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2024-04-19 22:12:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001206901 3383 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens Tax1 (human T-cell leukemia virus type I) binding
protein 1 (TAX1BP1), transcript variant 3, mRNA.
ACCESSION NM_001206901
VERSION NM_001206901.1 GI:332634739
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3383)
AUTHORS Charoenthongtrakul,S., Gao,L., Parvatiyar,K., Lee,D. and
Harhaj,E.W.
TITLE RING finger protein 11 targets TBK1/IKKi kinases to inhibit
antiviral signaling
JOURNAL PLoS ONE 8 (1), E53717 (2013)
PUBMED 23308279
REMARK GeneRIF: RNF11 functions together with TAX1BP1 to restrict
antiviral signaling and IFN-beta production.
REFERENCE 2 (bases 1 to 3383)
AUTHORS Komkov,A.Iu., Maschan,M.A., Shvets,V.I. and Lebedev,Iu.B.
TITLE [The functional analysis of polymorphic insertions of Alu
retroelements at acute lymphoblastic leukemia]
JOURNAL Bioorg. Khim. 38 (3), 351-364 (2012)
PUBMED 22997707
REMARK GeneRIF: Allele frequencies of three Alu insertions that are
located in MEF2C (two of them) and TAX1BP1 genes significantly
differ between cohorts of healthy donors and ALL(acute
lymphoblastic leukemia) patients.
REFERENCE 3 (bases 1 to 3383)
AUTHORS Newman,A.C., Scholefield,C.L., Kemp,A.J., Newman,M., McIver,E.G.,
Kamal,A. and Wilkinson,S.
TITLE TBK1 kinase addiction in lung cancer cells is mediated via
autophagy of Tax1bp1/Ndp52 and non-canonical NF-kappaB signalling
JOURNAL PLoS ONE 7 (11), E50672 (2012)
PUBMED 23209807
REMARK GeneRIF: Autophagy of Tax1bp1/Ndp52 promotes non-canonical
NF-kappaB signalling.
REFERENCE 4 (bases 1 to 3383)
AUTHORS Gao,L., Coope,H., Grant,S., Ma,A., Ley,S.C. and Harhaj,E.W.
TITLE ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit
antiviral signaling
JOURNAL J. Biol. Chem. 286 (42), 36592-36602 (2011)
PUBMED 21885437
REMARK GeneRIF: ABIN1 requires its ubiquitin binding domain and cooperates
with TAX1BP1 and A20 to restrict antiviral signaling.
REFERENCE 5 (bases 1 to 3383)
AUTHORS Borbulevych,O.Y., Piepenbrink,K.H. and Baker,B.M.
TITLE Conformational melding permits a conserved binding geometry in TCR
recognition of foreign and self molecular mimics
JOURNAL J. Immunol. 186 (5), 2950-2958 (2011)
PUBMED 21282516
REMARK GeneRIF: In a link with T cell leukemia virus-1-associated
myelopathy/tropical spastic paraparesis, an alphabeta T cell
receptor recognizes a self peptide from neuronal protein HuD in
context of histocompatibility antigen HLA-A2.
REFERENCE 6 (bases 1 to 3383)
AUTHORS Dodon,M.D., Hamaia,S., Martin,J. and Gazzolo,L.
TITLE Heterogeneous nuclear ribonucleoprotein A1 interferes with the
binding of the human T cell leukemia virus type 1 rex regulatory
protein to its response element
JOURNAL J. Biol. Chem. 277 (21), 18744-18752 (2002)
PUBMED 11893730
REFERENCE 7 (bases 1 to 3383)
AUTHORS Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
TITLE Functional redundancy of the zinc fingers of A20 for inhibition of
NF-kappaB activation and protein-protein interactions
JOURNAL FEBS Lett. 498 (1), 93-97 (2001)
PUBMED 11389905
REFERENCE 8 (bases 1 to 3383)
AUTHORS Ling,L. and Goeddel,D.V.
TITLE T6BP, a TRAF6-interacting protein involved in IL-1 signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9567-9572 (2000)
PUBMED 10920205
REFERENCE 9 (bases 1 to 3383)
AUTHORS De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
Fiers,W., Jeang,K.T. and Beyaert,R.
TITLE The zinc finger protein A20 interacts with a novel anti-apoptotic
protein which is cleaved by specific caspases
JOURNAL Oncogene 18 (29), 4182-4190 (1999)
PUBMED 10435631
REFERENCE 10 (bases 1 to 3383)
AUTHORS Gachon,F., Peleraux,A., Thebault,S., Dick,J., Lemasson,I.,
Devaux,C. and Mesnard,J.M.
TITLE CREB-2, a cellular CRE-dependent transcription repressor, functions
in association with Tax as an activator of the human T-cell
leukemia virus type 1 promoter
JOURNAL J. Virol. 72 (10), 8332-8337 (1998)
PUBMED 9733879
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK299729.1, AF090891.1,
AL136586.1 and BU679319.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes a HTLV-1 tax1 binding protein. The
encoded protein interacts with TNFAIP3, and inhibits TNF-induced
apoptosis by mediating the TNFAIP3 anti-apoptotic activity.
Degradation of this protein by caspase-3-like family proteins is
associated with apoptosis induced by TNF. This protein may also
have a role in the inhibition of inflammatory signaling pathways.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.[provided by RefSeq, May
2011].
Transcript Variant: This variant (3) contains an alternate 5'
non-coding exon, and uses an alternate in-frame donor splice site
at an internal coding exon compared to variant 1. This results in a
shorter isoform (2, also known as TXBP151-L) missing an internal
protein segment compared to isoform 1. Variants 2 and 3 encode the
same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK299729.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-851 AK299729.1 1-851
852-2481 AF090891.1 767-2396
2482-2861 AL136586.1 2512-2891
2862-3383 BU679319.1 1-522 c
FEATURES Location/Qualifiers
source 1..3383
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p15"
gene 1..3383
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="Tax1 (human T-cell leukemia virus type I) binding
protein 1"
/db_xref="GeneID:8887"
/db_xref="HGNC:11575"
/db_xref="MIM:605326"
exon 1..178
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 107
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="t"
/db_xref="dbSNP:148614766"
misc_feature 123..125
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="upstream in-frame stop codon"
variation 131
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:184855260"
variation 167
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="t"
/db_xref="dbSNP:375225509"
exon 179..347
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
CDS 186..2429
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="isoform 2 is encoded by transcript variant 3;
TRAF6-binding protein"
/codon_start=1
/product="tax1-binding protein 1 isoform 2"
/protein_id="NP_001193830.1"
/db_xref="GI:332634740"
/db_xref="CCDS:CCDS43561.1"
/db_xref="GeneID:8887"
/db_xref="HGNC:11575"
/db_xref="MIM:605326"
/translation="
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
"
misc_feature 234..>1595
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="Calcium binding and coiled-coil domain (CALCOCO1)
like; Region: CALCOCO1; pfam07888"
/db_xref="CDD:116500"
variation 191
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:201351489"
variation 200
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:376420843"
variation 268
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:200518839"
variation 305
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:368766669"
exon 348..450
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 358
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:7809260"
variation 380
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:79805575"
variation 393
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:11540484"
variation 419
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:150254620"
variation 428
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:374567926"
exon 451..638
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 497
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:184845751"
variation 498
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:367927936"
STS 499..637
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="RH65631"
/db_xref="UniSTS:64116"
variation 552
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:372106777"
variation 566
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:201587778"
variation 567
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:199836430"
variation 569
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:374194011"
variation 575
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:9829"
variation 628
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:144279541"
exon 639..797
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 669
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:143497095"
variation 675
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:199574204"
variation 692
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:147311025"
variation 693
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:34347226"
variation 751
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:368515652"
variation 770
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:372499342"
exon 798..946
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 875
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:7795659"
variation 877
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:144826085"
variation 896
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:187463889"
variation 913
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:148512801"
variation 935
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:139970643"
variation 945
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:376669585"
exon 947..1037
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 970
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:376415438"
variation 990
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:142832236"
variation 993
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:371052683"
variation 1009
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:199893082"
variation 1023
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:373589178"
exon 1038..1223
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1040
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:370955901"
variation 1104
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:11540483"
variation 1105
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:141015886"
variation 1134
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:184528287"
variation 1172
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:200588230"
variation 1192
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:143687148"
exon 1224..1448
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1254
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:377033381"
variation 1322
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:370318377"
variation 1330
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:200041605"
variation 1345
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:201012389"
variation 1355
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:371768103"
variation 1363
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:200115275"
variation 1368
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:146488468"
variation 1371
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:200880289"
variation 1385
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:375088303"
variation 1427
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:35521804"
exon 1449..1595
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1472
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:114874327"
variation 1475
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:148898077"
variation 1505
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:369476152"
exon 1596..1719
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1608
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:1802841"
variation 1628
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:376725530"
variation 1648
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:35469533"
variation 1669
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:75969039"
variation 1684
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:35085537"
variation 1698
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:143459175"
variation 1718
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:113897474"
exon 1720..1823
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1735
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:147980008"
variation 1743
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:61739691"
variation 1745
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:1043151"
variation 1758
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:200687127"
variation 1823
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:147154541"
exon 1824..1949
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1836
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:199588505"
variation 1864
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:369666491"
variation 1902
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:199556359"
variation 1926
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:139268186"
exon 1950..1995
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 1950
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="g"
/replace="t"
/db_xref="dbSNP:75265603"
variation 1964
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:143177155"
variation 1967
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:370551887"
exon 1996..2144
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 2002
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:375645372"
variation 2024
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:373849057"
variation 2098
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:377595038"
exon 2145..2227
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 2163
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:202210451"
variation 2164
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:11091"
variation 2194
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:112084378"
exon 2228..3367
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation 2255
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:367746678"
STS 2259..3004
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="TAX1BP1_2449"
/db_xref="UniSTS:281039"
STS 2315..2414
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="SGC31789"
/db_xref="UniSTS:2823"
variation 2324
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:77750724"
variation 2327
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:111505296"
variation 2333
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:376787714"
variation 2361
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:144255675"
variation 2388
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:375080539"
variation 2408
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:116615727"
variation 2412
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:375566844"
variation 2443
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:190937938"
variation 2449
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:369865240"
variation 2461
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:182920258"
variation 2464..2465
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace=""
/replace="a"
/db_xref="dbSNP:34270007"
variation 2465..2466
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:67783818"
variation 2474..2475
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace=""
/replace="a"
/db_xref="dbSNP:72426082"
variation 2483
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="c"
/db_xref="dbSNP:188352965"
variation 2511
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="g"
/db_xref="dbSNP:116071040"
polyA_signal 2610..2615
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 2652
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_signal 2704..2709
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
STS 2727..2828
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="SGC32601"
/db_xref="UniSTS:62629"
polyA_site 2747
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
variation 2748
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:183483565"
polyA_signal 2839..2844
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 2861
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
variation 2950
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="c"
/replace="t"
/db_xref="dbSNP:79198426"
STS 3197..3327
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="WI-11921"
/db_xref="UniSTS:57725"
polyA_signal 3251..3256
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 3277
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_signal 3332..3337
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
variation 3336..3339
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace=""
/replace="aaga"
/db_xref="dbSNP:369185424"
variation 3358
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:73075348"
polyA_site 3367
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
ORIGIN
acggcaacagaagactatgatgaattcgaatgggacacatttgcttctgtggagttacgattcaaactgaatgtccaatataggaaggcaacatatacaacaagcaaaagtgattttagaaataacagaacgcgggagaaaattcacacacggaaaatgatacggataacaaaagcagattcacaatgacatcctttcaagaagtcccattgcagacttccaactttgcccatgtcatctttcaaaatgtggccaagagttaccttcctaatgcacacctggaatgtcattacaccttaactccatatattcatccacatccaaaagattgggttggtatattcaaggttggatggagtactgctcgtgattattacacgtttttatggtcccctatgcctgaacattatgtggaaggatcaacagtcaattgtgtactagcattccaaggatattaccttccaaatgatgatggagaattttatcagttctgttacgttacccataagggtgaaattcgtggagcaagtacacctttccagtttcgagcttcttctccagttgaagagctgcttactatggaagatgaaggaaattctgacatgttagtggtgaccacaaaagcaggccttcttgagttgaaaattgagaaaaccatgaaagaaaaagaagaactgttaaagttaattgccgttctggaaaaagaaacagcacaacttcgagaacaagttgggagaatggaaagagaacttaaccatgagaaagaaagatgtgaccaactgcaagcagaacaaaagggtcttactgaagtaacacaaagcttaaaaatggaaaatgaagagtttaagaagaggttcagtgatgctacatccaaagcccatcagcttgaggaagatattgtgtcagtaacacataaagcaattgaaaaagaaaccgaattagacagtttaaaggacaaactcaagaaggcacaacatgaaagagaacaacttgaatgtcagttgaagacagagaaggatgaaaaggaactttataaggtacatttgaagaatacagaaatagaaaataccaagcttatgtcagaggtccagactttaaaaaatttagatgggaacaaagaaagcgtgattactcatttcaaagaagagattggcaggctgcagttatgtttggctgaaaaggaaaatctgcaaagaactttcctgcttacaacctcaagtaaagaagatacttgttttttaaaggagcaacttcgtaaagcagaggaacaggttcaggcaactcggcaagaagttgtctttctggctaaagaactcagtgatgctgtcaacgtacgagacagaacgatggcagacctgcatactgcacgcttggaaaacgagaaagtgaaaaagcagttagctgatgcagtggcagaacttaaactaaatgctatgaaaaaagatcaggacaagactgatacactggaacacgaactaagaagagaagttgaagatctgaaactccgtcttcagatggctgcagaccattataaagaaaaatttaaggaatgccaaaggctccaaaaacaaataaacaaactttcagatcaatcagctaataataataatgtcttcacaaagaaaacggggaatcagcagaaagtgaatgatgcttcagtaaacacagacccagccacttctgcctctactgtagatgtaaagccatcaccttctgcagcagaggcagattttgacatagtaacaaaggggcaagtctgtgaaatgaccaaagaaattgctgacaaaacagaaaagtataataaatgtaaacaactcttgcaggatgagaaagcaaaatgcaataaatatgctgatgaacttgcaaaaatggagctgaaatggaaagaacaagtgaaaattgctgaaaatgtaaaacttgaactagctgaagtacaggacaattataaagaacttaaaaggagtctagaaaatccagcagaaaggaaaatggaagatggagcagatggtgctttttacccagatgaaatacaaaggccacctgtcagagtcccctcttggggactggaagacaatgttgtctgcagccagcctgctcgaaactttagtcggcctgatggcttagaggactctgaggatagcaaagaagatgagaatgtgcctactgctcctgatcctccaagtcaacatttacgtgggcatgggacaggcttttgctttgattccagctttgatgttcacaagaagtgtcccctctgtgagttaatgtttcctcctaactatgatcagagcaaatttgaagaacatgttgaaagtcactggaaggtgtgcccgatgtgcagcgagcagttccctcctgactatgaccagcaggtgtttgaaaggcatgtgcagacccattttgatcagaatgttctaaattttgactagttactttttattatgagttaatatagtttagcagtaaaaaaaaaaaaaaaaaccacacctaaaatagaccactgaggagaccatagagcggatgctttcatgcaccctttactgcactttctgaccaggagctactttgagtttggtgttactaggatcagggtcagtctttggcttatcaataaattttaatctctgttaatcttacctgctttaaaaaaaagttcttgtgtgttcgtatctttatttattccctagtttgcagaactgtctgaataaaggatacaaggattatttcaatgttactgcactgaaaaacgtgtatgtattagtgtgctagattatttagcagaatattcacaagtttctgttgaccttgttgattgagcatgactactaaatattatgtaataaaaagcatttgtcataacagtcttatgaagtagttcttcgaatatagaaagttctataatttagcccatgaaatgataggtttttaattttcagaaatggagctgcatgtagaatgagatcacatgcttttatatgtgaaatattggttttagcaattaacagaaggcatactttgctaattttatggcaaaattttagaataacctgaatgattatttttaaactatcttgaagttgtatgtatatatctaatgggaaaatggaacaagagatgtcagtataattgttttcctattaaatgatctcataacaggggtgtttgtggcataaaaatcatagaatatatatcagtatcttttttacattttcctgatgagaatataaatttgaaatattctcagtaagtgattaaaagtacaatacataaacccaaatcaaagtaatgtgtttcttcagttatgtctgtgctgtatagaactgtcactaacattaaagaaagaggacacatttttcaagatctgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8887 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8887 -> Molecular function: GO:0019900 [kinase binding] evidence: ISS
GeneID:8887 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8887 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: ISS
GeneID:8887 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
GeneID:8887 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:8887 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:8887 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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