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2024-04-19 22:01:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001230 5777 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens caspase 10, apoptosis-related cysteine peptidase
(CASP10), transcript variant 3, mRNA.
ACCESSION NM_001230
VERSION NM_001230.4 GI:98985796
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5777)
AUTHORS Lisa-Santamaria,P., Jimenez,A. and Revuelta,J.L.
TITLE The protein factor-arrest 11 (Far11) is essential for the toxicity
of human caspase-10 in yeast and participates in the regulation of
autophagy and the DNA damage signaling
JOURNAL J. Biol. Chem. 287 (35), 29636-29647 (2012)
PUBMED 22782902
REMARK GeneRIF: The protein factor-arrest 11 (Far11) is essential for the
toxicity of human caspase-10 in yeast and participates in the
regulation of autophagy and the DNA damage signaling.
REFERENCE 2 (bases 1 to 5777)
AUTHORS Schleich,K., Warnken,U., Fricker,N., Ozturk,S., Richter,P.,
Kammerer,K., Schnolzer,M., Krammer,P.H. and Lavrik,I.N.
TITLE Stoichiometry of the CD95 death-inducing signaling complex:
experimental and modeling evidence for a death effector domain
chain model
JOURNAL Mol. Cell 47 (2), 306-319 (2012)
PUBMED 22683265
REMARK GeneRIF: analysis of stoichiometry of the CD95 death-inducing
signaling complex and demonstration of how procaspase-8,
procaspase-10, and c-FLIP form DED chains at the DISC, enabling the
formation of dimers and efficient activation of caspase-8
REFERENCE 3 (bases 1 to 5777)
AUTHORS Ekchariyawat,P., Thitithanyanont,A., Sirisinha,S. and
Utaisincharoen,P.
TITLE Apoptosis induced by avian H5N1 virus in human monocyte-derived
macrophages involves TRAIL-inducing caspase-10 activation
JOURNAL Innate Immun 18 (3), 390-397 (2012)
PUBMED 21911414
REMARK GeneRIF: induces apoptosis in avian virus H5N1-infected human
monocyte-derived macrophages
REFERENCE 4 (bases 1 to 5777)
AUTHORS Yan,S., Li,Y.Z., Zhu,J.W., Liu,C.L., Wang,P. and Liu,Y.L.
TITLE Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE
review and meta-analysis
JOURNAL Genet. Mol. Res. 11 (4), 3998-4007 (2012)
PUBMED 23212337
REMARK GeneRIF: This meta-analysis suggests that the rs13006529 T carrier
in the CASP-10 gene might be a risk factor for cancer
susceptibility, especially for breast cancer.
Review article
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 5777)
AUTHORS Qian,J., Qu,H.Q., Yang,L., Yin,M., Wang,Q., Gu,S., Wu,Q., Zhao,X.,
Wu,W., Wu,J., Tan,X., Chen,W., Wang,H., Wang,J., Fan,W., Chen,H.,
Han,B., Lu,D., Wei,Q. and Jin,L.
TITLE Association between CASP8 and CASP10 polymorphisms and toxicity
outcomes with platinum-based chemotherapy in Chinese patients with
non-small cell lung cancer
JOURNAL Oncologist 17 (12), 1551-1561 (2012)
PUBMED 22843554
REMARK GeneRIF: Genetic variations in CASP8 and CASP10 may act as
potential predictive biomarkers for platinum-based chemotherapy
toxicity in Chinese non-small cell lung cancer patients.
REFERENCE 6 (bases 1 to 5777)
AUTHORS Ng,P.W., Porter,A.G. and Janicke,R.U.
TITLE Molecular cloning and characterization of two novel pro-apoptotic
isoforms of caspase-10
JOURNAL J. Biol. Chem. 274 (15), 10301-10308 (1999)
PUBMED 10187817
REFERENCE 7 (bases 1 to 5777)
AUTHORS Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J.,
Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G.
et al.
TITLE Mch3, a novel human apoptotic cysteine protease highly related to
CPP32
JOURNAL Cancer Res. 55 (24), 6045-6052 (1995)
PUBMED 8521391
REFERENCE 8 (bases 1 to 5777)
AUTHORS DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
Calos,M.P.
TITLE Analysis of mutation in human cells by using an Epstein-Barr virus
shuttle system
JOURNAL Mol. Cell. Biol. 7 (1), 379-387 (1987)
PUBMED 3031469
REFERENCE 9 (bases 1 to 5777)
AUTHORS Clements,G.B., Klein,G. and Povey,S.
TITLE Production by EBV infection of an EBNA-positive subline from an
EBNA-negative human lymphoma cell line without detectable EBV DNA
JOURNAL Int. J. Cancer 16 (1), 125-133 (1975)
PUBMED 170210
REFERENCE 10 (bases 1 to 5777)
AUTHORS Baumann,K., de Rouffignac,C., Roinel,N., Rumrich,G. and
Ullrich,K.J.
TITLE Renal phosphate transport: inhomogeneity of local proximal
transport rates and sodium dependence
JOURNAL Pflugers Arch. 356 (4), 287-298 (1975)
PUBMED 1171445
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA456072.1, U60519.1,
BC042844.1 and AC007283.3.
On May 18, 2006 this sequence version replaced gi:47078266.
Summary: This gene encodes a protein which is a member of the
cysteine-aspartic acid protease (caspase) family. Sequential
activation of caspases plays a central role in the execution-phase
of cell apoptosis. Caspases exist as inactive proenzymes which
undergo proteolytic processing at conserved aspartic residues to
produce two subunits, large and small, that dimerize to form the
active enzyme. This protein cleaves and activates caspases 3 and 7,
and the protein itself is processed by caspase 8. Mutations in this
gene are associated with type IIA autoimmune lymphoproliferative
syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively
spliced transcript variants encoding different isoforms have been
described for this gene. [provided by RefSeq, Apr 2011].
Transcript Variant: This variant (3) lacks two in-frame coding
exons compared to variant 1. This results in a shorter isoform (3,
also known as Mch4 and caspase-10/a) missing an internal protein
segment compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U60519.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025087 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-136 DA456072.1 18-153
137-545 DA456072.1 155-563
546-1852 U60519.1 275-1581
1853-2061 BC042844.1 1718-1926
2062-2524 AC007283.3 18113-18575 c
2525-4197 U60519.1 1864-3536
4198-5777 AC007283.3 14860-16439 c
FEATURES Location/Qualifiers
source 1..5777
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q33-q34"
gene 1..5777
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="caspase 10, apoptosis-related cysteine peptidase"
/db_xref="GeneID:843"
/db_xref="HGNC:1500"
/db_xref="HPRD:03458"
/db_xref="MIM:601762"
exon 1..411
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 59
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:41429849"
variation 213
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:16836789"
variation 229..230
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="c"
/db_xref="dbSNP:34296231"
variation 366..367
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="c"
/db_xref="dbSNP:35190763"
misc_feature 407..409
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="upstream in-frame stop codon"
exon 412..765
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
CDS 419..1858
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/EC_number="3.4.22.63"
/note="isoform 3 preproprotein is encoded by transcript
variant 3; caspase 10, apoptosis-related cysteine
protease; FADD-like ICE2; apoptotic protease MCH-4;
ICE-like apoptotic protease 4; interleukin-1B-converting
enzyme 2; caspase-10; CASP-10; FAS-associated death domain
protein interleukin-1B-converting enzyme 2"
/codon_start=1
/product="caspase-10 isoform 3 preproprotein"
/protein_id="NP_001221.2"
/db_xref="GI:47078267"
/db_xref="CCDS:CCDS2339.1"
/db_xref="GeneID:843"
/db_xref="HGNC:1500"
/db_xref="HPRD:03458"
/db_xref="MIM:601762"
/translation="
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
"
misc_feature 470..715
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="The Death Domain Superfamily of protein-protein
interaction domains; Region: DD_superfamily; cl14633"
/db_xref="CDD:209876"
misc_feature 752..988
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="Death Effector Domain, repeat 2, of Caspase-10;
Region: DED_Caspase_10_repeat2; cd08814"
/db_xref="CDD:176792"
misc_feature order(755..757,764..769,773..778,788..790,866..868,
878..880)
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="putative DED1/DED2 interface [polypeptide binding];
other site"
/db_xref="CDD:176792"
misc_feature 1064..1066
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1073..1075
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03458"
mat_peptide 1076..1534
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/product="caspase-10 isoform 3 large subunit"
misc_feature 1112..1831
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="Caspase, interleukin-1 beta converting enzyme (ICE)
homologues; Cysteine-dependent aspartate-directed
proteases that mediate programmed cell death (apoptosis).
Caspases are synthesized as inactive zymogens and
activated by proteolysis of the peptide...; Region: CASc;
cd00032"
/db_xref="CDD:28914"
misc_feature order(1187..1189,1364..1366,1484..1486,1505..1507,
1628..1645,1655..1660)
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="substrate pocket [chemical binding]; other site"
/db_xref="CDD:28914"
misc_feature order(1361..1363,1490..1492)
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="active site"
/db_xref="CDD:28914"
misc_feature order(1508..1510,1583..1588,1607..1609,1616..1618,
1625..1627,1694..1696,1721..1723,1739..1741,1781..1783,
1796..1801,1805..1807,1814..1819)
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28914"
misc_feature order(1511..1513,1580..1582)
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/note="proteolytic cleavage site; other site"
/db_xref="CDD:28914"
mat_peptide 1535..1855
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/product="caspase-10 isoform 3 small subunit"
variation 438
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200935960"
variation 480
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140813639"
variation 507
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:201782416"
variation 512
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375838979"
variation 544
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:146684884"
variation 560
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200012872"
variation 575
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804650"
variation 592
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:114625983"
variation 594
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:139417609"
variation 595
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:3900115"
variation 644
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:146696981"
variation 673
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:185792819"
variation 689
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148026756"
variation 700
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370492434"
variation 732
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200530667"
variation 743
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201601111"
variation 750
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:199600895"
exon 766..859
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 845
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376343637"
variation 858
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:121909776"
exon 860..995
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 920
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371962581"
variation 952
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:146233833"
variation 968
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200877813"
variation 971
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369231920"
exon 996..1102
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 1014
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200079223"
variation 1033
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373077581"
variation 1084
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:116125703"
variation 1100
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370134219"
variation 1101
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143882052"
variation 1102
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368583939"
exon 1103..1211
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 1105
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:113867411"
variation 1135
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:372906837"
variation 1142
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:17860403"
variation 1145
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:111719534"
variation 1168
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:369897442"
variation 1176
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:146654699"
variation 1202
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149912574"
exon 1212..1704
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 1219
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:149096064"
variation 1242
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:138931498"
variation 1272
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200424779"
STS 1299..1669
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/standard_name="PMC230316P3"
/db_xref="UniSTS:272181"
variation 1304
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:111775921"
variation 1312
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:114098515"
variation 1328
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:115264962"
variation 1357
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:111489269"
variation 1375
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369304578"
variation 1378
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148290917"
variation 1406
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372719084"
variation 1413
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375798142"
variation 1421
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:370138285"
variation 1486
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199626441"
variation 1505
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:80358239"
variation 1516
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371401141"
variation 1517
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:13010627"
variation 1530
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:28936699"
variation 1543
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140190607"
variation 1556
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:374332152"
variation 1585
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:41331850"
variation 1586
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200540853"
variation 1619
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:41513147"
variation 1626
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:17860405"
variation 1636
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147814983"
variation 1639
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:370670949"
variation 1684
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:199853584"
exon 1705..5777
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/inference="alignment:Splign:1.39.8"
variation 1741
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375762220"
variation 1748
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:376911298"
variation 1766
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:369901008"
variation 1791
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148939095"
variation 1826
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143632134"
variation 1851
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:200836551"
variation 1853
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:13006529"
variation 1870
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375389117"
variation 1892
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:377581981"
variation 1897
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372456822"
variation 1898
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:199884991"
variation 1935
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:191438878"
variation 1958
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:182870266"
variation 2099
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370987136"
variation 2135
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:3931696"
variation 2143
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:3851974"
variation 2225
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:41365346"
variation 2523
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142072849"
variation 2592
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="t"
/db_xref="dbSNP:41506545"
variation 2611
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:186862746"
variation 2673
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:17860409"
variation 2704
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41529249"
variation 2773
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:115679933"
STS 2842..3052
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/standard_name="RH70685"
/db_xref="UniSTS:32193"
variation 2995
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:374014099"
variation 3027
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:185024061"
variation 3036
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:187888242"
variation 3168
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:77842514"
variation 3188
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:41342848"
variation 3198
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:367793804"
variation 3300
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:372084524"
variation 3329
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:192319559"
variation 3378
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:41331447"
variation 3395
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:78596960"
variation 3400
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41484449"
variation 3482
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:150841386"
STS 3531..4381
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/standard_name="CASP10_482"
/db_xref="UniSTS:277051"
variation 3546
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41515650"
variation 3575
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149971137"
variation 3600
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145632258"
variation 3651
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:114760847"
variation 3682
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:199729683"
variation 3686
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:373636173"
variation 3772
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:185318287"
variation 3778
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:11885191"
variation 3813
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:139807893"
variation 3819
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:368898723"
variation 3823
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="t"
/db_xref="dbSNP:111572089"
variation 3824
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:79528144"
STS 3920..4043
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/standard_name="RH77986"
/db_xref="UniSTS:65780"
variation 4004
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147622791"
STS 4006..4136
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/standard_name="RH68751"
/db_xref="UniSTS:47132"
variation 4039
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:41443046"
variation 4147
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:41369551"
variation 4409
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:189798514"
variation 4445
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="t"
/db_xref="dbSNP:199859568"
variation 4446
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace=""
/replace="g"
/db_xref="dbSNP:41351949"
variation 4448
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:74267227"
variation 4453
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:72491092"
variation 4460
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41477650"
variation 4476
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41431151"
variation 4533
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376034565"
variation 4547
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41447745"
variation 4556
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:181477362"
variation 4584
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:372156178"
variation 4595
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41412149"
variation 4615
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:13414860"
variation 4618
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:41435647"
variation 4689
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:151162733"
variation 4708
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376511354"
variation 4869
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368336354"
variation 4895
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140099864"
variation 4929
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:41339144"
variation 4995
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="g"
/db_xref="dbSNP:41522046"
variation 5371
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:6752492"
variation 5417
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:184599061"
variation 5431
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368946094"
variation 5550
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:202089864"
variation 5551
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199723186"
variation 5552
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="g"
/replace="t"
/db_xref="dbSNP:200619033"
variation 5554
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="t"
/db_xref="dbSNP:201705079"
variation 5646
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:111444762"
variation 5650
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="c"
/replace="t"
/db_xref="dbSNP:41486645"
variation 5724
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
/replace="a"
/replace="c"
/db_xref="dbSNP:41486549"
polyA_signal 5756..5761
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
polyA_site 5776
/gene="CASP10"
/gene_synonym="ALPS2; FLICE2; MCH4"
ORIGIN
aaggaaatggagatccaaaggaaagcctgaagcactttgtggcttccacgggttcgtttctaggaagcttttgctttacctggggaaaccccaagctctacagtgagaaagttgtaaattagcctttaggagacgctgtttgtcaaagttatcttaaccctggaaaaggggagggaaaaaggcagataagcagtgatgacatcagcaggaaactagtatcaggctacccagtcctgaagattcagttttcacttaaacaaccagcaagtcttgaagtctcttcccaagcaaatgggagcttctttggaccttggagcacacagaggattctactttctttaaaactttgttttcaggcaatttccctgagaaccgtttacttccagaagattggtggagcttgatctgaaggctggccatgaaatctcaaggtcaacattggtattccagttcagataaaaactgtaaagtgagctttcgtgagaagcttctgattattgattcaaacctgggggtccaagatgtggagaacctcaagtttctctgcataggattggtccccaacaagaagctggagaagtccagctcagcctcagatgtttttgaacatctcttggcagaggatctgctgagtgaggaagaccctttcttcctggcagaactcctctatatcatacggcagaagaagctgctgcagcacctcaactgtaccaaagaggaagtggagcgactgctgcccacccgacaaagggtttctctgtttagaaacctgctctacgaactgtcagaaggcattgactcagagaacttaaaggacatgatcttccttctgaaagactcgcttcccaaaactgaaatgacctccctaagtttcctggcatttctagagaaacaaggtaaaatagatgaagataatctgacatgcctggaggacctctgcaaaacagttgtacctaaacttttgagaaacatagagaaatacaaaagagagaaagctatccagatagtgacacctcctgtagacaaggaagccgagtcgtatcaaggagaggaagaactagtttcccaaacagatgttaagacattcttggaagccttaccgagggcagctgtgtacaggatgaatcggaaccacagaggcctctgtgtcattgtcaacaaccacagctttacctccctgaaggacagacaaggaacccataaagatgctgagatcctgagtcatgtgttccagtggcttgggttcacagtgcatatacacaataatgtgacgaaagtggaaatggagatggtcctgcagaagcagaagtgcaatccagcccatgccgacggggactgcttcgtgttctgtattctgacccatgggagatttggagctgtctactcttcggatgaggccctcattcccattcgggagatcatgtctcacttcacagccctgcagtgccctagactggctgaaaaacctaaactctttttcatccaggcctgccaaggtgaagagatacagccttccgtatccatcgaagcagatgctctgaaccctgagcaggcacccacttccctgcaggacagtattcctgccgaggctgacttcctacttggtctggccactgtcccaggctatgtatcctttcggcatgtggaggaaggcagctggtatattcagtctctgtgtaatcatctgaagaaattggtcccaagacatgaagacatcttatccatcctcactgctgtcaacgatgatgtgagtcgaagagtggacaaacagggaacaaagaaacagatgccccagcctgctttcacactaaggaaaaaactagtattccctgtgcccctggatgcactttcattatagcagagagtttttgttggttcttagacctcaaacgaatcattggctataacctccagcctcctgcccagcacaggaatcggtggtctccacctgtcattctagaaacaggaaacaccgtgttttctgacacagtcaattctgattttctttttcttttgcaagtctaaatgttagaaaactttcttttttttggagatagtctcattctgtcacccagactggagtgcaggggggcaatcacggctcactgtagtctcgacctcccaggctcaagctgtcctcccgcctcagcttcccaagtagctgggaccacaggtgtgtaccaccgtgcccggattttttttattctttattttttgtagagatggagggatctcactttgttgcacaggctggtttcaaactcctaggcccaagtgatcctcccacctctgtccccaaaatactgggattataggcacgagccaccacacctggccagaaaactttcattattgaagacttggattgtagccttggttttggatgtctattctgaagacagagtaattggctttggtttgtgcaggtactttttctttgagacagagtcactccgtcacctgggctggagtgcagtggtgggatcactgttcactgcagccttgacctcccaggttcaagcgatcctcccacctcagcctcccaagtagctgagactacaggtgtgtgtccatgcacagctaactttttattttttttgtggagatggggtttcactatgttgcctaagctggtctcaaactcctgggctcaagcgatcctcccacctcagcttctcaaagttctgggactacaggcatgaaatactgtgcctggcctggggaccaggtgcattttaaggttccttggtgttcaaaaaccacgttcttagcctagattgagcttagattgcctctctagacaactaccccttagttataattctgtgtcccctctgcatgcccttaaacattggacagtgaggtcacagtccacccaccctctctctgatctcccccttcctaagacttctcttttgcacatctagtgaggtgaaaatttggtctatgccaggcccatttcctgcttttgtgtaaggaaggtgctcacataggaagtttttatttggttagagacaggtttccctgtaggaagatgatggctcatttacactcagctgctctgcaagcagaaactttacaacctgatgtcatattccattttggactgggtgcggtgactcatgcctgtaatcccagtactctgggaagccaaggcaggcagatcacttgaggtcaggagttcgagaccagcctggccaatacggcaaaacctcatcattactaaaaacacaaaaattagccaggtgtggcggcgagcacctgtaatcccagctactcgggaggctgagacaggagaatctcttgaatccaggaggcagaggctgtggtgagccaagatgacacaactgcactccagcttgggcaacagggcgagaccttgtttaaaaaaaaaattcaatattggggttggaacatttcagttgccattgacagaacacccaattcaaattgactgaagcaaagaagggaatttattgcctctttcacattgaaacccaggagtggataacactggcttcaggcaaagcttgaatcaggactcaatctacaggccagcacctttctcttggccggatgtcctcagggctggcagatgcagtagactgcagtggacagtccccaccttgttactgctactacactttgctcctctggcccaaggcatgaggagagaggctgtgtcagaaactgaagctgttctcaggatcactgggctcttcttggcagaggggatgtctggcttgcctgaagggagtggctctgtaaggacgccttgatgctttcttcattaagattttgagcatttttacgtacttgagcttttttttttttttttttcaatttctagaggaactttttctctgttaattcctggaactgtattttgaatccttaaaggtgagccctcatagggagatccaaagtcctgtggttaacgccttcatttatagatgaggcagctgaggcctggggatgtgaacaacctgctcacagtcctcatttactggatttgacttcagccaggtgaactggaatgccttggggcgtggaagggcattaggagtgtttcatttgatatgtgaatgctcataaaaaaatgtcaaggaatgaagaacaacaactctcagtggtgcctgcatttataattatttatgtgaaagtcaaattcatgtacagtaaatttgttataagaatattcacaagaacactgttctgatatctctgattgtcatgtggatttgaatgtagcttgacagagggaatgtctaatctatattgacagggcaggaacaccgtcatcttagacaaacaccgccactttaagttccagttccctttctagcctcatgcatttcaaggaaatcacttcttttctaacagcgagcagccagaaagagaagagagtaaaatacagataagacagctctggcatagagggaggtgggggggtgggggaagtctcttgggtaactgccaaactttgccttcatacaatgggttccaggaaaacaatgagccttaataagcacattcctttcccttcaggtgcactaagtggggaagctaaaagcagactggaggggggtggggtgtacctacagctgcagaaatattgtatgggaacggacacacaactctccctcccagataagcacagcaaagagacatagaagcaatccaagcctctgataaactctcccaccctaaatccttaaaaactcttagtctgtaagtgagtgggctctgacctaactcggccagaagcccctttcaaatttgttttctctaaaataaacctgtccttggctgtcaagccacctttcatgtttctttcctctttctttaattcttacacatgtgtcaggatgatctcccaaaaccgtgttcataacagtcagggccaaaagctagtggtcacagtccttgtccagttggcagaactgacatgtgaaggcaagtgaaggatggtgagatactgaggaaagagcaaaggatctggagatcaaagccctgcatttccattttgtcctgattcctttgctcagagacactaactaaatcaagctagcttttttcagccttgtctgtaaagtagagaaaacattagctgttgggaagacgaaaaagaatgtgtcctatgtgtgcatctatttaaatctaactgtgctgaggtgcatataaatgcctttaggtggtagggtcttccggttgtaactgcaacagaaatagcaggacttaagttcctttgtgcgtaattccagctgactttattagcggcaactcagcactagcattacccctgacatactctgagtaagatctaattcttccctcactggttcgtgatgtctaccgcagcagaaggccagctcttgactctgagttcagttggacaaaatgctgttgataaaacctcctgtcaggcctctgagcccaagctaagccatcatatcccttgtgacctgcacatatatatccagatggcctgaagtaactgaagaatcacaaaagaagtgaaaatggcctgttcctgccttaactgatgacattaccttgtgaaattccttctcctggctcatcctggctcaaaagctcccccagtgagcaccttgtgacccccatccctgccagccagagaacaaccccctttgactgtaattttccactacttacccaaatcctataaaacggccccacccctatctcccttcactgactttcttttcggactcagcccacctgcacccaggtgattaaaaagctttattgctcac
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:843 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IEA
GeneID:843 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:843 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:843 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:843 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: RCA
GeneID:843 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:843 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:843 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:843 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001221 -> EC 3.4.22.63
by
@meso_cacase at
DBCLS
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