2024-04-24 14:14:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001228 2914 bp mRNA linear PRI 09-JUN-2013 DEFINITION Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant A, mRNA. ACCESSION NM_001228 VERSION NM_001228.4 GI:122056470 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2914) AUTHORS Hong,S., Kim,H.Y., Kim,J., Ha,H.T., Kim,Y.M., Bae,E., Kim,T.H., Lee,K.C. and Kim,S.J. TITLE Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis JOURNAL J. Biol. Chem. 288 (5), 3560-3570 (2013) PUBMED 23255602 REMARK GeneRIF: Smad7 was able to activate the caspase 8 promoter through recruitment of the interferon regulatory factor 1 (IRF1) transcription factor to the interferon-stimulated response element (ISRE) site. REFERENCE 2 (bases 1 to 2914) AUTHORS Apelbaum,A., Yarden,G., Warszawski,S., Harari,D. and Schreiber,G. TITLE Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands JOURNAL Mol. Cell. Biol. 33 (4), 800-814 (2013) PUBMED 23230268 REMARK GeneRIF: Apoptosis-related genes such as the caspase-8, FLIP, and DR5 genes specifically interfere with interferon-induced apoptosis. REFERENCE 3 (bases 1 to 2914) AUTHORS Erdman,V.V., Nasibullin,T.R., Tuktarova,I.A. and Mustafina,O.E. TITLE [Association of polymorphic markers of CASP8, BCL2 and BAX genes with aging and longevity] JOURNAL Adv Gerontol 25 (3), 398-404 (2012) PUBMED 23289213 REMARK GeneRIF: An increase of genotype frequency of BCL2*C/*C and decrease of genotype frequency of CASP8*I/*D was observed in male of senile age REFERENCE 4 (bases 1 to 2914) AUTHORS Li,S.X., Chai,L., Cai,Z.G., Jin,L.J., Chen,Y., Wu,H.R. and Sun,Z. TITLE Expression of survivin and caspase 3 in oral squamous cell carcinoma and peritumoral tissue JOURNAL Asian Pac. J. Cancer Prev. 13 (10), 5027-5031 (2012) PUBMED 23244104 REMARK GeneRIF: Low expression of caspase 3 is associated with oral squamous cell carcinoma and peritumoral tissue. REFERENCE 5 (bases 1 to 2914) AUTHORS Kominami,K., Nagai,T., Sawasaki,T., Tsujimura,Y., Yashima,K., Sunaga,Y., Tsuchimochi,M., Nishimura,J., Chiba,K., Nakabayashi,J., Koyamada,K., Endo,Y., Yokota,H., Miyawaki,A., Manabe,N. and Sakamaki,K. TITLE In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis JOURNAL PLoS ONE 7 (11), E50218 (2012) PUBMED 23185580 REMARK GeneRIF: Focal activation of CASP8 is sufficient to propagate apoptotic signals through death receptors. REFERENCE 6 (bases 1 to 2914) AUTHORS Breckenridge,D.G., Nguyen,M., Kuppig,S., Reth,M. and Shore,G.C. TITLE The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (7), 4331-4336 (2002) PUBMED 11917123 REFERENCE 7 (bases 1 to 2914) AUTHORS Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J., Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G. et al. TITLE Mch3, a novel human apoptotic cysteine protease highly related to CPP32 JOURNAL Cancer Res. 55 (24), 6045-6052 (1995) PUBMED 8521391 REFERENCE 8 (bases 1 to 2914) AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. TITLE CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994) PUBMED 7983002 REFERENCE 9 (bases 1 to 2914) AUTHORS DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and Calos,M.P. TITLE Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system JOURNAL Mol. Cell. Biol. 7 (1), 379-387 (1987) PUBMED 3031469 REFERENCE 10 (bases 1 to 2914) AUTHORS Clements,G.B., Klein,G. and Povey,S. TITLE Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA JOURNAL Int. J. Cancer 16 (1), 125-133 (1975) PUBMED 170210 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420056.1, U60520.1, BC028223.2, AC007256.5 and AI351872.1. This sequence is a reference standard in the RefSeqGene project. On Jan 12, 2007 this sequence version replaced gi:73623018. Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U60520.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025084, ERS025088 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 DA420056.1 1-47 48-1204 U60520.1 1-1157 1205-1658 BC028223.2 1014-1467 1659-2639 AC007256.5 130031-131011 c 2640-2914 AI351872.1 1-275 c FEATURES Location/Qualifiers source 1..2914 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q33-q34" gene 1..2914 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="caspase 8, apoptosis-related cysteine peptidase" /db_xref="GeneID:841" /db_xref="HGNC:1509" /db_xref="HPRD:03459" /db_xref="MIM:601763" exon 1..180 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 161 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="g" /replace="t" /db_xref="dbSNP:34609836" variation 163 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:13020440" exon 181..277 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" misc_feature 274..276 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="upstream in-frame stop codon" exon 278..608 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 292 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="c" /db_xref="dbSNP:200484909" CDS 304..1794 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /EC_number="3.4.22.61" /note="isoform A precursor is encoded by transcript variant A; caspase 8, apoptosis-related cysteine protease; FADD-homologous ICE/CED-3-like protease; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; FADD-like ICE; apoptotic protease Mch-5; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog" /codon_start=1 /product="caspase-8 isoform A precursor" /protein_id="NP_001219.2" /db_xref="GI:15718704" /db_xref="CCDS:CCDS42799.1" /db_xref="GeneID:841" /db_xref="HGNC:1509" /db_xref="HPRD:03459" /db_xref="MIM:601763" /translation="
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
" misc_feature 310..555 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="Death effector domain, repeat 1, of Caspase-8; Region: DED_Caspase_8_repeat1; cd08333" /db_xref="CDD:176745" misc_feature order(349..354,364..366,373..378,382..387,493..495, 505..507) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="putative DED1/DED2 interface [polypeptide binding]; other site" /db_xref="CDD:176745" misc_feature order(355..357,514..516,520..522) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="charge triad; other site" /db_xref="CDD:176745" misc_feature 688..690 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" misc_feature 703..939 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633" /db_xref="CDD:209876" misc_feature 982..984 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" misc_feature 1000..1002 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" mat_peptide 1003..1323 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /product="caspase-8 isoform A subunit p18" misc_feature 1009..1011 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1027..1785 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cd00032" /db_xref="CDD:28914" misc_feature order(1132..1134,1306..1308,1426..1428,1447..1449, 1582..1599,1609..1614) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="substrate pocket [chemical binding]; other site" /db_xref="CDD:28914" misc_feature order(1303..1305,1432..1434) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="active site" /db_xref="CDD:28914" misc_feature order(1450..1452,1537..1542,1561..1563,1570..1572, 1579..1581,1648..1650,1675..1677,1693..1695,1735..1737, 1750..1755,1759..1761,1768..1773) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:28914" misc_feature order(1453..1455,1534..1536) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="proteolytic cleavage site; other site" /db_xref="CDD:28914" misc_feature 1474..1476 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" misc_feature 1504..1506 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" STS 304..549 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="RH70951" /db_xref="UniSTS:19740" variation 387 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368413113" variation 402 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="g" /replace="t" /db_xref="dbSNP:138862018" variation 462 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:200261147" variation 477 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:374717331" variation 560 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:61995876" variation 565 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:374010917" variation 605 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:376330981" exon 609..704 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 613 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:371728950" variation 618 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:377216101" variation 623 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:368609027" variation 625 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:372378810" variation 635 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="c" /db_xref="dbSNP:376590303" variation 697 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:11897628" exon 705..810 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 738 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:17860422" variation 769 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:373203074" variation 786 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368684291" variation 798 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:150515363" exon 811..949 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 830 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:142688117" variation 831 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:149933993" variation 842 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:148697064" variation 851 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:367807709" variation 894 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:201525799" exon 950..1014 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 994 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="g" /replace="t" /db_xref="dbSNP:146816437" variation 1009 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:35976359" exon 1015..1156 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 1033 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:143410219" variation 1096 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:17860424" variation 1121 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:112383550" variation 1143 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:35142591" exon 1157..1658 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 1169 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:139337151" variation 1197 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="c" /db_xref="dbSNP:199934929" variation 1206 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:138030956" variation 1207 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:1045485" variation 1245 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860426" variation 1246 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:146286958" STS 1248..1627 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="PMC230316P2" /db_xref="UniSTS:272180" variation 1266 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:139361998" variation 1273 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:148960588" variation 1314 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045487" variation 1326 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368087314" variation 1335 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:372973743" variation 1402 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:202185417" variation 1440 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:377204617" variation 1491 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:369704935" variation 1523 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:373673288" variation 1535..1536 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="c" /db_xref="dbSNP:34208389" variation 1536 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:190041873" variation 1538 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="t" /db_xref="dbSNP:150243843" exon 1659..2911 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 1846 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:34857899" variation 1854 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:13425113" STS 1857..1959 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="D11S2921" /db_xref="UniSTS:152074" STS 1864..1953 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="PMC156606P1" /db_xref="UniSTS:271408" variation 1865 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:41309822" variation 1877 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860428" variation 1892 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:36155452" variation 1893 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:13425383" variation 1901 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:184368293" variation 1909 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:370257689" variation 1916 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:3185378" variation 1940 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:201516518" variation 1960 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:35474602" variation 1969 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:2141331" STS 2076..2494 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="GDB:631813" /db_xref="UniSTS:158430" variation 2110 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:35419671" variation 2205 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:17860432" variation 2223 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860433" variation 2258 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:1045494" variation 2272 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045495" variation 2385 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:187758494" variation 2457 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:193117251" variation 2469 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:368491883" variation 2500 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:11551927" variation 2549 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:145519245" STS 2552..2697 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="RH78960" /db_xref="UniSTS:4072" variation 2568 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1128421" variation 2583 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1128423" variation 2585 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045501" variation 2606..2607 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="aa" /db_xref="dbSNP:71769639" variation 2615 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="t" /db_xref="dbSNP:34552705" variation 2639 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="t" /db_xref="dbSNP:13113" variation 2667 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:371966481" variation 2720..2721 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="at" /db_xref="dbSNP:34461625" variation 2721..2722 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="at" /db_xref="dbSNP:373026882" polyA_signal 2888..2893 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" polyA_site 2909 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" polyA_site 2911 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" ORIGIN
gtgctctgagtttttggtttctgtttcaccttgtgtctgagctggtctgaaggctggttgttcagactgagcttcctgcctgcctgtaccccgccaacagcttcagaagaaggtgactggtggctgcctgaggaataccagtgggcaagagaattagcatttctggagcatctgctgtctgagcagcccctgggtgcgtccactttctgggcacgtgaggttgggccttggccgcctgagcccttgagttggtcacttgaaccttgggaatattgagattatattctcctgccttttaaaaagatggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcctccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggatgccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtccttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaacactagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcctacaggttccacttctgccgcatgagctgggctgaagcaaacagccagtgccagacacagtctgtacctttctggcggagggtcgatcatctattaataagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtcttttaagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctggatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctgaaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaattcagcaaaggggaggagttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacagactttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaacaatcacaattttgcaaaagcacgggagaaagtgcccaaacttcacagcattagggacaggaatggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgagatcaagccccacgatgactgcacagtagagcaaatctatgagattttgaaaatctaccaactcatggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaagggcatcatctatggcactgatggacaggaggcccccatctatgagctgacatctcagttcactggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgtcagggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctatttagaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctgctggggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctggtacatccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctcaccatcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatggggaaacagatgcctcagcctactttcacactaagaaaaaaacttgtcttcccttctgattgatggtgctattttgtttgttttgttttgttttgtttttttgagacagaatctcgctctgtcgcccaggctggagtgcagtggcgtgatctcggctcaccgcaagctccgcctcccgggttcaggccattctcctgcctcagcctcccgagtagctgggactacaggggcccgccaccacacctggctaattttttaaaaatatttttagtagagacagggtttcactgtgttagccagggtggtcttgatctcctgacctcgtgatccacccacctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgcctggccgatggtactatttagatataacactatgtttatttactaattttctagattttctactttattaattgttttgcacttttttataagagctaaagttaaataggatattaacaacaataacactgtctcctttctcttatgcttaaggctttgggaatgtttttagctggtggcaataaataccagacacgtacaaaatccagctatgaatatagagggcttatgattcagattgttatctatcaactataagcccactgttaatattctattaactttaattctctttcaaagctaaattccacactaccacattaaaaaaattagaaagtagccacgtatggtggctcatgtctataatcccagcactttgggaggttgaggtgggaggattgcttgaacccaagaggtcaaggctgcagtgagccatgttcacaccgctgcactcaagcttgggtgacagaacaagaccccgtctcaaaaaaaattttttttttaataaaacaaaatttgtttgaaatcttttaaaaattcaaatgatttttacaagttttaaataagctctccccaaacttgctttatgccttcttattgcttttatgatatatatatgcttggctaactatatttgctttttgctaacaatgctctggggtctttttatgcatttgcatttgctctttcatctctgcttggattattttaaatcattaggaattaagttatctttaaaatttaagtatcttttttcaaaaacattttttaatagaataaaatataatttgatcttattaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:841 -> Molecular function: GO:0002020 [protease binding] evidence: IPI GeneID:841 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IDA GeneID:841 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: TAS GeneID:841 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IEA GeneID:841 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:841 -> Molecular function: GO:0008234 [cysteine-type peptidase activity] evidence: TAS GeneID:841 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:841 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA GeneID:841 -> Biological process: GO:0001841 [neural tube formation] evidence: IEA GeneID:841 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0006508 [proteolysis] evidence: IDA GeneID:841 -> Biological process: GO:0006915 [apoptotic process] evidence: IGI GeneID:841 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:841 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS GeneID:841 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:841 -> Biological process: GO:0007507 [heart development] evidence: IEA GeneID:841 -> Biological process: GO:0009409 [response to cold] evidence: IEA GeneID:841 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:841 -> Biological process: GO:0030225 [macrophage differentiation] evidence: IEA GeneID:841 -> Biological process: GO:0032025 [response to cobalt ion] evidence: IEA GeneID:841 -> Biological process: GO:0032355 [response to estradiol stimulus] evidence: IEA GeneID:841 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA GeneID:841 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IMP GeneID:841 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP GeneID:841 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:841 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:841 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:841 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA GeneID:841 -> Biological process: GO:0045651 [positive regulation of macrophage differentiation] evidence: IMP GeneID:841 -> Biological process: GO:0045862 [positive regulation of proteolysis] evidence: IDA GeneID:841 -> Biological process: GO:0046677 [response to antibiotic] evidence: IEA GeneID:841 -> Biological process: GO:0051291 [protein heterooligomerization] evidence: IEA GeneID:841 -> Biological process: GO:0051603 [proteolysis involved in cellular protein catabolic process] evidence: IMP GeneID:841 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP GeneID:841 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: IMP GeneID:841 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IDA GeneID:841 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0097202 [activation of cysteine-type endopeptidase activity] evidence: IDA GeneID:841 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:841 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:841 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:841 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:841 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:841 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:841 -> Cellular component: GO:0005813 [centrosome] evidence: IDA GeneID:841 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:841 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS GeneID:841 -> Cellular component: GO:0030690 [Noc1p-Noc2p complex] evidence: IEA GeneID:841 -> Cellular component: GO:0031264 [death-inducing signaling complex] evidence: IDA GeneID:841 -> Cellular component: GO:0031265 [CD95 death-inducing signaling complex] evidence: IEA GeneID:841 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA GeneID:841 -> Cellular component: GO:0044297 [cell body] evidence: IEA GeneID:841 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001219 -> EC 3.4.22.61
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@meso_cacase at
DBCLS
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