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2024-03-29 21:14:10, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256687            2342 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens maternal embryonic leucine zipper kinase (MELK),
            transcript variant 3, mRNA.
ACCESSION   NM_001256687
VERSION     NM_001256687.1  GI:375493535
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Choi,S. and Ku,J.L.
  TITLE     Resistance of colorectal cancer cells to radiation and 5-FU is
            associated with MELK expression
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
   PUBMED   21806965
  REMARK    GeneRIF: MELK could be associated with increased resistance of
            colorectal cancer cells against radiation and 5-FU.
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
            Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
            Viapiano,M. and Kornblum,H.I.
  TITLE     Siomycin A targets brain tumor stem cells partially through a
            MELK-mediated pathway
  JOURNAL   Neuro-oncology 13 (6), 622-634 (2011)
   PUBMED   21558073
  REMARK    GeneRIF: High MELK is associated with brain tumor.
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
            Mourtada-Maarabouni,M. and Williams,G.T.
  TITLE     Dysregulated expression of Fau and MELK is associated with poor
            prognosis in breast cancer
  JOURNAL   Breast Cancer Res. 11 (4), R60 (2009)
   PUBMED   19671159
  REMARK    GeneRIF: MELK expression is increased in breast cancer tissue and
            this is associated with poor survival. The most important factors
            controlling Bcl-G activity are post-translational modification by
            Fau & MELK.
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
            Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
            Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
  TITLE     Maternal embryonic leucine zipper kinase transcript abundance
            correlates with malignancy grade in human astrocytomas
  JOURNAL   Int. J. Cancer 122 (4), 807-815 (2008)
   PUBMED   17960622
  REMARK    GeneRIF: Maternal embryonic leucine zipper kinase transcript
            abundance correlates with malignancy grade in astrocytomas
REFERENCE   5  (bases 1 to 2342)
  AUTHORS   Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
            Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
            Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
            Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
            Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
  TITLE     Maternal embryonic leucine zipper kinase is a key regulator of the
            proliferation of malignant brain tumors, including brain tumor stem
            cells
  JOURNAL   J. Neurosci. Res. 86 (1), 48-60 (2008)
   PUBMED   17722061
  REMARK    GeneRIF: a critical role for MELK in the proliferation of brain
            tumors, including their stem cells, and suggest that MELK may be a
            compelling molecular target for treatment of high-grade brain
            tumors.
REFERENCE   6  (bases 1 to 2342)
  AUTHORS   Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
            Rider,M.H., Stalmans,W. and Bollen,M.
  TITLE     Inhibition of spliceosome assembly by the cell cycle-regulated
            protein kinase MELK and involvement of splicing factor NIPP1
  JOURNAL   J. Biol. Chem. 279 (10), 8642-8647 (2004)
   PUBMED   14699119
REFERENCE   7  (bases 1 to 2342)
  AUTHORS   Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
  TITLE     Human pEg3 kinase associates with and phosphorylates CDC25B
            phosphatase: a potential role for pEg3 in cell cycle regulation
  JOURNAL   Oncogene 21 (50), 7630-7641 (2002)
   PUBMED   12400006
  REMARK    GeneRIF: pEg3 is a potential regulator of the G2/M progression and
            may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
            able to specifically phosphorylate CDC25B in vitro. One
            phosphorylation site was identified and corresponded to serine 323
REFERENCE   8  (bases 1 to 2342)
  AUTHORS   Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
  TITLE     Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
            murine protein serine/threonine kinase 38 (MPK38)
  JOURNAL   Biochem. J. 361 (PT 3), 597-604 (2002)
   PUBMED   11802789
REFERENCE   9  (bases 1 to 2342)
  AUTHORS   Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
  TITLE     Cloning and expression of a cDNA encoding a novel protein
            serine/threonine kinase predominantly expressed in hematopoietic
            cells
  JOURNAL   Gene 195 (2), 295-301 (1997)
   PUBMED   9305775
REFERENCE   10 (bases 1 to 2342)
  AUTHORS   Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
  TITLE     New member of the Snf1/AMPK kinase family, Melk, is expressed in
            the mouse egg and preimplantation embryo
  JOURNAL   Mol. Reprod. Dev. 47 (2), 148-156 (1997)
   PUBMED   9136115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP365611.1, AK300761.1, BC014039.2, AI590871.1 and DB368226.1.
            
            Transcript Variant: This variant (3) lacks an exon in the 5' coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300761.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BP365611.1         3-37
            36-1459             AK300761.1         1-1424
            1460-1725           BC014039.2         1558-1823
            1726-1726           AI590871.1         619-619             c
            1727-2341           BC014039.2         1825-2439
            2342-2342           DB368226.1         1-1                 c
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..2342
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="maternal embryonic leucine zipper kinase"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
     exon            1..146
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368403180"
     variation       35
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188647479"
     variation       63
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73436949"
     variation       68
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139108274"
     variation       84
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192249789"
     variation       106..108
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="ctt"
                     /db_xref="dbSNP:143350018"
     variation       108..110
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="tct"
                     /db_xref="dbSNP:371278776"
     exon            147..242
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    167..169
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="upstream in-frame stop codon"
     variation       172
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182440001"
     CDS             185..1996
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 3 is encoded by transcript variant 3; pEg3
                     kinase; protein kinase PK38; protein kinase Eg3;
                     tyrosine-protein kinase MELK"
                     /codon_start=1
                     /product="maternal embryonic leucine zipper kinase isoform
                     3"
                     /protein_id="NP_001243616.1"
                     /db_xref="GI:375493536"
                     /db_xref="CCDS:CCDS59124.1"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
                     /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
     misc_feature    215..829
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    215..826
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:213116"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     440..445,446..451,455..457,488..490,497..499,548..559)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     440..445,446..451,455..457,488..490)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(245..247,446..448,497..499,548..559)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    order(485..505,548..559)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    1856..1993
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Kinase associated domain 1; Region: KA1; pfam02149"
                     /db_xref="CDD:190228"
     variation       220
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371313222"
     variation       235
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138204"
     exon            243..328
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       261
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114617403"
     variation       287
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13440297"
     variation       292
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199697478"
     variation       323
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201026444"
     exon            329..445
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       351
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35233455"
     variation       373
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200697039"
     variation       408
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147513197"
     variation       412
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148574125"
     variation       417
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115531852"
     exon            446..514
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       481
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146379072"
     variation       487
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374766454"
     variation       511
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139481227"
     exon            515..607
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       517
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374077047"
     variation       518
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199834356"
     variation       572
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149686898"
     variation       581
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115586289"
     exon            608..706
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       611
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199880240"
     variation       619
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374075415"
     variation       625
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146709588"
     variation       648
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369063583"
     variation       696
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35142210"
     variation       697
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144075335"
     exon            707..775
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       739
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111341110"
     variation       747
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376164595"
     variation       768
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112003774"
     exon            776..874
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       798
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211316"
     variation       800
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146486300"
     exon            875..961
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       886
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56115025"
     variation       898
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374946247"
     variation       899
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374744271"
     variation       907
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190200350"
     exon            962..1093
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       981
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116620621"
     variation       988
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368444354"
     variation       1016
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148081976"
     variation       1017
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146185715"
     variation       1031
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140963190"
     variation       1032
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146537035"
     variation       1038
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34655121"
     variation       1039
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372595506"
     variation       1048
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1137377"
     variation       1083
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55845414"
     variation       1092
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369940373"
     exon            1094..1216
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1101
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147502395"
     variation       1102
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138281295"
     variation       1123
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55637735"
     variation       1124
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377133091"
     variation       1146
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370552987"
     variation       1149
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144405877"
     variation       1159
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148610937"
     variation       1206
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147684393"
     variation       1210
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200203253"
     exon            1217..1448
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1258
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56223064"
     variation       1297
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369328430"
     variation       1306
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371627417"
     variation       1318
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201838679"
     variation       1346
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374730094"
     variation       1350
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139147189"
     variation       1419
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144052967"
     variation       1420
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369059064"
     exon            1449..1545
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1450
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377540320"
     variation       1461
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150974354"
     variation       1483
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56176668"
     variation       1498
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149745317"
     variation       1516
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145670187"
     variation       1528
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200256801"
     variation       1544
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148905986"
     exon            1546..1714
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1550
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200746617"
     variation       1559
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2068826"
     variation       1573
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376763778"
     variation       1584
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375073240"
     variation       1588
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370585219"
     variation       1608
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202227041"
     variation       1618
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375455193"
     variation       1659
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62637654"
     variation       1674
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147882939"
     variation       1688
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141614983"
     variation       1696
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115242044"
     variation       1697
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370307671"
     exon            1715..1818
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1726
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274473"
     variation       1735
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375021615"
     variation       1759
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372375679"
     variation       1781
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117713820"
     variation       1788
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141986091"
     variation       1812
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199547857"
     variation       1816
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150268458"
     exon            1819..2342
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1888
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200440363"
     variation       1985
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113044021"
     variation       1991
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138922465"
     variation       1997
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142248586"
     variation       2010
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201409152"
     variation       2019
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201509530"
     STS             2020..2192
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /standard_name="RH25391"
                     /db_xref="UniSTS:52302"
     variation       2020
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374341087"
     variation       2042
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368962453"
     variation       2083
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12685407"
     variation       2124
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375359642"
     variation       2151
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138890476"
     variation       2270
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12347708"
     variation       2307
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189562435"
     variation       2337
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141466859"
ORIGIN      
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgaggaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
            GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
            GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
            GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
            GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
            GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
            GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001243616 -> EC 2.7.10.2
            NP_001243616 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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