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2024-03-29 20:46:52, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001256135            3459 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L),
            transcript variant 2, mRNA.
ACCESSION   NM_001256135
VERSION     NM_001256135.1  GI:371502111
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3459)
  AUTHORS   Soldini,D., Montagna,C., Schuffler,P., Martin,V., Georgis,A.,
            Thiesler,T., Curioni-Fontecedro,A., Went,P., Bosshard,G.,
            Dehler,S., Mazzuchelli,L. and Tinguely,M.
  TITLE     A new diagnostic algorithm for Burkitt and diffuse large B-cell
            lymphomas based on the expression of CSE1L and STAT3 and on MYC
            rearrangement predicts outcome
  JOURNAL   Ann. Oncol. 24 (1), 193-201 (2013)
   PUBMED   22967991
  REMARK    GeneRIF: CSE1L- and inhibitor of DNA binding-3 (ID3)-overexpression
            was associated with the diagnosis of BL and signal transduction and
            transcription-3 (STAT3) with DLBCL (P<0.001 for all markers). All
            three markers were associated with patient outcome in DLBCL
REFERENCE   2  (bases 1 to 3459)
  AUTHORS   Chang,C.C., Tai,C.J., Su,T.C., Shen,K.H., Lin,S.H., Yeh,C.M.,
            Yeh,K.T., Lin,Y.M. and Jiang,M.C.
  TITLE     The prognostic significance of nuclear CSE1L in urinary bladder
            urothelial carcinomas
  JOURNAL   Ann Diagn Pathol 16 (5), 362-368 (2012)
   PUBMED   22476051
  REMARK    GeneRIF: Nuclear CSE1L may play an oncogenic role in bladder tumor
            progression and that immunohistochemical staining of nuclear CSE1L
            may be useful for the prognosis of bladder urothelial carcinomas.
REFERENCE   3  (bases 1 to 3459)
  AUTHORS   Zang,H., Zhao,J.M., Ji,D., Sun,Y.L., Zhou,G.D., Zhao,Y.L. and
            Chen,G.F.
  TITLE     [Expression of CAS in hepatocellular carcinoma tissues and its
            relationship with HBV infection]
  JOURNAL   Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 26 (4), 285-287
            (2012)
   PUBMED   23189846
  REMARK    GeneRIF: CAS protein expression is related closely to tumor
            differentiation in hepatocellular carcinoma tissues.
REFERENCE   4  (bases 1 to 3459)
  AUTHORS   Sillars-Hardebol,A.H., Carvalho,B., Belien,J.A., de Wit,M.,
            Delis-van Diemen,P.M., Tijssen,M., van de Wiel,M.A., Ponten,F.,
            Meijer,G.A. and Fijneman,R.J.
  TITLE     CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma
            progression
  JOURNAL   Cell Oncol (Dordr) 35 (4), 293-300 (2012)
   PUBMED   22711543
  REMARK    GeneRIF: Data show that CSE1L, DIDO1 and RBM39 mRNA expression
            levels correlated with chromosome 20q DNA copy number status.
REFERENCE   5  (bases 1 to 3459)
  AUTHORS   Liao,C.F., Lin,S.H., Chen,H.C., Tai,C.J., Chang,C.C., Li,L.T.,
            Yeh,C.M., Yeh,K.T., Chen,Y.C., Hsu,T.H., Shen,S.C., Lee,W.R.,
            Chiou,J.F., Luo,S.F. and Jiang,M.C.
  TITLE     CSE1L, a novel microvesicle membrane protein, mediates
            Ras-triggered microvesicle generation and metastasis of tumor cells
  JOURNAL   Mol. Med. 18, 1269-1280 (2012)
   PUBMED   22952058
  REMARK    GeneRIF: CSE1L may be involved in the 'early' and 'late' metastasis
            of tumor cells in tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3459)
  AUTHORS   Herold,A., Truant,R., Wiegand,H. and Cullen,B.R.
  TITLE     Determination of the functional domain organization of the importin
            alpha nuclear import factor
  JOURNAL   J. Cell Biol. 143 (2), 309-318 (1998)
   PUBMED   9786944
REFERENCE   7  (bases 1 to 3459)
  AUTHORS   Kutay,U., Bischoff,F.R., Kostka,S., Kraft,R. and Gorlich,D.
  TITLE     Export of importin alpha from the nucleus is mediated by a specific
            nuclear transport factor
  JOURNAL   Cell 90 (6), 1061-1071 (1997)
   PUBMED   9323134
REFERENCE   8  (bases 1 to 3459)
  AUTHORS   Brinkmann,U., Brinkmann,E., Gallo,M., Scherf,U. and Pastan,I.
  TITLE     Role of CAS, a human homologue to the yeast chromosome segregation
            gene CSE1, in toxin and tumor necrosis factor mediated apoptosis
  JOURNAL   Biochemistry 35 (21), 6891-6899 (1996)
   PUBMED   8639641
REFERENCE   9  (bases 1 to 3459)
  AUTHORS   Brinkmann,U., Gallo,M., Polymeropoulos,M.H. and Pastan,I.
  TITLE     The human CAS (cellular apoptosis susceptibility) gene mapping on
            chromosome 20q13 is amplified in BT474 breast cancer cells and part
            of aberrant chromosomes in breast and colon cancer cell lines
  JOURNAL   Genome Res. 6 (3), 187-194 (1996)
   PUBMED   8963895
REFERENCE   10 (bases 1 to 3459)
  AUTHORS   Brinkmann,U., Brinkmann,E., Gallo,M. and Pastan,I.
  TITLE     Cloning and characterization of a cellular apoptosis susceptibility
            gene, the human homologue to the yeast chromosome segregation gene
            CSE1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (22), 10427-10431 (1995)
   PUBMED   7479798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC402014.1, EF426455.1,
            BC109314.2, AI973168.1 and AI018123.1.
            
            Summary: Proteins that carry a nuclear localization signal (NLS)
            are transported into the nucleus by the importin-alpha/beta
            heterodimer. Importin-alpha binds the NLS, while importin-beta
            mediates translocation through the nuclear pore complex. After
            translocation, RanGTP binds importin-beta and displaces
            importin-alpha. Importin-alpha must then be returned to the
            cytoplasm, leaving the NLS protein behind. The protein encoded by
            this gene binds strongly to NLS-free importin-alpha, and this
            binding is released in the cytoplasm by the combined action of
            RANBP1 and RANGAP1. In addition, the encoded protein may play a
            role both in apoptosis and in cell proliferation. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon
            compared to variant 1. This results in a shorter isoform (2)
            missing an internal protein segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: EF426455.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    ERS025084, ERS025086 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DC402014.1         1-189
            190-1632            EF426455.1         1-1443
            1633-3219           BC109314.2         1714-3300
            3220-3442           AI973168.1         1-223               c
            3443-3459           AI018123.1         2-18                c
FEATURES             Location/Qualifiers
     source          1..3459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13"
     gene            1..3459
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="CSE1 chromosome segregation 1-like (yeast)"
                     /db_xref="GeneID:1434"
                     /db_xref="HGNC:2431"
                     /db_xref="MIM:601342"
     exon            1..178
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       32
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2273533"
     variation       41
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2252259"
     variation       99
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117725610"
     misc_feature    121..123
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="upstream in-frame stop codon"
     exon            179..274
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     CDS             190..2937
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     importin-alpha re-exporter; cellular apoptosis
                     susceptibility protein; exportin-2; exp2; chromosome
                     segregation 1-like protein"
                     /codon_start=1
                     /product="exportin-2 isoform 2"
                     /protein_id="NP_001243064.1"
                     /db_xref="GI:371502112"
                     /db_xref="CCDS:CCDS58773.1"
                     /db_xref="GeneID:1434"
                     /db_xref="HGNC:2431"
                     /db_xref="MIM:601342"
                     /translation="
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
"
     misc_feature    274..495
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="Importin-beta N-terminal domain; Region: IBN_N;
                     smart00913"
                     /db_xref="CDD:197981"
     misc_feature    655..1599
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="Region: Cse1; pfam08506"
                     /db_xref="CDD:117083"
     misc_feature    1600..2907
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="CAS/CSE protein, C-terminus; Region: CAS_CSE1;
                     pfam03378"
                     /db_xref="CDD:190619"
     variation       202
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372551577"
     variation       222
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145758236"
     exon            275..417
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       291
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369371888"
     variation       292
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2664535"
     variation       315
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372846963"
     variation       388
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2664556"
     variation       398
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112333627"
     variation       416
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145805814"
     exon            418..519
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       419
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200581090"
     variation       429
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141564653"
     variation       433
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201843660"
     variation       470
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377396767"
     exon            520..665
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       555
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370077115"
     variation       630
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370271126"
     exon            666..756
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       690
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368316233"
     variation       714
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372336608"
     variation       741
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201000044"
     exon            757..864
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       763
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370821480"
     variation       764
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374191395"
     variation       775
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150139793"
     variation       825
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2227946"
     variation       828
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368656942"
     exon            865..957
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       881..882
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3191924"
     variation       881
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1131754"
     variation       882
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1131755"
     variation       887
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1131756"
     variation       893
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184951470"
     variation       915
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051528"
     exon            958..1087
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       975
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374381262"
     variation       1033
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377449760"
     variation       1035
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140513534"
     exon            1088..1153
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     exon            1154..1356
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1196
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142187945"
     STS             1252..1353
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="YWHAB"
                     /db_xref="UniSTS:265998"
     variation       1276
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151168384"
     variation       1287
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373272778"
     variation       1298
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140221738"
     variation       1326
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371810198"
     variation       1335
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113209936"
     variation       1336
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113526104"
     exon            1357..1441
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1388
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377071060"
     variation       1426
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201792954"
     exon            1442..1503
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1460
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375038710"
     variation       1503
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192906243"
     exon            1504..1640
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1558
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149873330"
     variation       1562
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3209624"
     variation       1568
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374403159"
     variation       1578
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146427669"
     variation       1584
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140701703"
     variation       1606
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145901767"
     variation       1614
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371585267"
     exon            1641..1744
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1659
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368726403"
     variation       1665
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112036311"
     variation       1687
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200292430"
     variation       1694
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35437801"
     variation       1710..1711
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35542902"
     variation       1717
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200007210"
     variation       1744
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6095427"
     exon            1745..1842
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1794
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143358483"
     variation       1801
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148320954"
     variation       1806
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34221013"
     variation       1834
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372016863"
     exon            1843..1993
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       1851
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141477153"
     variation       1873
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202019379"
     variation       1897
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147450179"
     variation       1924
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138299846"
     variation       1926
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111650807"
     variation       1944
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372337206"
     variation       1962
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375924098"
     variation       1983
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369958107"
     exon            1994..2202
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2134
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143688296"
     variation       2154
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151233979"
     variation       2161
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375067125"
     variation       2162
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376962564"
     variation       2163
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369869448"
     variation       2171
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147216191"
     variation       2173
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371134165"
     variation       2197
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375000731"
     exon            2203..2300
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2232
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374989344"
     variation       2281
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229042"
     exon            2301..2386
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2302
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201854045"
     variation       2310
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199707942"
     variation       2365
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372218279"
     variation       2366
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139664090"
     exon            2387..2468
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2407
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201285684"
     variation       2430
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377319144"
     variation       2454
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7343500"
     exon            2469..2615
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2473
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:112338228"
     variation       2516
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28659989"
     variation       2550
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149713430"
     variation       2571
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3180705"
     variation       2607
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200756398"
     exon            2616..2847
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2632
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113498434"
     variation       2692
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144565007"
     variation       2777
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377701705"
     variation       2778
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370382903"
     STS             2844..2969
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="D20S575E"
                     /db_xref="UniSTS:27990"
     exon            2848..3459
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:1.39.8"
     variation       2853
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201892069"
     variation       2870
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148419512"
     STS             2876..3025
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="D20S1125"
                     /db_xref="UniSTS:1160"
     STS             2891..3040
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="A003P30"
                     /db_xref="UniSTS:7211"
     variation       2892
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35367415"
     variation       2899
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11965"
     variation       2923
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3505"
     variation       2949
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051705"
     STS             2952..3056
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="G61992"
                     /db_xref="UniSTS:139211"
     variation       2993
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051726"
     variation       3025
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17632"
     polyA_signal    3065..3070
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
     polyA_site      3087
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
     variation       3119
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145257031"
     variation       3150
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147474671"
     STS             3157..3268
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /standard_name="RH18314"
                     /db_xref="UniSTS:14814"
     variation       3186
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185873544"
     variation       3211
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189799183"
     variation       3299
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182415250"
     variation       3353
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139989717"
     polyA_signal    3422..3427
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
     polyA_site      3448
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
ORIGIN      
agagcattcctggccccgccccctgcagcgggccgctcgctcatgcgctctggcctcaggctcgctgtcgcgccattttgccggggtttgaatgtgaggcggagcggcggcaggagcgggtagtgccagctacggtccgcggctggggttccctcctccgtttctgtatccccacgagatcctatagcaatggaactcagcgatgcaaatctgcaaacactaacagaatatttaaagaaaacacttgatcctgatcctgccatccgacgtccagctgagaaatttcttgaatctgttgaaggaaatcagaattatccactgttgcttttgacattactggagaagtcccaggataatgttatcaaagtatgtgcttcagtaacattcaaaaactatattaaaaggaactggagaattgttgaagatgaaccaaacaaaatttgtgaagccgatcgagtggccattaaagccaacatagtgcacttgatgcttagcagcccagagcaaattcagaagcagttaagtgatgcaattagcattattggcagagaagattttccacagaaatggcctgacttgctgacagaaatggtgaatcgctttcagagtggagatttccatgttattaatggagtcctccgtacagcacattcattatttaaaagataccgtcatgaatttaagtcaaacgagttatggactgaaattaagcttgttctggatgcctttgctttgcctttgactaatctttttaaggccactattgaactctgcagtacccatgcaaatgatgcctctgccctgaggattctgttttcttccctgatcctgatctcaaaattgttctatagtttaaactttcaggatctccctgaattttttgaagataatatggaaacttggatgaataattttcatactctcttaacattggataataagcttttacaaactgatttggtaagtaatgcaattcaatttctggcttcagtttgtgagagacctcattataagaatctatttgaggaccagaacacgctgacaagtatctgtgaaaaggttattgtgcctaacatggaatttagagctgctgatgaagaagcatttgaagataattctgaggagtacataaggagagatttggaaggatctgatattgatactagacgcagggctgcttgtgatctggtacgaggattatgcaagttttttgagggacctgtgacaggaatcttctctggttatgttaattccatgctgcaggaatacgcaaaaaatccatctgtcaactggaaacacaaagatgcagccatctacctagtgacatctttggcatcaaaagcccaaacacagaagcatggaattacacaagcaaatgaacttgtaaacctaactgagttctttgtgaatcacatcctccctgatttaaaatcagctaatgtgaatgaatttcctgtccttaaagctgacggtatcaaatatattatgatttttagaaatcaagtgccaaaagaacatcttttagtctcgattcctctcttgattaatcatcttcaagctgaaagtattgttgttcatacttacgcagctcatgctcttgaacggctctttactatgcgagggcctaacaatgccactctctttacagctgcagaaatcgcaccgtttgttgagattctgctaacaaaccttttcaaagctctcacacttcctggctcttcagaaaatgaatatattatgaaagctatcatgagaagtttttctctcctacaagaagccataatcccctacatccctactctcatcactcagcttacacagaagctattagctgttagtaagaacccaagcaaacctcactttaatcactacatgtttgaagcaatatgtttatccataagaataacttgcaaagctaaccctgctgctgttgtaaattttgaggaggctttgtttttggtgtttactgaaatcttacaaaatgatgtgcaagaatttattccatacgtctttcaagtgatgtctttgcttctggaaacacacaaaaatgacatcccgtcttcctatatggccttatttcctcatctccttcagccagtgctttgggaaagaacaggaaatattcctgctctagtgaggcttcttcaagcattcttagaacgcggttcaaacacaatagcaagtgctgcagctgacaaaattcctgggttactaggtgtctttcagaagctgattgcatccaaagcaaatgaccaccaaggtttttatcttctaaacagtataatagagcacatgcctcctgaatcagttgaccaatataggaaacaaatcttcattctgctattccagagacttcagaattccaaaacaaccaagtttatcaagagttttttagtctttattaatttgtattgcataaaatatggggcactagcactacaagaaatatttgatggtatacaaccaaaaatgtttggaatggttttggaaaaaattattattcctgaaattcagaaggtatctggaaatgtagagaaaaagatctgtgcggttggcataaccaaattactaacagaatgtcccccaatgatggacactgagtataccaaactgtggactccattattacagtctttgattggtctttttgagttacccgaagatgataccattcctgatgaggaacattttattgacatagaagatacaccaggatatcagactgccttctcacagttggcatttgctgggaaaaaagagcatgatcctgtaggtcaaatggtgaataaccccaaaattcacctggcacagtcacttcacaagttgtctaccgcctgtccaggaagggttccatcaatggtgagcaccagcctgaatgcagaagcgctccagtatctccaagggtaccttcaggcagccagtgtgacactgctttaaactgcatttttctaatgggctaaacccagatggtttcctaggaaatcacaggcttctgagcacagctgcattaaaacaaaggaagttctccttttgaacttgtcacgaattccatcttgtaaaggatattaaatgttgctttaacctgaaccttgagcaaattagttggtttgtgtgatcatacagttatgtgggtggcttctagtttgcaacttcaagggacaagtattaatagttcagtgtatggcgttggtttgtgttgagcgtttgcacggtttggataatcttaaattttgacggacactgtggagactttctgttactaaatccttttgttttgaagctgttgctatttgtatttctcttgtcctttatattttttgtctgtttatttacgcttttattggaaatgtgaataagtaaagaattacttgtgttacttgccaagcagtgcacatttcatagtttcaaatctgtaatcagcaataaaaatcctaaaatatgtacctaagaacatcttaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1434 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1434 -> Molecular function: GO:0008262 [importin-alpha export receptor activity] evidence: TAS
            GeneID:1434 -> Molecular function: GO:0008536 [Ran GTPase binding] evidence: IEA
            GeneID:1434 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:1434 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:1434 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:1434 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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