,606..617)
/gene="MELK"
/gene_synonym="HPK38"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1914..2051
/gene="MELK"
/gene_synonym="HPK38"
/note="Kinase associated domain 1; Region: KA1; pfam02149"
/db_xref="CDD:190228"
variation 220
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:371313222"
variation 235
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:202138204"
exon 243..359
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 265
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:35233455"
variation 287
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200697039"
variation 322
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:147513197"
variation 326
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:148574125"
variation 331
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:115531852"
exon 360..503
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 362
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:142987107"
variation 389
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:377591615"
variation 392
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370732572"
variation 426
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:150500682"
variation 439
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370963407"
variation 464
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375693491"
exon 504..572
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 539
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146379072"
variation 545
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:374766454"
variation 569
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:139481227"
exon 573..665
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 575
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:374077047"
variation 576
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:199834356"
variation 630
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:149686898"
variation 639
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:115586289"
exon 666..764
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 669
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:199880240"
variation 677
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:374075415"
variation 683
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146709588"
variation 706
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:369063583"
variation 754
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:35142210"
variation 755
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:144075335"
exon 765..833
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 797
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:111341110"
variation 805
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:376164595"
variation 826
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:112003774"
exon 834..932
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 856
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201211316"
variation 858
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146486300"
exon 933..1019
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 944
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:56115025"
variation 956
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:374946247"
variation 957
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374744271"
variation 965
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:190200350"
exon 1020..1151
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1039
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:116620621"
variation 1046
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:368444354"
variation 1074
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:148081976"
variation 1075
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146185715"
variation 1089
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:140963190"
variation 1090
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:146537035"
variation 1096
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:34655121"
variation 1097
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:372595506"
variation 1106
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:1137377"
variation 1141
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:55845414"
variation 1150
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369940373"
exon 1152..1274
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1159
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:147502395"
variation 1160
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:138281295"
variation 1181
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:55637735"
variation 1182
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:377133091"
variation 1204
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:370552987"
variation 1207
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:144405877"
variation 1217
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:148610937"
variation 1264
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:147684393"
variation 1268
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:200203253"
exon 1275..1506
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1316
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:56223064"
variation 1355
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369328430"
variation 1364
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:371627417"
variation 1376
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:201838679"
variation 1404
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374730094"
variation 1408
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:139147189"
variation 1477
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:144052967"
variation 1478
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:369059064"
exon 1507..1603
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1508
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:377540320"
variation 1519
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:150974354"
variation 1541
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:56176668"
variation 1556
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:149745317"
variation 1574
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:145670187"
variation 1586
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200256801"
variation 1602
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:148905986"
exon 1604..1772
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1608
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:200746617"
variation 1617
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:2068826"
variation 1631
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:376763778"
variation 1642
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375073240"
variation 1646
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370585219"
variation 1666
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:202227041"
variation 1676
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:375455193"
variation 1717
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:62637654"
variation 1732
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="t"
/db_xref="dbSNP:147882939"
variation 1746
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:141614983"
variation 1754
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:115242044"
variation 1755
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:370307671"
exon 1773..1876
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1784
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:2274473"
variation 1793
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:375021615"
variation 1817
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:372375679"
variation 1839
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:117713820"
variation 1846
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:141986091"
variation 1870
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:199547857"
variation 1874
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:150268458"
exon 1877..2400
/gene="MELK"
/gene_synonym="HPK38"
/inference="alignment:Splign:1.39.8"
variation 1946
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/db_xref="dbSNP:200440363"
variation 2043
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:113044021"
variation 2049
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:138922465"
variation 2055
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:142248586"
variation 2068
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201409152"
variation 2077
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:201509530"
STS 2078..2250
/gene="MELK"
/gene_synonym="HPK38"
/standard_name="RH25391"
/db_xref="UniSTS:52302"
variation 2078
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:374341087"
variation 2100
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:368962453"
variation 2141
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="c"
/db_xref="dbSNP:12685407"
variation 2182
/gene="MELK"
/gene_synonym="HPK38"
/replace="c"
/replace="t"
/db_xref="dbSNP:375359642"
variation 2209
/gene="MELK"
/gene_synonym="HPK38"
/replace="g"
/replace="t"
/db_xref="dbSNP:138890476"
variation 2328
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:12347708"
variation 2365
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:189562435"
variation 2395
/gene="MELK"
/gene_synonym="HPK38"
/replace="a"
/replace="g"
/db_xref="dbSNP:141466859"
ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacagagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001243618 -> EC 2.7.10.2
NP_001243618 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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