2024-03-29 02:03:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001211 3749 bp mRNA linear PRI 01-JUL-2013 DEFINITION Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), mRNA. ACCESSION NM_001211 VERSION NM_001211.5 GI:168229167 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3749) AUTHORS Maciejczyk,A., Szelachowska,J., Czapiga,B., Matkowski,R., Halon,A., Gyorffy,B. and Surowiak,P. TITLE Elevated BUBR1 expression is associated with poor survival in early breast cancer patients: 15-year follow-up analysis JOURNAL J. Histochem. Cytochem. 61 (5), 330-339 (2013) PUBMED 23392733 REMARK GeneRIF: Elevated BUBR1 expression was associated with poor survival in early stage breast cancer patients REFERENCE 2 (bases 1 to 3749) AUTHORS Suijkerbuijk,S.J., Vleugel,M., Teixeira,A. and Kops,G.J. TITLE Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments JOURNAL Dev. Cell 23 (4), 745-755 (2012) PUBMED 23079597 REMARK GeneRIF: The PLK1 and BUBR1 cooperate to stabilize kinetochore-microtubule interactions by regulating PP2A-B56alpha-mediated dephosphorylation of Aurora B substrates at the kinetochore-microtubule interface. REFERENCE 3 (bases 1 to 3749) AUTHORS Guo,Y., Kim,C., Ahmad,S., Zhang,J. and Mao,Y. TITLE CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint JOURNAL J. Cell Biol. 198 (2), 205-217 (2012) PUBMED 22801780 REMARK GeneRIF: It was shown that the state of CENP-E-dependent BubR1 autophosphorylation in response to spindle microtubule capture by CENP-E is important for kinetochore function in achieving accurate chromosome segregation. REFERENCE 4 (bases 1 to 3749) AUTHORS Suijkerbuijk,S.J., van Dam,T.J., Karagoz,G.E., von Castelmur,E., Hubner,N.C., Duarte,A.M., Vleugel,M., Perrakis,A., Rudiger,S.G., Snel,B. and Kops,G.J. TITLE The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase JOURNAL Dev. Cell 22 (6), 1321-1329 (2012) PUBMED 22698286 REMARK GeneRIF: It was shown that Mad3/BUBR1 and BUB1 paralogous pairs arose by nine independent gene duplications throughout evolution. It was also shown that putative catalysis by human BUBR1 is dispensable for error-free chromosome segregation. REFERENCE 5 (bases 1 to 3749) AUTHORS Yang,F., Huang,Y. and Dai,W. TITLE Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing JOURNAL Cell Cycle 11 (4), 797-806 (2012) PUBMED 22374677 REMARK GeneRIF: Results reveal that BubR1 sumoylation plays an important role in its timely removal from the kinetochores and the checkpoint inactivation, thus allowing normal anaphase entry and chromosome segregation. REFERENCE 6 (bases 1 to 3749) AUTHORS Davenport,J.W., Fernandes,E.R., Harris,L.D., Neale,G.A. and Goorha,R. TITLE The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner JOURNAL Genomics 55 (1), 113-117 (1999) PUBMED 9889005 REFERENCE 7 (bases 1 to 3749) AUTHORS Chan,G.K., Schaar,B.T. and Yen,T.J. TITLE Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1 JOURNAL J. Cell Biol. 143 (1), 49-63 (1998) PUBMED 9763420 REFERENCE 8 (bases 1 to 3749) AUTHORS Taylor,S.S., Ha,E. and McKeon,F. TITLE The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase JOURNAL J. Cell Biol. 142 (1), 1-11 (1998) PUBMED 9660858 REFERENCE 9 (bases 1 to 3749) AUTHORS Donadelli,R., Benatti,L., Remuzzi,A., Morigi,M., Gullans,S.R., Benigni,A., Remuzzi,G. and Noris,M. TITLE Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress JOURNAL Biochem. Biophys. Res. Commun. 246 (3), 881-887 (1998) PUBMED 9618306 REFERENCE 10 (bases 1 to 3749) AUTHORS Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K., Markowitz,S.D., Kinzler,K.W. and Vogelstein,B. TITLE Mutations of mitotic checkpoint genes in human cancers JOURNAL Nature 392 (6673), 300-303 (1998) PUBMED 9521327 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025429.6, AF053306.1 and AI742619.1. This sequence is a reference standard in the RefSeqGene project. On Feb 21, 2008 this sequence version replaced gi:59814246. Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF053306.1, AB208782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025085 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-98 AC025429.6 79549-79646 99-1375 AF053306.1 71-1347 1376-1376 AC025429.6 115190-115190 1377-2554 AF053306.1 1349-2526 2555-2575 AC025429.6 128708-128728 2576-3729 AF053306.1 2548-3701 3730-3749 AI742619.1 1-20 c FEATURES Location/Qualifiers source 1..3749 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q15" gene 1..3749 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="BUB1 mitotic checkpoint serine/threonine kinase B" /db_xref="GeneID:701" /db_xref="HGNC:1149" /db_xref="MIM:602860" exon 1..247 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 20 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:191062828" variation 50 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:371647847" misc_feature 54..56 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="upstream in-frame stop codon" variation 98 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:2277559" variation 118 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:375434078" variation 171 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:183777343" CDS 213..3365 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /EC_number="2.7.11.1" /note="MAD3/BUB1-related protein kinase; mitotic checkpoint kinase MAD3L; budding uninhibited by benzimidazoles 1 homolog beta" /codon_start=1 /product="mitotic checkpoint serine/threonine-protein kinase BUB1 beta" /protein_id="NP_001202.4" /db_xref="GI:59814247" /db_xref="CCDS:CCDS10053.1" /db_xref="GeneID:701" /db_xref="HGNC:1149" /db_xref="MIM:602860" /translation="
MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETAQQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGALLFQ
" misc_feature 381..749 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="Mad3/BUB1 homology region 1; Region: Mad3_BUB1_I; pfam08311" /db_xref="CDD:191994" misc_feature 543..566 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (O60566.3); Region: Nuclear localization signal (Potential)" misc_feature 666..767 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (O60566.3); Region: Necessary for interaction with CASC5" misc_feature 882..908 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (O60566.3); Region: D-box" misc_feature 960..962 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, by PCAF; propagated from UniProtKB/Swiss-Prot (O60566.3); acetylation site" misc_feature 1515..1517 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 1839..1841 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 1947..1952 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by caspase-3; propagated from UniProtKB/Swiss-Prot (O60566.3); cleavage site" misc_feature 2040..2045 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by caspase-3; propagated from UniProtKB/Swiss-Prot (O60566.3); cleavage site" misc_feature 2220..2222 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 2238..2240 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PLK1; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 2586..2588 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by PLK1; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature order(2589..2591,2595..2597,2715..2717,2721..2729, 2739..2741,2745..2747,2856..2858,2862..2864,2868..2870, 2874..2876,2943..2945,2952..2954,2997..2999) /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="active site" /db_xref="CDD:173623" misc_feature order(2589..2591,2595..2597,2715..2717,2721..2729, 2739..2741,2856..2858,2862..2864,2868..2870,2874..2876, 2943..2945) /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature <2721..>2972 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:213116" misc_feature order(2739..2741,2745..2747,2856..2858,2862..2864, 2868..2870,2952..2954,2997..2999) /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(2940..2960,2997..2999) /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /note="activation loop (A-loop); other site" /db_xref="CDD:173623" misc_feature 3234..3236 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by PLK1; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 3336..3338 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" misc_feature 3336..3338 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 3339..3341 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (O60566.3); phosphorylation site" variation 221 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:7168394" variation 222 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:147549987" variation 227 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:374433718" variation 230 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:142313305" exon 248..391 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 273 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:201360106" variation 331 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:56079734" variation 337 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:368079817" variation 344 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:371958222" variation 363 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:375885859" exon 392..451 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 411 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:200884355" variation 414..415 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="t" /db_xref="dbSNP:67905862" exon 452..596 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 459 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:147832586" variation 467 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:140273483" variation 494 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:1801389" variation 530 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:186580106" variation 534 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:373830262" variation 560 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:28989189" exon 597..793 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 599 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:149153123" variation 610 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:35923791" variation 696 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:77520855" variation 754 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:375798678" variation 762 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:145028054" variation 767 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:139794931" variation 785 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:138809057" variation 792 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:28989186" exon 794..963 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 877 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:199509124" variation 890 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:142284213" variation 915..916 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="a" /db_xref="dbSNP:68167836" variation 943 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:56158360" exon 964..1178 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 984 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:146387899" variation 995 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:376912927" variation 1017 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:148159407" variation 1033 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:199743655" variation 1084 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:371305662" variation 1109 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:374307209" variation 1139 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:200669983" variation 1157 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:200135586" exon 1179..1270 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1209 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:374682772" variation 1213 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:141953425" variation 1215 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:145184714" variation 1240 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:190909040" variation 1241 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:139094508" variation 1258 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:1801376" variation 1260 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:200788206" exon 1271..1500 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1278 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:370655726" variation 1312..1313 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="a" /db_xref="dbSNP:67799088" variation 1339 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:147150527" variation 1340 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:140278852" variation 1344 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:17851677" variation 1362 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:202114756" variation 1376 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:1047130" variation 1382 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:1017842" variation 1410..1411 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="a" /db_xref="dbSNP:67932329" variation 1439 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:28989188" variation 1442 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:61733369" variation 1473 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:201251790" variation 1474 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:150983783" exon 1501..1613 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1502 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:376379876" variation 1534..1535 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="a" /db_xref="dbSNP:67629850" variation 1573 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:373256667" variation 1580 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:201813238" variation 1583 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:141013408" variation 1590 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:75763304" exon 1614..1729 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1624 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:117485407" variation 1625 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:374560564" variation 1649 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:56292726" variation 1676 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:368023159" variation 1690 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:146795655" variation 1694 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:370274769" variation 1718 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:368420788" variation 1727 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:56109940" exon 1730..1779 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1751 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:140534961" exon 1780..1840 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1793 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:376880716" variation 1799 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:374320185" variation 1804 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:76546181" variation 1835 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:1129352" variation 1837 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:200997833" exon 1841..1946 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1842 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:138332995" variation 1861 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:28989187" variation 1911 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:145578529" exon 1947..2221 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 1948 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:149628229" variation 1958 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:373105304" variation 2065 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:1801528" variation 2088 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:184449375" variation 2107 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:376072541" variation 2131 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:370388424" variation 2155 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:148348158" variation 2185 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:373789523" exon 2222..2355 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2237 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:143559902" variation 2284 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:200060772" variation 2310 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:371124423" variation 2320 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:375388175" exon 2356..2496 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2428 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:202132335" variation 2469 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:201223946" variation 2476 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:372569297" exon 2497..2597 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2548 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:140368608" variation 2553 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:368996088" variation 2563 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:142705245" exon 2598..2747 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2601 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:150707631" variation 2610 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:139226455" variation 2650 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:149955447" variation 2653 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:28989182" variation 2686 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:145026343" variation 2693 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:76294284" variation 2697 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:367543489" variation 2720 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:181352808" variation 2735 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:34999621" variation 2742 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:28989181" exon 2748..2890 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2750 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:372003254" variation 2761 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:143346774" variation 2772 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:375105548" variation 2870 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:146821149" variation 2885 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:140574971" exon 2891..3062 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 2938 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:28989184" variation 2964 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:145639700" variation 2972 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:151035388" variation 2974 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="t" /db_xref="dbSNP:141119531" variation 2975 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:28989183" variation 2989 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:74380950" variation 2996 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:139066741" variation 2997 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:143232848" exon 3063..3169 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 3068 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:1802286" variation 3098..3099 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="t" /db_xref="dbSNP:67705483" variation 3117 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:144464637" variation 3121 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:377751129" variation 3146..3147 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="g" /db_xref="dbSNP:35549819" exon 3170..3742 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /inference="alignment:Splign:1.39.8" variation 3207 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:201246315" variation 3208 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:377612791" variation 3223 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:34998711" variation 3232 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:370506288" variation 3240 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:374968269" variation 3247 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:28989185" variation 3249 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="g" /replace="t" /db_xref="dbSNP:79104296" variation 3265..3266 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="a" /db_xref="dbSNP:67740151" variation 3306 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:34700927" variation 3311 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:35611758" variation 3326..3327 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="" /replace="g" /db_xref="dbSNP:35008769" variation 3359 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:376467292" variation 3378 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:370517481" variation 3472 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="t" /db_xref="dbSNP:149437374" variation 3476 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="g" /db_xref="dbSNP:8364" variation 3513 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:117341083" STS 3546..3665 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /standard_name="RH46590" /db_xref="UniSTS:61155" variation 3632 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="c" /replace="g" /db_xref="dbSNP:143807849" variation 3691 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" /replace="a" /replace="c" /db_xref="dbSNP:1047193" polyA_signal 3709..3714 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" polyA_site 3742 /gene="BUB1B" /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1" ORIGIN
aggggcgtggccacgtcgaccgcgcgggaccgttaaatttgaaacttggcggctaggggtgtgggcttgaggtggccggtttgttagggagtcgtgtacgtgccttggtcgcttctgtagctccgagggcaggttgcggaagaaagcccaggcggtctgtggcccagaggaaaggcctgcagcaggacgaggacctgagccaggaatgcaggatggcggcggtgaagaaggaagggggtgctctgagtgaagccatgtccctggagggagatgaatgggaactgagtaaagaaaatgtacaacctttaaggcaagggcggatcatgtccacgcttcagggagcactggcacaagaatctgcctgtaacaatactcttcagcagcagaaacgggcatttgaatatgaaattcgattttacactggaaatgaccctctggatgtttgggataggtatatcagctggacagagcagaactatcctcaaggtgggaaggagagtaatatgtcaacgttattagaaagagctgtagaagcactacaaggagaaaaacgatattatagtgatcctcgatttctcaatctctggcttaaattagggcgtttatgcaatgagcctttggatatgtacagttacttgcacaaccaagggattggtgtttcacttgctcagttctatatctcatgggcagaagaatatgaagctagagaaaactttaggaaagcagatgcgatatttcaggaagggattcaacagaaggctgaaccactagaaagactacagtcccagcaccgacaattccaagctcgagtgtctcggcaaactctgttggcacttgagaaagaagaagaggaggaagtttttgagtcttctgtaccacaacgaagcacactagctgaactaaagagcaaagggaaaaagacagcaagagctccaatcatccgtgtaggaggtgctctcaaggctccaagccagaacagaggactccaaaatccatttcctcaacagatgcaaaataatagtagaattactgtttttgatgaaaatgctgatgaggcttctacagcagagttgtctaagcctacagtccagccatggatagcaccccccatgcccagggccaaagagaatgagctgcaagcaggcccttggaacacaggcaggtccttggaacacaggcctcgtggcaatacagcttcactgatagctgtacccgctgtgcttcccagtttcactccatatgtggaagagactgcacaacagccagttatgacaccatgtaaaattgaacctagtataaaccacatcctaagcaccagaaagcctggaaaggaagaaggagatcctctacaaagggttcagagccatcagcaagcgtctgaggagaagaaagagaagatgatgtattgtaaggagaagatttatgcaggagtaggggaattctcctttgaagaaattcgggctgaagttttccggaagaaattaaaagagcaaagggaagccgagctattgaccagtgcagagaagagagcagaaatgcagaaacagattgaagagatggagaagaagctaaaagaaatccaaactactcagcaagaaagaacaggtgatcagcaagaagagacgatgcctacaaaggagacaactaaactgcaaattgcttccgagtctcagaaaataccaggaatgactctatccagttctgtttgtcaagtaaactgttgtgccagagaaacttcacttgcggagaacatttggcaggaacaacctcattctaaaggtcccagtgtacctttctccatttttgatgagtttcttctttcagaaaagaagaataaaagtcctcctgcagatcccccacgagttttagctcaacgaagaccccttgcagttctcaaaacctcagaaagcatcacctcaaatgaagatgtgtctccagatgtttgtgatgaatttacaggaattgaacccttgagcgaggatgccattatcacaggcttcagaaatgtaacaatttgtcctaacccagaagacacttgtgactttgccagagcagctcgttttgtatccactccttttcatgagataatgtccttgaaggatctcccttctgatcctgagagactgttaccggaagaagatctagatgtaaagacctctgaggaccagcagacagcttgtggcactatctacagtcagactctcagcatcaagaagctgagcccaattattgaagacagtcgtgaagccacacactcctctggcttctctggttcttctgcctcggttgcaagcacctcctccatcaaatgtcttcaaattcctgagaaactagaacttactaatgagacttcagaaaaccctactcagtcaccatggtgttcacagtatcgcagacagctactgaagtccctaccagagttaagtgcctctgcagagttgtgtatagaagacagaccaatgcctaagttggaaattgagaaggaaattgaattaggtaatgaggattactgcattaaacgagaatacctaatatgtgaagattacaagttattctgggtggcgccaagaaactctgcagaattaacagtaataaaggtatcttctcaacctgtcccatgggacttttatatcaacctcaagttaaaggaacgtttaaatgaagattttgatcatttttgcagctgttatcaatatcaagatggctgtattgtttggcaccaatatataaactgcttcacccttcaggatcttctccaacacagtgaatatattacccatgaaataacagtgttgattatttataaccttttgacaatagtggagatgctacacaaagcagaaatagtccatggtgacttgagtccaaggtgtctgattctcagaaacagaatccacgatccctatgattgtaacaagaacaatcaagctttgaagatagtggacttttcctacagtgttgaccttagggtgcagctggatgtttttaccctcagcggctttcggactgtacagatcctggaaggacaaaagatcctggctaactgttcttctccctaccaggtagacctgtttggtatagcagatttagcacatttactattgttcaaggaacacctacaggtcttctgggatgggtccttctggaaacttagccaaaatatttctgagctaaaagatggtgaattgtggaataaattctttgtgcggattctgaatgccaatgatgaggccacagtgtctgttcttggggagcttgcagcagaaatgaatggggtttttgacactacattccaaagtcacctgaacaaagccttatggaaggtagggaagttaactagtcctggggctttgctctttcagtgagctaggcaatcaagtctcacagattgctgcctcagagcaatggttgtattgtggaacactgaaactgtatgtgctgtaatttaatttaggacacatttagatgcactaccattgctgttctactttttggtacaggtatattttgacgtcactgatattttttatacagtgatatacttactcatggccttgtctaacttttgtgaagaactattttattctaaacagactcattacaaatggttaccttgttatttaacccatttgtctctacttttccctgtacttttcccatttgtaatttgtaaaatgttctcttatgatcaccatgtattttgtaaataataaaatagtatctgttaaatttgtgcttctaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:701 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS GeneID:701 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:701 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:701 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:701 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:701 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:701 -> Biological process: GO:0007049 [cell cycle] evidence: NAS GeneID:701 -> Biological process: GO:0007051 [spindle organization] evidence: NAS GeneID:701 -> Biological process: GO:0007067 [mitosis] evidence: NAS GeneID:701 -> Biological process: GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] evidence: IEA GeneID:701 -> Biological process: GO:0007093 [mitotic cell cycle checkpoint] evidence: TAS GeneID:701 -> Biological process: GO:0007094 [mitotic spindle assembly checkpoint] evidence: TAS GeneID:701 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS GeneID:701 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:701 -> Biological process: GO:0034501 [protein localization to kinetochore] evidence: IPI GeneID:701 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: NAS GeneID:701 -> Biological process: GO:0051301 [cell division] evidence: IEA GeneID:701 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:701 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:701 -> Biological process: GO:0071459 [protein localization to chromosome, centromeric region] evidence: IEA GeneID:701 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA GeneID:701 -> Cellular component: GO:0000776 [kinetochore] evidence: NAS GeneID:701 -> Cellular component: GO:0000776 [kinetochore] evidence: TAS GeneID:701 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IDA GeneID:701 -> Cellular component: GO:0000778 [condensed nuclear chromosome kinetochore] evidence: IEA GeneID:701 -> Cellular component: GO:0000940 [condensed chromosome outer kinetochore] evidence: IDA GeneID:701 -> Cellular component: GO:0005680 [anaphase-promoting complex] evidence: TAS GeneID:701 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:701 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA GeneID:701 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:701 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA GeneID:701 -> Cellular component: GO:0051233 [spindle midzone] evidence: NAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001202 -> EC 2.7.11.1
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