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2024-04-25 10:40:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001243198 7898 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens huntingtin interacting protein 1 (HIP1), transcript
variant 2, mRNA.
ACCESSION NM_001243198
VERSION NM_001243198.1 GI:342307095
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7898)
AUTHORS Sistani,L., Rodriguez,P.Q., Hultenby,K., Uhlen,M., Betsholtz,C.,
Jalanko,H., Tryggvason,K., Wernerson,A. and Patrakka,J.
TITLE Neuronal proteins are novel components of podocyte major processes
and their expression in glomerular crescents supports their role in
crescent formation
JOURNAL Kidney Int. 83 (1), 63-71 (2013)
PUBMED 22913984
REMARK GeneRIF: Three neuronal proteins (Huntingtin interacting protein 1,
neurofascin, and olfactomedin-like 2a) are novel components of
podocyte major processes and their expression in glomerular
crescents supports their role in crescent formation.
REFERENCE 2 (bases 1 to 7898)
AUTHORS Fontaine,S.N., Bauer,S.P., Lin,X., Poorfarahani,S. and Ybe,J.A.
TITLE Replacement of charged and polar residues in the coiled-coiled
interface of huntingtin-interacting protein 1 (HIP1) causes
aggregation and cell death
JOURNAL FEBS Lett. 586 (19), 3030-3036 (2012)
PUBMED 22835334
REMARK GeneRIF: flexibility of the HIP1 coiled-coil domain is important
for normal function and may lead to new insights into Huntington's
disease
REFERENCE 3 (bases 1 to 7898)
AUTHORS Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
TITLE Proteomic analysis identifies dysfunction in cellular transport,
energy, and protein metabolism in different brain regions of
atypical frontotemporal lobar degeneration
JOURNAL J. Proteome Res. 11 (4), 2533-2543 (2012)
PUBMED 22360420
REMARK GeneRIF: A protein encoded by this locus was found to be
differentially expressed in postmortem brains from patients with
atypical frontotemporal lobar degeneration.
REFERENCE 4 (bases 1 to 7898)
AUTHORS Ames,H.M., Bichakjian,C.K., Liu,G.Y., Oravecz-Wilson,K.I.,
Fullen,D.R., Verhaegen,M.E., Johnson,T.M., Dlugosz,A.A. and
Ross,T.S.
TITLE Huntingtin-interacting protein 1: a Merkel cell carcinoma marker
that interacts with c-Kit
JOURNAL J. Invest. Dermatol. 131 (10), 2113-2120 (2011)
PUBMED 21697888
REMARK GeneRIF: Huntingtin-interacting protein 1 is a Merkel cell
carcinoma marker that interacts with c-Kit
REFERENCE 5 (bases 1 to 7898)
AUTHORS Heath,A.C., Whitfield,J.B., Martin,N.G., Pergadia,M.L., Goate,A.M.,
Lind,P.A., McEvoy,B.P., Schrage,A.J., Grant,J.D., Chou,Y.L.,
Zhu,R., Henders,A.K., Medland,S.E., Gordon,S.D., Nelson,E.C.,
Agrawal,A., Nyholt,D.R., Bucholz,K.K., Madden,P.A. and
Montgomery,G.W.
TITLE A quantitative-trait genome-wide association study of alcoholism
risk in the community: findings and implications
JOURNAL Biol. Psychiatry 70 (6), 513-518 (2011)
PUBMED 21529783
REFERENCE 6 (bases 1 to 7898)
AUTHORS Ross,T.S., Bernard,O.A., Berger,R. and Gilliland,D.G.
TITLE Fusion of Huntingtin interacting protein 1 to platelet-derived
growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic
leukemia with t(5;7)(q33;q11.2)
JOURNAL Blood 91 (12), 4419-4426 (1998)
PUBMED 9616134
REFERENCE 7 (bases 1 to 7898)
AUTHORS Wedemeyer,N., Peoples,R., Himmelbauer,H., Lehrach,H., Francke,U.
and Wanker,E.E.
TITLE Localization of the human HIP1 gene close to the elastin (ELN)
locus on 7q11.23
JOURNAL Genomics 46 (2), 313-315 (1997)
PUBMED 9417924
REFERENCE 8 (bases 1 to 7898)
AUTHORS Kalchman,M.A., Koide,H.B., McCutcheon,K., Graham,R.K., Nichol,K.,
Nishiyama,K., Kazemi-Esfarjani,P., Lynn,F.C., Wellington,C.,
Metzler,M., Goldberg,Y.P., Kanazawa,I., Gietz,R.D. and Hayden,M.R.
TITLE HIP1, a human homologue of S. cerevisiae Sla2p, interacts with
membrane-associated huntingtin in the brain
JOURNAL Nat. Genet. 16 (1), 44-53 (1997)
PUBMED 9140394
REFERENCE 9 (bases 1 to 7898)
AUTHORS Wanker,E.E., Rovira,C., Scherzinger,E., Hasenbank,R., Walter,S.,
Tait,D., Colicelli,J. and Lehrach,H.
TITLE HIP-I: a huntingtin interacting protein isolated by the yeast
two-hybrid system
JOURNAL Hum. Mol. Genet. 6 (3), 487-495 (1997)
PUBMED 9147654
REFERENCE 10 (bases 1 to 7898)
AUTHORS Puigvert,A.
TITLE Caliceal urodynamics
JOURNAL Urol. Int. 30 (4), 282-296 (1975)
PUBMED 1189126
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP282107.1, U79734.1,
AK304738.1, AC018720.5 and BE350891.1.
Summary: The product of this gene is a membrane-associated protein
that colocalizes with huntingtin. This protein has similarities to
cytoskeleton proteins and its interaction with huntingtin is
thought to play a functional role in the cell filament network.
Loss of normal huntingtin-HIP1 interaction in Huntington disease
may contribute to a defect in membrane-cytoskeletal integrity in
the brain. This gene could help in the understanding of the normal
function of huntingtin and also the pathogenesis of Huntington
disease. It also has been implicated in the pathogenesis of
hematopoietic malignancies. Two transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Aug 2011].
Transcript Variant: This variant (2) lacks an alternate in-frame
coding segment compared to variant 1. The resulting isoform (2) has
the same N- and C-termini but is shorter compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK304738.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-587 BP282107.1 1-587
588-1116 U79734.1 418-946
1117-2681 AK304738.1 1093-2657
2682-3154 U79734.1 2665-3137
3155-7873 AC018720.5 42019-46737
7874-7898 BE350891.1 1-25 c
FEATURES Location/Qualifiers
source 1..7898
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q11.23"
gene 1..7898
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="huntingtin interacting protein 1"
/db_xref="GeneID:3092"
/db_xref="HGNC:4913"
/db_xref="MIM:601767"
exon 1..165
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
CDS 46..3006
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="isoform 2 is encoded by transcript variant 2;
huntingtin-interacting protein I; HIP-I"
/codon_start=1
/product="huntingtin-interacting protein 1 isoform 2"
/protein_id="NP_001230127.1"
/db_xref="GI:342307096"
/db_xref="CCDS:CCDS59060.1"
/db_xref="GeneID:3092"
/db_xref="HGNC:4913"
/db_xref="MIM:601767"
/translation="
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE
"
misc_feature 166..504
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="ANTH domain family; composed of adaptor protein 180
(AP180), clathrin assembly lymphoid myeloid leukemia
protein (CALM) and similar proteins. A set of proteins
previously designated as harboring an ENTH domain in fact
contains a highly similar, yet...; Region:
ANTH_AP180_CALM; cd03564"
/db_xref="CDD:48660"
misc_feature order(181..183,211..213,217..222)
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="PtdIns(4,5)P2-binding site; other site"
/db_xref="CDD:48660"
misc_feature 1213..1977
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="Uncharacterized archaeal coiled-coil protein
[Function unknown]; Region: COG1340"
/db_xref="CDD:31531"
misc_feature 1393..>1881
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="The Bin/Amphiphysin/Rvs (BAR) domain, a
dimerization module that binds membranes and detects
membrane curvature; Region: BAR; cl12013"
/db_xref="CDD:209413"
misc_feature <2461..2928
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="I/LWEQ domain; Region: ILWEQ; smart00307"
/db_xref="CDD:128602"
misc_feature 2461..2928
/gene="HIP1"
/gene_synonym="ILWEQ"
/note="I/LWEQ domain; Region: I_LWEQ; pfam01608"
/db_xref="CDD:201885"
exon 166..229
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
variation 209
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:202058558"
exon 230..372
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 373..429
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 430..510
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 511..587
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 588..649
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 650..790
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 791..848
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 849..924
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
STS 859..1029
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="HIP1"
/db_xref="UniSTS:504762"
exon 925..1065
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1066..1163
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1164..1236
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
STS 1165..1264
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="D7S3303"
/db_xref="UniSTS:254232"
exon 1237..1420
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1421..1509
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1510..1626
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1627..1728
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1729..1872
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 1873..2008
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2009..2095
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2096..2203
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
variation 2170
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:77320442"
exon 2204..2340
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2341..2451
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2452..2552
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
STS 2475..2601
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="GDB:4585037"
/db_xref="UniSTS:62321"
exon 2553..2658
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2659..2782
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
variation 2682
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:1167794"
exon 2783..2844
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2845..2953
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
exon 2954..7880
/gene="HIP1"
/gene_synonym="ILWEQ"
/inference="alignment:Splign:1.39.8"
STS 3143..3214
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="GDB:4585029"
/db_xref="UniSTS:411"
variation 3992
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:3801476"
variation 4537
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:2599326"
STS 5234..5350
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="D10S16"
/db_xref="UniSTS:155756"
STS 5343..6489
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
STS 5346..6535
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="G38154"
/db_xref="UniSTS:53341"
STS 5541..6571
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 5880..6491
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="L17705"
/db_xref="UniSTS:66091"
variation 6534
/gene="HIP1"
/gene_synonym="ILWEQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:75801816"
STS 6553..6641
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 7162..7230
/gene="HIP1"
/gene_synonym="ILWEQ"
/standard_name="GDB:4585453"
/db_xref="UniSTS:61651"
polyA_signal 7859..7864
/gene="HIP1"
/gene_synonym="ILWEQ"
polyA_site 7880
/gene="HIP1"
/gene_synonym="ILWEQ"
ORIGIN
atcccggggcagccgagggcccctgactcggctcctcgcggcgacatggatcggatggccagctccatgaagcaggtgcccaacccactgcccaaggtgctgagccggcgcggggtcggcgctgggctggaggcggcggagcgcgagagcttcgagcggactcagactgtcagcatcaataaggccattaatacgcaggaagtggctgtaaaggaaaaacacgccagaacgtgcatactgggcacccaccatgagaaaggggcacagaccttctggtctgttgtcaaccgcctgcctctgtctagcaacgcagtgctctgctggaagttctgccatgtgttccacaaactcctccgagatggacacccgaacgtcctgaaggactctctgagatacagaaatgaattgagtgacatgagcaggatgtggggccacctgagcgaggggtatggccagctgtgcagcatctacctgaaactgctaagaaccaagatggagtaccacaccaaaaatcccaggttcccaggcaacctgcagatgagtgaccgccagctggacgaggctggagaaagtgacgtgaacaactttttccagttaacagtggagatgtttgactacctggagtgtgaactcaacctcttccaaacagtattcaactccctggacatgtcccgctctgtgtccgtgacggcagcagggcagtgccgcctcgccccgctgatccaggtcatcttggactgcagccacctttatgactacactgtcaagcttctcttcaaactccactcctgcctcccagctgacaccctgcaaggccaccgggaccgcttcatggagcagtttacaaagttgaaagatctgttctaccgctccagcaacctgcagtacttcaagcggctcattcagatcccccagctgcctgagaacccacccaacttcctgcgagcctcagccctgtcagaacatatcagccctgtggtggtgatccctgcagaggcctcatcccccgacagcgagccagtcctagagaaggatgacctcatggacatggatgcctctcagcagaatttatttgacaacaagtttgatgacatctttggcagttcattcagcagtgatcccttcaatttcaacagtcaaaatggtgtgaacaaggatgagaaggaccacttaattgagcgactatacagagagatcagtggattgaaggcacagctagaaaacatgaagactgagagccagcgggttgtgctgcagctgaagggccacgtcagcgagctggaagcagatctggccgagcagcagcacctgcggcagcaggcggccgacgactgtgaattcctgcgggcagaactggacgagctcaggaggcagcgggaggacaccgagaaggctcagcggagcctgtctgagatagaaaggaaagctcaagccaatgaacagcgatatagcaagctaaaggagaagtacagcgagctggttcagaaccacgctgacctgctgcggaagaatgcagaggtgaccaaacaggtgtccatggccagacaagcccaggtagatttggaacgagagaaaaaagagctggaggattcgttggagcgcatcagtgaccagggccagcggaagactcaagaacagctggaagttctagagagcttgaagcaggaacttgccacaagccaacgggagcttcaggttctgcaaggcagcctggaaacttctgcccagtcagaagcaaactgggcagccgagttcgccgagctagagaaggagcgggacagcctggtgagtggcgcagctcatagggaggaggaattatctgctcttcggaaagaactgcaggacactcagctcaaactggccagcacagaggaatctatgtgccagcttgccaaagaccaacgaaaaatgcttctggtggggtccaggaaggctgcggagcaggtgatacaagacgccctgaaccagcttgaagaacctcctctcatcagctgcgctgggtctgcagatcacctcctctccacggtcacatccatttccagctgcatcgagcaactggagaaaagctggagccagtatctggcctgcccagaagacatcagtggacttctccattccataaccctgctggcccacttgaccagcgacgccattgctcatggtgccaccacctgcctcagagccccacctgagcctgccgactcactgaccgaggcctgtaagcagtatggcagggaaaccctcgcctacctggcctccctggaggaagagggaagccttgagaatgccgacagcacagccatgaggaactgcctgagcaagatcaaggccatcggcgaggagctcctgcccaggggactggacatcaagcaggaggagctgggggacctggtggacaaggagatggcggccacttcagctgctattgaaactgccacggccagaatagagggtacagcatcccctaaagagttttatgccaagaactctcgatggacagaaggacttatctcagcctccaaggctgtgggctggggagccactgtcatggtggatgcagctgatctggtggtacaaggcagagggaaatttgaggagctaatggtgtgttctcatgaaattgctgctagcacagcccagcttgtggctgcatccaaggtgaaagctgataaggacagccccaacctagcccagctgcagcaggcctctcggggagtgaaccaggccactgccggcgttgtggcctcaaccatttccggcaaatcacagatcgaagagacagacaacatggacttctcaagcatgacgctgacacagatcaaacgccaagagatggattctcaggttagggtgctagagctagaaaatgaattgcagaaggagcgtcaaaaactgggagagcttcggaaaaagcactacgagcttgctggtgttgctgagggctgggaagaaggaacagaggcatctccacctacactgcaagaagtggtaaccgaaaaagaatagagccaaaccaacaccccatatgtcagtgtaaatccttgttacctatctcgtgtgtgttatttccccagccacaggccaaatccttggagtcccaggggcagccacaccactgccattacccagtgccgaggacatgcatgacacttccaaagactccctccatagcgacaccctttctgtttggacccatggtcatctctgttcttttcccgcctccctagttagcatccaggctggccagtgctgcccatgagcaagcctaggtacgaagaggggtggtggggggcagggccactcaacagagaggaccaacatccagtcctgctgactatttgacccccacaacaatgggtatccttaatagaggagctgcttgttgtttgttgacagcttggaaagggaagatcttatgccttttcttttctgttttcttctcagtcttttcagtttcatcatttgcacaaacttgtgagcatcagagggctgatggattccaaaccaggacactaccctgagatctgcacagtcagaaggacggcaggagtgtcctggctgtgaatgccaaagccattctccccctctttgggcagtgccatggatttccactgcttcttatggtggttggttgggttttttggttttgtttttttttttaagtttcactcacatagccaactctcccaaagggcacacccctggggctgagtctccagggccccccaactgtggtagctccagcgatggtgctgcccaggcctctcggtgctccatctccgcctccacactgaccaagtgctggcccacccagtccatgctccagggtcaggcggagctgctgagtgacagctttcctcaaaaagcagaaggagagtgagtgcctttccctcctaaagctgaatcccggcggaaagcctctgtccgcctttacaagggagaagacaacagaaagagggacaagagggttcacacagcccagttcccgtgacgaggctcaaaaacttgatcacatgcttgaatggagctggtgagatcaacaacactacttccctgccggaatgaactgtccgtgaatggtctctgtcaagcgggccgtctcccttggcccagagacggagtgtgggagtgattcccaactcctttctgcagacgtctgccttggcatcctcttgaataggaagatcgttccaccttctacgcaattgacaaacccggaagatcagatgcaattgctcccatcagggaagaaccctatacttggtttgctacccttagtatttattactaacctcccttaagcagcaacagcctacaaagagatgcttggagcaatcagaacttcaggtgtgactctagcaaggctcatctttctgcccggctacatcagccttcaagaatcagaagaaaggccaaggtgctggactgttactgacttggatcccaaagcaaggagatcatttggagctcttgggtcagagaaaatgagaaaggacagagccagcggctccaactcctttcagccacatgccccaggctctcgctgccctgtggacaggatgaggacagagggcacatgaacagcttgccagggatgggcagcccaacagcacttttcctcttctagatggaccccagcatttaagtgaccttctgatcttggaaaaacagcgtcttccttctttatctatagcaactcattggtggtagccatcaagcacttcccaggatctgctccaacagaatattgctaggttttgctacatgacgggttgtgagacttctgtttgatcactgtgaaccaacccccatctccctagcccacccccctccccaactccctctctgtgcattttctaagtgggacattcaaaaaactctctcccaggacctcggatgaccatactcagacgtgtgacctccatactgggctaaggaagtatcagcactagaaattgggcagtcttaatgttgaatgctgctttctgcttagtatttttttgattcaaggctcagaaggaatggtgcgtggcttccctgtcccagttgtggcaactaaaccaatcggtgtgttcttgatgcgggtcaacatttccaaaagtggctagtcctcacttctagatctcagccattctaactcatatgttcccaattaccaaggggtggccgggcacagtggctcacgcctgtaatcccagcactttgagaggctgaggtggtaggatcacctgaggtcaggagttcaagaccagcctgtccaacatggtgaaacccccatctctactaaaaataccaaaaattagccgagcgtagtgacgggtgcccgtaatcccagctactcaggaggctgagacaggagaatcacctgaaccccagaggcagaggttgcagtgagctgagatcacgccattgtactccagcctgggcaacaagagcaaaactccgtctcaaaaaaaaaaaaaaattacaaatggggcaaacagtctagtgtaatggatcaaattaagattctctgcccagccgggcacagtggcgcatgcctgtaatcccagaactttgggaggccaagacgggatgattgcttgagctcaggagtttgagaccaggctgggcatcatagcaagacctcatctctactaaaattcaaaaacaaaattagccgggcatgatggtgcatgcctgtagtctcagctagttggggagctaaggtgggagaattgcttgagcttgggaagtcgaggctgcagtcagccctgattgtgccagtgcactccggcctgggtgacagagtgagaccctgtctcaaaaaaaaaaagattctgtgtcagagcccagcccaggagtttgaggctgcaatgagccatgatttcccactgcactccagcctgagtgacagagcgagactccatctctttaaaaacaaacaaaaaattatctgaatgatcctgtctctaaaaagaagccacagaaatgtttaaaaacttcatcgacttagcctgagtcataacggttaagaaagcacttaaacagaagcagaggctaattcagtgtcacatgaggaagtagctgtcagatgtcacataattactttcgtaatagctcagattagaatggctaccccattctctagacaaaatcaaattgtcctattgtgactcttctaaaaatgaagatgaagagctatttaatgacacaccttggattaaaacgggaatcacatcttaaagctaaaaatgaacctgcaagccttctaaatgagtcactgagcatcactagtgacaagtctcgggtgagcgtaaatgggtcatgacaagatgggacagcaacaaaatcatggcttaggatcgacaagaagttaaaaaacagctgcatctgttacttaagtttgtaagacagtgccctgagacctctagagaaaagatgtttgtttacataagagaaagaggccagacatggtgtctcacacgtttaatcccagcactttgggaggcaggggcgggtggatcacctgaggtcaggagttcaagactagcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccgggcatggtggcaggcgcctataatcccagctactggggaggctgaggcaggagaatcacttgaacccgggggacagaggttgtagtgagccaagatcgcaccactgcactccagcctgggtcacagagtgagactccatctcaaaaaaaaaaaagagagagagagagaaagaaatagaagagaagagccatcttggcagggttattttatatctgagcaaggagtttaaatgagactagtttagattgtctgctgatgcagccgtccatagcagtacccctaaaatcccaccagaatacgggtccctctaacccagtggctggaagaaccactgtctagagcaacttttcttggaactgtcccagctaccaagtcagacaccaaggtttatgccaccaggtaacacgggaatcacaggtacatgtcgctccggtcagattagttggctttggcccctcgaccctgtgcaggagctagttctcagcttgcagctggaagttccctcttagctccttagtctagaggggtctcctggctccatttgaccctggtctttaataaccggtcagcatcttgctaccttctaccacctttccaaatctctggaaatcctgccagggaaagcctccagttccaacattggctttccaagcaaactggctttgccctctctctgccatccttgtcctccagagactgcaccacctgtagcatagaaaaccaccaccacggacctgccagccattggcgcagcaaaccagccagctgtttgctgccaaattccttcctctcccaggtccagaccaaatacaagatcagcaccacaccgtggtgttgtcaggagccaaagcaacaggaaacaattcaatgctgttgggttcgattctgagagtagatttttccagacatgtctttcaggtgaccctcaactacctcaggtttgaaggccctaaatgaaactgattaccactcatagggacaaaccgagggggttcggttacatcttggtgataatgcagttgtctcaaacttataacagactctttcacatttcagtttgcagggatagggttgggtttgtttttcttctgtttttaacctttcccctgggtttccattagggtagttccttgaaatgaatttcatttttcactgagtgcctaccttcccagggcaggtggccactggcttctgtttccctccaacaatacttttattatggtattaagacctttctttgtataatacattgcatctgtgttttcaatttttcaaataaatatttccgcctggcaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3092 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:3092 -> Molecular function: GO:0005200 [structural constituent of cytoskeleton] evidence: TAS
GeneID:3092 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3092 -> Molecular function: GO:0030276 [clathrin binding] evidence: IDA
GeneID:3092 -> Molecular function: GO:0035091 [phosphatidylinositol binding] evidence: IDA
GeneID:3092 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:3092 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:3092 -> Biological process: GO:0006897 [endocytosis] evidence: IEA
GeneID:3092 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:3092 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:3092 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:3092 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IDA
GeneID:3092 -> Biological process: GO:0048260 [positive regulation of receptor-mediated endocytosis] evidence: IMP
GeneID:3092 -> Biological process: GO:0048268 [clathrin coat assembly] evidence: IDA
GeneID:3092 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: IDA
GeneID:3092 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:3092 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3092 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:3092 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS
GeneID:3092 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:3092 -> Cellular component: GO:0030136 [clathrin-coated vesicle] evidence: IDA
GeneID:3092 -> Cellular component: GO:0030665 [clathrin-coated vesicle membrane] evidence: IEA
GeneID:3092 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
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