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2024-03-29 00:23:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256293            1901 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens keratin 8 (KRT8), transcript variant 3, mRNA.
ACCESSION   NM_001256293
VERSION     NM_001256293.1  GI:372466576
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Fortier,A.M., Asselin,E. and Cadrin,M.
  TITLE     Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation
  JOURNAL   J. Biol. Chem. 288 (16), 11555-11571 (2013)
   PUBMED   23449973
  REMARK    GeneRIF: K8/18 expression can influence the phenotype of epithelial
            cancer cells at a transcriptional level and supports the hypothesis
            that keratins play an active role in cancer progression.
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
  TITLE     Keratin 8/18 regulation of glucose metabolism in normal versus
            cancerous hepatic cells through differential modulation of
            hexokinase status and insulin signaling
  JOURNAL   Exp. Cell Res. 319 (4), 474-486 (2013)
   PUBMED   23164509
  REMARK    GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
            and cancerous hepatic cells through differential modulations of
            mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
            Omary,M.B.
  TITLE     Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
            by lysine acetylation
  JOURNAL   J. Cell Biol. 200 (3), 241-247 (2013)
   PUBMED   23358244
  REMARK    GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
            among type II keratins, is up-regulated upon hyperglycemia and
            down-regulated by SIRT2.
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
            Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
  TITLE     Understanding the role of keratins 8 and 18 in neoplastic potential
            of breast cancer derived cell lines
  JOURNAL   PLoS ONE 8 (1), E53532 (2013)
   PUBMED   23341946
  REMARK    GeneRIF: These results indicate the role of K8/18 in modulating
            invasion in breast cancer.
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
  TITLE     An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
            expression in breast papillomas and papillary carcinomas
  JOURNAL   Diagn Pathol 8, 8 (2013)
   PUBMED   23327593
  REMARK    GeneRIF: Report keratin 8 expression in breast papillomas and
            papillary carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
            Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
  TITLE     Distribution of individual components of basement membrane in human
            colon polyps and adenocarcinomas as revealed by monoclonal
            antibodies
  JOURNAL   Int. J. Cancer 50 (4), 562-566 (1992)
   PUBMED   1371500
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
  TITLE     Embryonic simple epithelial keratins 8 and 18: chromosomal location
            emphasizes difference from other keratin pairs
  JOURNAL   New Biol. 2 (5), 464-478 (1990)
   PUBMED   1705144
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
  TITLE     Cloning and sequence of cDNA for human placental cytokeratin 8.
            Regulation of the mRNA in trophoblastic cells by cAMP
  JOURNAL   Mol. Endocrinol. 4 (3), 370-374 (1990)
   PUBMED   1692965
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
            Lane,B., Leigh,I. and Vooijs,P.
  TITLE     Changing patterns of keratin expression during progression of
            cervical intraepithelial neoplasia
  JOURNAL   Am. J. Pathol. 136 (3), 657-668 (1990)
   PUBMED   1690513
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Krauss,S. and Franke,W.W.
  TITLE     Organization and sequence of the human gene encoding cytokeratin 8
  JOURNAL   Gene 86 (2), 241-249 (1990)
   PUBMED   1691124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA051933.1, AK290938.1,
            AK310257.1, BC063513.1 and CX166336.1.
            
            Summary: This gene is a member of the type II keratin family
            clustered on the long arm of chromosome 12. Type I and type II
            keratins heteropolymerize to form intermediate-sized filaments in
            the cytoplasm of epithelial cells. The product of this gene
            typically dimerizes with keratin 18 to form an intermediate
            filament in simple single-layered epithelial cells. This protein
            plays a role in maintaining cellular structural integrity and also
            functions in signal transduction and cellular differentiation.
            Mutations in this gene cause cryptogenic cirrhosis. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (3) has an alternate 5' exon,
            which results in a downstream AUG start codon, compared to variant
            1. The encoded isoform (2) has a shorter N-terminus, compared to
            isoform 1. Variants 2 and 3 encode the same isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290938.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025088 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA051933.1         1-42
            43-194              AK290938.1         1-152
            195-1781            AK310257.1         101-1687
            1782-1887           BC063513.1         1652-1757
            1888-1901           CX166336.1         767-780
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1901
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="keratin 8"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="MIM:148060"
     exon            1..152
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    130..132
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="upstream in-frame stop codon"
     exon            153..522
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       177..178
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554493"
     variation       195
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065306"
     CDS             199..1650
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="isoform 2 is encoded by transcript variant 3;
                     keratin, type II cytoskeletal 8; cytokeratin 8;
                     cytokeratin-8; type-II keratin Kb8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 8 isoform 2"
                     /protein_id="NP_001243222.1"
                     /db_xref="GI:372466577"
                     /db_xref="CCDS:CCDS8841.1"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="MIM:148060"
                     /translation="
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
"
     misc_feature    199..468
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Head"
     misc_feature    223..225
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC/PRKCE; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    259..261
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    268..270
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC/PRKCE; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    277..279
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    298..300
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    304..306
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    307..309
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    325..327
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    418..420
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by MAPK; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    466..1377
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:200948"
     misc_feature    469..1392
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Rod"
     misc_feature    469..576
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 1A"
     misc_feature    499..501
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-malonyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); modified site"
     misc_feature    547..549
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    577..627
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Linker 1"
     misc_feature    628..903
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 1B"
     misc_feature    817..819
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    904..975
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Linker 12"
     misc_feature    955..957
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    970..972
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    976..1392
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Coil 2"
     misc_feature    979..1344
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Necessary for interaction with PNN"
     misc_feature    1081..1083
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1171..1173
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1186..1188
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1222..1224
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); other site"
     misc_feature    1237..1239
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); acetylation site"
     misc_feature    1393..1647
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05787.7);
                     Region: Tail"
     misc_feature    1396..1398
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1426..1428
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1492..1494
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CaMK2 and MAPK; propagated from
                     UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
     misc_feature    1621..1623
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     misc_feature    1630..1632
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05787.7); phosphorylation site"
     variation       250
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554484"
     variation       309
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554498"
     variation       318
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554488"
     variation       449
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554494"
     variation       462
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554492"
     variation       465
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554497"
     exon            523..731
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            732..792
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            793..888
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            889..1179
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       907
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554490"
     variation       1003
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554280"
     variation       1034
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554499"
     variation       1045
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554487"
     variation       1122
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1065311"
     variation       1154
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554486"
     variation       1156
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554483"
     exon            1180..1400
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       1197
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7750"
     variation       1273
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57626370"
     variation       1302
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1065362"
     exon            1401..1459
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1405..1811
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="GDB:277179"
                     /db_xref="UniSTS:156366"
     exon            1460..1891
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1463..1880
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="KRT8_7288"
                     /db_xref="UniSTS:466264"
     variation       1556
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554491"
     STS             1588..1823
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="D17S1697"
                     /db_xref="UniSTS:153850"
     STS             1590..1837
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH79790"
                     /db_xref="UniSTS:88364"
     STS             1604..1729
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH47175"
                     /db_xref="UniSTS:57916"
     variation       1748
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1065710"
     polyA_signal    1862..1867
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
     polyA_site      1891
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN      
acaggcctttccttacctccctccatgctgtccacttcctctgtaaagctctcaaccctgtccccttccccctctctcctgggaaagagccctcccatgcctagctgctgctcttagggaccctgtggctaggtgcgcggatggaaatccaggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
            GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
            GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
            GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
            GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA

by @meso_cacase at DBCLS
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