2024-04-19 08:19:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001205220 1903 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens cysteine-rich secretory protein 1 (CRISP1), transcript variant 3, mRNA. ACCESSION NM_001205220 VERSION NM_001205220.1 GI:327315371 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1903) AUTHORS Legare,C., Boudreau,L., Thimon,V., Thabet,M. and Sullivan,R. TITLE Vasectomy affects cysteine-rich secretory protein expression along the human epididymis and its association with ejaculated spermatozoa following vasectomy surgical reversal JOURNAL J. Androl. 31 (6), 573-583 (2010) PUBMED 20378925 REMARK GeneRIF: CRISP1 was in the seminal plasma of normal and vasovasostomized men, but not in that of vasectomized men. The soluble concentration of CRISP1 was significantly higher in the seminal plasma of vasovasostomized men as compared with that from normal men. REFERENCE 2 (bases 1 to 1903) AUTHORS Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L., Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E., Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J., Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O., Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J., Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M., Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K., Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J., Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L., Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P., Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J., Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M., Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L., Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R., Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M., King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J., Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L., McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J., Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K., Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I., Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y., Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K., Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L., Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J., Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S., Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E., Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M., Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Dunham,I., Rogers,J. and Beck,S. TITLE The DNA sequence and analysis of human chromosome 6 JOURNAL Nature 425 (6960), 805-811 (2003) PUBMED 14574404 REFERENCE 3 (bases 1 to 1903) AUTHORS Evans,J.P. TITLE The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization JOURNAL Hum. Reprod. Update 8 (4), 297-311 (2002) PUBMED 12206465 REMARK Review article REFERENCE 4 (bases 1 to 1903) AUTHORS Cuasnicu,P.S., Ellerman,D.A., Cohen,D.J., Busso,D., Morgenfeld,M.M. and Da Ros,V.G. TITLE Molecular mechanisms involved in mammalian gamete fusion JOURNAL Arch. Med. Res. 32 (6), 614-618 (2001) PUBMED 11750738 REMARK Review article REFERENCE 5 (bases 1 to 1903) AUTHORS Cohen,D.J., Ellerman,D.A., Busso,D., Morgenfeld,M.M., Piazza,A.D., Hayashi,M., Young,E.T., Kasahara,M. and Cuasnicu,P.S. TITLE Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg JOURNAL Biol. Reprod. 65 (4), 1000-1005 (2001) PUBMED 11566719 REFERENCE 6 (bases 1 to 1903) AUTHORS Kirchhoff,C. TITLE Molecular characterization of epididymal proteins JOURNAL Rev. Reprod. 3 (2), 86-95 (1998) PUBMED 9685187 REMARK Review article REFERENCE 7 (bases 1 to 1903) AUTHORS Hayashi,M., Fujimoto,S., Takano,H., Ushiki,T., Abe,K., Ishikura,H., Yoshida,M.C., Kirchhoff,C., Ishibashi,T. and Kasahara,M. TITLE Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1) JOURNAL Genomics 32 (3), 367-374 (1996) PUBMED 8838800 REFERENCE 8 (bases 1 to 1903) AUTHORS Kratzschmar,J., Haendler,B., Eberspaecher,U., Roosterman,D., Donner,P. and Schleuning,W.D. TITLE The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3 JOURNAL Eur. J. Biochem. 236 (3), 827-836 (1996) PUBMED 8665901 REFERENCE 9 (bases 1 to 1903) AUTHORS Hayashi,M. TITLE [Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization] JOURNAL Hokkaido Igaku Zasshi 70 (5), 743-753 (1995) PUBMED 8543280 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359458.17, BC028577.1 and X95237.1. Summary: Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. Transcript Variant: This variant (3) contains an alternate 5' terminal non-coding exon, thus differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC028577.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025084 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-4 AL359458.17 56750-56753 c 5-476 BC028577.1 10-481 477-1794 X95237.1 460-1777 1795-1795 AL359458.17 14018-14018 c 1796-1903 X95237.1 1779-1886 FEATURES Location/Qualifiers source 1..1903 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6p21.3" gene 1..1903 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /note="cysteine-rich secretory protein 1" /db_xref="GeneID:167" /db_xref="HGNC:304" /db_xref="MIM:601193" exon 1..88 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" exon 89..156 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" CDS 91..840 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /note="isoform 1 precursor is encoded by transcript variant 3; acidic epididymal glycoprotein-like 1; cysteine-rich secretory protein-1 delta; AEG-related protein; AEG-like protein; acidic epididymal glycoprotein homolog" /codon_start=1 /product="cysteine-rich secretory protein 1 isoform 1 precursor" /protein_id="NP_001192149.1" /db_xref="GI:327315372" /db_xref="CCDS:CCDS4931.1" /db_xref="GeneID:167" /db_xref="HGNC:304" /db_xref="MIM:601193" /translation="
MEIKHLLFLVAAACLLPMLSMKKKSARDQFNKLVTDLPNVQEEIVNIHNALRRRVVPPASNMLKMSWSEEAAQNARIFSKYCDMTESNPLERRLPNTFCGENMHMTSYPVSWSSVIGVWYSESTSFKHGEWTTTDDDITTDHYTQIVWATSYLIGCAIASCRQQGSPRYLYVCHYCHEGNDPETKNEPYKTGVPCEACPSNCEDKLCTNPCIYYDEYFDCDIQVHYLGCNHSTTILFCKATCLCDTEIK
" sig_peptide 91..153 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 154..837 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /product="cysteine-rich secretory protein 1 isoform 1" misc_feature 205..621 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /note="SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; Region: SCP_CRISP; cd05383" /db_xref="CDD:88562" misc_feature 673..837 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /note="Crisp; Region: Crisp; pfam08562" /db_xref="CDD:117137" variation 154 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /replace="a" /replace="g" /db_xref="dbSNP:3204891" exon 157..285 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" exon 286..376 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" exon 377..525 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" variation 379 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:3209304" exon 526..623 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" exon 624..712 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" exon 713..1899 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /inference="alignment:Splign:1.39.8" STS 755..993 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /standard_name="RH80559" /db_xref="UniSTS:90398" STS 863..1138 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /standard_name="STS-X95237" /db_xref="UniSTS:36213" variation 1067 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /replace="c" /replace="t" /db_xref="dbSNP:1053497" STS 1195..1298 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /standard_name="AEGL1" /db_xref="UniSTS:479934" polyA_signal 1274..1279 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" polyA_site 1296 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" polyA_signal 1873..1878 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" variation 1898..1899 /gene="CRISP1" /gene_synonym="AEGL1; ARP; CRISP-1; HSCRISP1D; HSCRISP1G; HUMARP" /replace="" /replace="a" /db_xref="dbSNP:71002694" ORIGIN
agtttctttgcagctaccaggacagagcttggtgagataattcttttattcttcaacttttattttaacttcaatggtacatgtgcagggatggaaattaaacacctcttgtttttggttgctgctgcttgcttactgcctatgttgtccatgaaaaagaaatcagctagagaccaatttaataagctcgtcaccgacttgccaaatgtacaagaagagatcgttaatatacacaacgccctcaggagaagagtagttccaccagccagcaacatgctgaagatgagttggagtgaagaggctgcacaaaatgccagaattttttcaaagtattgtgatatgacagagagcaacccccttgagaggagacttccaaataccttttgtggagaaaatatgcatatgacatcttatcctgtatcatggtcaagtgtaattggagtctggtacagtgagtctacaagtttcaaacatggagaatggacaacaacggatgatgacataactactgaccactacactcagattgtttgggccacatcttacctgattggctgtgccattgcatcttgccgccaacaaggatcacctcgatatctctacgtttgtcactattgtcatgagggaaatgatcctgaaacaaagaatgaaccttataagacaggcgtcccatgtgaagcctgcccaagtaactgtgaagacaaactttgcactaacccctgcatctactatgatgaatacttcgactgtgacatacaagtccattatctgggatgcaaccactcaacaactatcctattctgtaaagccacttgtctgtgtgacactgagataaaataggtctttgttattttcaactgttctatgctgtgacgatgaggaggagatgtctgttggattcatgtcttttgctatagttcagtagcttctgctaaatttcactgattttaatcatgctggagaccttaactcccatcctgatacatcctgaagtaacactgttttaaactttcttagtgctggagtaaaaggtcaagtccaacacctgccttaaatttaaatcatgtgatttatagtttttaagttggcataattcaacttatggtataactgggtccctcaacagtaacctgggctaaaataggtcttatgtggttcaactcccacccccgccttccccatattttcaaccactctgattatcttccctgcacaactaacatccagtaataattcttcacttttaaaattttacttctactttaaatcaatcattaaaggaatccacaaagcaaacagagttcagtctcatcttgcaaggtaaatatcatttaattggaagtagtttaaatgtctcattgttttattgacacatctatatatacatttgtgaagcaagaaacaataaaaaagcttcgtatgccattaatttaacaaaatatgtattcagtactgattgcatacaagatgcatgtttatatatatggaaggaatatagtttcatttcattgcaaaggcagtataaaagatatataaaatagcataatatgagaaattaagtccctaaagacatataggtcacatattattattgccagatgagcataaatagcttctgtttggagattcaggaaagccttagggtggaatgaggaacatcttctgagtaaacagggttgcaaaggttatgattatttcaacacaatggaagagcacagttaaggccaactaacgtaaaatgcactgaagccttagggaatattgaagggcctgacatggggaaagggaaggctaaaaatacttggtcaaattttaacattataccaaagttatacccagttctacctacttgtatatttctttactcatttcaataaagtgtttgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:167 -> Biological process: GO:0007342 [fusion of sperm to egg plasma membrane] evidence: TAS GeneID:167 -> Cellular component: GO:0005615 [extracellular space] evidence: TAS
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