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2024-04-24 07:56:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001244676 2169 bp mRNA linear PRI 20-APR-2013
DEFINITION Homo sapiens threonine synthase-like 2 (S. cerevisiae) (THNSL2),
transcript variant 2, mRNA.
ACCESSION NM_001244676
VERSION NM_001244676.1 GI:347658948
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2169)
AUTHORS Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
and Borecki,I.B.
CONSRTM GIANT Consortium; MAGIC Consortium; GLGC Consortium
TITLE Genome-wide association for abdominal subcutaneous and visceral
adipose reveals a novel locus for visceral fat in women
JOURNAL PLoS Genet. 8 (5), E1002695 (2012)
PUBMED 22589738
REFERENCE 2 (bases 1 to 2169)
AUTHORS Mason,C.C., Hanson,R.L., Ossowski,V., Bian,L., Baier,L.J.,
Krakoff,J. and Bogardus,C.
TITLE Bimodal distribution of RNA expression levels in human skeletal
muscle tissue
JOURNAL BMC Genomics 12, 98 (2011)
PUBMED 21299892
REMARK GeneRIF: THNSL2 was found to have bimodal expression in human
skeletal muscle tissue.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2169)
AUTHORS Rifas,L. and Weitzmann,M.N.
TITLE A novel T cell cytokine, secreted osteoclastogenic factor of
activated T cells, induces osteoclast formation in a
RANKL-independent manner
JOURNAL Arthritis Rheum. 60 (11), 3324-3335 (2009)
PUBMED 19877052
REMARK GeneRIF: A cytokine named SOFAT (secreted osteoclastogenic factor
of activated T cells) can induce osteoblastic IL-6 production and
osteoclast formation in the absence of osteoblasts or RANKL. It is
insensitive to RANKL inhibitor osteoprotegerin.
REFERENCE 4 (bases 1 to 2169)
AUTHORS Donini,S., Percudani,R., Credali,A., Montanini,B., Sartori,A. and
Peracchi,A.
TITLE A threonine synthase homolog from a mammalian genome
JOURNAL Biochem. Biophys. Res. Commun. 350 (4), 922-928 (2006)
PUBMED 17034760
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI765911.1, AC092836.4,
BC064423.1 and AI313402.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes a threonine synthase-like protein. A
similar enzyme in mouse can catalyze the degradation of
O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia.
This protein also has phospho-lyase activity on both gamma and beta
phosphorylated substrates. In mouse an alternatively spliced form
of this protein has been shown to act as a cytokine and can induce
the production of the inflammatory cytokine IL6 in osteoblasts.
Alternate splicing results in multiple transcript variants.
[provided by RefSeq, Sep 2011].
Transcript Variant: This variant (2) has a longer 5' UTR and uses
an alternate exon in the 3' coding region, which results in a
frameshift, compared to variant 1. The resulting protein (isoform
2) has a distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC064423.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-19 BI765911.1 5-23
20-103 AC092836.4 103499-103582
104-295 BC064423.1 1-192
296-296 AC092836.4 106457-106457
297-1143 BC064423.1 194-1040
1144-1144 AC092836.4 116151-116151
1145-1981 BC064423.1 1042-1878
1982-2152 BC064423.1 1880-2050
2153-2169 AI313402.1 1-17 c
FEATURES Location/Qualifiers
source 1..2169
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p11.2"
gene 1..2169
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="threonine synthase-like 2 (S. cerevisiae)"
/db_xref="GeneID:55258"
/db_xref="HGNC:25602"
/db_xref="MIM:611261"
exon 1..162
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:188854408"
variation 50
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:6547758"
variation 78
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:116594156"
variation 121..127
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace=""
/replace="cgcgccc"
/db_xref="dbSNP:72312334"
variation 145..158
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace=""
/replace="gccccgcgccccgc"
/db_xref="dbSNP:56213803"
variation 152..158
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace=""
/replace="gccccgc"
/db_xref="dbSNP:61547350"
exon 163..397
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
CDS 175..1392
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/EC_number="4.2.3.-"
/note="isoform 2 is encoded by transcript variant 2;
secreted osteoclastogenic factor of activated T cells"
/codon_start=1
/product="threonine synthase-like 2 isoform 2"
/protein_id="NP_001231605.1"
/db_xref="GI:347658949"
/db_xref="CCDS:CCDS58718.1"
/db_xref="GeneID:55258"
/db_xref="HGNC:25602"
/db_xref="MIM:611261"
/translation="
MWYVSTRGVAPRVNFEGALFSGYAPDGGLFMPEELPQLDRGTLCQWSTLSYPGLVKELCALFIGSELLPKDELNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLSCTTQFLQYFLEKREKHVTVVVGTSGDTGSAAIESVQGAKNMDIIVLLPKGHCTKIQELQMTTVLKQNVHVFGVEGNSDELDEPIKTVFADVAFVKKHNLMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPLVEVVVPTGAAGNLAAGYIAQKIGLPIRLVVAVNRNDIIHRTVQQGDFSLSEAVKSTLASAMDIQVPYNMERVFWLLSGSDSQVTRALMEQFERTQSVNLPKELHSKWERQDYEKMAVMECDGCCVELCLGNCGPRRGSVTDIPGTAMVRGGG
"
misc_feature 175..1251
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="Threonine synthase [Amino acid transport and
metabolism]; Region: ThrC; COG0498"
/db_xref="CDD:30844"
misc_feature 178..>1251
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="Threonine synthase catalyzes the final step of
threonine biosynthesis. The conversion of
O-phosphohomoserine into threonine and inorganic phosphate
is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD
includes members from higher plants, cyanobacteria;
Region: Thr-synth_2; cd01560"
/db_xref="CDD:107203"
misc_feature order(511..513,955..960)
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:107203"
misc_feature 511..513
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="catalytic residue [active]"
/db_xref="CDD:107203"
variation 198
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367785526"
variation 206
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374311669"
variation 209
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139953850"
variation 239
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369820777"
variation 242
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151033743"
variation 251
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373551702"
variation 252
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:114858196"
variation 296
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:4129190"
variation 303
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370944153"
variation 305
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146704484"
variation 314
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:143468353"
variation 316
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142011143"
variation 337
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:147509382"
variation 388
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:199500112"
exon 398..592
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 405
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371211298"
variation 406
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:34841493"
variation 410
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376146285"
variation 413
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:142704703"
variation 428
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376220295"
variation 454
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143431033"
variation 477
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199609866"
variation 493
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145369179"
variation 496
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35541720"
variation 513
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:149024211"
variation 535
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143018511"
variation 538
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143306537"
variation 563
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:111555319"
variation 569
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:137996561"
variation 576
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149479181"
variation 577
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:192084638"
exon 593..745
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 603
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:75522866"
variation 643
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375276075"
variation 656
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:139757275"
variation 697
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:144678899"
variation 706
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="t"
/db_xref="dbSNP:372908030"
variation 712
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374885568"
variation 713
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369239668"
variation 730
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371602854"
exon 746..976
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 768
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146726960"
variation 785
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:34136143"
variation 789
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150966723"
variation 795
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:116861191"
variation 796
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369508046"
variation 902
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34250376"
variation 915
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149200089"
variation 961
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370334316"
variation 964
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141464891"
exon 977..1125
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 988
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:371763302"
variation 993
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73949231"
variation 1013
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375483620"
variation 1017
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35051888"
variation 1020
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:148640386"
variation 1021
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147776956"
variation 1033
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368558816"
variation 1044
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:145009340"
variation 1053
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200402354"
variation 1070
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:375964297"
variation 1095
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141094872"
exon 1126..1251
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 1132
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138871561"
variation 1144
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:17855905"
variation 1145
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199612488"
variation 1147
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376687469"
variation 1155
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:36125522"
variation 1186
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369834788"
variation 1238
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374321239"
exon 1252..1425
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 1266
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:116768700"
variation 1269
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369418272"
variation 1270
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:188212837"
variation 1277
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:181348308"
variation 1331
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76063088"
variation 1336
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78406786"
variation 1348
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76505901"
exon 1426..2165
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 1448
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:76963547"
variation 1465
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:377665314"
variation 1511
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200685654"
variation 1512
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375608550"
variation 1525
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368148454"
variation 1532
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200077966"
variation 1534
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370502681"
variation 1544
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143087335"
variation 1560
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151161854"
variation 1589
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367584313"
variation 1590
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372281823"
variation 1641
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141207786"
variation 1651
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:3210976"
variation 1710
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78594831"
variation 1717
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146940055"
STS 1846..2150
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/standard_name="D2S2610"
/db_xref="UniSTS:37791"
variation 1932
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3183983"
variation 1977..1978
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace=""
/replace="c"
/db_xref="dbSNP:3215271"
STS 2002..2136
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/standard_name="RH47580"
/db_xref="UniSTS:63546"
variation 2008
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115884283"
variation 2036
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127735"
variation 2080
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127736"
variation 2087
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1127738"
polyA_signal 2133..2139
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
polyA_site 2165
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
ORIGIN
cactgcgaagctgagaaccctagctccggccccgaccggaagccccaccgcaccgtcagggacgcggactcgggagtgcgcacattcgcagcccgggcagccctgctgcgcaccgggcctcgcgccccgcgccccgcgccccgcgccccgcgccccgcaccggcctccaggatcatgtggtatgtcagcaccaggggcgtagccccacgggtcaactttgagggggccctcttctctggctatgcacctgacgggggcctctttatgcctgaagagctcccacagttggacagagggaccctgtgccagtggagcacactctcctatcctggcctggtgaaggagctgtgtgccctcttcattggctctgagctccttccaaaagatgaattaaatgatctgatcgaccgagccttcagcagattccgtcacagagaagtggtccatctgtccaggttgaggaatgggctgaacgtgttggagctgtggcatggcgtcacatatgcatttaaggacctgtccctgtcctgcacaacacagttcctgcagtacttcctggagaagagggagaagcacgtcactgtggttgtaggaacatctggggacacaggaagtgctgccattgagagtgttcaaggggcaaagaacatggacattatcgttctgctgcccaaaggtcactgcacaaagattcaggagctccagatgacaacggtgctgaagcagaacgtacatgtgtttggagtggagggaaacagcgatgagctcgatgagccgatcaagactgtgtttgccgatgtggcttttgtcaagaagcacaatctgatgagcctgaattcgatcaactggtcccgggtcctggtgcagatggcccatcacttctttgcttacttccagtgtacgccatccttggacacacatcccctacccctggtggaggtggttgtgccaacaggggctgccggtaaccttgcagctgggtacattgctcaaaagataggcctgcccatccgtctggtcgtggcagtgaaccgcaatgacatcatccacaggactgtccagcagggagacttctctctctctgaggctgttaaatcaaccttggcatcagctatggacattcaggtgccctacaacatggagagggtgttctggctgctctctggctctgacagccaggtgacaagagccctcatggagcagtttgaaaggacccaaagtgtgaatctgcccaaggaactgcacagcaagtgggagagacaggactacgaaaaaatggctgtaatggagtgtgatgggtgctgtgtggaactgtgccttggaaactgtgggcccagaagagggagcgtgacagatatcccagggacagccatggtcagaggtggtggctgagctggcctccaaccaggaggagcagtttgccagcactccccggtgctgcctcgcccctgcctctgcagccaagttcccggaagctgtcctggctgctggcctgacccctgagactcccgcggagatcgtagccctggagcacaaggagacacgctgcaccctgatgcggagaggtgacaactggatgctgatgcttcgggacaccattgaggaccttagccgacagtggaggagtcatgccctcaacacctcccagtagcctggctggaggtggctttctttaggcttcagatcccaggaagatgcaccttctgagctgccttgtgcaccctccccattaagcgtaggttaggaggtttccgggaggctgctcagctggatctggagccagctggctttgctccgttccctggctagtctgtgcctggtcaccagggaggctgagtgaggggctgtgaacagttgccggaagcaccccctccctccccggcccgtgcagcagtgtctgagctgtagtgaaagtttcagggcctgcaaaagaagaggcttgggcacaggactgaccatggctccaggggtttaggaccccagacctgtgaaggtgggagcagctcaccaccttcacgcaggctttgtatgttctctgagccttagttgattttggcccccaaaccaaatccaaaggttctggcccaccttgtcagaggcttccaccctgctcacatgttgggaatccctggaataaaatgcttgttcagtgtgatggagcggcaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55258 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:55258 -> Molecular function: GO:0005125 [cytokine activity] evidence: IEA
GeneID:55258 -> Molecular function: GO:0016829 [lyase activity] evidence: IEA
GeneID:55258 -> Molecular function: GO:0030170 [pyridoxal phosphate binding] evidence: ISS
GeneID:55258 -> Molecular function: GO:0070905 [serine binding] evidence: ISS
GeneID:55258 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:55258 -> Biological process: GO:0009071 [serine family amino acid catabolic process] evidence: ISS
GeneID:55258 -> Biological process: GO:0016311 [dephosphorylation] evidence: ISS
GeneID:55258 -> Biological process: GO:0046360 [2-oxobutyrate biosynthetic process] evidence: ISS
GeneID:55258 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:55258 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001231605 -> EC 4.2.3.-
by
@meso_cacase at
DBCLS
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