2024-04-27 03:26:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256688 2273 bp mRNA linear PRI 18-APR-2013 DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 4, mRNA. ACCESSION NM_001256688 VERSION NM_001256688.1 GI:375493537 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2273) AUTHORS Choi,S. and Ku,J.L. TITLE Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011) PUBMED 21806965 REMARK GeneRIF: MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU. REFERENCE 2 (bases 1 to 2273) AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D., Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S., Viapiano,M. and Kornblum,H.I. TITLE Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway JOURNAL Neuro-oncology 13 (6), 622-634 (2011) PUBMED 21558073 REMARK GeneRIF: High MELK is associated with brain tumor. REFERENCE 3 (bases 1 to 2273) AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L., Mourtada-Maarabouni,M. and Williams,G.T. TITLE Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JOURNAL Breast Cancer Res. 11 (4), R60 (2009) PUBMED 19671159 REMARK GeneRIF: MELK expression is increased in breast cancer tissue and this is associated with poor survival. The most important factors controlling Bcl-G activity are post-translational modification by Fau & MELK. REFERENCE 4 (bases 1 to 2273) AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M., Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S., Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L. TITLE Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JOURNAL Int. J. Cancer 122 (4), 807-815 (2008) PUBMED 17960622 REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas REFERENCE 5 (bases 1 to 2273) AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S., Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A., Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M., Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F., Mischel,P.S., Terskikh,A.V. and Kornblum,H.I. TITLE Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008) PUBMED 17722061 REMARK GeneRIF: a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. REFERENCE 6 (bases 1 to 2273) AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A., Rider,M.H., Stalmans,W. and Bollen,M. TITLE Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004) PUBMED 14699119 REFERENCE 7 (bases 1 to 2273) AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P. TITLE Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation JOURNAL Oncogene 21 (50), 7630-7641 (2002) PUBMED 12400006 REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 REFERENCE 8 (bases 1 to 2273) AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H. TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002) PUBMED 11802789 REFERENCE 9 (bases 1 to 2273) AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H. TITLE Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JOURNAL Gene 195 (2), 295-301 (1997) PUBMED 9305775 REFERENCE 10 (bases 1 to 2273) AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L. TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997) PUBMED 9136115 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP365611.1, AK293284.1, BC014039.2, AI590871.1 and DB368226.1. Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293284.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-35 BP365611.1 3-37 36-1252 AK293284.1 1-1217 1253-1656 BC014039.2 1420-1823 1657-1657 AI590871.1 619-619 c 1658-2272 BC014039.2 1825-2439 2273-2273 DB368226.1 1-1 c FEATURES Location/Qualifiers source 1..2273 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..2273 /gene="MELK" /gene_synonym="HPK38" /note="maternal embryonic leucine zipper kinase" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" exon 1..146 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 30 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:368403180" variation 35 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:188647479" variation 63 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:73436949" variation 68 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:139108274" variation 84 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:192249789" variation 106..108 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="ctt" /db_xref="dbSNP:143350018" variation 108..110 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="tct" /db_xref="dbSNP:371278776" exon 147..242 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" misc_feature 167..169 /gene="MELK" /gene_synonym="HPK38" /note="upstream in-frame stop codon" variation 172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:182440001" CDS 185..1927 /gene="MELK" /gene_synonym="HPK38" /EC_number="2.7.11.1" /EC_number="2.7.10.2" /note="isoform 4 is encoded by transcript variant 4; pEg3 kinase; protein kinase PK38; protein kinase Eg3; tyrosine-protein kinase MELK" /codon_start=1 /product="maternal embryonic leucine zipper kinase isoform 4" /protein_id="NP_001243617.1" /db_xref="GI:375493538" /db_xref="CCDS:CCDS59125.1" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
" misc_feature 215..760 /gene="MELK" /gene_synonym="HPK38" /note="Protein kinase domain; Region: Pkinase; pfam00069" /db_xref="CDD:200973" misc_feature 233..>445 /gene="MELK" /gene_synonym="HPK38" /note="Catalytic domain of Protein Kinases; Region: PKc; cd00180" /db_xref="CDD:173623" misc_feature order(233..247,257..259,296..298,302..304,392..394, 440..445) /gene="MELK" /gene_synonym="HPK38" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature 350..352 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature <470..757 /gene="MELK" /gene_synonym="HPK38" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:213116" misc_feature 1787..1924 /gene="MELK" /gene_synonym="HPK38" /note="Kinase associated domain 1; Region: KA1; pfam02149" /db_xref="CDD:190228" variation 220 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:371313222" variation 235 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:202138204" exon 243..328 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 261 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:114617403" variation 287 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:13440297" variation 292 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199697478" variation 323 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201026444" exon 329..445 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 351 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:35233455" variation 373 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200697039" variation 408 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:147513197" variation 412 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:148574125" variation 417 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115531852" exon 446..538 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 448 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:374077047" variation 449 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199834356" variation 503 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:149686898" variation 512 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:115586289" exon 539..637 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 542 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199880240" variation 550 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:374075415" variation 556 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146709588" variation 579 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:369063583" variation 627 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:35142210" variation 628 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144075335" exon 638..706 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 670 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:111341110" variation 678 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:376164595" variation 699 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:112003774" exon 707..805 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 729 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201211316" variation 731 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146486300" exon 806..892 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 817 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:56115025" variation 829 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374946247" variation 830 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374744271" variation 838 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:190200350" exon 893..1024 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 912 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:116620621" variation 919 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:368444354" variation 947 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:148081976" variation 948 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146185715" variation 962 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:140963190" variation 963 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146537035" variation 969 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:34655121" variation 970 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372595506" variation 979 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:1137377" variation 1014 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55845414" variation 1023 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369940373" exon 1025..1147 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1032 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147502395" variation 1033 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:138281295" variation 1054 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55637735" variation 1055 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:377133091" variation 1077 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:370552987" variation 1080 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144405877" variation 1090 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148610937" variation 1137 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:147684393" variation 1141 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:200203253" exon 1148..1379 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1189 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56223064" variation 1228 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369328430" variation 1237 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:371627417" variation 1249 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:201838679" variation 1277 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374730094" variation 1281 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:139147189" variation 1350 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:144052967" variation 1351 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369059064" exon 1380..1476 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1381 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377540320" variation 1392 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:150974354" variation 1414 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56176668" variation 1429 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:149745317" variation 1447 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:145670187" variation 1459 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200256801" variation 1475 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148905986" exon 1477..1645 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1481 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200746617" variation 1490 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:2068826" variation 1504 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:376763778" variation 1515 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375073240" variation 1519 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370585219" variation 1539 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:202227041" variation 1549 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375455193" variation 1590 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:62637654" variation 1605 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147882939" variation 1619 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141614983" variation 1627 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115242044" variation 1628 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370307671" exon 1646..1749 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1657 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:2274473" variation 1666 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375021615" variation 1690 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372375679" variation 1712 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:117713820" variation 1719 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:141986091" variation 1743 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199547857" variation 1747 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:150268458" exon 1750..2273 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1819 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:200440363" variation 1916 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:113044021" variation 1922 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138922465" variation 1928 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142248586" variation 1941 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201409152" variation 1950 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201509530" STS 1951..2123 /gene="MELK" /gene_synonym="HPK38" /standard_name="RH25391" /db_xref="UniSTS:52302" variation 1951 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374341087" variation 1973 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:368962453" variation 2014 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:12685407" variation 2055 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375359642" variation 2082 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138890476" variation 2201 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:12347708" variation 2238 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:189562435" variation 2268 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141466859" ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001243617 -> EC 2.7.10.2 NP_001243617 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.