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2024-03-28 19:18:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256685            2363 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens maternal embryonic leucine zipper kinase (MELK),
            transcript variant 2, mRNA.
ACCESSION   NM_001256685
VERSION     NM_001256685.1  GI:375493531
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Choi,S. and Ku,J.L.
  TITLE     Resistance of colorectal cancer cells to radiation and 5-FU is
            associated with MELK expression
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
   PUBMED   21806965
  REMARK    GeneRIF: MELK could be associated with increased resistance of
            colorectal cancer cells against radiation and 5-FU.
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
            Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
            Viapiano,M. and Kornblum,H.I.
  TITLE     Siomycin A targets brain tumor stem cells partially through a
            MELK-mediated pathway
  JOURNAL   Neuro-oncology 13 (6), 622-634 (2011)
   PUBMED   21558073
  REMARK    GeneRIF: High MELK is associated with brain tumor.
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
            Mourtada-Maarabouni,M. and Williams,G.T.
  TITLE     Dysregulated expression of Fau and MELK is associated with poor
            prognosis in breast cancer
  JOURNAL   Breast Cancer Res. 11 (4), R60 (2009)
   PUBMED   19671159
  REMARK    GeneRIF: MELK expression is increased in breast cancer tissue and
            this is associated with poor survival. The most important factors
            controlling Bcl-G activity are post-translational modification by
            Fau & MELK.
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
            Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
            Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
  TITLE     Maternal embryonic leucine zipper kinase transcript abundance
            correlates with malignancy grade in human astrocytomas
  JOURNAL   Int. J. Cancer 122 (4), 807-815 (2008)
   PUBMED   17960622
  REMARK    GeneRIF: Maternal embryonic leucine zipper kinase transcript
            abundance correlates with malignancy grade in astrocytomas
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
            Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
            Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
            Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
            Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
  TITLE     Maternal embryonic leucine zipper kinase is a key regulator of the
            proliferation of malignant brain tumors, including brain tumor stem
            cells
  JOURNAL   J. Neurosci. Res. 86 (1), 48-60 (2008)
   PUBMED   17722061
  REMARK    GeneRIF: a critical role for MELK in the proliferation of brain
            tumors, including their stem cells, and suggest that MELK may be a
            compelling molecular target for treatment of high-grade brain
            tumors.
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
            Rider,M.H., Stalmans,W. and Bollen,M.
  TITLE     Inhibition of spliceosome assembly by the cell cycle-regulated
            protein kinase MELK and involvement of splicing factor NIPP1
  JOURNAL   J. Biol. Chem. 279 (10), 8642-8647 (2004)
   PUBMED   14699119
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
  TITLE     Human pEg3 kinase associates with and phosphorylates CDC25B
            phosphatase: a potential role for pEg3 in cell cycle regulation
  JOURNAL   Oncogene 21 (50), 7630-7641 (2002)
   PUBMED   12400006
  REMARK    GeneRIF: pEg3 is a potential regulator of the G2/M progression and
            may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
            able to specifically phosphorylate CDC25B in vitro. One
            phosphorylation site was identified and corresponded to serine 323
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
  TITLE     Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
            murine protein serine/threonine kinase 38 (MPK38)
  JOURNAL   Biochem. J. 361 (PT 3), 597-604 (2002)
   PUBMED   11802789
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
  TITLE     Cloning and expression of a cDNA encoding a novel protein
            serine/threonine kinase predominantly expressed in hematopoietic
            cells
  JOURNAL   Gene 195 (2), 295-301 (1997)
   PUBMED   9305775
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
  TITLE     New member of the Snf1/AMPK kinase family, Melk, is expressed in
            the mouse egg and preimplantation embryo
  JOURNAL   Mol. Reprod. Dev. 47 (2), 148-156 (1997)
   PUBMED   9136115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP365611.1, AK299164.1, BC014039.2, AI590871.1 and DB368226.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299164.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BP365611.1         3-50
            49-390              AK299164.1         1-342
            391-391             BP365611.1         393-393
            392-1252            AK299164.1         344-1204
            1253-1746           BC014039.2         1330-1823
            1747-1747           AI590871.1         619-619             c
            1748-2362           BC014039.2         1825-2439
            2363-2363           DB368226.1         1-1                 c
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..2363
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="maternal embryonic leucine zipper kinase"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
     exon            1..146
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368403180"
     variation       35
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188647479"
     variation       63
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73436949"
     variation       68
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139108274"
     variation       84
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192249789"
     variation       106..108
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="ctt"
                     /db_xref="dbSNP:143350018"
     variation       108..110
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="tct"
                     /db_xref="dbSNP:371278776"
     exon            147..242
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    167..169
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="upstream in-frame stop codon"
     variation       172
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182440001"
     CDS             185..2017
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2; pEg3
                     kinase; protein kinase PK38; protein kinase Eg3;
                     tyrosine-protein kinase MELK"
                     /codon_start=1
                     /product="maternal embryonic leucine zipper kinase isoform
                     2"
                     /protein_id="NP_001243614.1"
                     /db_xref="GI:375493532"
                     /db_xref="CCDS:CCDS59123.1"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="MIM:607025"
                     /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
     misc_feature    215..973
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    233..970
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Catalytic domain of AGC family Protein
                     Serine/Threonine Kinases; Region: STKc_AGC; cd05123"
                     /db_xref="CDD:173660"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     440..445,449..451,461..463,467..469,578..580,584..586,
                     590..595,599..601,629..634,641..643,686..703,785..787,
                     803..805,812..814)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="active site"
                     /db_xref="CDD:173660"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     443..451,461..463,578..580,584..586,590..595,599..601,
                     629..634)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173660"
     misc_feature    order(245..247,461..463,467..469,578..580,584..586,
                     590..592,641..643,686..703,785..787,803..805,812..814)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173660"
     misc_feature    order(629..646,650..655,683..703)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173660"
     misc_feature    1877..2014
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Kinase associated domain 1; Region: KA1; pfam02149"
                     /db_xref="CDD:190228"
     variation       220
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371313222"
     variation       235
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138204"
     exon            243..328
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       261
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114617403"
     variation       287
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13440297"
     variation       292
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199697478"
     variation       323
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201026444"
     exon            329..445
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       351
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35233455"
     variation       373
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200697039"
     variation       408
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147513197"
     variation       412
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148574125"
     variation       417
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115531852"
     exon            446..589
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       448
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142987107"
     variation       475
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377591615"
     variation       478
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370732572"
     variation       512
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150500682"
     variation       525
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370963407"
     variation       550
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375693491"
     exon            590..658
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       625
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146379072"
     variation       631
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374766454"
     variation       655
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139481227"
     exon            659..751
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       661
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374077047"
     variation       662
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199834356"
     variation       716
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149686898"
     variation       725
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115586289"
     exon            752..850
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       755
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199880240"
     variation       763
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374075415"
     variation       769
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146709588"
     variation       792
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369063583"
     variation       840
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35142210"
     variation       841
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144075335"
     exon            851..919
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       883
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111341110"
     variation       891
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376164595"
     variation       912
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112003774"
     exon            920..1018
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       942
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211316"
     variation       944
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146486300"
     exon            1019..1105
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1030
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56115025"
     variation       1042
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374946247"
     variation       1043
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374744271"
     variation       1051
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190200350"
     exon            1106..1237
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1125
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116620621"
     variation       1132
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368444354"
     variation       1160
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148081976"
     variation       1161
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146185715"
     variation       1175
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140963190"
     variation       1176
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146537035"
     variation       1182
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34655121"
     variation       1183
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372595506"
     variation       1192
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1137377"
     variation       1227
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55845414"
     variation       1236
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369940373"
     exon            1238..1469
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1279
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56223064"
     variation       1318
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369328430"
     variation       1327
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371627417"
     variation       1339
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201838679"
     variation       1367
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374730094"
     variation       1371
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139147189"
     variation       1440
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144052967"
     variation       1441
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369059064"
     exon            1470..1566
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1471
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377540320"
     variation       1482
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150974354"
     variation       1504
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56176668"
     variation       1519
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149745317"
     variation       1537
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145670187"
     variation       1549
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200256801"
     variation       1565
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148905986"
     exon            1567..1735
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1571
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200746617"
     variation       1580
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2068826"
     variation       1594
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376763778"
     variation       1605
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375073240"
     variation       1609
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370585219"
     variation       1629
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202227041"
     variation       1639
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375455193"
     variation       1680
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62637654"
     variation       1695
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147882939"
     variation       1709
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141614983"
     variation       1717
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115242044"
     variation       1718
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370307671"
     exon            1736..1839
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1747
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274473"
     variation       1756
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375021615"
     variation       1780
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372375679"
     variation       1802
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117713820"
     variation       1809
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141986091"
     variation       1833
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199547857"
     variation       1837
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150268458"
     exon            1840..2363
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1909
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200440363"
     variation       2006
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113044021"
     variation       2012
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138922465"
     variation       2018
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142248586"
     variation       2031
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201409152"
     variation       2040
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201509530"
     STS             2041..2213
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /standard_name="RH25391"
                     /db_xref="UniSTS:52302"
     variation       2041
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374341087"
     variation       2063
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368962453"
     variation       2104
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12685407"
     variation       2145
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375359642"
     variation       2172
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138890476"
     variation       2291
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12347708"
     variation       2328
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189562435"
     variation       2358
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141466859"
ORIGIN      
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
            GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
            GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
            GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
            GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
            GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
            GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001243614 -> EC 2.7.10.2
            NP_001243614 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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