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2018-11-22 03:47:57, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001206833            2191 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens K(lysine) acetyltransferase 5 (KAT5), transcript
            variant 4, mRNA.
ACCESSION   NM_001206833
VERSION     NM_001206833.1  GI:332205930
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Kaidi,A. and Jackson,S.P.
  TITLE     KAT5 tyrosine phosphorylation couples chromatin sensing to ATM
            signalling
  JOURNAL   Nature 498 (7452), 70-74 (2013)
   PUBMED   23708966
  REMARK    GeneRIF: tyrosine phosphorylation of KAT5 increases after DNA
            damage in a manner that promotes KAT5 binding to the histone mark
            H3K9me3; this triggers KAT5-mediated acetylation of the ATM kinase,
            promoting DNA-damage-checkpoint activation and cell survival
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Jha,S., Gupta,A., Dar,A. and Dutta,A.
  TITLE     RVBs are required for assembling a functional TIP60 complex
  JOURNAL   Mol. Cell. Biol. 33 (6), 1164-1174 (2013)
   PUBMED   23297341
  REMARK    GeneRIF: RVBs are also required for heat stability of TIP60.com by
            a p400-independent pathway.
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Muller,T., Schrotter,A., Loosse,C., Pfeiffer,K., Theiss,C.,
            Kauth,M., Meyer,H.E. and Marcus,K.
  TITLE     A ternary complex consisting of AICD, FE65, and TIP60
            down-regulates Stathmin1
  JOURNAL   Biochim. Biophys. Acta 1834 (1), 387-394 (2013)
   PUBMED   22902274
  REMARK    GeneRIF: A ternary complex consisting of AICD, FE65, and TIP60
            down-regulates Stathmin1.
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Laurberg,J.R., Brems-Eskildsen,A.S., Nordentoft,I., Fristrup,N.,
            Schepeler,T., Ulhoi,B.P., Agerbaek,M., Hartmann,A., Bertz,S.,
            Wittlinger,M., Fietkau,R., Rodel,C., Borre,M., Jensen,J.B.,
            Orntoft,T. and Dyrskjot,L.
  TITLE     Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic
            recombination 11 homolog) predict treatment-specific outcome of
            localised invasive bladder cancer
  JOURNAL   BJU Int. 110 (11 PT C), E1228-E1236 (2012)
   PUBMED   23046361
  REMARK    GeneRIF: TIP60 protein expression was a predictive marker for DSS
            after cystectomy in two independent cohorts. This novel marker was
            the strongest predictive factor in multivariate analysis in
            patients receiving cystectomy.
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Coffey,K., Blackburn,T.J., Cook,S., Golding,B.T., Griffin,R.J.,
            Hardcastle,I.R., Hewitt,L., Huberman,K., McNeill,H.V., Newell,D.R.,
            Roche,C., Ryan-Munden,C.A., Watson,A. and Robson,C.N.
  TITLE     Characterisation of a Tip60 specific inhibitor, NU9056, in prostate
            cancer
  JOURNAL   PLoS ONE 7 (10), E45539 (2012)
   PUBMED   23056207
  REMARK    GeneRIF: Studies indicate histone acetyltransferase Tip60 as a
            potential therapeutic target for the treatment of prostate cancer.
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Brady,M.E., Ozanne,D.M., Gaughan,L., Waite,I., Cook,S., Neal,D.E.
            and Robson,C.N.
  TITLE     Tip60 is a nuclear hormone receptor coactivator
  JOURNAL   J. Biol. Chem. 274 (25), 17599-17604 (1999)
   PUBMED   10364196
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Dechend,R., Hirano,F., Lehmann,K., Heissmeyer,V., Ansieau,S.,
            Wulczyn,F.G., Scheidereit,C. and Leutz,A.
  TITLE     The Bcl-3 oncoprotein acts as a bridging factor between
            NF-kappaB/Rel and nuclear co-regulators
  JOURNAL   Oncogene 18 (22), 3316-3323 (1999)
   PUBMED   10362352
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Kimura,A. and Horikoshi,M.
  TITLE     Tip60 acetylates six lysines of a specific class in core histones
            in vitro
  JOURNAL   Genes Cells 3 (12), 789-800 (1998)
   PUBMED   10096020
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Yamamoto,T. and Horikoshi,M.
  TITLE     Novel substrate specificity of the histone acetyltransferase
            activity of HIV-1-Tat interactive protein Tip60
  JOURNAL   J. Biol. Chem. 272 (49), 30595-30598 (1997)
   PUBMED   9388189
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   Kamine,J., Elangovan,B., Subramanian,T., Coleman,D. and
            Chinnadurai,G.
  TITLE     Identification of a cellular protein that specifically interacts
            with the essential cysteine region of the HIV-1 Tat transactivator
  JOURNAL   Virology 216 (2), 357-366 (1996)
   PUBMED   8607265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB003934.1, DB103287.1,
            AK304664.1, BC013211.1 and BU737532.1.
            
            Summary: The protein encoded by this gene belongs to the MYST
            family of histone acetyl transferases (HATs) and was originally
            isolated as an HIV-1 TAT-interactive protein. HATs play important
            roles in regulating chromatin remodeling, transcription and other
            nuclear processes by acetylating histone and nonhistone proteins.
            This protein is a histone acetylase that has a role in DNA repair
            and apoptosis and is thought to play an important role in signal
            transduction. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The resulting
            protein (isoform 4) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000166.3, AK304664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               DB003934.1         1-110
            111-250             DB103287.1         78-217
            251-1934            AK304664.1         1-1684
            1935-2158           BC013211.1         1809-2032
            2159-2191           BU737532.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13"
     gene            1..2191
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="K(lysine) acetyltransferase 5"
                     /db_xref="GeneID:10524"
                     /db_xref="HGNC:5275"
                     /db_xref="MIM:601409"
     exon            1..444
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       35..36
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:139060964"
     variation       35
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:4645910"
     variation       106
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:373551156"
     variation       118
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:4645911"
     variation       156
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112313136"
     variation       185
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375270159"
     STS             214..1788
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /db_xref="UniSTS:483047"
     misc_feature    222..224
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="upstream in-frame stop codon"
     variation       234
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71455780"
     variation       251
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201205470"
     variation       255
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186911544"
     variation       259
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375275397"
     variation       262
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367676300"
     CDS             267..1751
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /EC_number="2.3.1.48"
                     /note="isoform 4 is encoded by transcript variant 4; cPLA2
                     interacting protein; HIV-1 Tat interactive protein, 60kDa;
                     K-acetyltransferase 5; Tat interacting protein, 60kDa;
                     histone acetyltransferase KAT5; cPLA(2)-interacting
                     protein; 60 kDa Tat-interactive protein; histone
                     acetyltransferase HTATIP"
                     /codon_start=1
                     /product="histone acetyltransferase KAT5 isoform 4"
                     /protein_id="NP_001193762.1"
                     /db_xref="GI:332205931"
                     /db_xref="CCDS:CCDS55771.1"
                     /db_xref="GeneID:10524"
                     /db_xref="HGNC:5275"
                     /db_xref="MIM:601409"
                     /translation="
MAEVVSPVPGAGRREPGEVGRARGPPVADPGVALSPQGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
"
     misc_feature    381..1709
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="Histone acetyltransferase (MYST family) [Chromatin
                     structure and dynamics]; Region: SAS2; COG5027"
                     /db_xref="CDD:34632"
     misc_feature    435..593
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="Chromatin organization modifier (chromo) domain is
                     a conserved region of around 50 amino acids found in a
                     variety of chromosomal proteins, which appear to play a
                     role in the functional organization of the eukaryotic
                     nucleus. Experimental evidence...; Region: CHROMO;
                     cd00024"
                     /db_xref="CDD:28908"
     misc_feature    order(441..443,498..500,504..506,513..515,525..527,
                     537..539,549..554)
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="histone binding site; other site"
                     /db_xref="CDD:28908"
     misc_feature    1062..1640
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /note="MOZ/SAS family; Region: MOZ_SAS; pfam01853"
                     /db_xref="CDD:202012"
     variation       273
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71455781"
     variation       285
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371801645"
     variation       345
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149844051"
     variation       351
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202097241"
     variation       361
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146788368"
     variation       383
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140468859"
     variation       395
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145735863"
     variation       413
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138317008"
     exon            445..513
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       458
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149093594"
     variation       464
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4645914"
     exon            514..650
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       591
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369527314"
     variation       597
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11541271"
     variation       599
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11541269"
     variation       608
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372595844"
     variation       615
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115896676"
     variation       616
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11541270"
     variation       632
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116830965"
     variation       641
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201415653"
     exon            651..725
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       695
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147419775"
     variation       704
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:137945879"
     exon            726..800
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       733
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143413716"
     variation       748
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:386834229"
     variation       754
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369137034"
     variation       766
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372880133"
     variation       779
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201879725"
     exon            801..1049
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       818
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368421147"
     variation       823
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200974760"
     variation       867
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:4645921"
     variation       875
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371854405"
     variation       906
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139506891"
     variation       925
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200620312"
     variation       930
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149683297"
     variation       941
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144349144"
     variation       978
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114058675"
     variation       983
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368796194"
     variation       1016
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111345240"
     variation       1019
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148757761"
     exon            1050..1139
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1054
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111512947"
     variation       1092
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143910658"
     exon            1140..1280
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1154
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376820640"
     variation       1174
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368959604"
     variation       1193
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146875234"
     variation       1220
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140561633"
     variation       1227
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199667540"
     variation       1233
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377274648"
     variation       1250
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144191296"
     exon            1281..1374
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1307
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200248772"
     variation       1352
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146588319"
     variation       1370
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201020447"
     exon            1375..1534
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1406
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11227272"
     variation       1476
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370970433"
     variation       1496
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150212692"
     variation       1507
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375524599"
     variation       1508
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114460328"
     variation       1526
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368492530"
     exon            1535..1616
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1597
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200625753"
     exon            1617..2176
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /inference="alignment:Splign:1.39.8"
     variation       1672
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145568166"
     variation       1695
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199674306"
     variation       1697
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11385"
     variation       1780
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199779470"
     variation       1781
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200332583"
     variation       1783
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201309659"
     variation       1801
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370375120"
     variation       1811
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186106053"
     STS             1930..2145
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /standard_name="IB3011"
                     /db_xref="UniSTS:46906"
     STS             1931..2161
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /standard_name="STS-U40989"
                     /db_xref="UniSTS:64845"
     STS             1973..2172
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /standard_name="HSC0AE062"
                     /db_xref="UniSTS:47861"
     variation       1982
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375782368"
     STS             2003..2136
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /standard_name="RH18259"
                     /db_xref="UniSTS:56059"
     variation       2043
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190723966"
     variation       2095
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:554051"
     variation       2098
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199982885"
     polyA_signal    2153..2158
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
     variation       2165
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3177082"
     polyA_site      2174
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
     variation       2175
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3180585"
     polyA_site      2176
                     /gene="KAT5"
                     /gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
                     TIP60; ZC2HC5"
ORIGIN      
gcacccggtgggcgtcacgtgacggactcagtagaccgccactggctgtgcacgttatggggtttccacctagggctcggcctgaggcttgtaacactccgttttcccccgagtcacaggggcagtcttgcccctcgcagctgggtcgcggtgtctctcaaaggtccccctctacaggggcttcgtgaggcccgggcccacagggcgctcggtcccggaagtgacgtctcccagaggggccggaagtggcagtggagggagggaagatggcggaggtggtgagtccggtgcccggggcggggcggagggagccaggggaggtgggtagagcccgaggccccccagtagccgaccctggcgtcgcgctgtctccccagggggagataatcgagggctgccgcctacccgtgctgcggcggaaccaggacaacgaagatgagtggcccctggccgagatcctgagcgtgaaggacatcagtggccggaagcttttctacgtccattacattgacttcaacaaacgtctggatgaatgggtgacgcatgagcggctggacctaaagaagatccagttccccaagaaagaggccaagacccccactaagaacggacttcctgggtcccgtcctggctctccagagagagaggtgaaacggaaggtggaggtggtttcaccagcaactccagtgcccagcgagacagccccggcctcggtttttccccagaatggagccgcccgtagggcagtggcagcccagccaggacggaagcgaaaatcgaattgtttgggcactgatgaggactcccaggacagctctgatggaataccgtcagcaccacgcatgactggcagcctggtgtctgatcgaagccacgacgacatcgtcacccggatgaagaacattgagtgcattgagctgggccggcaccgcctcaagccgtggtacttctccccgtacccacaggaactcaccacattgcctgtcctctacctgtgcgagttctgcctcaagtacggccgtagtctcaagtgtcttcagcgtcatttgaccaagtgtgacctacgacatcctccaggcaatgagatttaccgcaagggcaccatctccttctttgagattgatggacgtaagaacaagagttattcccagaacctgtgtcttttggccaagtgtttccttgaccataagacactgtactatgacacagaccctttcctcttctacgtcatgacagagtatgactgtaagggcttccacatcgtgggctacttctccaaggagaaagaatcaacggaagactacaatgtggcctgcatcctaaccctgcctccctaccagcgccggggctacggcaagctgctgatcgagttcagctatgaactctccaaagtggaagggaaaacagggacccctgagaagcccctctcagaccttggcctcctatcctatcgaagctactggtcccagaccatcctggagatcctgatggggctgaagtcggagagcggggagaggccacagatcaccatcaatgagattagtgaaatcaccagcatcaagaaggaggatgtcatctccactctgcagtacctcaatctcatcaactactacaagggccagtacatcctcacactgtcagaggacatcgtggatggccatgagcgggccatgctcaagcggctcctgcggatcgactccaagtgtctgcacttcactcccaaggactggagcaagagggggaagtggtgaccagacactgcccactgcagtgccaagacggcagcaggactggggctgatagcccaccccgcccccactgcagctcccacaaagcactctaagggagatggggctgaggacagctcaaaaaggagaggacaggcctggcaggggcccactggtgcccagcaccaaggcgagctccgggctcagaccaactccaaggtcagctggccacaggcccaggcctcctctgaagcagggaccagagggagccaggcagctgtgtacagtgagaagggatccggatgggggagctctgtacagagggctggtgattgtaaaaatttcttttgtaaagtagaagttgggggtggggtgggtgctggctgcaaaaatttctggcttctcttacccctattgcccccggcaataaattgtttctatatgccagaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: IDA
            GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS
            GeneID:10524 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
            GeneID:10524 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10524 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
            GeneID:10524 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:10524 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS
            GeneID:10524 -> Molecular function: GO:0070491 [repressing transcription factor binding] evidence: IPI
            GeneID:10524 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:10524 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
            GeneID:10524 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:10524 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IDA
            GeneID:10524 -> Biological process: GO:0016573 [histone acetylation] evidence: IDA
            GeneID:10524 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:10524 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS
            GeneID:10524 -> Biological process: GO:0032703 [negative regulation of interleukin-2 production] evidence: IDA
            GeneID:10524 -> Biological process: GO:0040008 [regulation of growth] evidence: IEA
            GeneID:10524 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:10524 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:10524 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
            GeneID:10524 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:10524 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:10524 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:10524 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:10524 -> Cellular component: GO:0032777 [Piccolo NuA4 histone acetyltransferase complex] evidence: IDA
            GeneID:10524 -> Cellular component: GO:0035267 [NuA4 histone acetyltransferase complex] evidence: IDA
            GeneID:10524 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001193762 -> EC 2.3.1.48

by @meso_cacase at DBCLS
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