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2024-04-25 16:33:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001205254 6221 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens occludin (OCLN), transcript variant 2, mRNA.
ACCESSION NM_001205254 XM_003118540
VERSION NM_001205254.1 GI:327478413
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6221)
AUTHORS Wu,H.L., Gao,X., Jiang,Z.D., Duan,Z.T., Wang,S.K., He,B.S.,
Zhang,Z.Y. and Xie,H.G.
TITLE Attenuated expression of the tight junction proteins is involved in
clopidogrel-induced gastric injury through p38 MAPK activation
JOURNAL Toxicology 304, 41-48 (2013)
PUBMED 23220562
REMARK GeneRIF: It is concluded that attenuated expression of the TJ
proteins occludin and ZO-1 in human gastric epithelial cells could
be involved in clopidogrel-induced gastric mucosal injury through
activation of the p38 MAPK pathway
REFERENCE 2 (bases 1 to 6221)
AUTHORS Yu,T.X., Rao,J.N., Zou,T., Liu,L., Xiao,L., Ouyang,M., Cao,S.,
Gorospe,M. and Wang,J.Y.
TITLE Competitive binding of CUGBP1 and HuR to occludin mRNA controls its
translation and modulates epithelial barrier function
JOURNAL Mol. Biol. Cell 24 (2), 85-99 (2013)
PUBMED 23155001
REMARK GeneRIF: HuR promotes occludin translation by blocking occludin
mRNA translocation to P-bodies via the displacement of CUGBP1.
REFERENCE 3 (bases 1 to 6221)
AUTHORS Den Beste,K.A., Hoddeson,E.K., Parkos,C.A., Nusrat,A. and Wise,S.K.
TITLE Epithelial permeability alterations in an in vitro air-liquid
interface model of allergic fungal rhinosinusitis
JOURNAL Int Forum Allergy Rhinol 3 (1), 19-25 (2013)
PUBMED 22927233
REMARK GeneRIF: Sinonasal epithelium in allergic fungal rhinosinusitis
displays increased epithelial permeability and an altered
expression of occludin.
REFERENCE 4 (bases 1 to 6221)
AUTHORS O'Driscoll,M.C., Daly,S.B., Urquhart,J.E., Black,G.C., Pilz,D.T.,
Brockmann,K., McEntagart,M., Abdel-Salam,G., Zaki,M., Wolf,N.I.,
Ladda,R.L., Sell,S., D'Arrigo,S., Squier,W., Dobyns,W.B.,
Livingston,J.H. and Crow,Y.J.
TITLE Recessive mutations in the gene encoding the tight junction protein
occludin cause band-like calcification with simplified gyration and
polymicrogyria
JOURNAL Am. J. Hum. Genet. 87 (3), 354-364 (2010)
PUBMED 20727516
REMARK GeneRIF: The tight junction protein occludin (encoded by the OCLN
gene) is involved in the pathogenesis of malformations of cortical
development.
REFERENCE 5 (bases 1 to 6221)
AUTHORS Kohaar,I., Ploss,A., Korol,E., Mu,K., Schoggins,J.W., O'Brien,T.R.,
Rice,C.M. and Prokunina-Olsson,L.
TITLE Splicing diversity of the human OCLN gene and its biological
significance for hepatitis C virus entry
JOURNAL J. Virol. 84 (14), 6987-6994 (2010)
PUBMED 20463075
REMARK GeneRIF: Data suggest that the natural splicing diversity of
occludin might contribute to hepatitis C virus tissue tropism and
possibly modify the outcome of HCV infection in humans.
REFERENCE 6 (bases 1 to 6221)
AUTHORS Mankertz,J., Waller,J.S., Hillenbrand,B., Tavalali,S., Florian,P.,
Schoneberg,T., Fromm,M. and Schulzke,J.D.
TITLE Gene expression of the tight junction protein occludin includes
differential splicing and alternative promoter usage
JOURNAL Biochem. Biophys. Res. Commun. 298 (5), 657-666 (2002)
PUBMED 12419305
REMARK GeneRIF: different occludin variants were identified on the mRNA
level
REFERENCE 7 (bases 1 to 6221)
AUTHORS Kimura,Y., Shiozaki,H., Hirao,M., Maeno,Y., Doki,Y., Inoue,M.,
Monden,T., Ando-Akatsuka,Y., Furuse,M., Tsukita,S. and Monden,M.
TITLE Expression of occludin, tight-junction-associated protein, in human
digestive tract
JOURNAL Am. J. Pathol. 151 (1), 45-54 (1997)
PUBMED 9212730
REFERENCE 8 (bases 1 to 6221)
AUTHORS Van Itallie,C.M. and Anderson,J.M.
TITLE Occludin confers adhesiveness when expressed in fibroblasts
JOURNAL J. Cell. Sci. 110 (PT 9), 1113-1121 (1997)
PUBMED 9175707
REFERENCE 9 (bases 1 to 6221)
AUTHORS Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A.,
Itoh,M., Yonemura,S., Furuse,M. and Tsukita,S.
TITLE Interspecies diversity of the occludin sequence: cDNA cloning of
human, mouse, dog, and rat-kangaroo homologues
JOURNAL J. Cell Biol. 133 (1), 43-47 (1996)
PUBMED 8601611
REFERENCE 10 (bases 1 to 6221)
AUTHORS Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S.,
Tsukita,S. and Tsukita,S.
TITLE Direct association of occludin with ZO-1 and its possible
involvement in the localization of occludin at tight junctions
JOURNAL J. Cell Biol. 127 (6 PT 1), 1617-1626 (1994)
PUBMED 7798316
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB226845.1, BC029886.1,
AK290697.1, AC147575.1 and AI093221.1.
On Apr 5, 2011 this sequence version replaced gi:310119539.
Summary: This gene encodes an integral membrane protein that is
required for cytokine-induced regulation of the tight junction
paracellular permeability barrier. Mutations in this gene are
thought to be a cause of band-like calcification with simplified
gyration and polymicrogyria (BLC-PMG), an autosomal recessive
neurologic disorder that is also known as pseudo-TORCH syndrome.
Alternative splicing results in multiple transcript variants. A
related pseudogene is present 1.5 Mb downstream on the q arm of
chromosome 5. [provided by RefSeq, Apr 2011].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Both variants 1 and 2 encode the same isoform (a).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC029886.1, AK290697.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025091 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-28 DB226845.1 1-28
29-903 BC029886.1 1-875
904-1142 AK290697.1 866-1104
1143-2410 BC029886.1 1115-2382
2411-6168 AC147575.1 3515-7272 c
6169-6221 AI093221.1 1-53 c
FEATURES Location/Qualifiers
source 1..6221
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q13.1"
gene 1..6221
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="occludin"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="MIM:602876"
exon 1..138
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 57
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:149758143"
variation 104
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374588737"
exon 139..256
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 183
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:201102823"
misc_feature 195..197
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="upstream in-frame stop codon"
CDS 207..1775
/gene="OCLN"
/gene_synonym="BLCPMG"
/EC_number="2.1.1.67"
/note="isoform a is encoded by transcript variant 2; tight
junction protein occludin"
/codon_start=1
/product="occludin isoform a"
/protein_id="NP_001192183.1"
/db_xref="GI:327478414"
/db_xref="CCDS:CCDS4006.1"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="MIM:602876"
/translation="
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSAILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT
"
misc_feature 378..836
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="Membrane-associating domain; Region: MARVEL;
pfam01284"
/db_xref="CDD:201710"
misc_feature 405..473
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 612..686
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 717..791
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 936..1001
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 1398..1400
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1410..1412
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1413..1415
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC/PRKCH; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1416..1418
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC/PRKCH; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1464..1763
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="Occludin homology domain; Region: Occludin_ELL;
pfam07303"
/db_xref="CDD:115928"
misc_feature 1674..1676
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q16625.1); phosphorylation site"
variation 210
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113706384"
variation 229
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:139272416"
exon 257..935
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 262
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:368281009"
variation 263
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370812139"
STS 268..436
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="PMC310929P1"
/db_xref="UniSTS:272816"
variation 276
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:147125035"
variation 312
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:373915080"
variation 318
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201821077"
variation 323
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:201027704"
variation 335
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:374099764"
variation 385
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200344104"
variation 403
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:116363086"
variation 439
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201378122"
variation 536
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:367815590"
variation 564
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:138515133"
variation 579
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370941532"
variation 590
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:150730577"
variation 658
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:28562785"
variation 659
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:149492224"
variation 661
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:142569075"
variation 675
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:139928771"
variation 760
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:372258308"
variation 772
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200330025"
variation 784
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201347125"
variation 786
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:143065857"
variation 809
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:374218912"
variation 827
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:148225175"
variation 862
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:267606926"
variation 870
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:377288243"
variation 881
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:143335340"
variation 888
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:369493872"
variation 891
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:141127898"
variation 904
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:17852716"
variation 905
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:35107257"
variation 913
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:200609277"
variation 914
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201492433"
exon 936..1097
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 937
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:148494605"
variation 940
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371270934"
variation 943
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:199655841"
variation 960
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:142683205"
variation 970
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:28418826"
variation 979
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:79095497"
variation 991
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:151045915"
variation 1066
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:200654651"
variation 1077
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:373344533"
variation 1085
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:140924340"
exon 1098..1243
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1128
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:369518478"
variation 1209
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:372766137"
variation 1210
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201673353"
variation 1240
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377673456"
exon 1244..1459
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1250..1251
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="g"
/db_xref="dbSNP:34401791"
variation 1306
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374647565"
variation 1338
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377718385"
variation 1399
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370970569"
variation 1411
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:144743806"
variation 1421
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666582"
STS 1449..1640
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="Ocln"
/db_xref="UniSTS:495893"
exon 1460..1631
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 1632..1673
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 1674..6208
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1682
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:370469574"
variation 1718
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666626"
variation 1779
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374897366"
variation 1908
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576903"
variation 1908
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:76080549"
STS 2070..2231
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-U19251"
/db_xref="UniSTS:77742"
variation 2083
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201056955"
STS 2194..2340
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-H94471"
/db_xref="UniSTS:52040"
variation 2206
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371132365"
polyA_signal 2389..2394
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 2410
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 2432
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:79809021"
variation 2475
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2576904"
variation 2475
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:187688506"
variation 2532
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2561166"
variation 2685
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:192491213"
variation 2707
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576905"
variation 2754
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:75912442"
variation 2845
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112593689"
variation 2921
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666599"
variation 2921
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71622295"
variation 2957
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:111663327"
variation 2975..2976
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:71957719"
variation 3060
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:370879112"
variation 3061
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374446243"
variation 3062
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:185678833"
variation 3064
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:368766545"
variation 3065..3066
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="ag"
/db_xref="dbSNP:34202353"
variation 3100
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2568329"
variation 3100
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371435086"
STS 3143..3564
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3143..3231
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3185
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2568330"
variation 3199
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:6868400"
variation 3199
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:76123058"
variation 3240
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:146986409"
variation 3243
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:6892155"
variation 3243
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:66660167"
STS 3294..3491
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
variation 3341..3342
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gt"
/db_xref="dbSNP:373178468"
variation 3361
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:55639523"
variation 3363
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306264"
variation 3365
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374793047"
variation 3384..3385
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:56388078"
STS 3434..3649
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="RH80030"
/db_xref="UniSTS:87680"
STS 3471..3564
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3565
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:188890364"
variation 3574
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666598"
variation 3574
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371941973"
variation 3621
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:192095324"
variation 3664
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244907"
variation 3664
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:375565190"
variation 3697
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:369899490"
variation 3697
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2666597"
variation 3818
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:256925"
variation 3818
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:55909787"
variation 3840
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:184412724"
variation 3858
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:111417042"
polyA_signal 4463..4468
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 4484
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_signal 4744..4749
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 4763
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 4811
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200157655"
variation 5307
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:699901"
variation 5307
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374275248"
variation 5326
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113964466"
variation 5448
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:189167216"
variation 5632
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:112951447"
variation 5735
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71576927"
variation 5744
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112695697"
variation 5763
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:77392451"
variation 5949
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2244652"
variation 6154
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200773462"
variation 6184
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244645"
polyA_site 6208
/gene="OCLN"
/gene_synonym="BLCPMG"
ORIGIN
agaagggggaggagacgtccccagcccagtccccggctgagcgctggcggtcggtgcggcgtcaggtgcgcccgccaggtgagcgcgctccctggcaccgttggcccccggagggtcgggcccagttgcggcgagcggattggtttatcttggaagctaaagggcattgctcatcctgaagatcagctgaccattgacaatcagccatgtcatccaggcctcttgaaagtccacctccttacaggcctgatgaattcaaaccgaatcattatgcaccaagcaatgacatatatggtggagagatgcatgttcgaccaatgctctctcagccagcctactctttttacccagaagatgaaattcttcacttctacaaatggacctctcctccaggagtgattcggatcctgtctatgctcattattgtgatgtgcattgccatctttgcctgtgtggcctccacgcttgcctgggacagaggctatggaacttcccttttaggaggtagtgtaggctacccttatggaggaagtggctttggtagctacggaagtggctatggctatggctatggttatggctatggctacggaggctatacagacccaagagcagcaaagggcttcatgttggccatggctgccttttgtttcattgccgcgttggtgatctttgttaccagtgttataagatctgaaatgtccagaacaagaagatactacttaagtgtgataatagtgagtgctatcctgggcatcatggtgtttattgccacaattgtctatataatgggagtgaacccaactgctcagtcttctggatctctatatggttcacaaatatatgccctctgcaaccaattttatacacctgcagctactggactctacgtggatcagtatttgtatcactactgtgttgtggatccccaggaggccattgccattgtactggggttcatgattattgtggcttttgctttaataattttctttgctgtgaaaactcgaagaaagatggacaggtatgacaagtccaatattttgtgggacaaggaacacatttatgatgagcagccccccaatgtcgaggagtgggttaaaaatgtgtctgcaggcacacaggacgtgccttcacccccatctgactatgtggaaagagttgacagtcccatggcatactcttccaatggcaaagtgaatgacaagcggttttatccagagtcttcctataaatccacgccggttcctgaagtggttcaggagcttccattaacttcgcctgtggatgacttcaggcagcctcgttacagcagcggtggtaactttgagacaccttcaaaaagagcacctgcaaagggaagagcaggaaggtcaaagagaacagagcaagatcactatgagacagactacacaactggcggcgagtcctgtgatgagctggaggaggactggatcagggaatatccacctatcacttcagatcaacaaagacaactgtacaagaggaattttgacactggcctacaggaatacaagagcttacaatcagaacttgatgagatcaataaagaactctcccgtttggataaagaattggatgactatagagaagaaagtgaagagtacatggctgctgctgatgaatacaatagactgaagcaagtgaagggatctgcagattacaaaagtaagaagaatcattgcaagcagttaaagagcaaattgtcacacatcaagaagatggttggagactatgatagacagaaaacatagaaggctgatgccaagttgtttgagaaattaagtatctgacatctctgcaatcttctcagaaggcaaatgactttggaccataaccccggaagccaaacctctgtgagcatcacaaagttttggttgctttaacatcatcagtattgaagcattttataaatcgcttttgataatcaactgggctgaacactccaattaaggattttatgctttaaacattggttcttgtattaagaatgaaatactgtttgaggtttttaagccttaaaggaaggttctggtgtgaactaaactttcacaccccagacgatgtcttcatacctacatgtatttgtttgcataggtgatctcatttaatcctctcaaccacctttcagataactgttatttataatcacttttttccacataaggaaactgggttcctgcaatgaagtctctgaagtgaaactgcttgtttcctagcacacacttttggttaagtctgttttatgacttcattaataataaattccctggcctttcatattttagctactatatatgtgatgatctaccagcctccctattttttttctgttatataaatggttaaaagaggtttttcttaaataataaagatcatgtaaaagtaacaaatgtgtgaaatttaaagattgtaaatatatatttacttttttaagatcaaagtttaaaccccgtggttagaattttgtgtgtttttaaatactttttatctttttgcatgccttttttaaaaaaccaactagaacttttcattatatcagaatatctgattacatttataattcaattgtgacttgaactgtatcttacaggaatgttcaatttctatacatattttataaggtattaaacctggtgttttctttccataataacctgtttgatgttattagtgctgttaacatacagcaatggaaaaccacactcaggagttgtatctgttgttgtttatactcctttggatgctgtgctggttagtcgtttcccattcctttggctgtaagaatgctgatatgtctgggaatagaatgctataccacgaaataccaaataatttcaaatggtgcccttaaattgtatcacttttttaaaaattcagattcttattagtaaaattagttgatagcactgtgctgaccaagttgattgtgatcatcccagcttagacttttctaaaaacttttttttagaataatctataaactgaactttagtatgcatttcagatatttaggtatataatttttttttttttttgagacagagtctcactctcacccaggctggaatgcagtggtgctatcttggctcactgcaacctccacctcccgggttcaagcaattctcctgcctcagcctctcgagtagttgagactacaggtgcccatcaccatgcgtggctaatttttgtatttttaatagagacggggttttaccatagtggccaggttggtcttgaactcctgaccttgtggtctgcctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccatgcctggcctaagtgtgtgtgtgtgtgtgtgtgtgtatttttttttttttttttttgagatggagttttgctcttgttgaacaggctggagtgcaatgtcgcgatctcagctcaccacaacctccgcctcccaggttcaaacaattctcctgcctcggcctcccgagtagctgggattacaggcatgcgccaccacacctggctaattttttttttgtatttttagtagagatggggtttctccatgttggtcaggctggtctcgaactcctgacctcaggtgatccatccacctcggcctcccaaagtgctgggattagaggcgtgagccactgtgcccggcctataatttttgatagatgattttgaattattttccagagataaaattttaaatgtttccattatatcactgatttatttctgcaaattgaataaattcttaattttctgcatgcacataatacaaaaggtattttcatagttttggatttataccaaatgaaaaggattctcttgatgagcacctttaactgatttttctgttaaagttttaacaatttgttcttggaagtcagttcgtgaaggcaagtttgtcagtattttcacaaaactattcagctgaatccagaaagtgaaacagcaagaatttgcattgtaaaattgtgttataaaattggactttgaaatttcaaaaataagaaaaattttcatgtgtatttatactaaataccgttttaggaaactaggatcagggtgtttctgttggcgttggcattaactagctggatgtaaatttgaaaagccactcaagcagcttcctagtctagaaagtcagaggtttagattagatttccgacatcccttccatttctgacctgtagttcttgtctggaattctgctttgttataaactattgttctaaggagtttgttgtgatagcacatagttcattttgtaaagattccctgcgtataaagtgatgccctacatatgtgattttgtattaaaagtatataggatcattattttattttgaaaaatttaaatacagaaaagtataaaatataagtaccatccgcccagaaataacatgtgttaatgttttgtcatatgtgctttatattttttgaaataaagtgaagtcaactagtatttatagtaaataagttacatacacataagtacatatatgatatttaatcctcacaacgatcttttgacatgtgaccatttcttattcttcttttatagacaaggaactaatgatatgatagattaactggctgttgtcacactagcaagtggcaaaacaagggattaggatcttagtctcttcaactgttagattctatacttccatcctgtgttgactttgttaatggattggataatgtgagatcactctgatgtaaataaagtatcctatattaatttcgagtgcattttaagtacttgtaacataaatgcttcctgtgaaatatctgtaaagacctgaatgggtacatgtgtgtaaagaagaatcagggcagaaaagtgcttttatcatggctccggggaccttagcttcagttggtgttgtgagaattcctcacacaaggacattctccttgcttcagcatcaggatggaagtgtttctcatctggactttttcaaagactcagctggaggaatcagaattcataatttcctggcagctcatgattctgctacactacaccatgccatctcttgtgtgaaaggacagatttgatggaggactatgtcatccctcatgcgtttcttattgtctacatttattctaatgggaagaagtgagcaaaaacacctcaataatttgggtagtttttagaaaaccttgttagtaaattagaatagtgccactttggcattatgagaaagaagcatggatacataactagggttttgtgtatgactacaacgaaatgcagaatggtgtctccaaaaggtttccaattgctgccacaagaactgcttggtattgcctacatgtgttgtcctatttttgctttgcccttctgcagttacttgctgtgggaccttggagaaattaacttagcctctctgtacttcagttttttgtatttgtaaaatatatttgtaataatctcatagttaagaaggtagttaatgtgtgactcagtccttgtctaaaagtaaatatgcctagctacccccatcttccaaagccagaaggtgaaactttaacaagttttctaaaagcaaattgtgttttttaaaagtgcatgtgtcatccaatcccatatgattgatctgtgctgggtgcagccttagaatgtaaattcttttgaattctaggcagagaatgcaggattggcattctaaatatttgtacatgataaacaaatgcttctttaggttagagcaaatagtttacttatcaagatcacaattgttagatactgttgtcaattacagaggttttagatgaggctttctggaatgatttagtttccctgtaagggagcctgtctattggaatagacaggttcacttctcccagtctttcaagttgcatgctttttatatctgattccactggctgagctgattgtgaatgtcctaaccctgttgattgtgtctggccactcatgggcaaagaacagattatccattctttatagttgtcttttagttttacaagttgaaaaaacatctgagtaggttagataatttattctaccactttgtaaatgattagaatatgtcagtcataatcatgccaagagattatggatttatgcatattttgttttgctgtagtaccattcctagttgaatcttaacatccatgtctaaaatctatacagaacaaatattacagttgggaaaactgaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:100506658 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:100506658 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:100506658 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:100506658 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: IMP
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:100506658 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005923 [tight junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016327 [apicolateral plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0030054 [cell junction] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001192183 -> EC 2.1.1.67
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.