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2024-03-28 20:05:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001247987            5388 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens synaptotagmin XIII (SYT13), transcript variant 2,
            mRNA.
ACCESSION   NM_001247987
VERSION     NM_001247987.1  GI:351542145
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5388)
  AUTHORS   Jahn,J.E., Best,D.H. and Coleman,W.B.
  TITLE     Exogenous expression of synaptotagmin XIII suppresses the
            neoplastic phenotype of a rat liver tumor cell line through
            molecular pathways related to mesenchymal to epithelial transition
  JOURNAL   Exp. Mol. Pathol. 89 (3), 209-216 (2010)
   PUBMED   20840848
  REMARK    GeneRIF: These studies combine to suggest that SYT13 is a liver
            tumor suppressor gene and that its function may be mediated through
            pathways implicated in mesenchymal to epithelial transition
REFERENCE   2  (bases 1 to 5388)
  AUTHORS   Jahn,J.E. and Coleman,W.B.
  TITLE     Re-expression of tumorigenicity after attenuation of human
            synaptotagmin 13 in a suppressed microcell hybrid cell line
  JOURNAL   Int. J. Oncol. 32 (2), 441-449 (2008)
   PUBMED   18202767
  REMARK    GeneRIF: human SYT13 functions as a liver tumor suppressor gene
            that complements a molecular defect in rat liver tumor cells
            resulting in a normalized cellular phenotype in vitro and
            suppression of tumorigenicity in vivo
REFERENCE   3  (bases 1 to 5388)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   4  (bases 1 to 5388)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem. J. 354 (PT 2), 249-257 (2001)
   PUBMED   11171101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103736.5, AC103681.4,
            AK308841.1 and W45345.1.
            
            Summary: This gene encodes a member of the large synaptotagmin
            protein family. Family members have an extracellular N-terminal
            transmembrane domain and a cytoplasmic C terminus with two tandem
            C2 domains (C2A and C2B). Synaptotogmin family members can form
            homo- and heteromeric complexes with each other. They also have
            different biochemical properties and developmental profiles, and
            patterns of tissue distribution. Synaptotagmins function as
            membrane traffickers in multicellular organisms. Two alternatively
            spliced transcript variants that encode different protein isoforms
            have been described for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) contains additional exons in
            the 5' end, which result in the use of a downstream start codon,
            compared to variant 1. The resulting protein (isoform 2) is shorter
            when it is compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308841.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AC103736.5         65803-66111         c
            310-411             AC103681.4         12769-12870
            412-527             AC103681.4         23781-23896
            528-1976            AK308841.1         262-1710
            1977-5325           AC103681.4         38577-41925
            5326-5388           W45345.1           1-63                c
FEATURES             Location/Qualifiers
     source          1..5388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12-p11"
     gene            1..5388
                     /gene="SYT13"
                     /note="synaptotagmin XIII"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:14962"
                     /db_xref="MIM:607716"
     exon            1..309
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     STS             77..1675
                     /gene="SYT13"
                     /db_xref="UniSTS:480820"
     STS             79..1669
                     /gene="SYT13"
                     /db_xref="UniSTS:483650"
     STS             219..1367
                     /gene="SYT13"
                     /standard_name="Syt13"
                     /db_xref="UniSTS:507260"
     exon            310..411
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            412..527
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     variation       491
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4755940"
     misc_feature    507..509
                     /gene="SYT13"
                     /note="upstream in-frame stop codon"
     exon            528..753
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            754..888
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     CDS             777..1625
                     /gene="SYT13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptotagmin-13; sytXIII"
                     /codon_start=1
                     /product="synaptotagmin-13 isoform 2"
                     /protein_id="NP_001234916.1"
                     /db_xref="GI:351542146"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:14962"
                     /db_xref="MIM:607716"
                     /translation="
METWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEAVTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEEELPTATLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAGAGEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFELPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAMWHQLHL
"
     misc_feature    822..1175
                     /gene="SYT13"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:212363"
     misc_feature    1206..1619
                     /gene="SYT13"
                     /note="C2 domain second repeat present in Synaptotagmin
                     13; Region: C2B_Synaptotagmin-13; cd08407"
                     /db_xref="CDD:176052"
     exon            889..1190
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            1191..1320
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            1321..5375
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     STS             2667..2841
                     /gene="SYT13"
                     /standard_name="HSC1SF092"
                     /db_xref="UniSTS:76282"
     STS             2716..2841
                     /gene="SYT13"
                     /standard_name="WI-14707"
                     /db_xref="UniSTS:76281"
     variation       3427
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:714720"
     variation       3657
                     /gene="SYT13"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3168293"
     variation       3888
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3180446"
     variation       4162
                     /gene="SYT13"
                     /replace=""
                     /replace="g"
                     /replace="ggg"
                     /db_xref="dbSNP:5791668"
     STS             4748..4930
                     /gene="SYT13"
                     /standard_name="RH18313"
                     /db_xref="UniSTS:63018"
     variation       5102
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8929"
ORIGIN      
gtccccgcccctctggcggcgggagagctgctggctcgcccggatcccgggagctgcctggaggcgggcccggcccggggaaggtgagcggctgcgggacccagcccctcgccgggagcgggcaccatggtgctgtcggtgcctgtgatcgcgctgggcgccacgctgggcacagccaccagcatcctcgcgttgtgcggggtcacctgcctgtgtcggcacatgcaccccaagaaggggctgctgccgcgggaccaggaccccgacctggagaaggcgaagcccagcttgctcgggtctgcacaacagagcatctgttacatatgaagtttacagaggtggtggccaaagggctttgtgatgtgactgctgaaataatgcaggggccacctacaagaaggaaatctctagcctaaaaaagcaactcagaatgtggagtgggatagcctgcaaatcacttgtcacttaaggtgacggcccagagaggtgaaatgacctgcccaaagtgacccagctccagcggcaggttcaatgttaaaaagtccacggaacctgttcagccccgtgccctcctcaagttcccagacatctatggacccaggccagctgtgacggctccagaggtcatcaactatgcagactattcactgaggtctacggaggagcccactgcacctgccagcccccaacccccgaatgacagtcgcctcaagaggcaggtcacagaggagctgttcatcctccctcagaatggtgtggtggaggatgtctgtgtcatggagacctggaacccagagaaggctgccagttggaaccaggcccccaaactccactactgcctggactatgactgtcagaaggcagaattgtttgtgactcgcctggaagctgtgaccagcaaccacgacggaggctgtgactgctacgtccaagggagtgtggccaataggaccggctctgtggaggctcagacagccctaaagaagcggcagctgcacaccacctgggaggagggcctggtgctccccctggcggaggaggagctccccacagccaccctgacgctgaccttgaggacctgcgaccgcttctcccgtcacagcgtggccggggagctccgcctgggcctggacgggacatctgtgcctctaggggctgcccagtggggcgagctgaagacttcagcgaaggagccatctgcaggagctggagaggtcctactatccatcagctacctcccggctgccaaccgcctcctggtggtgctgattaaagccaagaacctccactctaaccagtccaaggagctcctggggaaggatgtctctgtcaaggtgaccttgaagcaccaggctcggaagctgaagaagaagcagactaaacgagctaagcacaagatcaaccccgtgtggaacgagatgatcatgtttgagctgcctgacgacctgctgcaggcctccagtgtggagctggaagtgctgggccaggacgattcagggcagagctgtgcgcttggccactgcagcctgggcctgcacacctcgggctctgagcgcagccactgggaggagatgctcaaaaaccctcgccggcagattgccatgtggcaccagctgcacctgtaaccagctgcccagctgcctcccttcttggacagccctgacccgtcctctgcaacctcctttctgtgcccctttcctcattctgacacccagaagacagtgacagatgtgtttgcaaggctgggatggctctctcatcatactcttgtttcttagaaataagcaagacagagcaggaaatggaatatgcgggtcacactgaggaatgcattttgctcatctgtgttattgaaggaggtgcttattaaatacagttcctatgcctgttttataggtggggttaggccagatgcagagaaagctaaatgtgggaatcatggatgcaaagaagaatttggctttttgaaaaacaagcatttcaaaaatgatgaaggaagtgaaagtatcctggatcaactcctagagttagagattgcccaggtggaaagaaaccttagccagcgttcaatcaagctcaccatgcagggcagtcacccggcagttctcaaactttagcatgtgaagagtcaccagcagattcctgggctcgcctggagacattcctagtcggtattcctggtcgaagcccaggagccttcctttttaacaagctgatgtagagggtggagcactgtatgtggagaaattccttctacaatattccacacaggtttttggccacagtccttgatggagtcccaaaaccatggtgcagccagttccaatgctggacacctcaaccatcagggtgaaatctggggcctcagctttttaatttaattattttaattcttaatactttaatttgtgcatttcataagccccctgctcttggactgaattttgtgctttttattgaagaattttattgtttttatcttaaaatcagtttctattatccttggggagaccatccctaacaaagtacaggtgggatctcctgtgagtcattggctgggttctgattgctagatgtcacacccaccagcatcaccaaagtgactctgagatagaccggtcccttctcagcgttccagtcacttcaggaggaatttagttattgacttagtctatgacatctggctacatgtaggtagagaagaaagataattttaaaaaggaaatcaggtcttttgcaactgtgcctccctctgtctgttttcacttgaatgggtaaataaccagcagctaggttttgaattcctaccttgttattctaaacagatgtccacattgttaattaaatctaaattatgagccttgctgagtggatacggtacttacacctgaaccaggattcctgggttctgttgttgacattgcccttcagcacctgtttggccagctgtgtaagataggactaatgactaggaagcctaccccaatgaatgatatactagatgaaatagtgttcaaaacctgtaggcactctctggctaaaaacaaactctgaggccaccagcagatcatctttaagctaagttactatttttcacctttttttttagacggagttttgctctttgttgcccaggctggagtgcagtggcacgatctcggctcactgcaacctccgcctcccaagttcaagcgattctcctctctcagcctcctgggtagctgggattacaggtgcccaccaacatgcctggctaatttttgtacttttagtagagatggggtttcaccatgttggccaggctggtcttcaactccagatctcaggtgatctaccctcctcggcctcccaaagtactgggattacaggcctgagccaccgcgcccggcctatttttcactttaatttggcagctgagaatgcccagaaagtgccagaagcatcgtggcatttccagaaccatggattctgcctttggacccctctctattaatattaaaactctgggccttcagatgtcaccctaatccacttccctaagacagaatttctggacaagatgggtaagggcttcattccttcaacaagtcaagtcatacttggcctctccctgagaatctgagcaggagccttataacctgtggtcattattttttctttctgtacagaaatagaaaagcattagaaataacttctaaccatcctctgaaaaaacagaaaaaatatcgaatccctctttcatgagaagtcttttggataattggaaaccttcatcactgaggttggccagcccctgccaagtgttgtgtaggcaaagcacttgttagtggcttcctatgaaatgttttagagatctcttcaccatactggtttcttctctttggttggtgtgggtaaaagaaaacaaaacatttcctataagctgaaagctgaccagcattctcttcttggtaacatctactactccaatctagaaaatttggattctagaccaaaaatcaggaaacatggctccttataaatctgtgcagctgccttatagtaccatcaaaggaatttcaggtgggctgggcggggccccgatcccagaattatcaactccacccatcatcatttggtcatgaagcatcctttcattcttcttcttcttttttttgggggggcggggcgggggagggatctcaaagttttagtcttccagaatccaaattaaaggttgcccctgatgggggccaggttccgccacagaacatcttagatgtcagccttgacctcacttagcagggattacagaaatgagatacattttgaaggagagttgtctgttatgttcactgtattctaagtgcctgggataaagctgtctcatgggtgctccatatatattcatatatatttgttgagtgaattaatgaattaagagtggctggcagagtaggcagaaaaagacactgcaaatggcataaaaattaaagtcctagctgagttctcaatggtaaaggcatcagatgtcttagcagtcaagctagaaattcatgacaatgagtattactatttgcctaatggcaactcattgctctccatgtaaatgtaatcaacagatgaagagaatataattgctctgcttttccactaaaactccatcttagtgaattttaaattatccagagatgtcaaactgccaaataaaaatatttcagtagtctttgcatcagcttaccttgtaccagaaacatttccaatttactatcaaattatagtaactgagcctgtgtgaagtatctcatcattttcgaaaggaacaccttgtgtgatgccagtgagcatttctaaaaagggtgtgaggtagaggtaaaaataaggtgagagaccatttcagaatgcactgttgctcaaaaaggtgatctggttctttcttcagagatttctacggggatagaaaatcgggagtctgccctcattaatctgtgattccacctcttgcaccaaatcaatatctatttgttgagcacttattgattaagaccttgcatatgtctgtccattttgatttgagatacaactttttgtgtgggttgaatgacaaatcactccaaacaaagctgggcacagagaatcagctaggagaccagttattcagggtccatttctcttggatgtaaaggagtcctgggtaaaatgtggctgtaacctaaaccaactagtccttgtgatttgtttctgccctctgtgtttcctgttgtcaaatgctaagtgtgtgttttgcagtcatgaactaaagcacaaaaagatgcatgagacattgtagtcatatgtctggtgtgacactttggagcaaaaaccttgcagtggtaaataaaaaatttccaacagggaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:57586 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IEA
            GeneID:57586 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
            GeneID:57586 -> Cellular component: GO:0030133 [transport vesicle] evidence: IDA

by @meso_cacase at DBCLS
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