2024-03-28 19:18:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256685 2363 bp mRNA linear PRI 18-APR-2013 DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 2, mRNA. ACCESSION NM_001256685 VERSION NM_001256685.1 GI:375493531 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2363) AUTHORS Choi,S. and Ku,J.L. TITLE Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011) PUBMED 21806965 REMARK GeneRIF: MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU. REFERENCE 2 (bases 1 to 2363) AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D., Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S., Viapiano,M. and Kornblum,H.I. TITLE Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway JOURNAL Neuro-oncology 13 (6), 622-634 (2011) PUBMED 21558073 REMARK GeneRIF: High MELK is associated with brain tumor. REFERENCE 3 (bases 1 to 2363) AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L., Mourtada-Maarabouni,M. and Williams,G.T. TITLE Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JOURNAL Breast Cancer Res. 11 (4), R60 (2009) PUBMED 19671159 REMARK GeneRIF: MELK expression is increased in breast cancer tissue and this is associated with poor survival. The most important factors controlling Bcl-G activity are post-translational modification by Fau & MELK. REFERENCE 4 (bases 1 to 2363) AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M., Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S., Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L. TITLE Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JOURNAL Int. J. Cancer 122 (4), 807-815 (2008) PUBMED 17960622 REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas REFERENCE 5 (bases 1 to 2363) AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S., Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A., Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M., Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F., Mischel,P.S., Terskikh,A.V. and Kornblum,H.I. TITLE Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008) PUBMED 17722061 REMARK GeneRIF: a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. REFERENCE 6 (bases 1 to 2363) AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A., Rider,M.H., Stalmans,W. and Bollen,M. TITLE Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004) PUBMED 14699119 REFERENCE 7 (bases 1 to 2363) AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P. TITLE Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation JOURNAL Oncogene 21 (50), 7630-7641 (2002) PUBMED 12400006 REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 REFERENCE 8 (bases 1 to 2363) AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H. TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002) PUBMED 11802789 REFERENCE 9 (bases 1 to 2363) AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H. TITLE Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JOURNAL Gene 195 (2), 295-301 (1997) PUBMED 9305775 REFERENCE 10 (bases 1 to 2363) AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L. TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997) PUBMED 9136115 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP365611.1, AK299164.1, BC014039.2, AI590871.1 and DB368226.1. Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299164.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-48 BP365611.1 3-50 49-390 AK299164.1 1-342 391-391 BP365611.1 393-393 392-1252 AK299164.1 344-1204 1253-1746 BC014039.2 1330-1823 1747-1747 AI590871.1 619-619 c 1748-2362 BC014039.2 1825-2439 2363-2363 DB368226.1 1-1 c FEATURES Location/Qualifiers source 1..2363 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..2363 /gene="MELK" /gene_synonym="HPK38" /note="maternal embryonic leucine zipper kinase" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" exon 1..146 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 30 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:368403180" variation 35 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:188647479" variation 63 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:73436949" variation 68 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:139108274" variation 84 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:192249789" variation 106..108 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="ctt" /db_xref="dbSNP:143350018" variation 108..110 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="tct" /db_xref="dbSNP:371278776" exon 147..242 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" misc_feature 167..169 /gene="MELK" /gene_synonym="HPK38" /note="upstream in-frame stop codon" variation 172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:182440001" CDS 185..2017 /gene="MELK" /gene_synonym="HPK38" /EC_number="2.7.11.1" /EC_number="2.7.10.2" /note="isoform 2 is encoded by transcript variant 2; pEg3 kinase; protein kinase PK38; protein kinase Eg3; tyrosine-protein kinase MELK" /codon_start=1 /product="maternal embryonic leucine zipper kinase isoform 2" /protein_id="NP_001243614.1" /db_xref="GI:375493532" /db_xref="CCDS:CCDS59123.1" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="MIM:607025" /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
" misc_feature 215..973 /gene="MELK" /gene_synonym="HPK38" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 233..970 /gene="MELK" /gene_synonym="HPK38" /note="Catalytic domain of AGC family Protein Serine/Threonine Kinases; Region: STKc_AGC; cd05123" /db_xref="CDD:173660" misc_feature order(233..247,257..259,296..298,302..304,392..394, 440..445,449..451,461..463,467..469,578..580,584..586, 590..595,599..601,629..634,641..643,686..703,785..787, 803..805,812..814) /gene="MELK" /gene_synonym="HPK38" /note="active site" /db_xref="CDD:173660" misc_feature order(233..247,257..259,296..298,302..304,392..394, 443..451,461..463,578..580,584..586,590..595,599..601, 629..634) /gene="MELK" /gene_synonym="HPK38" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173660" misc_feature order(245..247,461..463,467..469,578..580,584..586, 590..592,641..643,686..703,785..787,803..805,812..814) /gene="MELK" /gene_synonym="HPK38" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173660" misc_feature order(629..646,650..655,683..703) /gene="MELK" /gene_synonym="HPK38" /note="activation loop (A-loop); other site" /db_xref="CDD:173660" misc_feature 1877..2014 /gene="MELK" /gene_synonym="HPK38" /note="Kinase associated domain 1; Region: KA1; pfam02149" /db_xref="CDD:190228" variation 220 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:371313222" variation 235 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:202138204" exon 243..328 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 261 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:114617403" variation 287 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:13440297" variation 292 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199697478" variation 323 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201026444" exon 329..445 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 351 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:35233455" variation 373 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200697039" variation 408 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:147513197" variation 412 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:148574125" variation 417 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115531852" exon 446..589 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 448 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142987107" variation 475 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377591615" variation 478 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370732572" variation 512 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:150500682" variation 525 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370963407" variation 550 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375693491" exon 590..658 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 625 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146379072" variation 631 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374766454" variation 655 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:139481227" exon 659..751 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 661 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:374077047" variation 662 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199834356" variation 716 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:149686898" variation 725 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:115586289" exon 752..850 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 755 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199880240" variation 763 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:374075415" variation 769 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146709588" variation 792 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:369063583" variation 840 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:35142210" variation 841 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144075335" exon 851..919 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 883 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:111341110" variation 891 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:376164595" variation 912 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:112003774" exon 920..1018 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 942 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201211316" variation 944 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146486300" exon 1019..1105 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1030 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:56115025" variation 1042 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374946247" variation 1043 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374744271" variation 1051 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:190200350" exon 1106..1237 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1125 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:116620621" variation 1132 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:368444354" variation 1160 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:148081976" variation 1161 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146185715" variation 1175 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:140963190" variation 1176 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146537035" variation 1182 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:34655121" variation 1183 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372595506" variation 1192 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:1137377" variation 1227 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55845414" variation 1236 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369940373" exon 1238..1469 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1279 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56223064" variation 1318 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369328430" variation 1327 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:371627417" variation 1339 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:201838679" variation 1367 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374730094" variation 1371 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:139147189" variation 1440 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:144052967" variation 1441 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369059064" exon 1470..1566 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1471 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377540320" variation 1482 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:150974354" variation 1504 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56176668" variation 1519 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:149745317" variation 1537 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:145670187" variation 1549 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200256801" variation 1565 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148905986" exon 1567..1735 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1571 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200746617" variation 1580 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:2068826" variation 1594 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:376763778" variation 1605 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375073240" variation 1609 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370585219" variation 1629 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:202227041" variation 1639 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375455193" variation 1680 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:62637654" variation 1695 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147882939" variation 1709 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141614983" variation 1717 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115242044" variation 1718 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370307671" exon 1736..1839 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1747 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:2274473" variation 1756 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375021615" variation 1780 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372375679" variation 1802 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:117713820" variation 1809 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:141986091" variation 1833 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199547857" variation 1837 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:150268458" exon 1840..2363 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1909 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:200440363" variation 2006 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:113044021" variation 2012 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138922465" variation 2018 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142248586" variation 2031 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201409152" variation 2040 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201509530" STS 2041..2213 /gene="MELK" /gene_synonym="HPK38" /standard_name="RH25391" /db_xref="UniSTS:52302" variation 2041 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374341087" variation 2063 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:368962453" variation 2104 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:12685407" variation 2145 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375359642" variation 2172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138890476" variation 2291 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:12347708" variation 2328 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:189562435" variation 2358 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141466859" ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001243614 -> EC 2.7.10.2 NP_001243614 -> EC 2.7.11.1
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