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2024-03-29 14:36:00, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256282            1807 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens keratin 8 (KRT8), transcript variant 1, mRNA.
ACCESSION   NM_001256282
VERSION     NM_001256282.1  GI:372466571
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Fortier,A.M., Asselin,E. and Cadrin,M.
  TITLE     Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation
  JOURNAL   J. Biol. Chem. 288 (16), 11555-11571 (2013)
   PUBMED   23449973
  REMARK    GeneRIF: K8/18 expression can influence the phenotype of epithelial
            cancer cells at a transcriptional level and supports the hypothesis
            that keratins play an active role in cancer progression.
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
  TITLE     Keratin 8/18 regulation of glucose metabolism in normal versus
            cancerous hepatic cells through differential modulation of
            hexokinase status and insulin signaling
  JOURNAL   Exp. Cell Res. 319 (4), 474-486 (2013)
   PUBMED   23164509
  REMARK    GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
            and cancerous hepatic cells through differential modulations of
            mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
            Omary,M.B.
  TITLE     Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
            by lysine acetylation
  JOURNAL   J. Cell Biol. 200 (3), 241-247 (2013)
   PUBMED   23358244
  REMARK    GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
            among type II keratins, is up-regulated upon hyperglycemia and
            down-regulated by SIRT2.
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
            Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
  TITLE     Understanding the role of keratins 8 and 18 in neoplastic potential
            of breast cancer derived cell lines
  JOURNAL   PLoS ONE 8 (1), E53532 (2013)
   PUBMED   23341946
  REMARK    GeneRIF: These results indicate the role of K8/18 in modulating
            invasion in breast cancer.
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
  TITLE     An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
            expression in breast papillomas and papillary carcinomas
  JOURNAL   Diagn Pathol 8, 8 (2013)
   PUBMED   23327593
  REMARK    GeneRIF: Report keratin 8 expression in breast papillomas and
            papillary carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
            Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
  TITLE     Distribution of individual components of basement membrane in human
            colon polyps and adenocarcinomas as revealed by monoclonal
            antibodies
  JOURNAL   Int. J. Cancer 50 (4), 562-566 (1992)
   PUBMED   1371500
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
  TITLE     Embryonic simple epithelial keratins 8 and 18: chromosomal location
            emphasizes difference from other keratin pairs
  JOURNAL   New Biol. 2 (5), 464-478 (1990)
   PUBMED   1705144
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
  TITLE     Cloning and sequence of cDNA for human placental cytokeratin 8.
            Regulation of the mRNA in trophoblastic cells by cAMP
  JOURNAL   Mol. Endocrinol. 4 (3), 370-374 (1990)
   PUBMED   1692965
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
            Lane,B., Leigh,I. and Vooijs,P.
  TITLE     Changing patterns of keratin expression during progression of
            cervical intraepithelial neoplasia
  JOURNAL   Am. J. Pathol. 136 (3), 657-668 (1990)
   PUBMED   1690513
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Krauss,S. and Franke,W.W.
  TITLE     Organization and sequence of the human gene encoding cytokeratin 8
  JOURNAL   Gene 86 (2), 241-249 (1990)
   PUBMED   1691124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK310257.1, BC008200.1 and
            CX166336.1.
            
            Summary: This gene is a member of the type II keratin family
            clustered on the long arm of chromosome 12. Type I and type II
            keratins heteropolymerize to form intermediate-sized filaments in
            the cytoplasm of epithelial cells. The product of this gene
            typically dimerizes with keratin 18 to form an intermediate
            filament in simple single-layered epithelial cells. This protein
            plays a role in maintaining cellular structural integrity and also
            functions in signal transduction and cellular differentiation.
            Mutations in this gene cause cryptogenic cirrhosis. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK310257.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              AK310257.1         1-1687
            1688-1793           BC008200.1         1302-1407
            1794-1807           CX166336.1         767-780
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1807
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="keratin 8"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="MIM:148060"
     exon            1..58
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     CDS             21..1556
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type II cytoskeletal 8; cytokeratin 8;
                     cytokeratin-8; type-II keratin Kb8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 8 isoform 1"
                     /protein_id="NP_001243211.1"
                     /db_xref="GI:372466572"
                     /db_xref="CCDS:CCDS58234.1"
                     /db_xref="GeneID:3856"
                     /db_xref="HGNC:6446"
                     /db_xref="MIM:148060"
                     /translation="
MNGVSWSQDLQEGISAWFGPPASTPASTMSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
"
     misc_feature    372..1283
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:200948"
     exon            59..428
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       83..84
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554493"
     variation       101
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065306"
     variation       156
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554484"
     variation       215
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554498"
     variation       224
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554488"
     variation       355
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554494"
     variation       368
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554492"
     variation       371
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554497"
     exon            429..637
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            638..698
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            699..794
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     exon            795..1085
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       813
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554490"
     variation       909
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554280"
     variation       940
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554499"
     variation       951
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554487"
     variation       1028
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1065311"
     variation       1060
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11554486"
     variation       1062
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554483"
     exon            1086..1306
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     variation       1103
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7750"
     variation       1179
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57626370"
     variation       1208
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1065362"
     exon            1307..1365
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1311..1717
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="GDB:277179"
                     /db_xref="UniSTS:156366"
     exon            1366..1797
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /inference="alignment:Splign:1.39.8"
     STS             1369..1786
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="KRT8_7288"
                     /db_xref="UniSTS:466264"
     variation       1462
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11554491"
     STS             1494..1729
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="D17S1697"
                     /db_xref="UniSTS:153850"
     STS             1496..1743
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH79790"
                     /db_xref="UniSTS:88364"
     STS             1510..1635
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /standard_name="RH47175"
                     /db_xref="UniSTS:57916"
     variation       1654
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1065710"
     polyA_signal    1768..1773
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
     polyA_site      1797
                     /gene="KRT8"
                     /gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN      
attcagcaaatgtttgcggaatgaatggggtgagctggagccaggacctgcaggaagggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
            GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
            GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
            GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
            GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
            GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
            GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA

by @meso_cacase at DBCLS
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