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2024-03-29 16:27:09, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001206524            5705 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens caspase 10, apoptosis-related cysteine peptidase
            (CASP10), transcript variant 6, mRNA.
ACCESSION   NM_001206524
VERSION     NM_001206524.1  GI:330864822
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5705)
  AUTHORS   Lisa-Santamaria,P., Jimenez,A. and Revuelta,J.L.
  TITLE     The protein factor-arrest 11 (Far11) is essential for the toxicity
            of human caspase-10 in yeast and participates in the regulation of
            autophagy and the DNA damage signaling
  JOURNAL   J. Biol. Chem. 287 (35), 29636-29647 (2012)
   PUBMED   22782902
  REMARK    GeneRIF: The protein factor-arrest 11 (Far11) is essential for the
            toxicity of human caspase-10 in yeast and participates in the
            regulation of autophagy and the DNA damage signaling.
REFERENCE   2  (bases 1 to 5705)
  AUTHORS   Schleich,K., Warnken,U., Fricker,N., Ozturk,S., Richter,P.,
            Kammerer,K., Schnolzer,M., Krammer,P.H. and Lavrik,I.N.
  TITLE     Stoichiometry of the CD95 death-inducing signaling complex:
            experimental and modeling evidence for a death effector domain
            chain model
  JOURNAL   Mol. Cell 47 (2), 306-319 (2012)
   PUBMED   22683265
  REMARK    GeneRIF: analysis of stoichiometry of the CD95 death-inducing
            signaling complex and demonstration of how procaspase-8,
            procaspase-10, and c-FLIP form DED chains at the DISC, enabling the
            formation of dimers and efficient activation of caspase-8
REFERENCE   3  (bases 1 to 5705)
  AUTHORS   Ekchariyawat,P., Thitithanyanont,A., Sirisinha,S. and
            Utaisincharoen,P.
  TITLE     Apoptosis induced by avian H5N1 virus in human monocyte-derived
            macrophages involves TRAIL-inducing caspase-10 activation
  JOURNAL   Innate Immun 18 (3), 390-397 (2012)
   PUBMED   21911414
  REMARK    GeneRIF: induces apoptosis in avian virus H5N1-infected human
            monocyte-derived macrophages
REFERENCE   4  (bases 1 to 5705)
  AUTHORS   Yan,S., Li,Y.Z., Zhu,J.W., Liu,C.L., Wang,P. and Liu,Y.L.
  TITLE     Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE
            review and meta-analysis
  JOURNAL   Genet. Mol. Res. 11 (4), 3998-4007 (2012)
   PUBMED   23212337
  REMARK    GeneRIF: This meta-analysis suggests that the rs13006529 T carrier
            in the CASP-10 gene might be a risk factor for cancer
            susceptibility, especially for breast cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5705)
  AUTHORS   Qian,J., Qu,H.Q., Yang,L., Yin,M., Wang,Q., Gu,S., Wu,Q., Zhao,X.,
            Wu,W., Wu,J., Tan,X., Chen,W., Wang,H., Wang,J., Fan,W., Chen,H.,
            Han,B., Lu,D., Wei,Q. and Jin,L.
  TITLE     Association between CASP8 and CASP10 polymorphisms and toxicity
            outcomes with platinum-based chemotherapy in Chinese patients with
            non-small cell lung cancer
  JOURNAL   Oncologist 17 (12), 1551-1561 (2012)
   PUBMED   22843554
  REMARK    GeneRIF: Genetic variations in CASP8 and CASP10 may act as
            potential predictive biomarkers for platinum-based chemotherapy
            toxicity in Chinese non-small cell lung cancer patients.
REFERENCE   6  (bases 1 to 5705)
  AUTHORS   Ng,P.W., Porter,A.G. and Janicke,R.U.
  TITLE     Molecular cloning and characterization of two novel pro-apoptotic
            isoforms of caspase-10
  JOURNAL   J. Biol. Chem. 274 (15), 10301-10308 (1999)
   PUBMED   10187817
REFERENCE   7  (bases 1 to 5705)
  AUTHORS   Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J.,
            Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G.
            et al.
  TITLE     Mch3, a novel human apoptotic cysteine protease highly related to
            CPP32
  JOURNAL   Cancer Res. 55 (24), 6045-6052 (1995)
   PUBMED   8521391
REFERENCE   8  (bases 1 to 5705)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Barr virus
            shuttle system
  JOURNAL   Mol. Cell. Biol. 7 (1), 379-387 (1987)
   PUBMED   3031469
REFERENCE   9  (bases 1 to 5705)
  AUTHORS   Clements,G.B., Klein,G. and Povey,S.
  TITLE     Production by EBV infection of an EBNA-positive subline from an
            EBNA-negative human lymphoma cell line without detectable EBV DNA
  JOURNAL   Int. J. Cancer 16 (1), 125-133 (1975)
   PUBMED   170210
REFERENCE   10 (bases 1 to 5705)
  AUTHORS   Baumann,K., de Rouffignac,C., Roinel,N., Rumrich,G. and
            Ullrich,K.J.
  TITLE     Renal phosphate transport: inhomogeneity of local proximal
            transport rates and sodium dependence
  JOURNAL   Pflugers Arch. 356 (4), 287-298 (1975)
   PUBMED   1171445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA456072.1, BC042844.1,
            AC007283.3 and U60519.1.
            
            Summary: This gene encodes a protein which is a member of the
            cysteine-aspartic acid protease (caspase) family. Sequential
            activation of caspases plays a central role in the execution-phase
            of cell apoptosis. Caspases exist as inactive proenzymes which
            undergo proteolytic processing at conserved aspartic residues to
            produce two subunits, large and small, that dimerize to form the
            active enzyme. This protein cleaves and activates caspases 3 and 7,
            and the protein itself is processed by caspase 8. Mutations in this
            gene are associated with type IIA autoimmune lymphoproliferative
            syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (6) lacks two in-frame coding
            exons compared to variant 1. This results in a shorter isoform (6)
            missing an internal protein segment compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ487678.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025083, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               DA456072.1         18-153
            137-545             DA456072.1         155-563
            546-1139            BC042844.1         282-875
            1140-1989           BC042844.1         1077-1926
            1990-2452           AC007283.3         18113-18575         c
            2453-4125           U60519.1           1864-3536
            4126-5705           AC007283.3         14860-16439         c
FEATURES             Location/Qualifiers
     source          1..5705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33-q34"
     gene            1..5705
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="caspase 10, apoptosis-related cysteine peptidase"
                     /db_xref="GeneID:843"
                     /db_xref="HGNC:1500"
                     /db_xref="MIM:601762"
     exon            1..411
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       59
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41429849"
     variation       213
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16836789"
     variation       229..230
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34296231"
     variation       366..367
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35190763"
     misc_feature    407..409
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="upstream in-frame stop codon"
     exon            412..765
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     CDS             419..1786
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /EC_number="3.4.22.63"
                     /note="isoform 6 preproprotein is encoded by transcript
                     variant 6; caspase 10, apoptosis-related cysteine
                     protease; FADD-like ICE2; apoptotic protease MCH-4;
                     ICE-like apoptotic protease 4; interleukin-1B-converting
                     enzyme 2; caspase-10; CASP-10; FAS-associated death domain
                     protein interleukin-1B-converting enzyme 2"
                     /codon_start=1
                     /product="caspase-10 isoform 6 preproprotein"
                     /protein_id="NP_001193453.1"
                     /db_xref="GI:330864823"
                     /db_xref="CCDS:CCDS56159.1"
                     /db_xref="GeneID:843"
                     /db_xref="HGNC:1500"
                     /db_xref="MIM:601762"
                     /translation="
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
"
     misc_feature    470..715
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="The Death Domain Superfamily of protein-protein
                     interaction domains; Region: DD_superfamily; cl14633"
                     /db_xref="CDD:209876"
     misc_feature    752..988
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="Death Effector Domain, repeat 2, of Caspase-10;
                     Region: DED_Caspase_10_repeat2; cd08814"
                     /db_xref="CDD:176792"
     misc_feature    order(755..757,764..769,773..778,788..790,866..868,
                     878..880)
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="putative DED1/DED2 interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:176792"
     mat_peptide     1076..1462
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /product="caspase-10 isoform 6 large subunit"
     misc_feature    1139..1759
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:28914"
     misc_feature    order(1289..1291,1418..1420)
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="active site"
                     /db_xref="CDD:28914"
     misc_feature    order(1292..1294,1412..1414,1433..1435,1556..1573,
                     1583..1588)
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:28914"
     misc_feature    order(1436..1438,1511..1516,1535..1537,1544..1546,
                     1553..1555,1622..1624,1649..1651,1667..1669,1709..1711,
                     1724..1729,1733..1735,1742..1747)
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:28914"
     misc_feature    order(1439..1441,1508..1510)
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /note="proteolytic cleavage site; other site"
                     /db_xref="CDD:28914"
     mat_peptide     1463..1783
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /product="caspase-10 isoform 6 small subunit"
     variation       438
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200935960"
     variation       480
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140813639"
     variation       507
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201782416"
     variation       512
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375838979"
     variation       544
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146684884"
     variation       560
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200012872"
     variation       575
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1804650"
     variation       592
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114625983"
     variation       594
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139417609"
     variation       595
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3900115"
     variation       644
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146696981"
     variation       673
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:185792819"
     variation       689
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148026756"
     variation       700
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370492434"
     variation       732
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200530667"
     variation       743
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201601111"
     variation       750
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199600895"
     exon            766..859
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       845
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376343637"
     variation       858
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121909776"
     exon            860..995
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       920
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371962581"
     variation       952
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146233833"
     variation       968
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200877813"
     variation       971
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369231920"
     exon            996..1102
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       1014
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200079223"
     variation       1033
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373077581"
     variation       1084
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116125703"
     variation       1100
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370134219"
     variation       1101
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143882052"
     variation       1102
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368583939"
     exon            1103..1139
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       1133
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41473647"
     exon            1140..1632
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       1147
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149096064"
     variation       1170
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138931498"
     variation       1200
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200424779"
     STS             1227..1597
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /standard_name="PMC230316P3"
                     /db_xref="UniSTS:272181"
     variation       1232
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111775921"
     variation       1240
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114098515"
     variation       1256
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115264962"
     variation       1285
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:111489269"
     variation       1303
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369304578"
     variation       1306
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148290917"
     variation       1334
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372719084"
     variation       1341
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375798142"
     variation       1349
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370138285"
     variation       1414
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199626441"
     variation       1433
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80358239"
     variation       1444
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371401141"
     variation       1445
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13010627"
     variation       1458
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28936699"
     variation       1471
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140190607"
     variation       1484
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374332152"
     variation       1513
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41331850"
     variation       1514
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200540853"
     variation       1547
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41513147"
     variation       1554
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17860405"
     variation       1564
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147814983"
     variation       1567
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370670949"
     variation       1612
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199853584"
     exon            1633..5705
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /inference="alignment:Splign:1.39.8"
     variation       1669
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375762220"
     variation       1676
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376911298"
     variation       1694
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369901008"
     variation       1719
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148939095"
     variation       1754
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143632134"
     variation       1779
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200836551"
     variation       1781
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:13006529"
     variation       1798
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375389117"
     variation       1820
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377581981"
     variation       1825
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372456822"
     variation       1826
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199884991"
     variation       1863
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191438878"
     variation       1886
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182870266"
     variation       2027
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370987136"
     variation       2063
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3931696"
     variation       2071
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3851974"
     variation       2153
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41365346"
     variation       2451
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142072849"
     variation       2520
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:41506545"
     variation       2539
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186862746"
     variation       2601
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17860409"
     variation       2632
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41529249"
     variation       2701
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115679933"
     STS             2770..2980
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /standard_name="RH70685"
                     /db_xref="UniSTS:32193"
     variation       2923
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374014099"
     variation       2955
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:185024061"
     variation       2964
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187888242"
     variation       3096
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77842514"
     variation       3116
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41342848"
     variation       3126
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367793804"
     variation       3228
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372084524"
     variation       3257
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192319559"
     variation       3306
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41331447"
     variation       3323
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78596960"
     variation       3328
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41484449"
     variation       3410
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150841386"
     STS             3459..4309
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /standard_name="CASP10_482"
                     /db_xref="UniSTS:277051"
     variation       3474
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41515650"
     variation       3503
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149971137"
     variation       3528
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145632258"
     variation       3579
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114760847"
     variation       3610
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199729683"
     variation       3614
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373636173"
     variation       3700
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185318287"
     variation       3706
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11885191"
     variation       3741
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139807893"
     variation       3747
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368898723"
     variation       3751
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:111572089"
     variation       3752
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79528144"
     STS             3848..3971
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /standard_name="RH77986"
                     /db_xref="UniSTS:65780"
     variation       3932
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147622791"
     STS             3934..4064
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /standard_name="RH68751"
                     /db_xref="UniSTS:47132"
     variation       3967
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41443046"
     variation       4075
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41369551"
     variation       4337
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189798514"
     variation       4373
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199859568"
     variation       4374
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:41351949"
     variation       4376
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74267227"
     variation       4381
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72491092"
     variation       4388
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41477650"
     variation       4404
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41431151"
     variation       4461
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376034565"
     variation       4475
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41447745"
     variation       4484
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181477362"
     variation       4512
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372156178"
     variation       4523
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41412149"
     variation       4543
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13414860"
     variation       4546
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41435647"
     variation       4617
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151162733"
     variation       4636
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376511354"
     variation       4797
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368336354"
     variation       4823
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140099864"
     variation       4857
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41339144"
     variation       4923
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41522046"
     variation       5299
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6752492"
     variation       5345
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184599061"
     variation       5359
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368946094"
     variation       5478
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202089864"
     variation       5479
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199723186"
     variation       5480
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200619033"
     variation       5482
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201705079"
     variation       5574
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111444762"
     variation       5578
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41486645"
     variation       5652
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41486549"
     polyA_signal    5684..5689
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
     polyA_site      5704
                     /gene="CASP10"
                     /gene_synonym="ALPS2; FLICE2; MCH4"
ORIGIN      
aaggaaatggagatccaaaggaaagcctgaagcactttgtggcttccacgggttcgtttctaggaagcttttgctttacctggggaaaccccaagctctacagtgagaaagttgtaaattagcctttaggagacgctgtttgtcaaagttatcttaaccctggaaaaggggagggaaaaaggcagataagcagtgatgacatcagcaggaaactagtatcaggctacccagtcctgaagattcagttttcacttaaacaaccagcaagtcttgaagtctcttcccaagcaaatgggagcttctttggaccttggagcacacagaggattctactttctttaaaactttgttttcaggcaatttccctgagaaccgtttacttccagaagattggtggagcttgatctgaaggctggccatgaaatctcaaggtcaacattggtattccagttcagataaaaactgtaaagtgagctttcgtgagaagcttctgattattgattcaaacctgggggtccaagatgtggagaacctcaagtttctctgcataggattggtccccaacaagaagctggagaagtccagctcagcctcagatgtttttgaacatctcttggcagaggatctgctgagtgaggaagaccctttcttcctggcagaactcctctatatcatacggcagaagaagctgctgcagcacctcaactgtaccaaagaggaagtggagcgactgctgcccacccgacaaagggtttctctgtttagaaacctgctctacgaactgtcagaaggcattgactcagagaacttaaaggacatgatcttccttctgaaagactcgcttcccaaaactgaaatgacctccctaagtttcctggcatttctagagaaacaaggtaaaatagatgaagataatctgacatgcctggaggacctctgcaaaacagttgtacctaaacttttgagaaacatagagaaatacaaaagagagaaagctatccagatagtgacacctcctgtagacaaggaagccgagtcgtatcaaggagaggaagaactagtttcccaaacagatgttaagacattcttggaagccttaccgcaggagtcctggcaaaataagcatgcaggtagtaatgagatcctgagtcatgtgttccagtggcttgggttcacagtgcatatacacaataatgtgacgaaagtggaaatggagatggtcctgcagaagcagaagtgcaatccagcccatgccgacggggactgcttcgtgttctgtattctgacccatgggagatttggagctgtctactcttcggatgaggccctcattcccattcgggagatcatgtctcacttcacagccctgcagtgccctagactggctgaaaaacctaaactctttttcatccaggcctgccaaggtgaagagatacagccttccgtatccatcgaagcagatgctctgaaccctgagcaggcacccacttccctgcaggacagtattcctgccgaggctgacttcctacttggtctggccactgtcccaggctatgtatcctttcggcatgtggaggaaggcagctggtatattcagtctctgtgtaatcatctgaagaaattggtcccaagacatgaagacatcttatccatcctcactgctgtcaacgatgatgtgagtcgaagagtggacaaacagggaacaaagaaacagatgccccagcctgctttcacactaaggaaaaaactagtattccctgtgcccctggatgcactttcattatagcagagagtttttgttggttcttagacctcaaacgaatcattggctataacctccagcctcctgcccagcacaggaatcggtggtctccacctgtcattctagaaacaggaaacaccgtgttttctgacacagtcaattctgattttctttttcttttgcaagtctaaatgttagaaaactttcttttttttggagatagtctcattctgtcacccagactggagtgcaggggggcaatcacggctcactgtagtctcgacctcccaggctcaagctgtcctcccgcctcagcttcccaagtagctgggaccacaggtgtgtaccaccgtgcccggattttttttattctttattttttgtagagatggagggatctcactttgttgcacaggctggtttcaaactcctaggcccaagtgatcctcccacctctgtccccaaaatactgggattataggcacgagccaccacacctggccagaaaactttcattattgaagacttggattgtagccttggttttggatgtctattctgaagacagagtaattggctttggtttgtgcaggtactttttctttgagacagagtcactccgtcacctgggctggagtgcagtggtgggatcactgttcactgcagccttgacctcccaggttcaagcgatcctcccacctcagcctcccaagtagctgagactacaggtgtgtgtccatgcacagctaactttttattttttttgtggagatggggtttcactatgttgcctaagctggtctcaaactcctgggctcaagcgatcctcccacctcagcttctcaaagttctgggactacaggcatgaaatactgtgcctggcctggggaccaggtgcattttaaggttccttggtgttcaaaaaccacgttcttagcctagattgagcttagattgcctctctagacaactaccccttagttataattctgtgtcccctctgcatgcccttaaacattggacagtgaggtcacagtccacccaccctctctctgatctcccccttcctaagacttctcttttgcacatctagtgaggtgaaaatttggtctatgccaggcccatttcctgcttttgtgtaaggaaggtgctcacataggaagtttttatttggttagagacaggtttccctgtaggaagatgatggctcatttacactcagctgctctgcaagcagaaactttacaacctgatgtcatattccattttggactgggtgcggtgactcatgcctgtaatcccagtactctgggaagccaaggcaggcagatcacttgaggtcaggagttcgagaccagcctggccaatacggcaaaacctcatcattactaaaaacacaaaaattagccaggtgtggcggcgagcacctgtaatcccagctactcgggaggctgagacaggagaatctcttgaatccaggaggcagaggctgtggtgagccaagatgacacaactgcactccagcttgggcaacagggcgagaccttgtttaaaaaaaaaattcaatattggggttggaacatttcagttgccattgacagaacacccaattcaaattgactgaagcaaagaagggaatttattgcctctttcacattgaaacccaggagtggataacactggcttcaggcaaagcttgaatcaggactcaatctacaggccagcacctttctcttggccggatgtcctcagggctggcagatgcagtagactgcagtggacagtccccaccttgttactgctactacactttgctcctctggcccaaggcatgaggagagaggctgtgtcagaaactgaagctgttctcaggatcactgggctcttcttggcagaggggatgtctggcttgcctgaagggagtggctctgtaaggacgccttgatgctttcttcattaagattttgagcatttttacgtacttgagcttttttttttttttttttcaatttctagaggaactttttctctgttaattcctggaactgtattttgaatccttaaaggtgagccctcatagggagatccaaagtcctgtggttaacgccttcatttatagatgaggcagctgaggcctggggatgtgaacaacctgctcacagtcctcatttactggatttgacttcagccaggtgaactggaatgccttggggcgtggaagggcattaggagtgtttcatttgatatgtgaatgctcataaaaaaatgtcaaggaatgaagaacaacaactctcagtggtgcctgcatttataattatttatgtgaaagtcaaattcatgtacagtaaatttgttataagaatattcacaagaacactgttctgatatctctgattgtcatgtggatttgaatgtagcttgacagagggaatgtctaatctatattgacagggcaggaacaccgtcatcttagacaaacaccgccactttaagttccagttccctttctagcctcatgcatttcaaggaaatcacttcttttctaacagcgagcagccagaaagagaagagagtaaaatacagataagacagctctggcatagagggaggtgggggggtgggggaagtctcttgggtaactgccaaactttgccttcatacaatgggttccaggaaaacaatgagccttaataagcacattcctttcccttcaggtgcactaagtggggaagctaaaagcagactggaggggggtggggtgtacctacagctgcagaaatattgtatgggaacggacacacaactctccctcccagataagcacagcaaagagacatagaagcaatccaagcctctgataaactctcccaccctaaatccttaaaaactcttagtctgtaagtgagtgggctctgacctaactcggccagaagcccctttcaaatttgttttctctaaaataaacctgtccttggctgtcaagccacctttcatgtttctttcctctttctttaattcttacacatgtgtcaggatgatctcccaaaaccgtgttcataacagtcagggccaaaagctagtggtcacagtccttgtccagttggcagaactgacatgtgaaggcaagtgaaggatggtgagatactgaggaaagagcaaaggatctggagatcaaagccctgcatttccattttgtcctgattcctttgctcagagacactaactaaatcaagctagcttttttcagccttgtctgtaaagtagagaaaacattagctgttgggaagacgaaaaagaatgtgtcctatgtgtgcatctatttaaatctaactgtgctgaggtgcatataaatgcctttaggtggtagggtcttccggttgtaactgcaacagaaatagcaggacttaagttcctttgtgcgtaattccagctgactttattagcggcaactcagcactagcattacccctgacatactctgagtaagatctaattcttccctcactggttcgtgatgtctaccgcagcagaaggccagctcttgactctgagttcagttggacaaaatgctgttgataaaacctcctgtcaggcctctgagcccaagctaagccatcatatcccttgtgacctgcacatatatatccagatggcctgaagtaactgaagaatcacaaaagaagtgaaaatggcctgttcctgccttaactgatgacattaccttgtgaaattccttctcctggctcatcctggctcaaaagctcccccagtgagcaccttgtgacccccatccctgccagccagagaacaaccccctttgactgtaattttccactacttacccaaatcctataaaacggccccacccctatctcccttcactgactttcttttcggactcagcccacctgcacccaggtgattaaaaagctttattgctcac
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:843 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IEA
            GeneID:843 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:843 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:843 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:843 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
            GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
            GeneID:843 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: RCA
            GeneID:843 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:843 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:843 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:843 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001193453 -> EC 3.4.22.63

by @meso_cacase at DBCLS
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