2024-03-29 16:27:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001206524 5705 bp mRNA linear PRI 16-JUN-2013 DEFINITION Homo sapiens caspase 10, apoptosis-related cysteine peptidase (CASP10), transcript variant 6, mRNA. ACCESSION NM_001206524 VERSION NM_001206524.1 GI:330864822 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5705) AUTHORS Lisa-Santamaria,P., Jimenez,A. and Revuelta,J.L. TITLE The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling JOURNAL J. Biol. Chem. 287 (35), 29636-29647 (2012) PUBMED 22782902 REMARK GeneRIF: The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. REFERENCE 2 (bases 1 to 5705) AUTHORS Schleich,K., Warnken,U., Fricker,N., Ozturk,S., Richter,P., Kammerer,K., Schnolzer,M., Krammer,P.H. and Lavrik,I.N. TITLE Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model JOURNAL Mol. Cell 47 (2), 306-319 (2012) PUBMED 22683265 REMARK GeneRIF: analysis of stoichiometry of the CD95 death-inducing signaling complex and demonstration of how procaspase-8, procaspase-10, and c-FLIP form DED chains at the DISC, enabling the formation of dimers and efficient activation of caspase-8 REFERENCE 3 (bases 1 to 5705) AUTHORS Ekchariyawat,P., Thitithanyanont,A., Sirisinha,S. and Utaisincharoen,P. TITLE Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation JOURNAL Innate Immun 18 (3), 390-397 (2012) PUBMED 21911414 REMARK GeneRIF: induces apoptosis in avian virus H5N1-infected human monocyte-derived macrophages REFERENCE 4 (bases 1 to 5705) AUTHORS Yan,S., Li,Y.Z., Zhu,J.W., Liu,C.L., Wang,P. and Liu,Y.L. TITLE Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis JOURNAL Genet. Mol. Res. 11 (4), 3998-4007 (2012) PUBMED 23212337 REMARK GeneRIF: This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer. Review article Publication Status: Online-Only REFERENCE 5 (bases 1 to 5705) AUTHORS Qian,J., Qu,H.Q., Yang,L., Yin,M., Wang,Q., Gu,S., Wu,Q., Zhao,X., Wu,W., Wu,J., Tan,X., Chen,W., Wang,H., Wang,J., Fan,W., Chen,H., Han,B., Lu,D., Wei,Q. and Jin,L. TITLE Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer JOURNAL Oncologist 17 (12), 1551-1561 (2012) PUBMED 22843554 REMARK GeneRIF: Genetic variations in CASP8 and CASP10 may act as potential predictive biomarkers for platinum-based chemotherapy toxicity in Chinese non-small cell lung cancer patients. REFERENCE 6 (bases 1 to 5705) AUTHORS Ng,P.W., Porter,A.G. and Janicke,R.U. TITLE Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10 JOURNAL J. Biol. Chem. 274 (15), 10301-10308 (1999) PUBMED 10187817 REFERENCE 7 (bases 1 to 5705) AUTHORS Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J., Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G. et al. TITLE Mch3, a novel human apoptotic cysteine protease highly related to CPP32 JOURNAL Cancer Res. 55 (24), 6045-6052 (1995) PUBMED 8521391 REFERENCE 8 (bases 1 to 5705) AUTHORS DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and Calos,M.P. TITLE Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system JOURNAL Mol. Cell. Biol. 7 (1), 379-387 (1987) PUBMED 3031469 REFERENCE 9 (bases 1 to 5705) AUTHORS Clements,G.B., Klein,G. and Povey,S. TITLE Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA JOURNAL Int. J. Cancer 16 (1), 125-133 (1975) PUBMED 170210 REFERENCE 10 (bases 1 to 5705) AUTHORS Baumann,K., de Rouffignac,C., Roinel,N., Rumrich,G. and Ullrich,K.J. TITLE Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence JOURNAL Pflugers Arch. 356 (4), 287-298 (1975) PUBMED 1171445 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA456072.1, BC042844.1, AC007283.3 and U60519.1. Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]. Transcript Variant: This variant (6) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (6) missing an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ487678.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025083, ERS025084 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 DA456072.1 18-153 137-545 DA456072.1 155-563 546-1139 BC042844.1 282-875 1140-1989 BC042844.1 1077-1926 1990-2452 AC007283.3 18113-18575 c 2453-4125 U60519.1 1864-3536 4126-5705 AC007283.3 14860-16439 c FEATURES Location/Qualifiers source 1..5705 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q33-q34" gene 1..5705 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="caspase 10, apoptosis-related cysteine peptidase" /db_xref="GeneID:843" /db_xref="HGNC:1500" /db_xref="MIM:601762" exon 1..411 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 59 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:41429849" variation 213 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:16836789" variation 229..230 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="c" /db_xref="dbSNP:34296231" variation 366..367 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="c" /db_xref="dbSNP:35190763" misc_feature 407..409 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="upstream in-frame stop codon" exon 412..765 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" CDS 419..1786 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /EC_number="3.4.22.63" /note="isoform 6 preproprotein is encoded by transcript variant 6; caspase 10, apoptosis-related cysteine protease; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase-10; CASP-10; FAS-associated death domain protein interleukin-1B-converting enzyme 2" /codon_start=1 /product="caspase-10 isoform 6 preproprotein" /protein_id="NP_001193453.1" /db_xref="GI:330864823" /db_xref="CCDS:CCDS56159.1" /db_xref="GeneID:843" /db_xref="HGNC:1500" /db_xref="MIM:601762" /translation="
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
" misc_feature 470..715 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633" /db_xref="CDD:209876" misc_feature 752..988 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="Death Effector Domain, repeat 2, of Caspase-10; Region: DED_Caspase_10_repeat2; cd08814" /db_xref="CDD:176792" misc_feature order(755..757,764..769,773..778,788..790,866..868, 878..880) /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="putative DED1/DED2 interface [polypeptide binding]; other site" /db_xref="CDD:176792" mat_peptide 1076..1462 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /product="caspase-10 isoform 6 large subunit" misc_feature 1139..1759 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cd00032" /db_xref="CDD:28914" misc_feature order(1289..1291,1418..1420) /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="active site" /db_xref="CDD:28914" misc_feature order(1292..1294,1412..1414,1433..1435,1556..1573, 1583..1588) /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="substrate pocket [chemical binding]; other site" /db_xref="CDD:28914" misc_feature order(1436..1438,1511..1516,1535..1537,1544..1546, 1553..1555,1622..1624,1649..1651,1667..1669,1709..1711, 1724..1729,1733..1735,1742..1747) /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:28914" misc_feature order(1439..1441,1508..1510) /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /note="proteolytic cleavage site; other site" /db_xref="CDD:28914" mat_peptide 1463..1783 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /product="caspase-10 isoform 6 small subunit" variation 438 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:200935960" variation 480 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:140813639" variation 507 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:201782416" variation 512 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:375838979" variation 544 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:146684884" variation 560 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:200012872" variation 575 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:1804650" variation 592 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:114625983" variation 594 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:139417609" variation 595 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:3900115" variation 644 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:146696981" variation 673 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:185792819" variation 689 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:148026756" variation 700 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:370492434" variation 732 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:200530667" variation 743 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:201601111" variation 750 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:199600895" exon 766..859 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 845 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:376343637" variation 858 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:121909776" exon 860..995 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 920 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:371962581" variation 952 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:146233833" variation 968 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:200877813" variation 971 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:369231920" exon 996..1102 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 1014 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:200079223" variation 1033 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:373077581" variation 1084 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:116125703" variation 1100 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:370134219" variation 1101 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:143882052" variation 1102 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:368583939" exon 1103..1139 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 1133 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:41473647" exon 1140..1632 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 1147 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:149096064" variation 1170 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:138931498" variation 1200 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:200424779" STS 1227..1597 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /standard_name="PMC230316P3" /db_xref="UniSTS:272181" variation 1232 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:111775921" variation 1240 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:114098515" variation 1256 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:115264962" variation 1285 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:111489269" variation 1303 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:369304578" variation 1306 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:148290917" variation 1334 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:372719084" variation 1341 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:375798142" variation 1349 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:370138285" variation 1414 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:199626441" variation 1433 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:80358239" variation 1444 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:371401141" variation 1445 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:13010627" variation 1458 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:28936699" variation 1471 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:140190607" variation 1484 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:374332152" variation 1513 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:41331850" variation 1514 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:200540853" variation 1547 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:41513147" variation 1554 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:17860405" variation 1564 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:147814983" variation 1567 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:370670949" variation 1612 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:199853584" exon 1633..5705 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /inference="alignment:Splign:1.39.8" variation 1669 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:375762220" variation 1676 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:376911298" variation 1694 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:369901008" variation 1719 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:148939095" variation 1754 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:143632134" variation 1779 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:200836551" variation 1781 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:13006529" variation 1798 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:375389117" variation 1820 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:377581981" variation 1825 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:372456822" variation 1826 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:199884991" variation 1863 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:191438878" variation 1886 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:182870266" variation 2027 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:370987136" variation 2063 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:3931696" variation 2071 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:3851974" variation 2153 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:41365346" variation 2451 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:142072849" variation 2520 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="t" /db_xref="dbSNP:41506545" variation 2539 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:186862746" variation 2601 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:17860409" variation 2632 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41529249" variation 2701 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:115679933" STS 2770..2980 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /standard_name="RH70685" /db_xref="UniSTS:32193" variation 2923 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:374014099" variation 2955 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:185024061" variation 2964 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:187888242" variation 3096 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:77842514" variation 3116 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:41342848" variation 3126 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:367793804" variation 3228 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:372084524" variation 3257 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:192319559" variation 3306 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:41331447" variation 3323 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:78596960" variation 3328 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41484449" variation 3410 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:150841386" STS 3459..4309 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /standard_name="CASP10_482" /db_xref="UniSTS:277051" variation 3474 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41515650" variation 3503 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:149971137" variation 3528 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:145632258" variation 3579 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:114760847" variation 3610 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:199729683" variation 3614 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:373636173" variation 3700 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:185318287" variation 3706 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:11885191" variation 3741 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:139807893" variation 3747 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:368898723" variation 3751 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="t" /db_xref="dbSNP:111572089" variation 3752 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:79528144" STS 3848..3971 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /standard_name="RH77986" /db_xref="UniSTS:65780" variation 3932 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:147622791" STS 3934..4064 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /standard_name="RH68751" /db_xref="UniSTS:47132" variation 3967 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:41443046" variation 4075 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:41369551" variation 4337 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:189798514" variation 4373 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="t" /db_xref="dbSNP:199859568" variation 4374 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="" /replace="g" /db_xref="dbSNP:41351949" variation 4376 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:74267227" variation 4381 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:72491092" variation 4388 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41477650" variation 4404 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41431151" variation 4461 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:376034565" variation 4475 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41447745" variation 4484 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:181477362" variation 4512 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:372156178" variation 4523 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41412149" variation 4543 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:13414860" variation 4546 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:41435647" variation 4617 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:151162733" variation 4636 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:376511354" variation 4797 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:368336354" variation 4823 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:140099864" variation 4857 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:41339144" variation 4923 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="g" /db_xref="dbSNP:41522046" variation 5299 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:6752492" variation 5345 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:184599061" variation 5359 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:368946094" variation 5478 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:202089864" variation 5479 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="g" /db_xref="dbSNP:199723186" variation 5480 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="g" /replace="t" /db_xref="dbSNP:200619033" variation 5482 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="t" /db_xref="dbSNP:201705079" variation 5574 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:111444762" variation 5578 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="c" /replace="t" /db_xref="dbSNP:41486645" variation 5652 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" /replace="a" /replace="c" /db_xref="dbSNP:41486549" polyA_signal 5684..5689 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" polyA_site 5704 /gene="CASP10" /gene_synonym="ALPS2; FLICE2; MCH4" ORIGIN
aaggaaatggagatccaaaggaaagcctgaagcactttgtggcttccacgggttcgtttctaggaagcttttgctttacctggggaaaccccaagctctacagtgagaaagttgtaaattagcctttaggagacgctgtttgtcaaagttatcttaaccctggaaaaggggagggaaaaaggcagataagcagtgatgacatcagcaggaaactagtatcaggctacccagtcctgaagattcagttttcacttaaacaaccagcaagtcttgaagtctcttcccaagcaaatgggagcttctttggaccttggagcacacagaggattctactttctttaaaactttgttttcaggcaatttccctgagaaccgtttacttccagaagattggtggagcttgatctgaaggctggccatgaaatctcaaggtcaacattggtattccagttcagataaaaactgtaaagtgagctttcgtgagaagcttctgattattgattcaaacctgggggtccaagatgtggagaacctcaagtttctctgcataggattggtccccaacaagaagctggagaagtccagctcagcctcagatgtttttgaacatctcttggcagaggatctgctgagtgaggaagaccctttcttcctggcagaactcctctatatcatacggcagaagaagctgctgcagcacctcaactgtaccaaagaggaagtggagcgactgctgcccacccgacaaagggtttctctgtttagaaacctgctctacgaactgtcagaaggcattgactcagagaacttaaaggacatgatcttccttctgaaagactcgcttcccaaaactgaaatgacctccctaagtttcctggcatttctagagaaacaaggtaaaatagatgaagataatctgacatgcctggaggacctctgcaaaacagttgtacctaaacttttgagaaacatagagaaatacaaaagagagaaagctatccagatagtgacacctcctgtagacaaggaagccgagtcgtatcaaggagaggaagaactagtttcccaaacagatgttaagacattcttggaagccttaccgcaggagtcctggcaaaataagcatgcaggtagtaatgagatcctgagtcatgtgttccagtggcttgggttcacagtgcatatacacaataatgtgacgaaagtggaaatggagatggtcctgcagaagcagaagtgcaatccagcccatgccgacggggactgcttcgtgttctgtattctgacccatgggagatttggagctgtctactcttcggatgaggccctcattcccattcgggagatcatgtctcacttcacagccctgcagtgccctagactggctgaaaaacctaaactctttttcatccaggcctgccaaggtgaagagatacagccttccgtatccatcgaagcagatgctctgaaccctgagcaggcacccacttccctgcaggacagtattcctgccgaggctgacttcctacttggtctggccactgtcccaggctatgtatcctttcggcatgtggaggaaggcagctggtatattcagtctctgtgtaatcatctgaagaaattggtcccaagacatgaagacatcttatccatcctcactgctgtcaacgatgatgtgagtcgaagagtggacaaacagggaacaaagaaacagatgccccagcctgctttcacactaaggaaaaaactagtattccctgtgcccctggatgcactttcattatagcagagagtttttgttggttcttagacctcaaacgaatcattggctataacctccagcctcctgcccagcacaggaatcggtggtctccacctgtcattctagaaacaggaaacaccgtgttttctgacacagtcaattctgattttctttttcttttgcaagtctaaatgttagaaaactttcttttttttggagatagtctcattctgtcacccagactggagtgcaggggggcaatcacggctcactgtagtctcgacctcccaggctcaagctgtcctcccgcctcagcttcccaagtagctgggaccacaggtgtgtaccaccgtgcccggattttttttattctttattttttgtagagatggagggatctcactttgttgcacaggctggtttcaaactcctaggcccaagtgatcctcccacctctgtccccaaaatactgggattataggcacgagccaccacacctggccagaaaactttcattattgaagacttggattgtagccttggttttggatgtctattctgaagacagagtaattggctttggtttgtgcaggtactttttctttgagacagagtcactccgtcacctgggctggagtgcagtggtgggatcactgttcactgcagccttgacctcccaggttcaagcgatcctcccacctcagcctcccaagtagctgagactacaggtgtgtgtccatgcacagctaactttttattttttttgtggagatggggtttcactatgttgcctaagctggtctcaaactcctgggctcaagcgatcctcccacctcagcttctcaaagttctgggactacaggcatgaaatactgtgcctggcctggggaccaggtgcattttaaggttccttggtgttcaaaaaccacgttcttagcctagattgagcttagattgcctctctagacaactaccccttagttataattctgtgtcccctctgcatgcccttaaacattggacagtgaggtcacagtccacccaccctctctctgatctcccccttcctaagacttctcttttgcacatctagtgaggtgaaaatttggtctatgccaggcccatttcctgcttttgtgtaaggaaggtgctcacataggaagtttttatttggttagagacaggtttccctgtaggaagatgatggctcatttacactcagctgctctgcaagcagaaactttacaacctgatgtcatattccattttggactgggtgcggtgactcatgcctgtaatcccagtactctgggaagccaaggcaggcagatcacttgaggtcaggagttcgagaccagcctggccaatacggcaaaacctcatcattactaaaaacacaaaaattagccaggtgtggcggcgagcacctgtaatcccagctactcgggaggctgagacaggagaatctcttgaatccaggaggcagaggctgtggtgagccaagatgacacaactgcactccagcttgggcaacagggcgagaccttgtttaaaaaaaaaattcaatattggggttggaacatttcagttgccattgacagaacacccaattcaaattgactgaagcaaagaagggaatttattgcctctttcacattgaaacccaggagtggataacactggcttcaggcaaagcttgaatcaggactcaatctacaggccagcacctttctcttggccggatgtcctcagggctggcagatgcagtagactgcagtggacagtccccaccttgttactgctactacactttgctcctctggcccaaggcatgaggagagaggctgtgtcagaaactgaagctgttctcaggatcactgggctcttcttggcagaggggatgtctggcttgcctgaagggagtggctctgtaaggacgccttgatgctttcttcattaagattttgagcatttttacgtacttgagcttttttttttttttttttcaatttctagaggaactttttctctgttaattcctggaactgtattttgaatccttaaaggtgagccctcatagggagatccaaagtcctgtggttaacgccttcatttatagatgaggcagctgaggcctggggatgtgaacaacctgctcacagtcctcatttactggatttgacttcagccaggtgaactggaatgccttggggcgtggaagggcattaggagtgtttcatttgatatgtgaatgctcataaaaaaatgtcaaggaatgaagaacaacaactctcagtggtgcctgcatttataattatttatgtgaaagtcaaattcatgtacagtaaatttgttataagaatattcacaagaacactgttctgatatctctgattgtcatgtggatttgaatgtagcttgacagagggaatgtctaatctatattgacagggcaggaacaccgtcatcttagacaaacaccgccactttaagttccagttccctttctagcctcatgcatttcaaggaaatcacttcttttctaacagcgagcagccagaaagagaagagagtaaaatacagataagacagctctggcatagagggaggtgggggggtgggggaagtctcttgggtaactgccaaactttgccttcatacaatgggttccaggaaaacaatgagccttaataagcacattcctttcccttcaggtgcactaagtggggaagctaaaagcagactggaggggggtggggtgtacctacagctgcagaaatattgtatgggaacggacacacaactctccctcccagataagcacagcaaagagacatagaagcaatccaagcctctgataaactctcccaccctaaatccttaaaaactcttagtctgtaagtgagtgggctctgacctaactcggccagaagcccctttcaaatttgttttctctaaaataaacctgtccttggctgtcaagccacctttcatgtttctttcctctttctttaattcttacacatgtgtcaggatgatctcccaaaaccgtgttcataacagtcagggccaaaagctagtggtcacagtccttgtccagttggcagaactgacatgtgaaggcaagtgaaggatggtgagatactgaggaaagagcaaaggatctggagatcaaagccctgcatttccattttgtcctgattcctttgctcagagacactaactaaatcaagctagcttttttcagccttgtctgtaaagtagagaaaacattagctgttgggaagacgaaaaagaatgtgtcctatgtgtgcatctatttaaatctaactgtgctgaggtgcatataaatgcctttaggtggtagggtcttccggttgtaactgcaacagaaatagcaggacttaagttcctttgtgcgtaattccagctgactttattagcggcaactcagcactagcattacccctgacatactctgagtaagatctaattcttccctcactggttcgtgatgtctaccgcagcagaaggccagctcttgactctgagttcagttggacaaaatgctgttgataaaacctcctgtcaggcctctgagcccaagctaagccatcatatcccttgtgacctgcacatatatatccagatggcctgaagtaactgaagaatcacaaaagaagtgaaaatggcctgttcctgccttaactgatgacattaccttgtgaaattccttctcctggctcatcctggctcaaaagctcccccagtgagcaccttgtgacccccatccctgccagccagagaacaaccccctttgactgtaattttccactacttacccaaatcctataaaacggccccacccctatctcccttcactgactttcttttcggactcagcccacctgcacccaggtgattaaaaagctttattgctcac
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:843 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IEA GeneID:843 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:843 -> Biological process: GO:0006508 [proteolysis] evidence: IEA GeneID:843 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:843 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: RCA GeneID:843 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:843 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:843 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:843 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001193453 -> EC 3.4.22.63
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@meso_cacase at
DBCLS
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