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2024-03-29 06:52:44, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001242784            6953 bp    mRNA    linear   PRI 20-APR-2013
DEFINITION  Homo sapiens holocarboxylase synthetase
            (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
            (HLCS), transcript variant 3, mRNA.
ACCESSION   NM_001242784
VERSION     NM_001242784.1  GI:338753396
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6953)
  AUTHORS   Esaki,S., Malkaram,S.A. and Zempleni,J.
  TITLE     Effects of single-nucleotide polymorphisms in the human
            holocarboxylase synthetase gene on enzyme catalysis
  JOURNAL   Eur. J. Hum. Genet. 20 (4), 428-433 (2012)
   PUBMED   22027809
  REMARK    GeneRIF: individuals with HLCS SNPs may benefit from supplemental
            biotin, yet to different extents depending on the genotype
REFERENCE   2  (bases 1 to 6953)
  AUTHORS   Bao,B., Wijeratne,S.S., Rodriguez-Melendez,R. and Zempleni,J.
  TITLE     Human holocarboxylase synthetase with a start site at methionine-58
            is the predominant nuclear variant of this protein and has
            catalytic activity
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (1), 115-120 (2011)
   PUBMED   21802411
  REMARK    GeneRIF: HLCS methionine-58 is a functional translation start site
            in human cells.
REFERENCE   3  (bases 1 to 6953)
  AUTHORS   Bao,B., Pestinger,V., Hassan,Y.I., Borgstahl,G.E., Kolar,C. and
            Zempleni,J.
  TITLE     Holocarboxylase synthetase is a chromatin protein and interacts
            directly with histone H3 to mediate biotinylation of K9 and K18
  JOURNAL   J. Nutr. Biochem. 22 (5), 470-475 (2011)
   PUBMED   20688500
  REMARK    GeneRIF: Holocarboxylase synthetase interacts directly with histone
            H3, causing biotinylation of lysine K9 and K18.
REFERENCE   4  (bases 1 to 6953)
  AUTHORS   Bao,B., Rodriguez-Melendez,R., Wijeratne,S.S. and Zempleni,J.
  TITLE     Biotin regulates the expression of holocarboxylase synthetase in
            the miR-539 pathway in HEK-293 cells
  JOURNAL   J. Nutr. 140 (9), 1546-1551 (2010)
   PUBMED   20592104
  REMARK    GeneRIF: The results of this study suggest that miR-539 is among
            the factors sensing biotin and regulating holocarboxylase
            synthetase expression.
REFERENCE   5  (bases 1 to 6953)
  AUTHORS   Bailey,L.M., Wallace,J.C. and Polyak,S.W.
  TITLE     Holocarboxylase synthetase: correlation of protein localisation
            with biological function
  JOURNAL   Arch. Biochem. Biophys. 496 (1), 45-52 (2010)
   PUBMED   20153287
  REMARK    GeneRIF: the localisation of HCS and its isoforms
REFERENCE   6  (bases 1 to 6953)
  AUTHORS   Aoki,Y., Suzuki,Y., Sakamoto,O., Li,X., Takahashi,K., Ohtake,A.,
            Sakuta,R., Ohura,T., Miyabayashi,S. and Narisawa,K.
  TITLE     Molecular analysis of holocarboxylase synthetase deficiency: a
            missense mutation and a single base deletion are predominant in
            Japanese patients
  JOURNAL   Biochim. Biophys. Acta 1272 (3), 168-174 (1995)
   PUBMED   8541348
REFERENCE   7  (bases 1 to 6953)
  AUTHORS   Leon-Del-Rio,A., Leclerc,D., Akerman,B., Wakamatsu,N. and
            Gravel,R.A.
  TITLE     Isolation of a cDNA encoding human holocarboxylase synthetase by
            functional complementation of a biotin auxotroph of Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4626-4630 (1995)
   PUBMED   7753853
REFERENCE   8  (bases 1 to 6953)
  AUTHORS   Suzuki,Y., Aoki,Y., Ishida,Y., Chiba,Y., Iwamatsu,A., Kishino,T.,
            Niikawa,N., Matsubara,Y. and Narisawa,K.
  TITLE     Isolation and characterization of mutations in the human
            holocarboxylase synthetase cDNA
  JOURNAL   Nat. Genet. 8 (2), 122-128 (1994)
   PUBMED   7842009
REFERENCE   9  (bases 1 to 6953)
  AUTHORS   Chiba,Y., Suzuki,Y., Aoki,Y., Ishida,Y. and Narisawa,K.
  TITLE     Purification and properties of bovine liver holocarboxylase
            synthetase
  JOURNAL   Arch. Biochem. Biophys. 313 (1), 8-14 (1994)
   PUBMED   8053691
REFERENCE   10 (bases 1 to 6953)
  AUTHORS   Narisawa,K., Arai,N., Igarashi,Y., Satoh,T., Tada,K. and Hirooka,Y.
  TITLE     Clinical and biochemical findings on a child with multiple
            biotin-responsive carboxylase deficiencies
  JOURNAL   J. Inherit. Metab. Dis. 5 (2), 67-68 (1982)
   PUBMED   6133032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB290499.1, D87328.1,
            AP000698.1 and AP000697.1.
            
            Summary: This gene encodes an enzyme that catalyzes the binding of
            biotin to carboxylases and histones. The protein plays an important
            role in gluconeogenesis, fatty acid synthesis and branched chain
            amino acid catabolism. Defects in this gene are the cause of
            holocarboxylase synthetase deficiency. Multiple alternatively
            spliced variants, encoding the same protein, have been
            identified.[provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               DB290499.1         1-205
            206-3085            D87328.1           23-2902
            3086-3086           AP000698.1         8414-8414           c
            3087-6322           D87328.1           2904-6139
            6323-6953           AP000697.1         124311-124941       c
FEATURES             Location/Qualifiers
     source          1..6953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13"
     gene            1..6953
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="holocarboxylase synthetase
                     (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing))
                     ligase)"
                     /db_xref="GeneID:3141"
                     /db_xref="HGNC:4976"
                     /db_xref="MIM:609018"
     exon            1..213
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            214..348
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            349..1303
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     STS             369..471
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="D11S2921"
                     /db_xref="UniSTS:152074"
     misc_feature    1301..1303
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="upstream in-frame stop codon"
     exon            1304..1466
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     CDS             1415..3595
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /EC_number="6.3.4.10"
                     /EC_number="6.3.4.11"
                     /EC_number="6.3.4.15"
                     /EC_number="6.3.4.9"
                     /note="holocarboxylase synthetase
                     (biotin-(proprionyl-Coenzyme A-carboxylase
                     (ATP-hydrolysing)) ligase); biotin apo-protein ligase;
                     biotin--[methylmalonyl-CoA-carboxytransferase] ligase;
                     biotin--[methylcrotonoyl-CoA-carboxylase] ligase;
                     biotin--[acetyl-CoA-carboxylase] ligase"
                     /codon_start=1
                     /product="biotin--protein ligase"
                     /protein_id="NP_001229713.1"
                     /db_xref="GI:338753397"
                     /db_xref="CCDS:CCDS13647.1"
                     /db_xref="GeneID:3141"
                     /db_xref="HGNC:4976"
                     /db_xref="MIM:609018"
                     /translation="
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
"
     misc_feature    1853..1855
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P50747.1); phosphorylation site"
     misc_feature    2018..2794
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Type 1 glutamine amidotransferase (GATase1)-like
                     domain; Region: GAT_1; cl00020"
                     /db_xref="CDD:206787"
     misc_feature    2825..3562
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme
                     metabolism]; Region: BirA; COG0340"
                     /db_xref="CDD:30688"
     misc_feature    2888..3223
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin/lipoate A/B protein ligase family; Region:
                     BPL_LplA_LipB; pfam03099"
                     /db_xref="CDD:202534"
     misc_feature    3419..3562
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /note="Biotin protein ligase C terminal domain; Region:
                     BPL_C; pfam02237"
                     /db_xref="CDD:111161"
     exon            1467..2410
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     variation       1699
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230182"
     variation       2248
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065758"
     exon            2411..2593
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     variation       2467
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065759"
     exon            2594..2865
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2866..2933
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            2934..3094
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            3095..3209
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            3210..3423
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     exon            3424..6953
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /inference="alignment:Splign:1.39.8"
     STS             3547..3660
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-52086"
                     /db_xref="UniSTS:22825"
     STS             3632..3906
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-12620"
                     /db_xref="UniSTS:31493"
     STS             3926..4050
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="WI-15188"
                     /db_xref="UniSTS:77963"
     STS             4780..5018
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-53043"
                     /db_xref="UniSTS:6445"
     variation       4783
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3191054"
     variation       5199
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1050706"
     variation       5201
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1050707"
     polyA_signal    5771..5776
                     /gene="HLCS"
                     /gene_synonym="HCS"
     STS             5782..5941
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-87611"
                     /db_xref="UniSTS:81190"
     polyA_site      5791
                     /gene="HLCS"
                     /gene_synonym="HCS"
     STS             5934..6120
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-52136"
                     /db_xref="UniSTS:55079"
     variation       6217
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:14407"
     STS             6532..6660
                     /gene="HLCS"
                     /gene_synonym="HCS"
                     /standard_name="SHGC-87607"
                     /db_xref="UniSTS:51963"
     polyA_signal    6627..6632
                     /gene="HLCS"
                     /gene_synonym="HCS"
     polyA_site      6649
                     /gene="HLCS"
                     /gene_synonym="HCS"
ORIGIN      
cctgccggcggcgcggccatgctcatcacgctgtgctacctgtacctgtgggcgcgctggggtcgccggccggctgagctcgtgcgcgccacggtgcggcggctgcgtgcctcgcgctgttccttcaccttctgcggcgcggccgcgcagcccccgggcgcccgcgtgtgcctgagccgtggcggccgcgtcttctgcgtcagcgacagccagtccattgaagacttgaacaagtgggccctatttcttgtgtctccttttatacttgaagcagaacacatagcatttgtgacggagagcatttgggtacaaagtgagaatttacagagatcatcctcttcagaaacaacggagtgtcgttctgtcgtccaggctggagtgcagtggtgtggtctcggctcaccacaacctctgcctactgggttccagtgattctcctgcctcagcatcccgagtagctgggactacaggtgcacgctaccatgcccggctaatttttgtatttttagtagaggcgggggtttcaccatgccatccaggctggtttcgaactcctgacctcgtgatccacctgtctcggcctcccaaagtgctgggattacaggtgtgagccaccgcgcctggccctgtattttcaaattctttacctctgcgtttccagccttgctccatccaatttgttactagagctttttaacaatttcacgttgaattaagatgatttggaagaggagaaacaagagtcagaaaaattagcagcatccgtgatctgactctgggtaccagtgggttgttgagatttctgttccccactcactgcagagctgctgcctgccaatgccccctgttgggcagggccacctgtgctagtttaacctggggtctttcactcccggactgcttcttggatgtgagttttaagttgagcagagaagatatgccttgcctgctgccatacattgtaacatcaagtcaagagctttagttacttaacagatttctgctggctgctattataggaggaaactcctttgtttagggacagccagggcttccttagctttgatctttgggagtgagccttttgcttgacttcccttctcttttccatgcctttgtttccatctcgaagtgcaaatttaaagtgtcctgtttgcctttatccactggaaggcaaacaccctggacgacgtatcagtgacagcgcggttctgctttgatcggagcacccagcgctgcttgaaggcgtttgcatggtccatggctcatggaccacgctcctagaaaacggaaatgcacttagattgtcaagtggtcagactgttgtttgccattagcttgcagacctggggatccttatcggctaattgctgaagcaagtgtggacaacttcagcaagctgggggtggcgttcatggaagatagactccacatggataatggactggtaccccaaaagattgtgtcggtgcacttgcaggactccactctgaaggaagttaaggatcaggtctcaaacaagcaagcccagatcctagagccgaagcctgaaccttctcttgagattaagcctgagcaggacggtatggagcatgttggcagagatgacccaaaggctcttggtgaagaacccaaacaaaggagaggcagtgcctctgggagtgagcctgctggggacagtgacaggggagggggccccgttgagcattatcacctccatctgtctagttgccacgagtgtctggaacttgagaacagcaccattgagtcagtcaagtttgcgtctgccgagaacattccagaccttccctacgattatagcagcagtttggagagtgttgctgatgagacctcccccgaaagagaagggaggagagtcaacctcacgggaaaggcacccaacatcctcctctatgtgggctccgactcccaggaagccctcggccggttccacgaggtccggtctgtgctggccgactgtgtggacattgacagttatattctctaccacctgctggaggacagtgctctcagagacccgtggacggacaactgtctgctgttggtcattgctaccagggagtccattcccgaagacctgtaccagaagttcatggcctatctttctcagggagggaaggtgttgggcctgtcttcatccttcacctttggtggctttcaggtgacaagcaagggtgcactgcacaagacagtccagaacttggttttctccaaggctgaccagagcgaggtgaagctcagcgtcttgagcagtggctgcaggtaccaggaaggccccgtccggctcagccccggcaggctccagggccacctggagaatgaggacaaggacaggatgattgtgcatgtgccttttggaactcgcgggggagaagctgttctttgccaggtgcacttagaactacctcccagctccaacatagtgcaaactccagaagattttaacttgctcaagtcaagcaattttagaagatacgaagtccttagagagattctgacaacccttggcctcagctgtgacatgaaacaagttcctgccttaactcctctttacttgctgtcagctgcggaggaaatcagggatcctcttatgcagtggcttgggaaacatgtggactccgagggagaaataaaatccggccagctctctcttagatttgtttcatcctacgtgtctgaagtagaaataaccccatcttgtatacctgtggtgaccaacatggaggccttctcatcagaacatttcaacttagagatctatcgccaaaatctgcagaccaagcagttggggaaagtaattttgtttgccgaagtgacccccacaacgatgcgtctcctggatgggctgatgtttcagacaccgcaggaaatgggcttaatagtgatcgcggcccggcagaccgagggcaaaggacggggagggaatgtgtggctgagccctgtgggatgtgctctttctactctgctcatctccattccactgagatcccagctgggacagaggatcccgtttgtccagcatctgatgtccgtggctgtcgtggaagcagtgaggtccattcccgagtatcaggatatcaacttacgagtgaagtggcccaacgatatttattacagtgacctcatgaagatcggcggagttctggttaactcaacactcatgggagaaacattttatatacttattggctgtggatttaatgtgactaacagtaaccctaccatctgcatcaacgacctcatcacagaatacaataaacaacacaaggcagaactgaagcccttaagagccgattatctcatcgccagagtcgtgactgtgctggagaaactgatcaaagagtttcaggacaaagggcccaacagcgtccttcccctttattaccgatactgggtccacagtggtcagcaagtccatctgggcagcgcagagggaccaaaggtgtccatcgttggcctggacgattctggcttcctccaggttcaccaggagggcggcgaggttgtgactgtgcacccggacggcaactccttcgacatgctgagaaacctcatcctccccaaacggcggtaatgccgggcgtccccgagacgcggctgcctgtccgtgcccatgcatctggaaatctaatttagagttgtaggtgaattttcttttcctccaattcatttgttaagtctttgttctttttctgtgtttctgtttgtttttaggtttgttttgttgtcgttttctttggtgtttgaagaggctctgggatagatggttaagaagtagaaaatttagtttagggaaagccctcccacaggtgggaaattgctctcccctctgtggcttggacttacgtttattgtcaaggggagtttttacatggaaatgacaatgggaaaattcagatattttcttagtagtgcagacctttacccctagtctatgaaaaaacaaaccaaaatatgctcttgcgcccaggccagtggtgagttagaggtatgctatcactgtttgtaagcatctggggaggtactgaactgtaagaacatgcttggacacttagtcattgttctgtgtttttattaatgaagaaaagggaagacagacttccaagagttactgtccacccggtggtgtggccccatagcgaagtctaaatgcctgtagagatagagctagctggtgtggttgcagtgaccttgtagaggaaatcagttcattactttgacatcattcagtgagctctcctttcctaaggaagtttaaatgtccttagttagggactgactttcttaagtaagtttaaatttactacatattgtgaagagacaggatcaagttcagaatccttaaatgtctgattaggcatcacttggatgaggaggtgggcgatttggctctgacagctggagatgaaggcacactcataccacatacaagggaggatttggagcttttaagccagtttcagatttactctgaaatgtggagcattcctgcaagactgtgcagctcacggaatatagaagacatggcattttactcagaagtcataagtttttgcccccctcatttacctcgtattaccaagaaagaaaatgttatcgatactaaacaccatcagttcagagggaggatgtgtgtgtgtgcccgcatatgtgtgtgcgtgcgtgtgtgcgcacatagctttaaaagaagacattcaaaatttgatgtgctacaagcctcatgaaagaacaaaagaaatgaagccttttgatatgcattcgctattcccagatgtacgccatgccttttccatgtccctcctatctctgttgaacttatgaatcatactcattacttttcagctttttaaaaggccaatttttgtccagttttctctcttccagtcccagctgaaattagtggaaagaaagtttgatggagctttcagctttgaacaaaatcccttcattgtaaactagcaccatctttatccaggtcttacccagtcaggctaattccagaaacttgtggtttttagtatagtctgtctacctttagccaggcacaggacagccctatgaaaaaatacccaatatatattttttggaaatgaaacattaaaagaacttaaaaagtaatttttggaaatgaggcttcaattagaattatttttctcaaaaaacaaacaaacaaaaaacacaaaaaaaaccactcttctccaaatgcccaagccttctttcaaaattagttagaaacttaagtaaaatacaagtccacaccatccccaaattacaaaatggacttacccttgagagggcatctgcagaatatcatcagggacaaagatctcgaggctaacgatgtaggtttcatttctcagactttgtaatataaggcaagccctctctcagagctgccatcatcactttttgaatttctttgggggttatttaatgaaaaacatgctatgttttgttttaagctgaagtcctattctggacactctgctttgggaaaaaatgttatcatttaatttcctttctgcaaattaaaactaatgaagtgtggccttgtcaaaggctatggagatgttccgggcatactgctgtgctctgtgctttccagcaggcgctcctccctcacgcaggagactcagttgtcctgagagagatgaagcagccttgaagcagatgctgcgttttccataaacctgattttgcctcacatgaaccaaagactctcaaaactccgcttctatagaattagctgaataaaggcattttactgatagctgttcgtgttagcgaaacctgtctacctgctatagcacactctccgatttgggccatttatgcaccccgcaacctgggatctcaaggagctttaaagtcttaatgggaacttggcattttcctgatgatctttaaaatgtggtcactaaactcaggattggcgtgtgcttttagaacactggagtagcccttgttttagaggctgtgcattgagtatcgaccgtattttgtaaaaggcaagatatcctcccttccaggctggtaacgggtttcaaggggactcttgaggaagtgccccctaaaatagaacacagcaataactgggcttcctgtccccacccccaccccagcagtgctctctggcactgggaactctgctagggagtggtggaagtaggaaggatttgtgtgcaaaggaaaatcgtggttgagtttcactgcagcaggctgacgttgcctgatgtgagagcaagtggccgactggggtgcgggtgcacaggtcgggggagcacaggccacagagcgcagcctctgggggtcccccaaggcacagcatatacagcatggtcgccccttgccctggagtctgggaacaaagagaggagccagcctccccgcactgcttcagatggaaaagggaggcagggtgggcttccgttctccagatctgtttgctcttaacaggcagaacatgggagaatccttattcctggttaatcactatgcatatttgaaataaaagaaagcgtaagcctctgcaattttaacttctcaaaggatgtctctgaaaagaatcactttaaaccaatgcctataaaaagcaagtctaccaaaataaactaagactttctatgtggtttgggctccctcttatttttacaagtttcatttttaaaagtaggcaactactttgggttacagtatttttattcatatttaaacatttttacaaaataaataaagtgttttacatagtaaggaatatgtacgtatttccaagtattaagaagccaagtgtttttttttttgacgtattattgacaaatgtattcagcgccatacacaagagaaatattattactccaaagaacgaaagttaacaaaactccaaagcaaaaacccttttaatggaggtgagaaataaatttaatgtaacaaca
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3141 -> Molecular function: GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:3141 -> Molecular function: GO:0009374 [biotin binding] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IDA
            GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IMP
            GeneID:3141 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:3141 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
            GeneID:3141 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0006768 [biotin metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0008283 [cell proliferation] evidence: IMP
            GeneID:3141 -> Biological process: GO:0009305 [protein biotinylation] evidence: IDA
            GeneID:3141 -> Biological process: GO:0016570 [histone modification] evidence: IDA
            GeneID:3141 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:3141 -> Biological process: GO:0070781 [response to biotin] evidence: IDA
            GeneID:3141 -> Biological process: GO:0071110 [histone biotinylation] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005652 [nuclear lamina] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
            GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:3141 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001229713 -> EC 6.3.4.10
            NP_001229713 -> EC 6.3.4.11
            NP_001229713 -> EC 6.3.4.15
            NP_001229713 -> EC 6.3.4.9

by @meso_cacase at DBCLS
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