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2024-04-20 12:53:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001205255 5404 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens occludin (OCLN), transcript variant 3, mRNA.
ACCESSION NM_001205255 XM_003118548 XM_003118549
VERSION NM_001205255.1 GI:327478415
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5404)
AUTHORS Wu,H.L., Gao,X., Jiang,Z.D., Duan,Z.T., Wang,S.K., He,B.S.,
Zhang,Z.Y. and Xie,H.G.
TITLE Attenuated expression of the tight junction proteins is involved in
clopidogrel-induced gastric injury through p38 MAPK activation
JOURNAL Toxicology 304, 41-48 (2013)
PUBMED 23220562
REMARK GeneRIF: It is concluded that attenuated expression of the TJ
proteins occludin and ZO-1 in human gastric epithelial cells could
be involved in clopidogrel-induced gastric mucosal injury through
activation of the p38 MAPK pathway
REFERENCE 2 (bases 1 to 5404)
AUTHORS Yu,T.X., Rao,J.N., Zou,T., Liu,L., Xiao,L., Ouyang,M., Cao,S.,
Gorospe,M. and Wang,J.Y.
TITLE Competitive binding of CUGBP1 and HuR to occludin mRNA controls its
translation and modulates epithelial barrier function
JOURNAL Mol. Biol. Cell 24 (2), 85-99 (2013)
PUBMED 23155001
REMARK GeneRIF: HuR promotes occludin translation by blocking occludin
mRNA translocation to P-bodies via the displacement of CUGBP1.
REFERENCE 3 (bases 1 to 5404)
AUTHORS Den Beste,K.A., Hoddeson,E.K., Parkos,C.A., Nusrat,A. and Wise,S.K.
TITLE Epithelial permeability alterations in an in vitro air-liquid
interface model of allergic fungal rhinosinusitis
JOURNAL Int Forum Allergy Rhinol 3 (1), 19-25 (2013)
PUBMED 22927233
REMARK GeneRIF: Sinonasal epithelium in allergic fungal rhinosinusitis
displays increased epithelial permeability and an altered
expression of occludin.
REFERENCE 4 (bases 1 to 5404)
AUTHORS O'Driscoll,M.C., Daly,S.B., Urquhart,J.E., Black,G.C., Pilz,D.T.,
Brockmann,K., McEntagart,M., Abdel-Salam,G., Zaki,M., Wolf,N.I.,
Ladda,R.L., Sell,S., D'Arrigo,S., Squier,W., Dobyns,W.B.,
Livingston,J.H. and Crow,Y.J.
TITLE Recessive mutations in the gene encoding the tight junction protein
occludin cause band-like calcification with simplified gyration and
polymicrogyria
JOURNAL Am. J. Hum. Genet. 87 (3), 354-364 (2010)
PUBMED 20727516
REMARK GeneRIF: The tight junction protein occludin (encoded by the OCLN
gene) is involved in the pathogenesis of malformations of cortical
development.
REFERENCE 5 (bases 1 to 5404)
AUTHORS Kohaar,I., Ploss,A., Korol,E., Mu,K., Schoggins,J.W., O'Brien,T.R.,
Rice,C.M. and Prokunina-Olsson,L.
TITLE Splicing diversity of the human OCLN gene and its biological
significance for hepatitis C virus entry
JOURNAL J. Virol. 84 (14), 6987-6994 (2010)
PUBMED 20463075
REMARK GeneRIF: Data suggest that the natural splicing diversity of
occludin might contribute to hepatitis C virus tissue tropism and
possibly modify the outcome of HCV infection in humans.
REFERENCE 6 (bases 1 to 5404)
AUTHORS Mankertz,J., Waller,J.S., Hillenbrand,B., Tavalali,S., Florian,P.,
Schoneberg,T., Fromm,M. and Schulzke,J.D.
TITLE Gene expression of the tight junction protein occludin includes
differential splicing and alternative promoter usage
JOURNAL Biochem. Biophys. Res. Commun. 298 (5), 657-666 (2002)
PUBMED 12419305
REMARK GeneRIF: different occludin variants were identified on the mRNA
level
REFERENCE 7 (bases 1 to 5404)
AUTHORS Kimura,Y., Shiozaki,H., Hirao,M., Maeno,Y., Doki,Y., Inoue,M.,
Monden,T., Ando-Akatsuka,Y., Furuse,M., Tsukita,S. and Monden,M.
TITLE Expression of occludin, tight-junction-associated protein, in human
digestive tract
JOURNAL Am. J. Pathol. 151 (1), 45-54 (1997)
PUBMED 9212730
REFERENCE 8 (bases 1 to 5404)
AUTHORS Van Itallie,C.M. and Anderson,J.M.
TITLE Occludin confers adhesiveness when expressed in fibroblasts
JOURNAL J. Cell. Sci. 110 (PT 9), 1113-1121 (1997)
PUBMED 9175707
REFERENCE 9 (bases 1 to 5404)
AUTHORS Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A.,
Itoh,M., Yonemura,S., Furuse,M. and Tsukita,S.
TITLE Interspecies diversity of the occludin sequence: cDNA cloning of
human, mouse, dog, and rat-kangaroo homologues
JOURNAL J. Cell Biol. 133 (1), 43-47 (1996)
PUBMED 8601611
REFERENCE 10 (bases 1 to 5404)
AUTHORS Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S.,
Tsukita,S. and Tsukita,S.
TITLE Direct association of occludin with ZO-1 and its possible
involvement in the localization of occludin at tight junctions
JOURNAL J. Cell Biol. 127 (6 PT 1), 1617-1626 (1994)
PUBMED 7798316
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U49184.1, FJ786083.1,
AC147575.1 and AI093221.1.
On or before Apr 5, 2011 this sequence version replaced
gi:310119555, gi:310119557.
Summary: This gene encodes an integral membrane protein that is
required for cytokine-induced regulation of the tight junction
paracellular permeability barrier. Mutations in this gene are
thought to be a cause of band-like calcification with simplified
gyration and polymicrogyria (BLC-PMG), an autosomal recessive
neurologic disorder that is also known as pseudo-TORCH syndrome.
Alternative splicing results in multiple transcript variants. A
related pseudogene is present 1.5 Mb downstream on the q arm of
chromosome 5. [provided by RefSeq, Apr 2011].
Transcript Variant: This variant (3) lacks a portion of the 5'
coding region and uses a downstream start codon, compared to
variant 1. The resulting isoform (b) is shorter at the N-terminus,
compared to isoform a. The 5' UTR of this variant is incomplete due
to a lack of 5'-complete transcripts containing this exon
combination and the presence of splicing ambiguity at the 5' end.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FJ786083.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-24 U49184.1 100-123
25-999 FJ786083.1 1-975
1000-5351 AC147575.1 3515-7866 c
5352-5404 AI093221.1 1-53 c
FEATURES Location/Qualifiers
source 1..5404
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q13.1"
gene 1..5404
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="occludin"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="MIM:602876"
exon 1..118
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 45
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:201102823"
variation 72
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113706384"
variation 91
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:139272416"
misc_feature 113..115
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="upstream in-frame stop codon"
exon 119..280
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 120
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:148494605"
variation 123
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371270934"
variation 126
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:199655841"
CDS 143..958
/gene="OCLN"
/gene_synonym="BLCPMG"
/EC_number="2.1.1.67"
/note="isoform b precursor is encoded by transcript
variant 3; tight junction protein occludin"
/codon_start=1
/product="occludin isoform b precursor"
/protein_id="NP_001192184.1"
/db_xref="GI:327478416"
/db_xref="CCDS:CCDS54864.1"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="MIM:602876"
/translation="
MIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT
"
sig_peptide 143..190
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 647..946
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="Occludin homology domain; Region: Occludin_ELL;
pfam07303"
/db_xref="CDD:115928"
variation 143
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:142683205"
variation 153
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:28418826"
variation 162
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:79095497"
variation 174
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:151045915"
variation 249
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:200654651"
variation 260
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:373344533"
variation 268
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:140924340"
exon 281..426
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 311
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:369518478"
variation 392
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:372766137"
variation 393
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201673353"
variation 423
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377673456"
exon 427..642
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 433..434
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="g"
/db_xref="dbSNP:34401791"
variation 489
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374647565"
variation 521
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377718385"
variation 582
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370970569"
variation 594
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:144743806"
variation 604
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666582"
STS 632..823
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="Ocln"
/db_xref="UniSTS:495893"
exon 643..814
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 815..856
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 857..5391
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 865
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:370469574"
variation 901
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666626"
variation 962
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374897366"
variation 1091
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576903"
variation 1091
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:76080549"
STS 1253..1414
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-U19251"
/db_xref="UniSTS:77742"
variation 1266
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201056955"
STS 1377..1523
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-H94471"
/db_xref="UniSTS:52040"
variation 1389
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371132365"
polyA_signal 1572..1577
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 1593
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 1615
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:79809021"
variation 1658
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2576904"
variation 1658
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:187688506"
variation 1715
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2561166"
variation 1868
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:192491213"
variation 1890
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576905"
variation 1937
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:75912442"
variation 2028
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112593689"
variation 2104
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666599"
variation 2104
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71622295"
variation 2140
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:111663327"
variation 2158..2159
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:71957719"
variation 2243
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:370879112"
variation 2244
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374446243"
variation 2245
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:185678833"
variation 2247
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:368766545"
variation 2248..2249
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="ag"
/db_xref="dbSNP:34202353"
variation 2283
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2568329"
variation 2283
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371435086"
STS 2326..2747
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2326..2414
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2368
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2568330"
variation 2382
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:6868400"
variation 2382
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:76123058"
variation 2423
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:146986409"
variation 2426
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:6892155"
variation 2426
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:66660167"
STS 2477..2674
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
variation 2524..2525
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gt"
/db_xref="dbSNP:373178468"
variation 2544
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:55639523"
variation 2546
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306264"
variation 2548
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374793047"
variation 2567..2568
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:56388078"
STS 2617..2832
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="RH80030"
/db_xref="UniSTS:87680"
STS 2654..2747
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2748
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:188890364"
variation 2757
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666598"
variation 2757
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371941973"
variation 2804
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:192095324"
variation 2847
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244907"
variation 2847
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:375565190"
variation 2880
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:369899490"
variation 2880
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2666597"
variation 3001
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:256925"
variation 3001
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:55909787"
variation 3023
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:184412724"
variation 3041
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:111417042"
polyA_signal 3646..3651
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 3667
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_signal 3927..3932
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 3946
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 3994
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200157655"
variation 4490
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:699901"
variation 4490
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374275248"
variation 4509
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113964466"
variation 4631
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:189167216"
variation 4815
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:112951447"
variation 4918
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71576927"
variation 4927
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112695697"
variation 4946
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:77392451"
variation 5132
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2244652"
variation 5337
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200773462"
variation 5367
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244645"
polyA_site 5391
/gene="OCLN"
/gene_synonym="BLCPMG"
ORIGIN
attggtttatcttggaagctaaagggcattgctcatcctgaagatcagctgaccattgacaatcagccatgtcatccaggcctcttgaaagtccacctccttacaggcctgatgaattgccattgccattgtactggggttcatgattattgtggcttttgctttaataattttctttgctgtgaaaactcgaagaaagatggacaggtatgacaagtccaatattttgtgggacaaggaacacatttatgatgagcagccccccaatgtcgaggagtgggttaaaaatgtgtctgcaggcacacaggacgtgccttcacccccatctgactatgtggaaagagttgacagtcccatggcatactcttccaatggcaaagtgaatgacaagcggttttatccagagtcttcctataaatccacgccggttcctgaagtggttcaggagcttccattaacttcgcctgtggatgacttcaggcagcctcgttacagcagcggtggtaactttgagacaccttcaaaaagagcacctgcaaagggaagagcaggaaggtcaaagagaacagagcaagatcactatgagacagactacacaactggcggcgagtcctgtgatgagctggaggaggactggatcagggaatatccacctatcacttcagatcaacaaagacaactgtacaagaggaattttgacactggcctacaggaatacaagagcttacaatcagaacttgatgagatcaataaagaactctcccgtttggataaagaattggatgactatagagaagaaagtgaagagtacatggctgctgctgatgaatacaatagactgaagcaagtgaagggatctgcagattacaaaagtaagaagaatcattgcaagcagttaaagagcaaattgtcacacatcaagaagatggttggagactatgatagacagaaaacatagaaggctgatgccaagttgtttgagaaattaagtatctgacatctctgcaatcttctcagaaggcaaatgactttggaccataaccccggaagccaaacctctgtgagcatcacaaagttttggttgctttaacatcatcagtattgaagcattttataaatcgcttttgataatcaactgggctgaacactccaattaaggattttatgctttaaacattggttcttgtattaagaatgaaatactgtttgaggtttttaagccttaaaggaaggttctggtgtgaactaaactttcacaccccagacgatgtcttcatacctacatgtatttgtttgcataggtgatctcatttaatcctctcaaccacctttcagataactgttatttataatcacttttttccacataaggaaactgggttcctgcaatgaagtctctgaagtgaaactgcttgtttcctagcacacacttttggttaagtctgttttatgacttcattaataataaattccctggcctttcatattttagctactatatatgtgatgatctaccagcctccctattttttttctgttatataaatggttaaaagaggtttttcttaaataataaagatcatgtaaaagtaacaaatgtgtgaaatttaaagattgtaaatatatatttacttttttaagatcaaagtttaaaccccgtggttagaattttgtgtgtttttaaatactttttatctttttgcatgccttttttaaaaaaccaactagaacttttcattatatcagaatatctgattacatttataattcaattgtgacttgaactgtatcttacaggaatgttcaatttctatacatattttataaggtattaaacctggtgttttctttccataataacctgtttgatgttattagtgctgttaacatacagcaatggaaaaccacactcaggagttgtatctgttgttgtttatactcctttggatgctgtgctggttagtcgtttcccattcctttggctgtaagaatgctgatatgtctgggaatagaatgctataccacgaaataccaaataatttcaaatggtgcccttaaattgtatcacttttttaaaaattcagattcttattagtaaaattagttgatagcactgtgctgaccaagttgattgtgatcatcccagcttagacttttctaaaaacttttttttagaataatctataaactgaactttagtatgcatttcagatatttaggtatataatttttttttttttttgagacagagtctcactctcacccaggctggaatgcagtggtgctatcttggctcactgcaacctccacctcccgggttcaagcaattctcctgcctcagcctctcgagtagttgagactacaggtgcccatcaccatgcgtggctaatttttgtatttttaatagagacggggttttaccatagtggccaggttggtcttgaactcctgaccttgtggtctgcctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccatgcctggcctaagtgtgtgtgtgtgtgtgtgtgtgtatttttttttttttttttttgagatggagttttgctcttgttgaacaggctggagtgcaatgtcgcgatctcagctcaccacaacctccgcctcccaggttcaaacaattctcctgcctcggcctcccgagtagctgggattacaggcatgcgccaccacacctggctaattttttttttgtatttttagtagagatggggtttctccatgttggtcaggctggtctcgaactcctgacctcaggtgatccatccacctcggcctcccaaagtgctgggattagaggcgtgagccactgtgcccggcctataatttttgatagatgattttgaattattttccagagataaaattttaaatgtttccattatatcactgatttatttctgcaaattgaataaattcttaattttctgcatgcacataatacaaaaggtattttcatagttttggatttataccaaatgaaaaggattctcttgatgagcacctttaactgatttttctgttaaagttttaacaatttgttcttggaagtcagttcgtgaaggcaagtttgtcagtattttcacaaaactattcagctgaatccagaaagtgaaacagcaagaatttgcattgtaaaattgtgttataaaattggactttgaaatttcaaaaataagaaaaattttcatgtgtatttatactaaataccgttttaggaaactaggatcagggtgtttctgttggcgttggcattaactagctggatgtaaatttgaaaagccactcaagcagcttcctagtctagaaagtcagaggtttagattagatttccgacatcccttccatttctgacctgtagttcttgtctggaattctgctttgttataaactattgttctaaggagtttgttgtgatagcacatagttcattttgtaaagattccctgcgtataaagtgatgccctacatatgtgattttgtattaaaagtatataggatcattattttattttgaaaaatttaaatacagaaaagtataaaatataagtaccatccgcccagaaataacatgtgttaatgttttgtcatatgtgctttatattttttgaaataaagtgaagtcaactagtatttatagtaaataagttacatacacataagtacatatatgatatttaatcctcacaacgatcttttgacatgtgaccatttcttattcttcttttatagacaaggaactaatgatatgatagattaactggctgttgtcacactagcaagtggcaaaacaagggattaggatcttagtctcttcaactgttagattctatacttccatcctgtgttgactttgttaatggattggataatgtgagatcactctgatgtaaataaagtatcctatattaatttcgagtgcattttaagtacttgtaacataaatgcttcctgtgaaatatctgtaaagacctgaatgggtacatgtgtgtaaagaagaatcagggcagaaaagtgcttttatcatggctccggggaccttagcttcagttggtgttgtgagaattcctcacacaaggacattctccttgcttcagcatcaggatggaagtgtttctcatctggactttttcaaagactcagctggaggaatcagaattcataatttcctggcagctcatgattctgctacactacaccatgccatctcttgtgtgaaaggacagatttgatggaggactatgtcatccctcatgcgtttcttattgtctacatttattctaatgggaagaagtgagcaaaaacacctcaataatttgggtagtttttagaaaaccttgttagtaaattagaatagtgccactttggcattatgagaaagaagcatggatacataactagggttttgtgtatgactacaacgaaatgcagaatggtgtctccaaaaggtttccaattgctgccacaagaactgcttggtattgcctacatgtgttgtcctatttttgctttgcccttctgcagttacttgctgtgggaccttggagaaattaacttagcctctctgtacttcagttttttgtatttgtaaaatatatttgtaataatctcatagttaagaaggtagttaatgtgtgactcagtccttgtctaaaagtaaatatgcctagctacccccatcttccaaagccagaaggtgaaactttaacaagttttctaaaagcaaattgtgttttttaaaagtgcatgtgtcatccaatcccatatgattgatctgtgctgggtgcagccttagaatgtaaattcttttgaattctaggcagagaatgcaggattggcattctaaatatttgtacatgataaacaaatgcttctttaggttagagcaaatagtttacttatcaagatcacaattgttagatactgttgtcaattacagaggttttagatgaggctttctggaatgatttagtttccctgtaagggagcctgtctattggaatagacaggttcacttctcccagtctttcaagttgcatgctttttatatctgattccactggctgagctgattgtgaatgtcctaaccctgttgattgtgtctggccactcatgggcaaagaacagattatccattctttatagttgtcttttagttttacaagttgaaaaaacatctgagtaggttagataatttattctaccactttgtaaatgattagaatatgtcagtcataatcatgccaagagattatggatttatgcatattttgttttgctgtagtaccattcctagttgaatcttaacatccatgtctaaaatctatacagaacaaatattacagttgggaaaactgaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:100506658 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:100506658 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:100506658 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:100506658 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: IMP
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:100506658 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005923 [tight junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016327 [apicolateral plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0030054 [cell junction] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001192184 -> EC 2.1.1.67
by
@meso_cacase at
DBCLS
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