2024-03-29 06:52:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001242784 6953 bp mRNA linear PRI 20-APR-2013 DEFINITION Homo sapiens holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (HLCS), transcript variant 3, mRNA. ACCESSION NM_001242784 VERSION NM_001242784.1 GI:338753396 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6953) AUTHORS Esaki,S., Malkaram,S.A. and Zempleni,J. TITLE Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis JOURNAL Eur. J. Hum. Genet. 20 (4), 428-433 (2012) PUBMED 22027809 REMARK GeneRIF: individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype REFERENCE 2 (bases 1 to 6953) AUTHORS Bao,B., Wijeratne,S.S., Rodriguez-Melendez,R. and Zempleni,J. TITLE Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity JOURNAL Biochem. Biophys. Res. Commun. 412 (1), 115-120 (2011) PUBMED 21802411 REMARK GeneRIF: HLCS methionine-58 is a functional translation start site in human cells. REFERENCE 3 (bases 1 to 6953) AUTHORS Bao,B., Pestinger,V., Hassan,Y.I., Borgstahl,G.E., Kolar,C. and Zempleni,J. TITLE Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18 JOURNAL J. Nutr. Biochem. 22 (5), 470-475 (2011) PUBMED 20688500 REMARK GeneRIF: Holocarboxylase synthetase interacts directly with histone H3, causing biotinylation of lysine K9 and K18. REFERENCE 4 (bases 1 to 6953) AUTHORS Bao,B., Rodriguez-Melendez,R., Wijeratne,S.S. and Zempleni,J. TITLE Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells JOURNAL J. Nutr. 140 (9), 1546-1551 (2010) PUBMED 20592104 REMARK GeneRIF: The results of this study suggest that miR-539 is among the factors sensing biotin and regulating holocarboxylase synthetase expression. REFERENCE 5 (bases 1 to 6953) AUTHORS Bailey,L.M., Wallace,J.C. and Polyak,S.W. TITLE Holocarboxylase synthetase: correlation of protein localisation with biological function JOURNAL Arch. Biochem. Biophys. 496 (1), 45-52 (2010) PUBMED 20153287 REMARK GeneRIF: the localisation of HCS and its isoforms REFERENCE 6 (bases 1 to 6953) AUTHORS Aoki,Y., Suzuki,Y., Sakamoto,O., Li,X., Takahashi,K., Ohtake,A., Sakuta,R., Ohura,T., Miyabayashi,S. and Narisawa,K. TITLE Molecular analysis of holocarboxylase synthetase deficiency: a missense mutation and a single base deletion are predominant in Japanese patients JOURNAL Biochim. Biophys. Acta 1272 (3), 168-174 (1995) PUBMED 8541348 REFERENCE 7 (bases 1 to 6953) AUTHORS Leon-Del-Rio,A., Leclerc,D., Akerman,B., Wakamatsu,N. and Gravel,R.A. TITLE Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4626-4630 (1995) PUBMED 7753853 REFERENCE 8 (bases 1 to 6953) AUTHORS Suzuki,Y., Aoki,Y., Ishida,Y., Chiba,Y., Iwamatsu,A., Kishino,T., Niikawa,N., Matsubara,Y. and Narisawa,K. TITLE Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA JOURNAL Nat. Genet. 8 (2), 122-128 (1994) PUBMED 7842009 REFERENCE 9 (bases 1 to 6953) AUTHORS Chiba,Y., Suzuki,Y., Aoki,Y., Ishida,Y. and Narisawa,K. TITLE Purification and properties of bovine liver holocarboxylase synthetase JOURNAL Arch. Biochem. Biophys. 313 (1), 8-14 (1994) PUBMED 8053691 REFERENCE 10 (bases 1 to 6953) AUTHORS Narisawa,K., Arai,N., Igarashi,Y., Satoh,T., Tada,K. and Hirooka,Y. TITLE Clinical and biochemical findings on a child with multiple biotin-responsive carboxylase deficiencies JOURNAL J. Inherit. Metab. Dis. 5 (2), 67-68 (1982) PUBMED 6133032 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB290499.1, D87328.1, AP000698.1 and AP000697.1. Summary: This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D87328.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-205 DB290499.1 1-205 206-3085 D87328.1 23-2902 3086-3086 AP000698.1 8414-8414 c 3087-6322 D87328.1 2904-6139 6323-6953 AP000697.1 124311-124941 c FEATURES Location/Qualifiers source 1..6953 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="21" /map="21q22.13" gene 1..6953 /gene="HLCS" /gene_synonym="HCS" /note="holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)" /db_xref="GeneID:3141" /db_xref="HGNC:4976" /db_xref="MIM:609018" exon 1..213 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 214..348 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 349..1303 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" STS 369..471 /gene="HLCS" /gene_synonym="HCS" /standard_name="D11S2921" /db_xref="UniSTS:152074" misc_feature 1301..1303 /gene="HLCS" /gene_synonym="HCS" /note="upstream in-frame stop codon" exon 1304..1466 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" CDS 1415..3595 /gene="HLCS" /gene_synonym="HCS" /EC_number="6.3.4.10" /EC_number="6.3.4.11" /EC_number="6.3.4.15" /EC_number="6.3.4.9" /note="holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase); biotin apo-protein ligase; biotin--[methylmalonyl-CoA-carboxytransferase] ligase; biotin--[methylcrotonoyl-CoA-carboxylase] ligase; biotin--[acetyl-CoA-carboxylase] ligase" /codon_start=1 /product="biotin--protein ligase" /protein_id="NP_001229713.1" /db_xref="GI:338753397" /db_xref="CCDS:CCDS13647.1" /db_xref="GeneID:3141" /db_xref="HGNC:4976" /db_xref="MIM:609018" /translation="
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
" misc_feature 1853..1855 /gene="HLCS" /gene_synonym="HCS" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P50747.1); phosphorylation site" misc_feature 2018..2794 /gene="HLCS" /gene_synonym="HCS" /note="Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020" /db_xref="CDD:206787" misc_feature 2825..3562 /gene="HLCS" /gene_synonym="HCS" /note="Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340" /db_xref="CDD:30688" misc_feature 2888..3223 /gene="HLCS" /gene_synonym="HCS" /note="Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099" /db_xref="CDD:202534" misc_feature 3419..3562 /gene="HLCS" /gene_synonym="HCS" /note="Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237" /db_xref="CDD:111161" exon 1467..2410 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" variation 1699 /gene="HLCS" /gene_synonym="HCS" /replace="c" /replace="t" /db_xref="dbSNP:2230182" variation 2248 /gene="HLCS" /gene_synonym="HCS" /replace="c" /replace="t" /db_xref="dbSNP:1065758" exon 2411..2593 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" variation 2467 /gene="HLCS" /gene_synonym="HCS" /replace="c" /replace="t" /db_xref="dbSNP:1065759" exon 2594..2865 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 2866..2933 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 2934..3094 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 3095..3209 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 3210..3423 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" exon 3424..6953 /gene="HLCS" /gene_synonym="HCS" /inference="alignment:Splign:1.39.8" STS 3547..3660 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-52086" /db_xref="UniSTS:22825" STS 3632..3906 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-12620" /db_xref="UniSTS:31493" STS 3926..4050 /gene="HLCS" /gene_synonym="HCS" /standard_name="WI-15188" /db_xref="UniSTS:77963" STS 4780..5018 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-53043" /db_xref="UniSTS:6445" variation 4783 /gene="HLCS" /gene_synonym="HCS" /replace="c" /replace="t" /db_xref="dbSNP:3191054" variation 5199 /gene="HLCS" /gene_synonym="HCS" /replace="a" /replace="c" /db_xref="dbSNP:1050706" variation 5201 /gene="HLCS" /gene_synonym="HCS" /replace="a" /replace="c" /db_xref="dbSNP:1050707" polyA_signal 5771..5776 /gene="HLCS" /gene_synonym="HCS" STS 5782..5941 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-87611" /db_xref="UniSTS:81190" polyA_site 5791 /gene="HLCS" /gene_synonym="HCS" STS 5934..6120 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-52136" /db_xref="UniSTS:55079" variation 6217 /gene="HLCS" /gene_synonym="HCS" /replace="a" /replace="g" /db_xref="dbSNP:14407" STS 6532..6660 /gene="HLCS" /gene_synonym="HCS" /standard_name="SHGC-87607" /db_xref="UniSTS:51963" polyA_signal 6627..6632 /gene="HLCS" /gene_synonym="HCS" polyA_site 6649 /gene="HLCS" /gene_synonym="HCS" ORIGIN
cctgccggcggcgcggccatgctcatcacgctgtgctacctgtacctgtgggcgcgctggggtcgccggccggctgagctcgtgcgcgccacggtgcggcggctgcgtgcctcgcgctgttccttcaccttctgcggcgcggccgcgcagcccccgggcgcccgcgtgtgcctgagccgtggcggccgcgtcttctgcgtcagcgacagccagtccattgaagacttgaacaagtgggccctatttcttgtgtctccttttatacttgaagcagaacacatagcatttgtgacggagagcatttgggtacaaagtgagaatttacagagatcatcctcttcagaaacaacggagtgtcgttctgtcgtccaggctggagtgcagtggtgtggtctcggctcaccacaacctctgcctactgggttccagtgattctcctgcctcagcatcccgagtagctgggactacaggtgcacgctaccatgcccggctaatttttgtatttttagtagaggcgggggtttcaccatgccatccaggctggtttcgaactcctgacctcgtgatccacctgtctcggcctcccaaagtgctgggattacaggtgtgagccaccgcgcctggccctgtattttcaaattctttacctctgcgtttccagccttgctccatccaatttgttactagagctttttaacaatttcacgttgaattaagatgatttggaagaggagaaacaagagtcagaaaaattagcagcatccgtgatctgactctgggtaccagtgggttgttgagatttctgttccccactcactgcagagctgctgcctgccaatgccccctgttgggcagggccacctgtgctagtttaacctggggtctttcactcccggactgcttcttggatgtgagttttaagttgagcagagaagatatgccttgcctgctgccatacattgtaacatcaagtcaagagctttagttacttaacagatttctgctggctgctattataggaggaaactcctttgtttagggacagccagggcttccttagctttgatctttgggagtgagccttttgcttgacttcccttctcttttccatgcctttgtttccatctcgaagtgcaaatttaaagtgtcctgtttgcctttatccactggaaggcaaacaccctggacgacgtatcagtgacagcgcggttctgctttgatcggagcacccagcgctgcttgaaggcgtttgcatggtccatggctcatggaccacgctcctagaaaacggaaatgcacttagattgtcaagtggtcagactgttgtttgccattagcttgcagacctggggatccttatcggctaattgctgaagcaagtgtggacaacttcagcaagctgggggtggcgttcatggaagatagactccacatggataatggactggtaccccaaaagattgtgtcggtgcacttgcaggactccactctgaaggaagttaaggatcaggtctcaaacaagcaagcccagatcctagagccgaagcctgaaccttctcttgagattaagcctgagcaggacggtatggagcatgttggcagagatgacccaaaggctcttggtgaagaacccaaacaaaggagaggcagtgcctctgggagtgagcctgctggggacagtgacaggggagggggccccgttgagcattatcacctccatctgtctagttgccacgagtgtctggaacttgagaacagcaccattgagtcagtcaagtttgcgtctgccgagaacattccagaccttccctacgattatagcagcagtttggagagtgttgctgatgagacctcccccgaaagagaagggaggagagtcaacctcacgggaaaggcacccaacatcctcctctatgtgggctccgactcccaggaagccctcggccggttccacgaggtccggtctgtgctggccgactgtgtggacattgacagttatattctctaccacctgctggaggacagtgctctcagagacccgtggacggacaactgtctgctgttggtcattgctaccagggagtccattcccgaagacctgtaccagaagttcatggcctatctttctcagggagggaaggtgttgggcctgtcttcatccttcacctttggtggctttcaggtgacaagcaagggtgcactgcacaagacagtccagaacttggttttctccaaggctgaccagagcgaggtgaagctcagcgtcttgagcagtggctgcaggtaccaggaaggccccgtccggctcagccccggcaggctccagggccacctggagaatgaggacaaggacaggatgattgtgcatgtgccttttggaactcgcgggggagaagctgttctttgccaggtgcacttagaactacctcccagctccaacatagtgcaaactccagaagattttaacttgctcaagtcaagcaattttagaagatacgaagtccttagagagattctgacaacccttggcctcagctgtgacatgaaacaagttcctgccttaactcctctttacttgctgtcagctgcggaggaaatcagggatcctcttatgcagtggcttgggaaacatgtggactccgagggagaaataaaatccggccagctctctcttagatttgtttcatcctacgtgtctgaagtagaaataaccccatcttgtatacctgtggtgaccaacatggaggccttctcatcagaacatttcaacttagagatctatcgccaaaatctgcagaccaagcagttggggaaagtaattttgtttgccgaagtgacccccacaacgatgcgtctcctggatgggctgatgtttcagacaccgcaggaaatgggcttaatagtgatcgcggcccggcagaccgagggcaaaggacggggagggaatgtgtggctgagccctgtgggatgtgctctttctactctgctcatctccattccactgagatcccagctgggacagaggatcccgtttgtccagcatctgatgtccgtggctgtcgtggaagcagtgaggtccattcccgagtatcaggatatcaacttacgagtgaagtggcccaacgatatttattacagtgacctcatgaagatcggcggagttctggttaactcaacactcatgggagaaacattttatatacttattggctgtggatttaatgtgactaacagtaaccctaccatctgcatcaacgacctcatcacagaatacaataaacaacacaaggcagaactgaagcccttaagagccgattatctcatcgccagagtcgtgactgtgctggagaaactgatcaaagagtttcaggacaaagggcccaacagcgtccttcccctttattaccgatactgggtccacagtggtcagcaagtccatctgggcagcgcagagggaccaaaggtgtccatcgttggcctggacgattctggcttcctccaggttcaccaggagggcggcgaggttgtgactgtgcacccggacggcaactccttcgacatgctgagaaacctcatcctccccaaacggcggtaatgccgggcgtccccgagacgcggctgcctgtccgtgcccatgcatctggaaatctaatttagagttgtaggtgaattttcttttcctccaattcatttgttaagtctttgttctttttctgtgtttctgtttgtttttaggtttgttttgttgtcgttttctttggtgtttgaagaggctctgggatagatggttaagaagtagaaaatttagtttagggaaagccctcccacaggtgggaaattgctctcccctctgtggcttggacttacgtttattgtcaaggggagtttttacatggaaatgacaatgggaaaattcagatattttcttagtagtgcagacctttacccctagtctatgaaaaaacaaaccaaaatatgctcttgcgcccaggccagtggtgagttagaggtatgctatcactgtttgtaagcatctggggaggtactgaactgtaagaacatgcttggacacttagtcattgttctgtgtttttattaatgaagaaaagggaagacagacttccaagagttactgtccacccggtggtgtggccccatagcgaagtctaaatgcctgtagagatagagctagctggtgtggttgcagtgaccttgtagaggaaatcagttcattactttgacatcattcagtgagctctcctttcctaaggaagtttaaatgtccttagttagggactgactttcttaagtaagtttaaatttactacatattgtgaagagacaggatcaagttcagaatccttaaatgtctgattaggcatcacttggatgaggaggtgggcgatttggctctgacagctggagatgaaggcacactcataccacatacaagggaggatttggagcttttaagccagtttcagatttactctgaaatgtggagcattcctgcaagactgtgcagctcacggaatatagaagacatggcattttactcagaagtcataagtttttgcccccctcatttacctcgtattaccaagaaagaaaatgttatcgatactaaacaccatcagttcagagggaggatgtgtgtgtgtgcccgcatatgtgtgtgcgtgcgtgtgtgcgcacatagctttaaaagaagacattcaaaatttgatgtgctacaagcctcatgaaagaacaaaagaaatgaagccttttgatatgcattcgctattcccagatgtacgccatgccttttccatgtccctcctatctctgttgaacttatgaatcatactcattacttttcagctttttaaaaggccaatttttgtccagttttctctcttccagtcccagctgaaattagtggaaagaaagtttgatggagctttcagctttgaacaaaatcccttcattgtaaactagcaccatctttatccaggtcttacccagtcaggctaattccagaaacttgtggtttttagtatagtctgtctacctttagccaggcacaggacagccctatgaaaaaatacccaatatatattttttggaaatgaaacattaaaagaacttaaaaagtaatttttggaaatgaggcttcaattagaattatttttctcaaaaaacaaacaaacaaaaaacacaaaaaaaaccactcttctccaaatgcccaagccttctttcaaaattagttagaaacttaagtaaaatacaagtccacaccatccccaaattacaaaatggacttacccttgagagggcatctgcagaatatcatcagggacaaagatctcgaggctaacgatgtaggtttcatttctcagactttgtaatataaggcaagccctctctcagagctgccatcatcactttttgaatttctttgggggttatttaatgaaaaacatgctatgttttgttttaagctgaagtcctattctggacactctgctttgggaaaaaatgttatcatttaatttcctttctgcaaattaaaactaatgaagtgtggccttgtcaaaggctatggagatgttccgggcatactgctgtgctctgtgctttccagcaggcgctcctccctcacgcaggagactcagttgtcctgagagagatgaagcagccttgaagcagatgctgcgttttccataaacctgattttgcctcacatgaaccaaagactctcaaaactccgcttctatagaattagctgaataaaggcattttactgatagctgttcgtgttagcgaaacctgtctacctgctatagcacactctccgatttgggccatttatgcaccccgcaacctgggatctcaaggagctttaaagtcttaatgggaacttggcattttcctgatgatctttaaaatgtggtcactaaactcaggattggcgtgtgcttttagaacactggagtagcccttgttttagaggctgtgcattgagtatcgaccgtattttgtaaaaggcaagatatcctcccttccaggctggtaacgggtttcaaggggactcttgaggaagtgccccctaaaatagaacacagcaataactgggcttcctgtccccacccccaccccagcagtgctctctggcactgggaactctgctagggagtggtggaagtaggaaggatttgtgtgcaaaggaaaatcgtggttgagtttcactgcagcaggctgacgttgcctgatgtgagagcaagtggccgactggggtgcgggtgcacaggtcgggggagcacaggccacagagcgcagcctctgggggtcccccaaggcacagcatatacagcatggtcgccccttgccctggagtctgggaacaaagagaggagccagcctccccgcactgcttcagatggaaaagggaggcagggtgggcttccgttctccagatctgtttgctcttaacaggcagaacatgggagaatccttattcctggttaatcactatgcatatttgaaataaaagaaagcgtaagcctctgcaattttaacttctcaaaggatgtctctgaaaagaatcactttaaaccaatgcctataaaaagcaagtctaccaaaataaactaagactttctatgtggtttgggctccctcttatttttacaagtttcatttttaaaagtaggcaactactttgggttacagtatttttattcatatttaaacatttttacaaaataaataaagtgttttacatagtaaggaatatgtacgtatttccaagtattaagaagccaagtgtttttttttttgacgtattattgacaaatgtattcagcgccatacacaagagaaatattattactccaaagaacgaaagttaacaaaactccaaagcaaaaacccttttaatggaggtgagaaataaatttaatgtaacaaca
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:3141 -> Molecular function: GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity] evidence: IEA GeneID:3141 -> Molecular function: GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity] evidence: IEA GeneID:3141 -> Molecular function: GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity] evidence: IEA GeneID:3141 -> Molecular function: GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity] evidence: IDA GeneID:3141 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:3141 -> Molecular function: GO:0009374 [biotin binding] evidence: IDA GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IDA GeneID:3141 -> Molecular function: GO:0018271 [biotin-protein ligase activity] evidence: IMP GeneID:3141 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI GeneID:3141 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA GeneID:3141 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS GeneID:3141 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS GeneID:3141 -> Biological process: GO:0006768 [biotin metabolic process] evidence: TAS GeneID:3141 -> Biological process: GO:0008283 [cell proliferation] evidence: IMP GeneID:3141 -> Biological process: GO:0009305 [protein biotinylation] evidence: IDA GeneID:3141 -> Biological process: GO:0016570 [histone modification] evidence: IDA GeneID:3141 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:3141 -> Biological process: GO:0070781 [response to biotin] evidence: IDA GeneID:3141 -> Biological process: GO:0071110 [histone biotinylation] evidence: IDA GeneID:3141 -> Cellular component: GO:0000785 [chromatin] evidence: IDA GeneID:3141 -> Cellular component: GO:0005652 [nuclear lamina] evidence: IDA GeneID:3141 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:3141 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:3141 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:3141 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001229713 -> EC 6.3.4.10 NP_001229713 -> EC 6.3.4.11 NP_001229713 -> EC 6.3.4.15 NP_001229713 -> EC 6.3.4.9
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