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2024-04-23 22:05:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001248001 2562 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens SET nuclear oncogene (SET), transcript variant 4,
mRNA.
ACCESSION NM_001248001
VERSION NM_001248001.1 GI:351721323
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2562)
AUTHORS Avet,C., Garrel,G., Denoyelle,C., Laverriere,J.N., Counis,R.,
Cohen-Tannoudji,J. and Simon,V.
TITLE SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
JOURNAL J. Biol. Chem. 288 (4), 2641-2654 (2013)
PUBMED 23233674
REMARK GeneRIF: SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
REFERENCE 2 (bases 1 to 2562)
AUTHORS Lam,B.D., Anthony,E.C. and Hordijk,P.L.
TITLE Cytoplasmic targeting of the proto-oncogene SET promotes cell
spreading and migration
JOURNAL FEBS Lett. 587 (2), 111-119 (2013)
PUBMED 23195690
REMARK GeneRIF: A SET mutant, lacking a nuclear localization signal,
SET(DeltaNLS), promotes cell spreading and motility. This was
accompanied by an increase in the number and frequency of membrane
ruffles.
REFERENCE 3 (bases 1 to 2562)
AUTHORS Almeida,L.O., Goto,R.N., Pestana,C.R., Uyemura,S.A., Gutkind,S.,
Curti,C. and Leopoldino,A.M.
TITLE SET overexpression decreases cell detoxification efficiency: ALDH2
and GSTP1 are downregulated, DDR is impaired and DNA damage
accumulates
JOURNAL FEBS J. 279 (24), 4615-4628 (2012)
PUBMED 23106910
REMARK GeneRIF: SET downregulated repair genes ATM, BRCA1 and CHEK2 and
upregulated TP53
REFERENCE 4 (bases 1 to 2562)
AUTHORS Kim,J.Y., Kim,K.B., Son,H.J., Chae,Y.C., Oh,S.T., Kim,D.W.,
Pak,J.H. and Seo,S.B.
TITLE H3K27 methylation and H3S28 phosphorylation-dependent
transcriptional regulation by INHAT subunit SET/TAF-Ibeta
JOURNAL FEBS Lett. 586 (19), 3159-3165 (2012)
PUBMED 22796192
REMARK GeneRIF: SET/TAF-Ibeta is sequentially recruited to the target gene
promoter ATF3 after the PRC2 complex via H3K27me recognition and
may offer additive effects in the repression of the target gene.
REFERENCE 5 (bases 1 to 2562)
AUTHORS Irie,A., Harada,K., Araki,N. and Nishimura,Y.
TITLE Phosphorylation of SET protein at Ser171 by protein kinase D2
diminishes its inhibitory effect on protein phosphatase 2A
JOURNAL PLoS ONE 7 (12), E51242 (2012)
PUBMED 23251465
REMARK GeneRIF: Recombinant SET with phosphorylation-mimic Ser171 to Glu
substitution reduced its inhibitory effects on PP2A phosphatase
activity compared with Ser171 to Ala substituted or wild-type SET
REFERENCE 6 (bases 1 to 2562)
AUTHORS Nagata,K., Kawase,H., Handa,H., Yano,K., Yamasaki,M., Ishimi,Y.,
Okuda,A., Kikuchi,A. and Matsumoto,K.
TITLE Replication factor encoded by a putative oncogene, set, associated
with myeloid leukemogenesis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4279-4283 (1995)
PUBMED 7753797
REFERENCE 7 (bases 1 to 2562)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification of in vivo phosphorylation sites of SET, a nuclear
phosphoprotein encoded by the translocation breakpoint in acute
undifferentiated leukemia
JOURNAL FEBS Lett. 340 (3), 231-235 (1994)
PUBMED 8131851
REFERENCE 8 (bases 1 to 2562)
AUTHORS Vaesen,M., Barnikol-Watanabe,S., Gotz,H., Awni,L.A., Cole,T.,
Zimmermann,B., Kratzin,H.D. and Hilschmann,N.
TITLE Purification and characterization of two putative HLA class II
associated proteins: PHAPI and PHAPII
JOURNAL Biol. Chem. Hoppe-Seyler 375 (2), 113-126 (1994)
PUBMED 8192856
REFERENCE 9 (bases 1 to 2562)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification and characterization of SET, a nuclear
phosphoprotein encoded by the translocation break point in acute
undifferentiated leukemia
JOURNAL J. Biol. Chem. 269 (3), 2258-2262 (1994)
PUBMED 8294483
REFERENCE 10 (bases 1 to 2562)
AUTHORS von Lindern,M., van Baal,S., Wiegant,J., Raap,A., Hagemeijer,A. and
Grosveld,G.
TITLE Can, a putative oncogene associated with myeloid leukemogenesis,
may be activated by fusion of its 3' half to different genes:
characterization of the set gene
JOURNAL Mol. Cell. Biol. 12 (8), 3346-3355 (1992)
PUBMED 1630450
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK300609.1, AL356481.16,
AL359678.15 and CA419540.1.
Summary: The protein encoded by this gene inhibits acetylation of
nucleosomes, especially histone H4, by histone acetylases (HAT).
This inhibition is most likely accomplished by masking histone
lysines from being acetylated, and the consequence is to silence
HAT-dependent transcription. The encoded protein is part of a
complex localized to the endoplasmic reticulum but is found in the
nucleus and inhibits apoptosis following attack by cytotoxic T
lymphocytes. This protein can also enhance DNA replication of the
adenovirus genome. Several transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (4) differs in the 5' UTR and
coding sequence compared to variant 1. The resulting isoform (4)
has a shorter and distinct N-terminus compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK300609.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-906 AK300609.1 2-907
907-1179 AL356481.16 175394-175666
1180-2073 AL359678.15 2001-2894
2074-2562 CA419540.1 1-489 c
FEATURES Location/Qualifiers
source 1..2562
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..2562
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="SET nuclear oncogene"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
exon 1..52
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
CDS 13..813
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="isoform 4 is encoded by transcript variant 4; SET
translocation (myeloid leukemia-associated); protein
phosphatase type 2A inhibitor; Template-Activating
Factor-I, chromatin remodelling factor; inhibitor of
granzyme A-activated DNase; HLA-DR-associated protein II;
inhibitor-2 of protein phosphatase-2A; phosphatase 2A
inhibitor I2PP2A"
/codon_start=1
/product="protein SET isoform 4"
/protein_id="NP_001234930.1"
/db_xref="GI:351721324"
/db_xref="CCDS:CCDS59150.1"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
/translation="
MMPRSHQPPPPPHEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
"
misc_feature 70..651
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="Nucleosome assembly protein (NAP); Region: NAP;
pfam00956"
/db_xref="CDD:216213"
misc_feature 112..642
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="(NAP-L) nucleosome assembly protein -L;
Provisional; Region: PTZ00007; cl08298"
/db_xref="CDD:244897"
exon 53..110
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
exon 111..253
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 177
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:372830096"
variation 204
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:148209973"
exon 254..357
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 279
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:62641744"
variation 295
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:141752935"
exon 358..471
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 372
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:146235252"
variation 376
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374932364"
variation 381
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375022413"
variation 408
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369280257"
exon 472..642
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 485
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139428399"
variation 488
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:142648600"
variation 497
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150832256"
variation 546
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200600519"
variation 570
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139252094"
variation 585
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:376525055"
variation 588
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:75427242"
variation 589
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:4836619"
exon 643..789
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 663
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:142411393"
variation 672
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:150020269"
variation 681
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:145251942"
variation 684
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:368663030"
variation 759
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:372294597"
variation 766
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:71497404"
exon 790..2545
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 798
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:201761796"
variation 815
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201084109"
variation 840
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374784143"
variation 860
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:371016083"
variation 884
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="t"
/db_xref="dbSNP:35778650"
variation 904
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:77610267"
variation 907..908
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="c"
/db_xref="dbSNP:201363886"
variation 916
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:10988092"
variation 995
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988093"
variation 1125
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061240"
variation 1142
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:78124756"
variation 1174
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988094"
variation 1216
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988095"
variation 1218
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988096"
variation 1299
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:10988097"
variation 1306
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139027346"
variation 1327
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:143324900"
variation 1360
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:60115664"
variation 1419
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:191018343"
variation 1476
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:369703905"
variation 1542
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373337066"
variation 1574
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:184069752"
polyA_signal 1659..1664
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
polyA_site 1685
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
variation 1877
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:189098066"
variation 1932
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377534760"
STS 1939..2278
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="WI-7839"
/db_xref="UniSTS:5472"
variation 1943..1944
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="ct"
/db_xref="dbSNP:201161315"
variation 2067
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375728256"
variation 2078..2079
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:34355767"
variation 2109
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141306"
variation 2136
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:192423121"
STS 2148..2241
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="RH69637"
/db_xref="UniSTS:84497"
variation 2427
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:11542566"
variation 2437
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:183084664"
polyA_signal 2517..2522
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
polyA_site 2545
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
ORIGIN
ttgtgctccgccatgatgcctcgctcccatcagccgccgccgccgccacatgaaaaagaacagcaagaagcgattgaacacattgatgaagtacaaaatgaaatagacagacttaatgaacaagccagtgaggagattttgaaagtagaacagaaatataacaaactccgccaaccattttttcagaagaggtcagaattgatcgccaaaatcccaaatttttgggtaacaacatttgtcaaccatccacaagtgtctgcactgcttggggaggaagatgaagaggcactgcattatttgaccagagttgaagtgacagaatttgaagatattaaatcaggttacagaatagatttttattttgatgaaaatccttactttgaaaataaagttctctccaaagaatttcatctgaatgagagtggtgatccatcttcgaagtccaccgaaatcaaatggaaatctggaaaggatttgacgaaacgttcgagtcaaacgcagaataaagccagcaggaagaggcagcatgaggaaccagagagcttctttacctggtttactgaccattctgatgcaggtgctgatgagttaggagaggtcatcaaagatgatatttggccaaacccattacagtactacttggttcccgatatggatgatgaagaaggagaaggagaagaagatgatgatgatgatgaagaggaggaaggattagaagatattgacgaagaaggggatgaggatgaaggtgaagaagatgaagatgatgatgaaggggaggaaggagaggaggatgaaggagaagatgactaaatagaacactgatggattccaaccttcctttttttaaattttctccagtccctgggagcaagttgcagtcttttttttttttttttttttttttccctcttgtgctcagtcgccctgttcttgaggtctcttttctctactccatggttctcaatttatttggggggaaataccttgagcagaatacaatgggaaaagagtctctacccctttctgttcgaagttcatttttatcccttcctgtctgaacaaaaactgtatggaatcaacaccaccgagctctgtgggaaaaaagaaaaacctgctcccttcgctctgctggaagctggagggtgctaggcccctgtgtagtagtgcatagaattctagcttttttcctcctttctctgtatattgggctcagagagtacactgtgtctctatgtgaatatggacagttagcatttaccaacatgtatctgtctactttctcttgtttaaaaaaagaaaaaaaaacttaaaaaaatggggttatagaaggtcagcaaagggtgggtttgagatgtttgggtgggttaagtgggcattttgacaacatggcttctcctttggcatgtttaattgtgatatttgacagacatccttgcagtttaagatgacacttttaaaataaattctctcctaatgatgacttgagccctgccactcaatgggagaatcagcagaacctgtaggatcttatttggaattgacattctctattgtaattttgttcctgtttatttttaaattttctttttgtttcactggaaaggaaagatgatgctcagttttaaacgttaaaagtgtacaagttgctttgttacaataaaactaaatgtgtacacaaaggatttgatgcttttctctcagcataggtatgcttactatgaccttccaagtttgacttgtataacatcactgtcaaactttgtcaccctaacttcgtattttttgatacgcactttgcaggatgacctcagggctatgtggattgagtaatgggatttgaatcaatgtattaatatctccatagctgggaaacgtgggttcaatttgccattggtttctgaaagtattcacatcatttgggataccagatagctcaatactctctgagtacattgtgcccttgatttttatctccaagtggcagtttttaaaattggccttttacctggatataaattaattgtgcctgccaccaccatccaacagacctggtgctctaatgccaagttatacacgggacagttgctggcatgtcttcattggctatataaaatgtggccaagaagataggctctcagtaagaagtctgatggtgagcagtaactgtccctgctttctggtataaagctctcaaatgtgaccatgtgaatctgggtgggataatggactcagctctgtctgctcaatgccattgtgcagagaagcaccctaatgcataagctttttaatgctgtaaaatatagtcgctgaaattaaatgccactttttcagaggtgaattaatggacagtctggtgaacttcaaaagctttttgatgtataaaacttgataaatggaactattccatcaataggcaaaagtgtaacaacctatctagatggatagtatgtaatttctgcacaggtctctgtttagtaaatacatcactgtataccgatcaggaatcttgctccaataaaggaacataaagattttttttggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6418 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6418 -> Molecular function: GO:0004864 [protein phosphatase inhibitor activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6418 -> Molecular function: GO:0008601 [protein phosphatase type 2A regulator activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0042393 [histone binding] evidence: TAS
GeneID:6418 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:6418 -> Biological process: GO:0006334 [nucleosome assembly] evidence: IEA
GeneID:6418 -> Biological process: GO:0006337 [nucleosome disassembly] evidence: TAS
GeneID:6418 -> Biological process: GO:0006913 [nucleocytoplasmic transport] evidence: NAS
GeneID:6418 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6418 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0035067 [negative regulation of histone acetylation] evidence: TAS
GeneID:6418 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IGI
GeneID:6418 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:6418 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:6418 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
GeneID:6418 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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