2024-04-18 13:56:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001247987 5388 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens synaptotagmin XIII (SYT13), transcript variant 2, mRNA. ACCESSION NM_001247987 VERSION NM_001247987.1 GI:351542145 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5388) AUTHORS Jahn,J.E., Best,D.H. and Coleman,W.B. TITLE Exogenous expression of synaptotagmin XIII suppresses the neoplastic phenotype of a rat liver tumor cell line through molecular pathways related to mesenchymal to epithelial transition JOURNAL Exp. Mol. Pathol. 89 (3), 209-216 (2010) PUBMED 20840848 REMARK GeneRIF: These studies combine to suggest that SYT13 is a liver tumor suppressor gene and that its function may be mediated through pathways implicated in mesenchymal to epithelial transition REFERENCE 2 (bases 1 to 5388) AUTHORS Jahn,J.E. and Coleman,W.B. TITLE Re-expression of tumorigenicity after attenuation of human synaptotagmin 13 in a suppressed microcell hybrid cell line JOURNAL Int. J. Oncol. 32 (2), 441-449 (2008) PUBMED 18202767 REMARK GeneRIF: human SYT13 functions as a liver tumor suppressor gene that complements a molecular defect in rat liver tumor cells resulting in a normalized cellular phenotype in vitro and suppression of tumorigenicity in vivo REFERENCE 3 (bases 1 to 5388) AUTHORS Craxton,M. TITLE Genomic analysis of synaptotagmin genes JOURNAL Genomics 77 (1-2), 43-49 (2001) PUBMED 11543631 REFERENCE 4 (bases 1 to 5388) AUTHORS Fukuda,M. and Mikoshiba,K. TITLE Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII) JOURNAL Biochem. J. 354 (PT 2), 249-257 (2001) PUBMED 11171101 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC103736.5, AC103681.4, AK308841.1 and W45345.1. Summary: This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. Transcript Variant: This variant (2) contains additional exons in the 5' end, which result in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK308841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025082, ERS025084 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-309 AC103736.5 65803-66111 c 310-411 AC103681.4 12769-12870 412-527 AC103681.4 23781-23896 528-1976 AK308841.1 262-1710 1977-5325 AC103681.4 38577-41925 5326-5388 W45345.1 1-63 c FEATURES Location/Qualifiers source 1..5388 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p12-p11" gene 1..5388 /gene="SYT13" /note="synaptotagmin XIII" /db_xref="GeneID:57586" /db_xref="HGNC:14962" /db_xref="MIM:607716" exon 1..309 /gene="SYT13" /inference="alignment:Splign:1.39.8" STS 77..1675 /gene="SYT13" /db_xref="UniSTS:480820" STS 79..1669 /gene="SYT13" /db_xref="UniSTS:483650" STS 219..1367 /gene="SYT13" /standard_name="Syt13" /db_xref="UniSTS:507260" exon 310..411 /gene="SYT13" /inference="alignment:Splign:1.39.8" exon 412..527 /gene="SYT13" /inference="alignment:Splign:1.39.8" variation 491 /gene="SYT13" /replace="a" /replace="g" /db_xref="dbSNP:4755940" misc_feature 507..509 /gene="SYT13" /note="upstream in-frame stop codon" exon 528..753 /gene="SYT13" /inference="alignment:Splign:1.39.8" exon 754..888 /gene="SYT13" /inference="alignment:Splign:1.39.8" CDS 777..1625 /gene="SYT13" /note="isoform 2 is encoded by transcript variant 2; synaptotagmin-13; sytXIII" /codon_start=1 /product="synaptotagmin-13 isoform 2" /protein_id="NP_001234916.1" /db_xref="GI:351542146" /db_xref="GeneID:57586" /db_xref="HGNC:14962" /db_xref="MIM:607716" /translation="
METWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEAVTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEEELPTATLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAGAGEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFELPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAMWHQLHL
" misc_feature 822..1175 /gene="SYT13" /note="C2 domain; Region: C2; cl14603" /db_xref="CDD:212363" misc_feature 1206..1619 /gene="SYT13" /note="C2 domain second repeat present in Synaptotagmin 13; Region: C2B_Synaptotagmin-13; cd08407" /db_xref="CDD:176052" exon 889..1190 /gene="SYT13" /inference="alignment:Splign:1.39.8" exon 1191..1320 /gene="SYT13" /inference="alignment:Splign:1.39.8" exon 1321..5375 /gene="SYT13" /inference="alignment:Splign:1.39.8" STS 2667..2841 /gene="SYT13" /standard_name="HSC1SF092" /db_xref="UniSTS:76282" STS 2716..2841 /gene="SYT13" /standard_name="WI-14707" /db_xref="UniSTS:76281" variation 3427 /gene="SYT13" /replace="a" /replace="g" /db_xref="dbSNP:714720" variation 3657 /gene="SYT13" /replace="c" /replace="t" /db_xref="dbSNP:3168293" variation 3888 /gene="SYT13" /replace="a" /replace="g" /db_xref="dbSNP:3180446" variation 4162 /gene="SYT13" /replace="" /replace="g" /replace="ggg" /db_xref="dbSNP:5791668" STS 4748..4930 /gene="SYT13" /standard_name="RH18313" /db_xref="UniSTS:63018" variation 5102 /gene="SYT13" /replace="a" /replace="g" /db_xref="dbSNP:8929" ORIGIN
gtccccgcccctctggcggcgggagagctgctggctcgcccggatcccgggagctgcctggaggcgggcccggcccggggaaggtgagcggctgcgggacccagcccctcgccgggagcgggcaccatggtgctgtcggtgcctgtgatcgcgctgggcgccacgctgggcacagccaccagcatcctcgcgttgtgcggggtcacctgcctgtgtcggcacatgcaccccaagaaggggctgctgccgcgggaccaggaccccgacctggagaaggcgaagcccagcttgctcgggtctgcacaacagagcatctgttacatatgaagtttacagaggtggtggccaaagggctttgtgatgtgactgctgaaataatgcaggggccacctacaagaaggaaatctctagcctaaaaaagcaactcagaatgtggagtgggatagcctgcaaatcacttgtcacttaaggtgacggcccagagaggtgaaatgacctgcccaaagtgacccagctccagcggcaggttcaatgttaaaaagtccacggaacctgttcagccccgtgccctcctcaagttcccagacatctatggacccaggccagctgtgacggctccagaggtcatcaactatgcagactattcactgaggtctacggaggagcccactgcacctgccagcccccaacccccgaatgacagtcgcctcaagaggcaggtcacagaggagctgttcatcctccctcagaatggtgtggtggaggatgtctgtgtcatggagacctggaacccagagaaggctgccagttggaaccaggcccccaaactccactactgcctggactatgactgtcagaaggcagaattgtttgtgactcgcctggaagctgtgaccagcaaccacgacggaggctgtgactgctacgtccaagggagtgtggccaataggaccggctctgtggaggctcagacagccctaaagaagcggcagctgcacaccacctgggaggagggcctggtgctccccctggcggaggaggagctccccacagccaccctgacgctgaccttgaggacctgcgaccgcttctcccgtcacagcgtggccggggagctccgcctgggcctggacgggacatctgtgcctctaggggctgcccagtggggcgagctgaagacttcagcgaaggagccatctgcaggagctggagaggtcctactatccatcagctacctcccggctgccaaccgcctcctggtggtgctgattaaagccaagaacctccactctaaccagtccaaggagctcctggggaaggatgtctctgtcaaggtgaccttgaagcaccaggctcggaagctgaagaagaagcagactaaacgagctaagcacaagatcaaccccgtgtggaacgagatgatcatgtttgagctgcctgacgacctgctgcaggcctccagtgtggagctggaagtgctgggccaggacgattcagggcagagctgtgcgcttggccactgcagcctgggcctgcacacctcgggctctgagcgcagccactgggaggagatgctcaaaaaccctcgccggcagattgccatgtggcaccagctgcacctgtaaccagctgcccagctgcctcccttcttggacagccctgacccgtcctctgcaacctcctttctgtgcccctttcctcattctgacacccagaagacagtgacagatgtgtttgcaaggctgggatggctctctcatcatactcttgtttcttagaaataagcaagacagagcaggaaatggaatatgcgggtcacactgaggaatgcattttgctcatctgtgttattgaaggaggtgcttattaaatacagttcctatgcctgttttataggtggggttaggccagatgcagagaaagctaaatgtgggaatcatggatgcaaagaagaatttggctttttgaaaaacaagcatttcaaaaatgatgaaggaagtgaaagtatcctggatcaactcctagagttagagattgcccaggtggaaagaaaccttagccagcgttcaatcaagctcaccatgcagggcagtcacccggcagttctcaaactttagcatgtgaagagtcaccagcagattcctgggctcgcctggagacattcctagtcggtattcctggtcgaagcccaggagccttcctttttaacaagctgatgtagagggtggagcactgtatgtggagaaattccttctacaatattccacacaggtttttggccacagtccttgatggagtcccaaaaccatggtgcagccagttccaatgctggacacctcaaccatcagggtgaaatctggggcctcagctttttaatttaattattttaattcttaatactttaatttgtgcatttcataagccccctgctcttggactgaattttgtgctttttattgaagaattttattgtttttatcttaaaatcagtttctattatccttggggagaccatccctaacaaagtacaggtgggatctcctgtgagtcattggctgggttctgattgctagatgtcacacccaccagcatcaccaaagtgactctgagatagaccggtcccttctcagcgttccagtcacttcaggaggaatttagttattgacttagtctatgacatctggctacatgtaggtagagaagaaagataattttaaaaaggaaatcaggtcttttgcaactgtgcctccctctgtctgttttcacttgaatgggtaaataaccagcagctaggttttgaattcctaccttgttattctaaacagatgtccacattgttaattaaatctaaattatgagccttgctgagtggatacggtacttacacctgaaccaggattcctgggttctgttgttgacattgcccttcagcacctgtttggccagctgtgtaagataggactaatgactaggaagcctaccccaatgaatgatatactagatgaaatagtgttcaaaacctgtaggcactctctggctaaaaacaaactctgaggccaccagcagatcatctttaagctaagttactatttttcacctttttttttagacggagttttgctctttgttgcccaggctggagtgcagtggcacgatctcggctcactgcaacctccgcctcccaagttcaagcgattctcctctctcagcctcctgggtagctgggattacaggtgcccaccaacatgcctggctaatttttgtacttttagtagagatggggtttcaccatgttggccaggctggtcttcaactccagatctcaggtgatctaccctcctcggcctcccaaagtactgggattacaggcctgagccaccgcgcccggcctatttttcactttaatttggcagctgagaatgcccagaaagtgccagaagcatcgtggcatttccagaaccatggattctgcctttggacccctctctattaatattaaaactctgggccttcagatgtcaccctaatccacttccctaagacagaatttctggacaagatgggtaagggcttcattccttcaacaagtcaagtcatacttggcctctccctgagaatctgagcaggagccttataacctgtggtcattattttttctttctgtacagaaatagaaaagcattagaaataacttctaaccatcctctgaaaaaacagaaaaaatatcgaatccctctttcatgagaagtcttttggataattggaaaccttcatcactgaggttggccagcccctgccaagtgttgtgtaggcaaagcacttgttagtggcttcctatgaaatgttttagagatctcttcaccatactggtttcttctctttggttggtgtgggtaaaagaaaacaaaacatttcctataagctgaaagctgaccagcattctcttcttggtaacatctactactccaatctagaaaatttggattctagaccaaaaatcaggaaacatggctccttataaatctgtgcagctgccttatagtaccatcaaaggaatttcaggtgggctgggcggggccccgatcccagaattatcaactccacccatcatcatttggtcatgaagcatcctttcattcttcttcttcttttttttgggggggcggggcgggggagggatctcaaagttttagtcttccagaatccaaattaaaggttgcccctgatgggggccaggttccgccacagaacatcttagatgtcagccttgacctcacttagcagggattacagaaatgagatacattttgaaggagagttgtctgttatgttcactgtattctaagtgcctgggataaagctgtctcatgggtgctccatatatattcatatatatttgttgagtgaattaatgaattaagagtggctggcagagtaggcagaaaaagacactgcaaatggcataaaaattaaagtcctagctgagttctcaatggtaaaggcatcagatgtcttagcagtcaagctagaaattcatgacaatgagtattactatttgcctaatggcaactcattgctctccatgtaaatgtaatcaacagatgaagagaatataattgctctgcttttccactaaaactccatcttagtgaattttaaattatccagagatgtcaaactgccaaataaaaatatttcagtagtctttgcatcagcttaccttgtaccagaaacatttccaatttactatcaaattatagtaactgagcctgtgtgaagtatctcatcattttcgaaaggaacaccttgtgtgatgccagtgagcatttctaaaaagggtgtgaggtagaggtaaaaataaggtgagagaccatttcagaatgcactgttgctcaaaaaggtgatctggttctttcttcagagatttctacggggatagaaaatcgggagtctgccctcattaatctgtgattccacctcttgcaccaaatcaatatctatttgttgagcacttattgattaagaccttgcatatgtctgtccattttgatttgagatacaactttttgtgtgggttgaatgacaaatcactccaaacaaagctgggcacagagaatcagctaggagaccagttattcagggtccatttctcttggatgtaaaggagtcctgggtaaaatgtggctgtaacctaaaccaactagtccttgtgatttgtttctgccctctgtgtttcctgttgtcaaatgctaagtgtgtgttttgcagtcatgaactaaagcacaaaaagatgcatgagacattgtagtcatatgtctggtgtgacactttggagcaaaaaccttgcagtggtaaataaaaaatttccaacagggaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:57586 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IEA GeneID:57586 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA GeneID:57586 -> Cellular component: GO:0030133 [transport vesicle] evidence: IDA
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