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2019-03-23 03:25:38, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001206902            3192 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens Tax1 (human T-cell leukemia virus type I) binding
            protein 1 (TAX1BP1), transcript variant 4, mRNA.
ACCESSION   NM_001206902
VERSION     NM_001206902.1  GI:332634743
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Charoenthongtrakul,S., Gao,L., Parvatiyar,K., Lee,D. and
            Harhaj,E.W.
  TITLE     RING finger protein 11 targets TBK1/IKKi kinases to inhibit
            antiviral signaling
  JOURNAL   PLoS ONE 8 (1), E53717 (2013)
   PUBMED   23308279
  REMARK    GeneRIF: RNF11 functions together with TAX1BP1 to restrict
            antiviral signaling and IFN-beta production.
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Komkov,A.Iu., Maschan,M.A., Shvets,V.I. and Lebedev,Iu.B.
  TITLE     [The functional analysis of polymorphic insertions of Alu
            retroelements at acute lymphoblastic leukemia]
  JOURNAL   Bioorg. Khim. 38 (3), 351-364 (2012)
   PUBMED   22997707
  REMARK    GeneRIF: Allele frequencies of three Alu insertions that are
            located in MEF2C (two of them) and TAX1BP1 genes significantly
            differ between cohorts of healthy donors and ALL(acute
            lymphoblastic leukemia) patients.
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Newman,A.C., Scholefield,C.L., Kemp,A.J., Newman,M., McIver,E.G.,
            Kamal,A. and Wilkinson,S.
  TITLE     TBK1 kinase addiction in lung cancer cells is mediated via
            autophagy of Tax1bp1/Ndp52 and non-canonical NF-kappaB signalling
  JOURNAL   PLoS ONE 7 (11), E50672 (2012)
   PUBMED   23209807
  REMARK    GeneRIF: Autophagy of Tax1bp1/Ndp52 promotes non-canonical
            NF-kappaB signalling.
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Gao,L., Coope,H., Grant,S., Ma,A., Ley,S.C. and Harhaj,E.W.
  TITLE     ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit
            antiviral signaling
  JOURNAL   J. Biol. Chem. 286 (42), 36592-36602 (2011)
   PUBMED   21885437
  REMARK    GeneRIF: ABIN1 requires its ubiquitin binding domain and cooperates
            with TAX1BP1 and A20 to restrict antiviral signaling.
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Borbulevych,O.Y., Piepenbrink,K.H. and Baker,B.M.
  TITLE     Conformational melding permits a conserved binding geometry in TCR
            recognition of foreign and self molecular mimics
  JOURNAL   J. Immunol. 186 (5), 2950-2958 (2011)
   PUBMED   21282516
  REMARK    GeneRIF: In a link with T cell leukemia virus-1-associated
            myelopathy/tropical spastic paraparesis, an alphabeta T cell
            receptor recognizes a self peptide from neuronal protein HuD in
            context of histocompatibility antigen HLA-A2.
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Dodon,M.D., Hamaia,S., Martin,J. and Gazzolo,L.
  TITLE     Heterogeneous nuclear ribonucleoprotein A1 interferes with the
            binding of the human T cell leukemia virus type 1 rex regulatory
            protein to its response element
  JOURNAL   J. Biol. Chem. 277 (21), 18744-18752 (2002)
   PUBMED   11893730
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett. 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   8  (bases 1 to 3192)
  AUTHORS   Ling,L. and Goeddel,D.V.
  TITLE     T6BP, a TRAF6-interacting protein involved in IL-1 signaling
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9567-9572 (2000)
   PUBMED   10920205
REFERENCE   9  (bases 1 to 3192)
  AUTHORS   De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
            Fiers,W., Jeang,K.T. and Beyaert,R.
  TITLE     The zinc finger protein A20 interacts with a novel anti-apoptotic
            protein which is cleaved by specific caspases
  JOURNAL   Oncogene 18 (29), 4182-4190 (1999)
   PUBMED   10435631
REFERENCE   10 (bases 1 to 3192)
  AUTHORS   Gachon,F., Peleraux,A., Thebault,S., Dick,J., Lemasson,I.,
            Devaux,C. and Mesnard,J.M.
  TITLE     CREB-2, a cellular CRE-dependent transcription repressor, functions
            in association with Tax as an activator of the human T-cell
            leukemia virus type 1 promoter
  JOURNAL   J. Virol. 72 (10), 8332-8337 (1998)
   PUBMED   9733879
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455556.1, DC424592.1,
            AF090891.1, AL136586.1 and BU679319.1.
            
            Summary: This gene encodes a HTLV-1 tax1 binding protein. The
            encoded protein interacts with TNFAIP3, and inhibits TNF-induced
            apoptosis by mediating the TNFAIP3 anti-apoptotic activity.
            Degradation of this protein by caspase-3-like family proteins is
            associated with apoptosis induced by TNF. This protein may also
            have a role in the inhibition of inflammatory signaling pathways.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (4) is missing an internal coding
            exon compared to variant 1. This results in the creation of an
            upstream ORF (uORF), translation of which will render this
            transcript a candidate for nonsense-mediated mRNA decay (NMD).
            However, since the uORF has a weak Kozak signal, translation from
            an in-frame downstream AUG is possible by leaky scanning, resulting
            in an isoform (3) with a shorter N-terminus and missing an internal
            protein segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB455556.1         1-3
            4-447               DC424592.1         1-444
            448-2290            AF090891.1         554-2396
            2291-2670           AL136586.1         2512-2891
            2671-3192           BU679319.1         1-522               c
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15"
     gene            1..3192
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="Tax1 (human T-cell leukemia virus type I) binding
                     protein 1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:11575"
                     /db_xref="MIM:605326"
     exon            1..175
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(96)
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200640891"
     exon            176..344
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            345..447
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    436..438
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="upstream in-frame stop codon"
     exon            448..606
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     CDS             466..2238
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="isoform 3 is encoded by transcript variant 4;
                     TRAF6-binding protein"
                     /codon_start=1
                     /product="tax1-binding protein 1 isoform 3"
                     /protein_id="NP_001193831.1"
                     /db_xref="GI:332634744"
                     /db_xref="CCDS:CCDS56471.1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:11575"
                     /db_xref="MIM:605326"
                     /translation="
MKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
"
     misc_feature    <469..>1404
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="Calcium binding and coiled-coil domain (CALCOCO1)
                     like; Region: CALCOCO1; pfam07888"
                     /db_xref="CDD:116500"
     misc_feature    <1048..1794
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:162739"
     exon            607..755
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            756..846
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            847..1032
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1033..1257
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1258..1404
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1405..1528
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1529..1632
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1633..1758
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1759..1804
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1805..1953
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            1954..2036
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     exon            2037..3176
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     STS             2068..2813
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="TAX1BP1_2449"
                     /db_xref="UniSTS:281039"
     STS             2124..2223
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="SGC31789"
                     /db_xref="UniSTS:2823"
     polyA_signal    2419..2424
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      2461
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_signal    2513..2518
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     STS             2536..2637
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="SGC32601"
                     /db_xref="UniSTS:62629"
     polyA_site      2556
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_signal    2648..2653
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      2670
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     STS             3006..3136
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="WI-11921"
                     /db_xref="UniSTS:57725"
     polyA_signal    3060..3065
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      3086
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_signal    3141..3146
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      3176
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
ORIGIN      
ggaagagaccgccccgtgggcggaagtgacgcaaggcctactgtcggctgggaggggaggtgtagccggtctttgggggtaggcggtagtggcggaagaggttcggcggctgatggcggatcaggatcggaagcctgcgtaactttctcccttgatccgggagtctttccactggattcacaatgacatcctttcaagaagtcccattgcagacttccaactttgcccatgtcatctttcaaaatgtggccaagagttaccttcctaatgcacacctggaatgtcattacaccttaactccatatattcatccacatccaaaagattgggttggtatattcaaggttggatggagtactgctcgtgattattacacgtttttatggtcccctatgcctgaacattatgtggaaggatcaacagtcaattgtgtactagcattccaagttgaaaattgagaaaaccatgaaagaaaaagaagaactgttaaagttaattgccgttctggaaaaagaaacagcacaacttcgagaacaagttgggagaatggaaagagaacttaaccatgagaaagaaagatgtgaccaactgcaagcagaacaaaagggtcttactgaagtaacacaaagcttaaaaatggaaaatgaagagtttaagaagaggttcagtgatgctacatccaaagcccatcagcttgaggaagatattgtgtcagtaacacataaagcaattgaaaaagaaaccgaattagacagtttaaaggacaaactcaagaaggcacaacatgaaagagaacaacttgaatgtcagttgaagacagagaaggatgaaaaggaactttataaggtacatttgaagaatacagaaatagaaaataccaagcttatgtcagaggtccagactttaaaaaatttagatgggaacaaagaaagcgtgattactcatttcaaagaagagattggcaggctgcagttatgtttggctgaaaaggaaaatctgcaaagaactttcctgcttacaacctcaagtaaagaagatacttgttttttaaaggagcaacttcgtaaagcagaggaacaggttcaggcaactcggcaagaagttgtctttctggctaaagaactcagtgatgctgtcaacgtacgagacagaacgatggcagacctgcatactgcacgcttggaaaacgagaaagtgaaaaagcagttagctgatgcagtggcagaacttaaactaaatgctatgaaaaaagatcaggacaagactgatacactggaacacgaactaagaagagaagttgaagatctgaaactccgtcttcagatggctgcagaccattataaagaaaaatttaaggaatgccaaaggctccaaaaacaaataaacaaactttcagatcaatcagctaataataataatgtcttcacaaagaaaacggggaatcagcagaaagtgaatgatgcttcagtaaacacagacccagccacttctgcctctactgtagatgtaaagccatcaccttctgcagcagaggcagattttgacatagtaacaaaggggcaagtctgtgaaatgaccaaagaaattgctgacaaaacagaaaagtataataaatgtaaacaactcttgcaggatgagaaagcaaaatgcaataaatatgctgatgaacttgcaaaaatggagctgaaatggaaagaacaagtgaaaattgctgaaaatgtaaaacttgaactagctgaagtacaggacaattataaagaacttaaaaggagtctagaaaatccagcagaaaggaaaatggaagatggagcagatggtgctttttacccagatgaaatacaaaggccacctgtcagagtcccctcttggggactggaagacaatgttgtctgcagccagcctgctcgaaactttagtcggcctgatggcttagaggactctgaggatagcaaagaagatgagaatgtgcctactgctcctgatcctccaagtcaacatttacgtgggcatgggacaggcttttgctttgattccagctttgatgttcacaagaagtgtcccctctgtgagttaatgtttcctcctaactatgatcagagcaaatttgaagaacatgttgaaagtcactggaaggtgtgcccgatgtgcagcgagcagttccctcctgactatgaccagcaggtgtttgaaaggcatgtgcagacccattttgatcagaatgttctaaattttgactagttactttttattatgagttaatatagtttagcagtaaaaaaaaaaaaaaaaaccacacctaaaatagaccactgaggagaccatagagcggatgctttcatgcaccctttactgcactttctgaccaggagctactttgagtttggtgttactaggatcagggtcagtctttggcttatcaataaattttaatctctgttaatcttacctgctttaaaaaaaagttcttgtgtgttcgtatctttatttattccctagtttgcagaactgtctgaataaaggatacaaggattatttcaatgttactgcactgaaaaacgtgtatgtattagtgtgctagattatttagcagaatattcacaagtttctgttgaccttgttgattgagcatgactactaaatattatgtaataaaaagcatttgtcataacagtcttatgaagtagttcttcgaatatagaaagttctataatttagcccatgaaatgataggtttttaattttcagaaatggagctgcatgtagaatgagatcacatgcttttatatgtgaaatattggttttagcaattaacagaaggcatactttgctaattttatggcaaaattttagaataacctgaatgattatttttaaactatcttgaagttgtatgtatatatctaatgggaaaatggaacaagagatgtcagtataattgttttcctattaaatgatctcataacaggggtgtttgtggcataaaaatcatagaatatatatcagtatcttttttacattttcctgatgagaatataaatttgaaatattctcagtaagtgattaaaagtacaatacataaacccaaatcaaagtaatgtgtttcttcagttatgtctgtgctgtatagaactgtcactaacattaaagaaagaggacacatttttcaagatctgtaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8887 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8887 -> Molecular function: GO:0019900 [kinase binding] evidence: ISS
            GeneID:8887 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:8887 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: ISS
            GeneID:8887 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
            GeneID:8887 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:8887 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:8887 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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