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2019-03-23 03:25:26, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001206901            3383 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens Tax1 (human T-cell leukemia virus type I) binding
            protein 1 (TAX1BP1), transcript variant 3, mRNA.
ACCESSION   NM_001206901
VERSION     NM_001206901.1  GI:332634739
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Charoenthongtrakul,S., Gao,L., Parvatiyar,K., Lee,D. and
            Harhaj,E.W.
  TITLE     RING finger protein 11 targets TBK1/IKKi kinases to inhibit
            antiviral signaling
  JOURNAL   PLoS ONE 8 (1), E53717 (2013)
   PUBMED   23308279
  REMARK    GeneRIF: RNF11 functions together with TAX1BP1 to restrict
            antiviral signaling and IFN-beta production.
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Komkov,A.Iu., Maschan,M.A., Shvets,V.I. and Lebedev,Iu.B.
  TITLE     [The functional analysis of polymorphic insertions of Alu
            retroelements at acute lymphoblastic leukemia]
  JOURNAL   Bioorg. Khim. 38 (3), 351-364 (2012)
   PUBMED   22997707
  REMARK    GeneRIF: Allele frequencies of three Alu insertions that are
            located in MEF2C (two of them) and TAX1BP1 genes significantly
            differ between cohorts of healthy donors and ALL(acute
            lymphoblastic leukemia) patients.
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Newman,A.C., Scholefield,C.L., Kemp,A.J., Newman,M., McIver,E.G.,
            Kamal,A. and Wilkinson,S.
  TITLE     TBK1 kinase addiction in lung cancer cells is mediated via
            autophagy of Tax1bp1/Ndp52 and non-canonical NF-kappaB signalling
  JOURNAL   PLoS ONE 7 (11), E50672 (2012)
   PUBMED   23209807
  REMARK    GeneRIF: Autophagy of Tax1bp1/Ndp52 promotes non-canonical
            NF-kappaB signalling.
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   Gao,L., Coope,H., Grant,S., Ma,A., Ley,S.C. and Harhaj,E.W.
  TITLE     ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit
            antiviral signaling
  JOURNAL   J. Biol. Chem. 286 (42), 36592-36602 (2011)
   PUBMED   21885437
  REMARK    GeneRIF: ABIN1 requires its ubiquitin binding domain and cooperates
            with TAX1BP1 and A20 to restrict antiviral signaling.
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Borbulevych,O.Y., Piepenbrink,K.H. and Baker,B.M.
  TITLE     Conformational melding permits a conserved binding geometry in TCR
            recognition of foreign and self molecular mimics
  JOURNAL   J. Immunol. 186 (5), 2950-2958 (2011)
   PUBMED   21282516
  REMARK    GeneRIF: In a link with T cell leukemia virus-1-associated
            myelopathy/tropical spastic paraparesis, an alphabeta T cell
            receptor recognizes a self peptide from neuronal protein HuD in
            context of histocompatibility antigen HLA-A2.
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Dodon,M.D., Hamaia,S., Martin,J. and Gazzolo,L.
  TITLE     Heterogeneous nuclear ribonucleoprotein A1 interferes with the
            binding of the human T cell leukemia virus type 1 rex regulatory
            protein to its response element
  JOURNAL   J. Biol. Chem. 277 (21), 18744-18752 (2002)
   PUBMED   11893730
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett. 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Ling,L. and Goeddel,D.V.
  TITLE     T6BP, a TRAF6-interacting protein involved in IL-1 signaling
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9567-9572 (2000)
   PUBMED   10920205
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
            Fiers,W., Jeang,K.T. and Beyaert,R.
  TITLE     The zinc finger protein A20 interacts with a novel anti-apoptotic
            protein which is cleaved by specific caspases
  JOURNAL   Oncogene 18 (29), 4182-4190 (1999)
   PUBMED   10435631
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Gachon,F., Peleraux,A., Thebault,S., Dick,J., Lemasson,I.,
            Devaux,C. and Mesnard,J.M.
  TITLE     CREB-2, a cellular CRE-dependent transcription repressor, functions
            in association with Tax as an activator of the human T-cell
            leukemia virus type 1 promoter
  JOURNAL   J. Virol. 72 (10), 8332-8337 (1998)
   PUBMED   9733879
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299729.1, AF090891.1,
            AL136586.1 and BU679319.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a HTLV-1 tax1 binding protein. The
            encoded protein interacts with TNFAIP3, and inhibits TNF-induced
            apoptosis by mediating the TNFAIP3 anti-apoptotic activity.
            Degradation of this protein by caspase-3-like family proteins is
            associated with apoptosis induced by TNF. This protein may also
            have a role in the inhibition of inflammatory signaling pathways.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (3) contains an alternate 5'
            non-coding exon, and uses an alternate in-frame donor splice site
            at an internal coding exon compared to variant 1. This results in a
            shorter isoform (2, also known as TXBP151-L) missing an internal
            protein segment compared to isoform 1. Variants 2 and 3 encode the
            same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-851               AK299729.1         1-851
            852-2481            AF090891.1         767-2396
            2482-2861           AL136586.1         2512-2891
            2862-3383           BU679319.1         1-522               c
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15"
     gene            1..3383
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="Tax1 (human T-cell leukemia virus type I) binding
                     protein 1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:11575"
                     /db_xref="MIM:605326"
     exon            1..178
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       107
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:148614766"
     misc_feature    123..125
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="upstream in-frame stop codon"
     variation       131
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:184855260"
     variation       167
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375225509"
     exon            179..347
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     CDS             186..2429
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="isoform 2 is encoded by transcript variant 3;
                     TRAF6-binding protein"
                     /codon_start=1
                     /product="tax1-binding protein 1 isoform 2"
                     /protein_id="NP_001193830.1"
                     /db_xref="GI:332634740"
                     /db_xref="CCDS:CCDS43561.1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:11575"
                     /db_xref="MIM:605326"
                     /translation="
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
"
     misc_feature    234..>1595
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="Calcium binding and coiled-coil domain (CALCOCO1)
                     like; Region: CALCOCO1; pfam07888"
                     /db_xref="CDD:116500"
     variation       191
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201351489"
     variation       200
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376420843"
     variation       268
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200518839"
     variation       305
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368766669"
     exon            348..450
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       358
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7809260"
     variation       380
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79805575"
     variation       393
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11540484"
     variation       419
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150254620"
     variation       428
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374567926"
     exon            451..638
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       497
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184845751"
     variation       498
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367927936"
     STS             499..637
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="RH65631"
                     /db_xref="UniSTS:64116"
     variation       552
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372106777"
     variation       566
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201587778"
     variation       567
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199836430"
     variation       569
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374194011"
     variation       575
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9829"
     variation       628
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144279541"
     exon            639..797
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       669
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143497095"
     variation       675
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199574204"
     variation       692
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147311025"
     variation       693
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34347226"
     variation       751
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368515652"
     variation       770
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372499342"
     exon            798..946
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       875
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7795659"
     variation       877
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144826085"
     variation       896
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187463889"
     variation       913
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148512801"
     variation       935
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139970643"
     variation       945
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376669585"
     exon            947..1037
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       970
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376415438"
     variation       990
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142832236"
     variation       993
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371052683"
     variation       1009
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199893082"
     variation       1023
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373589178"
     exon            1038..1223
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1040
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370955901"
     variation       1104
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11540483"
     variation       1105
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141015886"
     variation       1134
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184528287"
     variation       1172
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200588230"
     variation       1192
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143687148"
     exon            1224..1448
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1254
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377033381"
     variation       1322
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370318377"
     variation       1330
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200041605"
     variation       1345
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201012389"
     variation       1355
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371768103"
     variation       1363
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200115275"
     variation       1368
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146488468"
     variation       1371
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200880289"
     variation       1385
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375088303"
     variation       1427
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35521804"
     exon            1449..1595
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1472
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114874327"
     variation       1475
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148898077"
     variation       1505
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369476152"
     exon            1596..1719
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1608
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802841"
     variation       1628
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376725530"
     variation       1648
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35469533"
     variation       1669
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75969039"
     variation       1684
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35085537"
     variation       1698
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143459175"
     variation       1718
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113897474"
     exon            1720..1823
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1735
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147980008"
     variation       1743
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61739691"
     variation       1745
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1043151"
     variation       1758
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200687127"
     variation       1823
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147154541"
     exon            1824..1949
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1836
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199588505"
     variation       1864
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369666491"
     variation       1902
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199556359"
     variation       1926
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139268186"
     exon            1950..1995
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       1950
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75265603"
     variation       1964
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143177155"
     variation       1967
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370551887"
     exon            1996..2144
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       2002
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375645372"
     variation       2024
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373849057"
     variation       2098
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377595038"
     exon            2145..2227
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       2163
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202210451"
     variation       2164
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11091"
     variation       2194
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112084378"
     exon            2228..3367
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:1.39.8"
     variation       2255
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367746678"
     STS             2259..3004
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="TAX1BP1_2449"
                     /db_xref="UniSTS:281039"
     STS             2315..2414
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="SGC31789"
                     /db_xref="UniSTS:2823"
     variation       2324
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77750724"
     variation       2327
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111505296"
     variation       2333
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376787714"
     variation       2361
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144255675"
     variation       2388
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375080539"
     variation       2408
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116615727"
     variation       2412
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375566844"
     variation       2443
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190937938"
     variation       2449
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369865240"
     variation       2461
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182920258"
     variation       2464..2465
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34270007"
     variation       2465..2466
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace=""
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:67783818"
     variation       2474..2475
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:72426082"
     variation       2483
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188352965"
     variation       2511
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116071040"
     polyA_signal    2610..2615
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      2652
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_signal    2704..2709
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     STS             2727..2828
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="SGC32601"
                     /db_xref="UniSTS:62629"
     polyA_site      2747
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     variation       2748
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183483565"
     polyA_signal    2839..2844
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      2861
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     variation       2950
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79198426"
     STS             3197..3327
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /standard_name="WI-11921"
                     /db_xref="UniSTS:57725"
     polyA_signal    3251..3256
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      3277
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_signal    3332..3337
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     variation       3336..3339
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace=""
                     /replace="aaga"
                     /db_xref="dbSNP:369185424"
     variation       3358
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73075348"
     polyA_site      3367
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
ORIGIN      
acggcaacagaagactatgatgaattcgaatgggacacatttgcttctgtggagttacgattcaaactgaatgtccaatataggaaggcaacatatacaacaagcaaaagtgattttagaaataacagaacgcgggagaaaattcacacacggaaaatgatacggataacaaaagcagattcacaatgacatcctttcaagaagtcccattgcagacttccaactttgcccatgtcatctttcaaaatgtggccaagagttaccttcctaatgcacacctggaatgtcattacaccttaactccatatattcatccacatccaaaagattgggttggtatattcaaggttggatggagtactgctcgtgattattacacgtttttatggtcccctatgcctgaacattatgtggaaggatcaacagtcaattgtgtactagcattccaaggatattaccttccaaatgatgatggagaattttatcagttctgttacgttacccataagggtgaaattcgtggagcaagtacacctttccagtttcgagcttcttctccagttgaagagctgcttactatggaagatgaaggaaattctgacatgttagtggtgaccacaaaagcaggccttcttgagttgaaaattgagaaaaccatgaaagaaaaagaagaactgttaaagttaattgccgttctggaaaaagaaacagcacaacttcgagaacaagttgggagaatggaaagagaacttaaccatgagaaagaaagatgtgaccaactgcaagcagaacaaaagggtcttactgaagtaacacaaagcttaaaaatggaaaatgaagagtttaagaagaggttcagtgatgctacatccaaagcccatcagcttgaggaagatattgtgtcagtaacacataaagcaattgaaaaagaaaccgaattagacagtttaaaggacaaactcaagaaggcacaacatgaaagagaacaacttgaatgtcagttgaagacagagaaggatgaaaaggaactttataaggtacatttgaagaatacagaaatagaaaataccaagcttatgtcagaggtccagactttaaaaaatttagatgggaacaaagaaagcgtgattactcatttcaaagaagagattggcaggctgcagttatgtttggctgaaaaggaaaatctgcaaagaactttcctgcttacaacctcaagtaaagaagatacttgttttttaaaggagcaacttcgtaaagcagaggaacaggttcaggcaactcggcaagaagttgtctttctggctaaagaactcagtgatgctgtcaacgtacgagacagaacgatggcagacctgcatactgcacgcttggaaaacgagaaagtgaaaaagcagttagctgatgcagtggcagaacttaaactaaatgctatgaaaaaagatcaggacaagactgatacactggaacacgaactaagaagagaagttgaagatctgaaactccgtcttcagatggctgcagaccattataaagaaaaatttaaggaatgccaaaggctccaaaaacaaataaacaaactttcagatcaatcagctaataataataatgtcttcacaaagaaaacggggaatcagcagaaagtgaatgatgcttcagtaaacacagacccagccacttctgcctctactgtagatgtaaagccatcaccttctgcagcagaggcagattttgacatagtaacaaaggggcaagtctgtgaaatgaccaaagaaattgctgacaaaacagaaaagtataataaatgtaaacaactcttgcaggatgagaaagcaaaatgcaataaatatgctgatgaacttgcaaaaatggagctgaaatggaaagaacaagtgaaaattgctgaaaatgtaaaacttgaactagctgaagtacaggacaattataaagaacttaaaaggagtctagaaaatccagcagaaaggaaaatggaagatggagcagatggtgctttttacccagatgaaatacaaaggccacctgtcagagtcccctcttggggactggaagacaatgttgtctgcagccagcctgctcgaaactttagtcggcctgatggcttagaggactctgaggatagcaaagaagatgagaatgtgcctactgctcctgatcctccaagtcaacatttacgtgggcatgggacaggcttttgctttgattccagctttgatgttcacaagaagtgtcccctctgtgagttaatgtttcctcctaactatgatcagagcaaatttgaagaacatgttgaaagtcactggaaggtgtgcccgatgtgcagcgagcagttccctcctgactatgaccagcaggtgtttgaaaggcatgtgcagacccattttgatcagaatgttctaaattttgactagttactttttattatgagttaatatagtttagcagtaaaaaaaaaaaaaaaaaccacacctaaaatagaccactgaggagaccatagagcggatgctttcatgcaccctttactgcactttctgaccaggagctactttgagtttggtgttactaggatcagggtcagtctttggcttatcaataaattttaatctctgttaatcttacctgctttaaaaaaaagttcttgtgtgttcgtatctttatttattccctagtttgcagaactgtctgaataaaggatacaaggattatttcaatgttactgcactgaaaaacgtgtatgtattagtgtgctagattatttagcagaatattcacaagtttctgttgaccttgttgattgagcatgactactaaatattatgtaataaaaagcatttgtcataacagtcttatgaagtagttcttcgaatatagaaagttctataatttagcccatgaaatgataggtttttaattttcagaaatggagctgcatgtagaatgagatcacatgcttttatatgtgaaatattggttttagcaattaacagaaggcatactttgctaattttatggcaaaattttagaataacctgaatgattatttttaaactatcttgaagttgtatgtatatatctaatgggaaaatggaacaagagatgtcagtataattgttttcctattaaatgatctcataacaggggtgtttgtggcataaaaatcatagaatatatatcagtatcttttttacattttcctgatgagaatataaatttgaaatattctcagtaagtgattaaaagtacaatacataaacccaaatcaaagtaatgtgtttcttcagttatgtctgtgctgtatagaactgtcactaacattaaagaaagaggacacatttttcaagatctgtaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8887 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8887 -> Molecular function: GO:0019900 [kinase binding] evidence: ISS
            GeneID:8887 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:8887 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: ISS
            GeneID:8887 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
            GeneID:8887 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:8887 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:8887 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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