2024-03-29 21:14:10, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256687 2342 bp mRNA linear PRI 18-APR-2013 DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 3, mRNA. ACCESSION NM_001256687 VERSION NM_001256687.1 GI:375493535 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2342) AUTHORS Choi,S. and Ku,J.L. TITLE Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011) PUBMED 21806965 REMARK GeneRIF: MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU. REFERENCE 2 (bases 1 to 2342) AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D., Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S., Viapiano,M. and Kornblum,H.I. TITLE Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway JOURNAL Neuro-oncology 13 (6), 622-634 (2011) PUBMED 21558073 REMARK GeneRIF: High MELK is associated with brain tumor. REFERENCE 3 (bases 1 to 2342) AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L., Mourtada-Maarabouni,M. and Williams,G.T. TITLE Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JOURNAL Breast Cancer Res. 11 (4), R60 (2009) PUBMED 19671159 REMARK GeneRIF: MELK expression is increased in breast cancer tissue and this is associated with poor survival. The most important factors controlling Bcl-G activity are post-translational modification by Fau & MELK. REFERENCE 4 (bases 1 to 2342) AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M., Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S., Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L. TITLE Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JOURNAL Int. J. Cancer 122 (4), 807-815 (2008) PUBMED 17960622 REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas REFERENCE 5 (bases 1 to 2342) AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S., Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A., Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M., Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F., Mischel,P.S., Terskikh,A.V. and Kornblum,H.I. TITLE Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008) PUBMED 17722061 REMARK GeneRIF: a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. REFERENCE 6 (bases 1 to 2342) AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A., Rider,M.H., Stalmans,W. and Bollen,M. TITLE Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004) PUBMED 14699119 REFERENCE 7 (bases 1 to 2342) AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P. TITLE Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation JOURNAL Oncogene 21 (50), 7630-7641 (2002) PUBMED 12400006 REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 REFERENCE 8 (bases 1 to 2342) AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H. TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002) PUBMED 11802789 REFERENCE 9 (bases 1 to 2342) AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H. TITLE Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JOURNAL Gene 195 (2), 295-301 (1997) PUBMED 9305775 REFERENCE 10 (bases 1 to 2342) AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L. TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997) PUBMED 9136115 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP365611.1, AK300761.1, BC014039.2, AI590871.1 and DB368226.1. Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300761.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-35 BP365611.1 3-37 36-1459 AK300761.1 1-1424 1460-1725 BC014039.2 1558-1823 1726-1726 AI590871.1 619-619 c 1727-2341 BC014039.2 1825-2439 2342-2342 DB368226.1 1-1 c FEATURES Location/Qualifiers source 1..2342 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..2342 /gene="MELK" /gene_synonym="HPK38" /note="maternal embryonic leucine zipper kinase" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" exon 1..146 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 30 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:368403180" variation 35 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:188647479" variation 63 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:73436949" variation 68 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:139108274" variation 84 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:192249789" variation 106..108 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="ctt" /db_xref="dbSNP:143350018" variation 108..110 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="tct" /db_xref="dbSNP:371278776" exon 147..242 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" misc_feature 167..169 /gene="MELK" /gene_synonym="HPK38" /note="upstream in-frame stop codon" variation 172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:182440001" CDS 185..1996 /gene="MELK" /gene_synonym="HPK38" /EC_number="2.7.11.1" /EC_number="2.7.10.2" /note="isoform 3 is encoded by transcript variant 3; pEg3 kinase; protein kinase PK38; protein kinase Eg3; tyrosine-protein kinase MELK" /codon_start=1 /product="maternal embryonic leucine zipper kinase isoform 3" /protein_id="NP_001243616.1" /db_xref="GI:375493536" /db_xref="CCDS:CCDS59124.1" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
" misc_feature 215..829 /gene="MELK" /gene_synonym="HPK38" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 215..826 /gene="MELK" /gene_synonym="HPK38" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:213116" misc_feature order(233..247,257..259,296..298,302..304,392..394, 440..445,446..451,455..457,488..490,497..499,548..559) /gene="MELK" /gene_synonym="HPK38" /note="active site" /db_xref="CDD:173623" misc_feature order(233..247,257..259,296..298,302..304,392..394, 440..445,446..451,455..457,488..490) /gene="MELK" /gene_synonym="HPK38" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(245..247,446..448,497..499,548..559) /gene="MELK" /gene_synonym="HPK38" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(485..505,548..559) /gene="MELK" /gene_synonym="HPK38" /note="activation loop (A-loop); other site" /db_xref="CDD:173623" misc_feature 1856..1993 /gene="MELK" /gene_synonym="HPK38" /note="Kinase associated domain 1; Region: KA1; pfam02149" /db_xref="CDD:190228" variation 220 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:371313222" variation 235 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:202138204" exon 243..328 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 261 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:114617403" variation 287 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:13440297" variation 292 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199697478" variation 323 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201026444" exon 329..445 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 351 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:35233455" variation 373 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200697039" variation 408 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:147513197" variation 412 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:148574125" variation 417 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115531852" exon 446..514 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 481 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146379072" variation 487 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374766454" variation 511 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:139481227" exon 515..607 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 517 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:374077047" variation 518 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199834356" variation 572 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:149686898" variation 581 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:115586289" exon 608..706 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 611 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199880240" variation 619 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:374075415" variation 625 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146709588" variation 648 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:369063583" variation 696 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:35142210" variation 697 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144075335" exon 707..775 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 739 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:111341110" variation 747 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:376164595" variation 768 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:112003774" exon 776..874 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 798 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201211316" variation 800 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146486300" exon 875..961 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 886 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:56115025" variation 898 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374946247" variation 899 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374744271" variation 907 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:190200350" exon 962..1093 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 981 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:116620621" variation 988 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:368444354" variation 1016 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:148081976" variation 1017 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146185715" variation 1031 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:140963190" variation 1032 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146537035" variation 1038 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:34655121" variation 1039 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372595506" variation 1048 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:1137377" variation 1083 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55845414" variation 1092 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369940373" exon 1094..1216 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1101 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147502395" variation 1102 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:138281295" variation 1123 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55637735" variation 1124 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:377133091" variation 1146 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:370552987" variation 1149 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144405877" variation 1159 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148610937" variation 1206 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:147684393" variation 1210 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:200203253" exon 1217..1448 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1258 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56223064" variation 1297 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369328430" variation 1306 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:371627417" variation 1318 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:201838679" variation 1346 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374730094" variation 1350 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:139147189" variation 1419 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:144052967" variation 1420 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369059064" exon 1449..1545 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1450 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377540320" variation 1461 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:150974354" variation 1483 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56176668" variation 1498 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:149745317" variation 1516 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:145670187" variation 1528 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200256801" variation 1544 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148905986" exon 1546..1714 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1550 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200746617" variation 1559 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:2068826" variation 1573 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:376763778" variation 1584 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375073240" variation 1588 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370585219" variation 1608 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:202227041" variation 1618 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375455193" variation 1659 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:62637654" variation 1674 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147882939" variation 1688 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141614983" variation 1696 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115242044" variation 1697 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370307671" exon 1715..1818 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1726 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:2274473" variation 1735 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375021615" variation 1759 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372375679" variation 1781 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:117713820" variation 1788 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:141986091" variation 1812 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199547857" variation 1816 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:150268458" exon 1819..2342 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1888 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:200440363" variation 1985 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:113044021" variation 1991 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138922465" variation 1997 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142248586" variation 2010 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201409152" variation 2019 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201509530" STS 2020..2192 /gene="MELK" /gene_synonym="HPK38" /standard_name="RH25391" /db_xref="UniSTS:52302" variation 2020 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374341087" variation 2042 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:368962453" variation 2083 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:12685407" variation 2124 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375359642" variation 2151 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138890476" variation 2270 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:12347708" variation 2307 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:189562435" variation 2337 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141466859" ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgaggaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001243616 -> EC 2.7.10.2 NP_001243616 -> EC 2.7.11.1
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