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2024-04-24 09:07:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001243028 5187 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2),
transcript variant 3, mRNA.
ACCESSION NM_001243028
VERSION NM_001243028.1 GI:339895854
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5187)
AUTHORS Fohlin,H., Perez-Tenorio,G., Fornander,T., Skoog,L.,
Nordenskjold,B., Carstensen,J. and Stal,O.
TITLE Akt2 expression is associated with good long-term prognosis in
oestrogen receptor positive breast cancer
JOURNAL Eur. J. Cancer 49 (6), 1196-1204 (2013)
PUBMED 23305873
REMARK GeneRIF: Data indicate that the prognostic value of Akt2 increases
with higher oestrogen receptor (ER) expression, motivating further
mechanistic studies on the role of Akt2 in ER+ breast cancer.
REFERENCE 2 (bases 1 to 5187)
AUTHORS Choi,K.Y., Ahn,Y.H., Ahn,H.W., Cho,Y.J. and Hong,S.H.
TITLE Involvement of Akt2/protein kinase B beta (PKBbeta) in the
8-Cl-cAMP-induced cancer cell growth inhibition
JOURNAL J. Cell. Physiol. 228 (4), 890-902 (2013)
PUBMED 23018889
REMARK GeneRIF: An Akt2/PKBbeta-targeted siRNA inhibited the 8-Cl-cAMP-
and AICAR-mediated phosphorylation of AMPK and p38 MAPK.
REFERENCE 3 (bases 1 to 5187)
AUTHORS Friedrichsen,M., Birk,J.B., Richter,E.A., Ribel-Madsen,R.,
Pehmoller,C., Hansen,B.F., Beck-Nielsen,H., Hirshman,M.F.,
Goodyear,L.J., Vaag,A., Poulsen,P. and Wojtaszewski,J.F.
TITLE Akt2 influences glycogen synthase activity in human skeletal muscle
through regulation of NH(2)-terminal (sites 2 + 2a) phosphorylation
JOURNAL Am. J. Physiol. Endocrinol. Metab. 304 (6), E631-E639 (2013)
PUBMED 23321478
REMARK GeneRIF: Data suggest that although COOH-terminal dephosphorylation
is likely necessary for glycogen synthase (GS) activation,
Akt2-dependent NH2-terminal dephosphorylation is the site for
'fine-tuning' insulin-mediated GS activation in skeletal muscle.
REFERENCE 4 (bases 1 to 5187)
AUTHORS Shen,Y.H., Zhang,L., Ren,P., Nguyen,M.T., Zou,S., Wu,D., Wang,X.L.,
Coselli,J.S. and LeMaire,S.A.
TITLE AKT2 confers protection against aortic aneurysms and dissections
JOURNAL Circ. Res. 112 (4), 618-632 (2013)
PUBMED 23250987
REMARK GeneRIF: In cultured human aortic vascular smooth muscle cells,
AKT2 inhibited the expression of MMP-9 and stimulated the
expression of TIMP-1 by preventing the binding of transcription
factor forkhead box protein O1 to the MMP-9 and TIMP-1 promoters.
REFERENCE 5 (bases 1 to 5187)
AUTHORS Gillespie,E.F., Raychaudhuri,N., Papageorgiou,K.I., Atkins,S.J.,
Lu,Y., Charara,L.K., Mester,T., Smith,T.J. and Douglas,R.S.
TITLE Interleukin-6 production in CD40-engaged fibrocytes in
thyroid-associated ophthalmopathy: involvement of Akt and NF-kappaB
JOURNAL Invest. Ophthalmol. Vis. Sci. 53 (12), 7746-7753 (2012)
PUBMED 23092922
REMARK GeneRIF: CD40L-provoked signaling results in the production of
several cytokines. Among these, IL-6 expression is mediated through
Akt and NF-kappaB pathways.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 5187)
AUTHORS Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A.
TITLE Mitogenic activation, phosphorylation, and nuclear translocation of
protein kinase Bbeta
JOURNAL J. Biol. Chem. 272 (48), 30491-30497 (1997)
PUBMED 9374542
REFERENCE 7 (bases 1 to 5187)
AUTHORS Cheng,J.Q., Ruggeri,B., Klein,W.M., Sonoda,G., Altomare,D.A.,
Watson,D.K. and Testa,J.R.
TITLE Amplification of AKT2 in human pancreatic cells and inhibition of
AKT2 expression and tumorigenicity by antisense RNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3636-3641 (1996)
PUBMED 8622988
REFERENCE 8 (bases 1 to 5187)
AUTHORS Cheng,J.Q., Godwin,A.K., Bellacosa,A., Taguchi,T., Franke,T.F.,
Hamilton,T.C., Tsichlis,P.N. and Testa,J.R.
TITLE AKT2, a putative oncogene encoding a member of a subfamily of
protein-serine/threonine kinases, is amplified in human ovarian
carcinomas
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (19), 9267-9271 (1992)
PUBMED 1409633
REFERENCE 9 (bases 1 to 5187)
AUTHORS Jones,P.F., Jakubowicz,T. and Hemmings,B.A.
TITLE Molecular cloning of a second form of rac protein kinase
JOURNAL Cell Regul. 2 (12), 1001-1009 (1991)
PUBMED 1801921
REFERENCE 10 (bases 1 to 5187)
AUTHORS Staal,S.P.
TITLE Molecular cloning of the akt oncogene and its human homologues AKT1
and AKT2: amplification of AKT1 in a primary human gastric
adenocarcinoma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (14), 5034-5037 (1987)
PUBMED 3037531
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN351354.1, AK308006.1,
AC118344.2, AK122839.1 and BM675176.1.
Summary: This gene is a putative oncogene encoding a protein
belonging to a subfamily of serine/threonine kinases containing
SH2-like (Src homology 2-like) domains. The gene was shown to be
amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines
and 2 of 15 primary ovarian tumors. Overexpression contributes to
the malignant phenotype of a subset of human ductal pancreatic
cancers. The encoded protein is a general protein kinase capable of
phophorylating several known proteins. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (3) differs in the 5' UTR, lacks
an alternate exon in the 5' coding region, and initiates
translation at a downstream AUG. This results in a protein (isoform
2) with a shorter N-terminus, compared to isoform 1. Variants 2 and
3 encode isoform 2.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK308006.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-130 CN351354.1 1-130
131-586 AK308006.1 1-456
587-587 AC118344.2 125898-125898
588-1817 AK308006.1 457-1686
1818-3152 AK122839.1 3119-4453
3153-3770 AC118344.2 136121-136738
3771-5163 AC118344.2 136739-138131
5164-5187 BM675176.1 1-24 c
FEATURES Location/Qualifiers
source 1..5187
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.1-q13.2"
gene 1..5187
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="v-akt murine thymoma viral oncogene homolog 2"
/db_xref="GeneID:208"
/db_xref="HGNC:392"
/db_xref="MIM:164731"
exon 1..215
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
misc_feature 176..178
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="upstream in-frame stop codon"
exon 216..344
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
STS 345..467
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/standard_name="AKT2"
/db_xref="UniSTS:277960"
exon 345..456
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
CDS 356..1615
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 3; rac
protein kinase beta; RAC-beta serine/threonine-protein
kinase; murine thymoma viral (v-akt) homolog-2; PKB beta;
RAC-PK-beta; protein kinase Akt-2; protein kinase B beta"
/codon_start=1
/product="RAC-beta serine/threonine-protein kinase isoform
2"
/protein_id="NP_001229957.1"
/db_xref="GI:339895855"
/db_xref="GeneID:208"
/db_xref="HGNC:392"
/db_xref="MIM:164731"
/translation="
MKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
"
misc_feature <356..490
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
misc_feature 623..1396
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 635..1603
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Protein Kinase B; Region: STKc_PKB; cd05571"
/db_xref="CDD:173662"
misc_feature order(641..646,650..655,665..667,704..706,710..712,
746..748,755..757,806..808,854..865,875..877,881..883,
893..895,992..994,998..1000,1004..1009,1013..1015,
1043..1048,1055..1057,1097..1120,1193..1195,1211..1213,
1220..1222,1484..1486,1496..1498)
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="active site"
/db_xref="CDD:173662"
misc_feature order(641..646,650..652,665..667,704..706,710..712,
806..808,854..865,875..877,992..994,998..1000,1004..1009,
1013..1015,1043..1048,1484..1486)
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173662"
misc_feature order(653..655,746..748,755..757,875..877,881..883,
893..895,992..994,998..1000,1004..1006,1055..1057,
1097..1120,1193..1195,1211..1213,1220..1222,1496..1498)
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173662"
misc_feature 1043..1114
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173662"
misc_feature 1520..1522
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="turn motif phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:173662"
misc_feature 1577..1594
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173662"
STS 407..645
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/standard_name="MARC_6978-6979:992007604:1"
/db_xref="UniSTS:231294"
exon 457..610
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 611..742
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
variation 721
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1138528"
exon 743..808
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 809..877
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 878..1000
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
variation 962
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:1804324"
exon 1001..1129
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
STS 1055..1202
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/standard_name="SGC30851"
/db_xref="UniSTS:8286"
exon 1130..1344
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 1345..1432
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 1433..1535
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
exon 1536..5170
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/inference="alignment:Splign:1.39.8"
variation 1624
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:79275829"
variation 2768
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142291"
variation 2772
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142293"
variation 2776
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142294"
variation 2787
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:1142297"
variation 2789
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142298"
STS 4191..4317
/gene="AKT2"
/gene_synonym="HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA"
/standard_name="RH11487"
/db_xref="UniSTS:30867"
ORIGIN
tgggagggggcggtaagcgggggctggggggagggggcggggggggccgcgccgtgctagccgttgggcctgcctcggaggaggcgtcgccgccgccgctgccgctgccggcgccgttgccgctgccgggaaacacaaggaaagggaaccagcgcagcgtggcgatgggcgggggtagagccccgccggagaggctgggcggctgccggtgacaggtgaatacatcaagacctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggagaggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgccagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtggaccacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatgcgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatggactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtcagcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaagggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatgaagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgagagccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccagacccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccacctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtctcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaacctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggcatcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgaggtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatgtacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgagctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctgcttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgccaaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaagaagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgatgatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggcttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgcgagtgagcagtctgcccacgcagaggacgcacgctcgctgccatcaccgctgggtggttttttccccctaactttttacttagcctttttggtttgtgtccccacccccacctcctcaccccctttccagttcttcttcaggcccctcccagacgcaccccagcggcccctgcagcccctgcctccagcctccagcctcacctttgtgcccagactcgcatttggaagactccacctcccgcccaggcctgggctgttgggcggttggagattcaggttttaatccacacaagccccagtgaggggtgaagcatggcgcctggggcctgcctgagtttctggcctgggtgtcgtgctggtgtctgcctccgcgctgctgcatctggacgaaggctgccttctggtgggacgcgacacccggcagacagtggtgctgccttccaggccccgtggcctaggctcggagtggccaggcacggggcggtccaatcccccacccgctgtccccctatgggggcagaaaagcaataatgtccaggggcaggcaggggcccttgggagctgcagggctgggggttagggctgctccctggtgaatggagtcagatcctaggatctgtaccatggggaaccaggagtggccgggctgggtgccgcctcctggtccggcctcctccccaccaaactgtcctcaccctatggatgaggcaggaggaacatttggggccaaacctgcctgcctcccagccccgtgccttactagggcttccttccagctggccttacctcccgctggaccctgggcctggcctggccccactgggggctatgggctgggctcaccctctcctctgcgggggtggagggccaccagccttggctgttacaatcttacaccggacagtattgggccccatggacttggtcagggaggggtgggggtgggcatctctggtacctattggggtggggggcctctgaaaagggaggctcctaggcccccctcacccctccctctccccagggccccacgttctgcagccttaaggttgaacatgagtgcacgtccatgtcagtgctgtgggactcctgtgcgtgcctcggactgcgtgtgtcggcgggacgcaggcacacgtgggtgtgtgtgcatgtgtgtttgtgtgagggcagcgtgtcctccagtgtgcatggtgtgtgggcttgggccccatccctggcccgagcatttcatcctgtgggggaggggtgctgacctagtgggaggagccccactgtgatccatgagctgccctgcccacgcctcccctccctgtagcaacacctctgggtgtttggagtttagcttttgtgggtttgctctccctatcccatctcctgtactacacagttcatggcagggtggggaggggtggggttggttcgggtgggtgagggtctttttcctctgtgtgcgatgttgttatctgacagttctccgtccctactggcctttctcctcgtcttcatatttgtacggtacaagcaataaagacactcatttcagaccagggcccagcctgcactcacgccagcccaaccactctgggctttgccttggtgatggagtcagacccctgggccccagctcctcctgtactagccgttcccttcagcaaggagggcactgagctcagggtgagggcagctggggtgtgtgcaggagctcaggctggagagggtgggtggagctggtgctgtggggctgaggggtatgggaaggctccccgcatgtgggggtggggtggacagagaccactccaggccctcagtgctgcttaggctaagagaggtggggtggagggacagggctggaagatctgggtagcccagaatgaggagggtgcctgtgctgtcactgaatgagagggagtggttcattccacccggctgccgagcctcagaggggggcattcctatcctgccccacctccctgtttatgctgccacctggaagccttgaggcccccaaattccagtacagacccagtggtgtgttcatggtggcgtggttgctgtcacctgggagctcctgagcgtttggttagaaccctgttcagcttggggtcagccctcccctagtcactgccctttagcctggatgtgtctgggcccctgcacttcccgtgcttgagtcacgtggctgcatggccgggcgctggccggatggaacacctcccccagcaagggaccagggaccagagccctggcctgccctgctgagccctgctgtgcagagggcctggcacagatgaatttgagattttgccgcaaggtgttagcacttcacacccattgagtctttgagattttaagtgaatgtaagcagaaaaagtcagatccaatttacagaaatcagagttagctacagctaggactcgtttggttggggttttttagtttgtctttctaaagtcatgtggaccttaatttaattacaaaagtctaccctggtggtcataaaataggcaggcctatgaagaaaggccttttactcttccatctcatcccagccccgagttgacccacgttgctgctcctcacaccatggtgatgcaggtctcgtagtgtgggcacaggcctggctacctcatctttttagtgcctctctcctcttccacaggatggggtcccacagctgcagcagctggccccgtagttgagcatgtgtggttatcctgtagagcttttcccaagaagggtgtttgaacttagagtcttaataaaatcttaccaaataaattttgagtagaataatcgtcttttgcaatgtacattttaaaaatttcacacattcttttttgtatataaagaacagtgactgggcacagtggctcatgcctgtaatcccagcaatttgggaggccgaggcgggcgggtctcttgaggccaggggttcgagaccagcctgggcatcatagggagaccttcatctctacaaaaaatacaaaaattagctgggcatggtggtgcatgcctgcaatcccagctaacttggaaggctgaggtgaggtgggaagatcacttgagcccaggagtttgaggctgcagtgagctatgattgcggcactgcactgcagcctgggacaatgagactgtgtctctaaaaataaaaaaaaaaaaaacatgatacatgctattaaaaaagacagcaaagcaggagtataagaaaggaaattcacccgaggtcgcagggccttgagtactcattttggtgctgattacctctctgcaaatggacacggcatcataaattggtagtttcctgctctttttgtgtaatcttttccagttaatgtgaagcctctgggggctgccctcgtgcactgatggttgtgtggagtcgggggcggcagtgcgattcccttttagctgctgcatggggggaactcaggctttccagctgcttcctggggttccatggggtagacccctcaaccgcttcagctgccccgttaacaggaattgacttggtttcgtttggtgctaccagcagtcctgtaataaactagctatccatctgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:208 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:208 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:208 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:208 -> Molecular function: GO:0016301 [kinase activity] evidence: TAS
GeneID:208 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: ISS
GeneID:208 -> Biological process: GO:0005978 [glycogen biosynthetic process] evidence: IEA
GeneID:208 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
GeneID:208 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:208 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS
GeneID:208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:208 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IMP
GeneID:208 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:208 -> Biological process: GO:0008643 [carbohydrate transport] evidence: IEA
GeneID:208 -> Biological process: GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] evidence: IMP
GeneID:208 -> Biological process: GO:0010907 [positive regulation of glucose metabolic process] evidence: IMP
GeneID:208 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:208 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS
GeneID:208 -> Biological process: GO:0031340 [positive regulation of vesicle fusion] evidence: ISS
GeneID:208 -> Biological process: GO:0032000 [positive regulation of fatty acid beta-oxidation] evidence: IMP
GeneID:208 -> Biological process: GO:0032287 [peripheral nervous system myelin maintenance] evidence: IEA
GeneID:208 -> Biological process: GO:0032859 [activation of Ral GTPase activity] evidence: IEA
GeneID:208 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
GeneID:208 -> Biological process: GO:0045444 [fat cell differentiation] evidence: TAS
GeneID:208 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: IMP
GeneID:208 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IMP
GeneID:208 -> Biological process: GO:0046328 [regulation of JNK cascade] evidence: IEA
GeneID:208 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: TAS
GeneID:208 -> Biological process: GO:0065002 [intracellular protein transmembrane transport] evidence: ISS
GeneID:208 -> Biological process: GO:0071156 [regulation of cell cycle arrest] evidence: TAS
GeneID:208 -> Biological process: GO:0072659 [protein localization to plasma membrane] evidence: IEA
GeneID:208 -> Biological process: GO:0090314 [positive regulation of protein targeting to membrane] evidence: ISS
GeneID:208 -> Biological process: GO:2000147 [positive regulation of cell motility] evidence: IMP
GeneID:208 -> Biological process: GO:2001275 [positive regulation of glucose import in response to insulin stimulus] evidence: IEA
GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:208 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:208 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS
GeneID:208 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:208 -> Cellular component: GO:0005938 [cell cortex] evidence: ISS
GeneID:208 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA
GeneID:208 -> Cellular component: GO:0032587 [ruffle membrane] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001229957 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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