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2024-04-25 07:05:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001252124 4882 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens PAS domain containing serine/threonine kinase (PASK),
transcript variant 5, mRNA.
ACCESSION NM_001252124
VERSION NM_001252124.1 GI:355477268
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4882)
AUTHORS Hao,Y., Liu,X., Lu,X., Yang,X., Wang,L., Chen,S., Li,H., Li,J.,
Cao,J., Chen,J., Li,Y., Zhao,L., Shi,Y., Shen,C., Yan,W., He,J.,
Huang,J. and Gu,D.
TITLE Genome-wide association study in Han Chinese identifies three novel
loci for human height
JOURNAL Hum. Genet. 132 (6), 681-689 (2013)
PUBMED 23456168
REFERENCE 2 (bases 1 to 4882)
AUTHORS Semplici,F., Vaxillaire,M., Fogarty,S., Semache,M., Bonnefond,A.,
Fontes,G., Philippe,J., Meur,G., Diraison,F., Sessions,R.B.,
Rutter,J., Poitout,V., Froguel,P. and Rutter,G.A.
TITLE Human mutation within Per-Arnt-Sim (PAS) domain-containing protein
kinase (PASK) causes basal insulin hypersecretion
JOURNAL J. Biol. Chem. 286 (51), 44005-44014 (2011)
PUBMED 22065581
REMARK GeneRIF: Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK)
has a role in insulin hypersecretion
REFERENCE 3 (bases 1 to 4882)
AUTHORS MacDonald,P.E. and Rorsman,P.
TITLE Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon
secretion
JOURNAL Diabetologia 54 (4), 719-721 (2011)
PUBMED 21327866
REFERENCE 4 (bases 1 to 4882)
AUTHORS da Silva Xavier,G., Farhan,H., Kim,H., Caxaria,S., Johnson,P.,
Hughes,S., Bugliani,M., Marselli,L., Marchetti,P., Birzele,F.,
Sun,G., Scharfmann,R., Rutter,J., Siniakowicz,K., Weir,G.,
Parker,H., Reimann,F., Gribble,F.M. and Rutter,G.A.
TITLE Per-arnt-sim (PAS) domain-containing protein kinase is
downregulated in human islets in type 2 diabetes and regulates
glucagon secretion
JOURNAL Diabetologia 54 (4), 819-827 (2011)
PUBMED 21181396
REMARK GeneRIF: PASK is involved in the regulation of glucagon secretion
by glucose and may be a useful target for the treatment of type 2
diabetes.
REFERENCE 5 (bases 1 to 4882)
AUTHORS Grose,J.H. and Rutter,J.
TITLE The role of PAS kinase in PASsing the glucose signal
JOURNAL Sensors (Basel) 10 (6), 5668-5682 (2010)
PUBMED 22219681
REMARK GeneRIF: The role of PAS kinase in PASsing the glucose signal.
Review article
REFERENCE 6 (bases 1 to 4882)
AUTHORS Wilson,W.A., Skurat,A.V., Probst,B., de Paoli-Roach,A., Roach,P.J.
and Rutter,J.
TITLE Control of mammalian glycogen synthase by PAS kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (46), 16596-16601 (2005)
PUBMED 16275910
REFERENCE 7 (bases 1 to 4882)
AUTHORS da Silva Xavier,G., Rutter,J. and Rutter,G.A.
TITLE Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of
preproinsulin and pancreatic duodenum homeobox 1 gene expression by
glucose
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (22), 8319-8324 (2004)
PUBMED 15148392
REMARK GeneRIF: Results suggest that elevated glucose concentrations
rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet
beta cells, followed by up-regulation by glucose of preproinsulin
and pancreatic duodenum homeobox 1 gene expression.
REFERENCE 8 (bases 1 to 4882)
AUTHORS Amezcua,C.A., Harper,S.M., Rutter,J. and Gardner,K.H.
TITLE Structure and interactions of PAS kinase N-terminal PAS domain:
model for intramolecular kinase regulation
JOURNAL Structure 10 (10), 1349-1361 (2002)
PUBMED 12377121
REFERENCE 9 (bases 1 to 4882)
AUTHORS Hofer,T., Spielmann,P., Stengel,P., Stier,B., Katschinski,D.M.,
Desbaillets,I., Gassmann,M. and Wenger,R.H.
TITLE Mammalian PASKIN, a PAS-serine/threonine kinase related to
bacterial oxygen sensors
JOURNAL Biochem. Biophys. Res. Commun. 288 (4), 757-764 (2001)
PUBMED 11688972
REMARK GeneRIF: molecular cloning, gene expression, and comparison with
mouse protein
REFERENCE 10 (bases 1 to 4882)
AUTHORS Rutter,J., Michnoff,C.H., Harper,S.M., Gardner,K.H. and
McKnight,S.L.
TITLE PAS kinase: an evolutionarily conserved PAS domain-regulated
serine/threonine kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (16), 8991-8996 (2001)
PUBMED 11459942
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA104684.1, BC050565.1,
BC063585.1 and AL117400.1.
Summary: This gene encodes a member of the serine/threonine kinase
family that contains two PAS domains. Expression of this gene is
regulated by glucose, and the encoded protein plays a role in the
regulation of insulin gene expression. Downregulation of this gene
may play a role in type 2 diabetes. Alternatively spliced
transcript variants encoding multiple isoforms have been observed
for this gene. [provided by RefSeq, Nov 2011].
Transcript Variant: This variant (5) lacks a splice site in the 3'
coding region, which results in a frameshift and alternate 3' UTR
compared to variant 1. The encoded isoform (4) is shorter and has a
distinct C-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC050565.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-41 DA104684.1 1-41
42-100 BC050565.1 1-59
101-3317 BC063585.1 44-3260
3318-4067 BC050565.1 3277-4026
4068-4310 AL117400.1 4368-4610
4311-4882 AL117400.1 4612-5183
FEATURES Location/Qualifiers
source 1..4882
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q37.3"
gene 1..4882
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain containing serine/threonine kinase"
/db_xref="GeneID:23178"
/db_xref="HGNC:17270"
/db_xref="MIM:607505"
exon 1..91
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
misc_feature 59..61
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="upstream in-frame stop codon"
exon 92..329
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
CDS 134..3565
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/EC_number="2.7.11.1"
/note="isoform 4 is encoded by transcript variant 5; PAS
domain-containing serine/threonine-protein kinase;
per-arnt-sim (PAS) domain kinase"
/codon_start=1
/product="PAS domain-containing serine/threonine-protein
kinase isoform 4"
/protein_id="NP_001239053.1"
/db_xref="GI:355477269"
/db_xref="CCDS:CCDS58758.1"
/db_xref="GeneID:23178"
/db_xref="HGNC:17270"
/db_xref="MIM:607505"
/translation="
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTRFSL
"
misc_feature 530..829
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; PAS motifs appear in archaea,
eubacteria and eukarya. Probably the most surprising
identification of a PAS domain was that in EAG-like
K+-channels. PAS domains have been found to bind ligands,
and to act as sensors for light and oxygen in...; Region:
PAS; cd00130"
/db_xref="CDD:29035"
misc_feature 533..802
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; Region: PAS_9; pfam13426"
/db_xref="CDD:205604"
misc_feature order(572..574,584..586,602..604,641..652,740..742,
755..757)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="putative active site [active]"
/db_xref="CDD:29035"
misc_feature order(632..634,644..646,668..670,689..694,776..778,
782..784)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="heme pocket [chemical binding]; other site"
/db_xref="CDD:29035"
misc_feature 1163..1336
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; Region: PAS; smart00091"
/db_xref="CDD:197512"
misc_feature 3146..>3469
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(3146..3160,3170..3172,3209..3211,3215..3217,
3326..3328,3374..3385,3398..3400,3404..3406)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(3146..3160,3170..3172,3209..3211,3215..3217,
3326..3328,3374..3385,3398..3400)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
exon 330..562
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 563..733
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 734..874
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 875..1009
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
variation 881
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="a"
/replace="g"
/db_xref="dbSNP:1470414"
exon 1010..1270
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1271..1439
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1440..1596
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1597..2852
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 2853..3037
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3038..3205
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3206..3331
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3332..4874
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
variation 3781
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="a"
/replace="g"
/db_xref="dbSNP:3771355"
variation 3793..3794
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace=""
/replace="ag"
/db_xref="dbSNP:367679069"
variation 3795
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="c"
/replace="t"
/db_xref="dbSNP:2871579"
variation 4349
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="a"
/replace="g"
/db_xref="dbSNP:1056915"
variation 4398
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="c"
/replace="t"
/db_xref="dbSNP:1056916"
variation 4757
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="a"
/replace="g"
/db_xref="dbSNP:1444998"
polyA_signal 4844..4849
/gene="PASK"
/gene_synonym="PASKIN; STK37"
polyA_site 4874
/gene="PASK"
/gene_synonym="PASKIN; STK37"
ORIGIN
gtcgctgtgcgattggtcggtgggataaaagcgcggaagggctcctttccgtggtgtgtagccggcttggcgtgaccctcgcctgatccagttgttagagttggaagcttggcagttggcctcccttcttcccatggaggacgggggcttaacagcctttgaagaggaccagagatgcctttcccagagcctccccttgccagtgtcagcagagggcccagctgcacagaccactgctgagcccagcaggtcgttttcctcagcccacagacacctgagcagaaggaatgggctttccagactctgccagagcaggacagcgctctctgaagacagatggagctcctattgtctatcatcactggctgcccagaatatttgtacaagtaaactgcactgccctgctgcccctgagcacacggacccgtccgaaccgcggggcagtgtgtcctgctgctccctgctgcggggactgtcctcagggtggtcctcacctctgcttccggcccctgtgtgcaaccctaacaaggccatcttcacggtggatgccaagaccacagagatcctggttgctaacgacaaagcttgcgggctcctggggtacagcagccaggacctgattggccagaagctcacgcagttctttctgaggtcagattctgatgtggtggaggccctcagcgaggagcacatggaggccgacggccacgctgcggtggtgtttggcacggtggtggacatcatcagccgtagtggggagaagattccagtgtctgtgtggatgaagaggatgcggcaggagcgccgcctatgctgcgtggtggtcctggagcccgtggagagggtctcgacctgggtcgctttccagagcgatggcaccgtcacgtcatgtgacagtctctttgctcatcttcacgggtacgtgtctggggaggacgtggctgggcagcatatcacagacctgatcccttctgtgcagctccctccttctggccagcacatcccaaagaatctcaagattcagaggtctgttggaagagccagggacggtaccaccttccctctgagcttaaagctgaaatcccaacccagcagcgaggaggcgaccaccggtgaggcggcccctgtgagcggctaccgggcatctgtctgggtgttctgcaccatcagtggcctcatcaccctcctgccggatgggaccatccacggcatcaaccacagcttcgcgctgacactgtttggttacggaaagacggagctcctgggcaagaatatcactttcctgattcctggtttctacagctacatggaccttgcgtacaacagctcattacagctcccagacctggccagctgcctggacgtcggcaatgagagtgggtgtggggagagaaccttggacccgtggcagggccaggacccagctgaggggggccaggatccaaggattaatgtcgtgcttgctggtggccacgttgtgccccgagatgagatccggaagctgatggaaagccaagacatcttcaccgggactcagactgagctgattgctggaggccagctcctttcctgcctctcacctcagcctgctccaggggtggacaatgtcccagaaggaagcctgccagtgcacggtgaacaggcgctgcccaaggaccagcaaatcactgccttggggagagaggaacctgtggcaatagagagccccggacaggatcttctgggagaaagcaggtctgaaccagtggatgtgaagccatttgcttcctgcgaagattctgaagctccagtcccagctgaggatgggggcagtgatgctggcatgtgtggcctgtgtcagaaggcccagctagagcggatgggagtcagtggtcccagcggttcagacctttgggctggggctgccgtggccaagccccaggccaagggtcagctggcggggggcagcctcctgatgcactgcccttgctatgggagtgaatggggcttgtggtggcgaagccaggacttggcccccagcccctctgggatggcaggcctctcgtttgggacacctactctagatgagccgtggctgggagtggaaaacgaccgagaagagctgcagacctgcttgattaaggagcagctgtcccagttgagccttgcaggagccctggatgtcccccacgccgaactcgttccgacagagtgccaggctgtcaccgctcctgtgtcgtcctgcgatctgggaggcagagacctgtgcggtggctgcacgggcagctcctcagcctgctatgccttggccacggacctccctgggggcctggaagcagtggaggcccaggaggttgatgtgaattcgttttcctggaacctcaaggaactctttttcagtgaccagacagaccaaacgtcatcaaattgttcctgtgctacgtctgaactcagagagacaccctcttccttggcagtgggctccgatccagatgtaggcagtctccaggaacaggggtcgtgtgtcctggatgacagggagctgttactactgaccggcacctgtgttgaccttggccaaggccgacggttccgggagagctgtgtgggacatgatccaacagaaccgcttgaggtttgtttggtgtcctctgagcattatgcagcaagcgacagagaaagcccaggacacgttccttccacgttggatgctggccctgaggacacgtgcccatcagcagaggagccaaggctgaacgtccaggtcacctccacgcccgtgatcgtgatgcgcggggctgctggcctgcagcgggagatccaggagggtgcctactccgggagctgctaccatcgagatggcttacggctgagtatacagtttgaggtgaggcgggtggagctccagggccccacacctctgttctgctgctggctggtgaaagacctcctccacagccaacgcgactcagccgccaggacccgcctgttccttgccagcctgcccggctccacccactctaccgctgctgagctcaccggacccagcctggtggaagtgctcagagccagaccctggtttgaggagccccccaaggctgtggaactggaggggttggcggcctgtgagggcgagtactcccaaaagtacagtaccatgagcccgctgggcagtggggccttcggcttcgtgtggactgctgtggacaaggaaaaaaacaaggaggtggtggtgaagtttattaagaaggagaaggtcttggaggattgttggattgaggatcccaaacttgggaaagttactttagagatcgcaattctatccagggtggagcacgccaatatcatcaaggtattggatatatttgaaaaccaagggttcttccagcttgtgatggagaagcacggctccggcctagacctcttcgctttcatcgaccgccaccccaggctggatgagcccctggcgagctacatcttccgacaagtgagagcaggccagagccgtgttagtgtgaacgcaggcctgggtgcctgggtccggtggctgcaaagatcagtgatccatactcggttctctctctgagctggatctagccttctgtgtggggatttcatggagtaggatatatattttgagaagaaaattctatgattgaagtagagaaagtgaggttgggaaggaaggatgaggccagatacagtcctggaatgactgagaaagtatgtttaatggttaaggtttatttacatacataaaatatccacaacaatcataaaaattaaccagtaagggttaggatgcagccagagagcgtctcaaaggcatgtgtgcggcacagcggcctgcaggttgtaagtgcccactaaatggtggctgttgaggtaattaaccagcaaaactgagatcctgacattctcacttttcagtaagtatttgtcttgatctgtttcgtgtctaattacatattgaacttcggccattattttattggaatgggagagtgatgatccaaataggaaggcaccctagcagagggacagggggaagaaacggtaactcgtgttgggttttaaggagagggtggcggttccatcctgtactgctcccagctcccccagaagaactggagaaataccagcaaagggctgtgtagacaactcacatttgctcttggattgtttgctggggacaactcgatttctaatgacagcttccgtgaatcaacatttcttccttaaagctacacactctcgggttgttgggtttccgaagtttagtttctcaggctcctacttgtaagtttcagatattatggttctgcaaaaaagggtcacctctctccctcttcctgtgttggaaggtgacgtcctccctttagtttgtggccaacacttgtttctgaaactttttacagcaaacagagtatctgtatgaggttatgttgagggtcgcttgttaaaagctgctgcctgacagctgttaattctggggctagtgagacacataattatggtgtttatactctaaaatttttgccaaaagaatctctaccccttttgtaaatatatagacataaatgttattctatgtaaatacagatgcacaattttataaagtatatgatcgcacatcaatgtatgtaggaatcatgctggttctcagggcattgcctgtcagctccagattcatcaggacctgctcagcagcggggtcggggagctgggcctgggaacagccctggcttggttcaggccgctccagggcagcatggccagtccagggcacagaagcatctgcaggaagagcagctttcttcaagtcgctctttagccctttgtggttaatctctcagtactagttaataaatcttaatgaaactttccatgttcaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23178 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:23178 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:23178 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23178 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:23178 -> Molecular function: GO:0035091 [phosphatidylinositol binding] evidence: IDA
GeneID:23178 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:23178 -> Biological process: GO:0043576 [regulation of respiratory gaseous exchange] evidence: ISS
GeneID:23178 -> Biological process: GO:0045719 [negative regulation of glycogen biosynthetic process] evidence: IDA
GeneID:23178 -> Biological process: GO:0045727 [positive regulation of translation] evidence: TAS
GeneID:23178 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:23178 -> Biological process: GO:0070092 [regulation of glucagon secretion] evidence: ISS
GeneID:23178 -> Biological process: GO:2000505 [regulation of energy homeostasis] evidence: ISS
GeneID:23178 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:23178 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:23178 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001239053 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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