2024-03-29 01:10:21, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001204878 4370 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 2, mRNA. ACCESSION NM_001204878 VERSION NM_001204878.1 GI:325910868 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4370) AUTHORS Reuland,S.N., Smith,S.M., Bemis,L.T., Goldstein,N.B., Almeida,A.R., Partyka,K.A., Marquez,V.E., Zhang,Q., Norris,D.A. and Shellman,Y.G. TITLE MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD) JOURNAL J. Invest. Dermatol. 133 (5), 1286-1293 (2013) PUBMED 23190898 REMARK GeneRIF: MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD). REFERENCE 2 (bases 1 to 4370) AUTHORS Kelly,J.L., Novak,A.J., Fredericksen,Z.S., Liebow,M., Ansell,S.M., Dogan,A., Wang,A.H., Witzig,T.E., Call,T.G., Kay,N.E., Habermann,T.M., Slager,S.L. and Cerhan,J.R. TITLE Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma JOURNAL Cancer Epidemiol. Biomarkers Prev. 19 (11), 2847-2858 (2010) PUBMED 20855536 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 4370) AUTHORS Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC and Anand S. CONSRTM DREAM investigators TITLE Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study JOURNAL Diabetes Care 33 (10), 2250-2253 (2010) PUBMED 20628086 REMARK GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) REFERENCE 4 (bases 1 to 4370) AUTHORS Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE and Hingorani AD. CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium TITLE Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009) PUBMED 19913121 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 5 (bases 1 to 4370) AUTHORS Tao,H.F., Hu,Q., Fang,J.L., Liu,A.G., Liu,S.Y., Zhang,L.Q. and Hu,Y. TITLE [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs] JOURNAL Zhongguo Shi Yan Xue Ye Xue Za Zhi 15 (3), 501-505 (2007) PUBMED 17605853 REMARK GeneRIF: Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway. REFERENCE 6 (bases 1 to 4370) AUTHORS Eichholtz-Wirth,H. and Sagan,D. TITLE Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells JOURNAL Anticancer Res. 22 (1A), 235-240 (2002) PUBMED 12017295 REMARK GeneRIF: Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. REFERENCE 7 (bases 1 to 4370) AUTHORS Antoku,K., Maser,R.S., Scully,W.J. Jr., Delach,S.M. and Johnson,D.E. TITLE Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein JOURNAL Biochem. Biophys. Res. Commun. 286 (5), 1003-1010 (2001) PUBMED 11527400 REFERENCE 8 (bases 1 to 4370) AUTHORS Frisch,S.M. TITLE Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis JOURNAL Curr. Biol. 9 (18), 1047-1049 (1999) PUBMED 10508612 REFERENCE 9 (bases 1 to 4370) AUTHORS Jiang,Y., Woronicz,J.D., Liu,W. and Goeddel,D.V. TITLE Prevention of constitutive TNF receptor 1 signaling by silencer of death domains JOURNAL Science 283 (5401), 543-546 (1999) PUBMED 9915703 REMARK Erratum:[Science 1999 Mar 19;283(5409):1852] REFERENCE 10 (bases 1 to 4370) AUTHORS Takayama,S., Xie,Z. and Reed,J.C. TITLE An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators JOURNAL J. Biol. Chem. 274 (2), 781-786 (1999) PUBMED 9873016 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000800.1, AC084024.17 and BM683128.1. Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000800.1, AK304072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1539 BC000800.1 1-1539 1540-3884 AC084024.17 96142-98486 3885-4370 BM683128.1 1-486 c FEATURES Location/Qualifiers source 1..4370 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8p11.23" gene 1..4370 /gene="BAG4" /gene_synonym="BAG-4; SODD" /note="BCL2-associated athanogene 4" /db_xref="GeneID:9530" /db_xref="HGNC:940" /db_xref="MIM:603884" exon 1..552 /gene="BAG4" /gene_synonym="BAG-4; SODD" /inference="alignment:Splign:1.39.8" variation 23 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:150735540" variation 35..36 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="g" /db_xref="dbSNP:34846134" variation 89 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:7000184" variation 90 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:113937856" misc_feature 106..108 /gene="BAG4" /gene_synonym="BAG-4; SODD" /note="upstream in-frame stop codon" variation 109 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:77568784" variation 177 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:112343580" variation 179 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:55962869" variation 237 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:143677476" variation 244 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:190213515" variation 273 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:376268617" CDS 283..1548 /gene="BAG4" /gene_synonym="BAG-4; SODD" /note="isoform 2 is encoded by transcript variant 2; BAG-family molecular chaperone regulator-4; silencer of death domains; BAG family molecular chaperone regulator 4; bcl-2-associated athanogene 4" /codon_start=1 /product="BAG family molecular chaperone regulator 4 isoform 2" /protein_id="NP_001191807.1" /db_xref="GI:325910869" /db_xref="CCDS:CCDS56533.1" /db_xref="GeneID:9530" /db_xref="HGNC:940" /db_xref="MIM:603884" /translation="
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
" misc_feature 1309..1542 /gene="BAG4" /gene_synonym="BAG-4; SODD" /note="BAG domains, present in regulator of Hsp70 proteins; Region: BAG; smart00264" /db_xref="CDD:197613" variation 297 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:61731143" variation 353 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:369467061" variation 355 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:61731142" variation 479 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:35041562" variation 507 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:369666639" exon 553..807 /gene="BAG4" /gene_synonym="BAG-4; SODD" /inference="alignment:Splign:1.39.8" variation 562 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:377544370" variation 569 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:371334530" variation 573 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:375515884" variation 589 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:192353336" variation 598 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:377654190" variation 648 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:374977832" variation 684 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:17853839" variation 691 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:140270832" variation 694 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:375790383" variation 718 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:367677262" variation 724 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:143334197" variation 728 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:61754115" variation 732 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:372261481" variation 751 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:139408020" variation 769 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:150045830" variation 797 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:200494674" exon 808..1062 /gene="BAG4" /gene_synonym="BAG-4; SODD" /inference="alignment:Splign:1.39.8" variation 847 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:145302681" variation 856 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:369685431" variation 867 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:190953663" variation 890 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:111978086" variation 899 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:202100571" variation 900 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:140078461" variation 916 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:143665459" variation 949 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:201302425" variation 957 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:146791444" variation 971 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:376249751" exon 1063..4356 /gene="BAG4" /gene_synonym="BAG-4; SODD" /inference="alignment:Splign:1.39.8" variation 1065 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:147569371" variation 1096 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:140547293" variation 1112 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:140266447" variation 1127 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:143644289" variation 1146 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:151234579" variation 1162 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:201044060" variation 1178 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:199793591" variation 1269 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:201309879" variation 1304 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:376216479" variation 1307 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:140388982" variation 1308 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:377644522" variation 1343 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:371081339" variation 1347 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:376393739" variation 1363 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:150352965" STS 1373..1502 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="SGC34731" /db_xref="UniSTS:22143" STS 1396..2142 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="BAG4_88" /db_xref="UniSTS:277023" variation 1408 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:10725" variation 1422 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:200905499" variation 1464 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:374076675" variation 1555 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:187571848" variation 1637 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:377003478" variation 1640 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:111385150" variation 1661 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:80041165" variation 1743 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:193259612" STS 1847..2035 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="RH78257" /db_xref="UniSTS:21968" variation 1861 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:1043782" STS 1928..2053 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="SHGC-30117" /db_xref="UniSTS:1122" variation 1957 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:3313" variation 2055 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:144321800" variation 2151..2152 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="g" /db_xref="dbSNP:371085485" variation 2257 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:76098501" variation 2259 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:79588397" variation 2280..2281 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="t" /db_xref="dbSNP:72159699" variation 2334 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:184097066" variation 2335..2341 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="ataaaat" /db_xref="dbSNP:144659234" variation 2343 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:112471179" variation 2383 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:4579494" variation 2439 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:78509021" variation 2448 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:142140385" variation 2542..2543 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="t" /db_xref="dbSNP:34203247" variation 2559 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:113784638" variation 2583 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:187833453" STS 2601..2689 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="D8S1432E" /db_xref="UniSTS:151221" STS 2617..2822 /gene="BAG4" /gene_synonym="BAG-4; SODD" /standard_name="RH25151" /db_xref="UniSTS:88759" variation 2680 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:142541037" variation 2801 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:192460147" variation 2898 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="g" /db_xref="dbSNP:184086295" variation 2969 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:143366565" variation 3045 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:60530611" variation 3100 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:188766347" variation 3134 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:372784467" variation 3264 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:113567191" variation 3282 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:372560655" variation 3326..3329 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="ttac" /db_xref="dbSNP:370930659" variation 3469 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:192014496" variation 3502..3503 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="" /replace="c" /db_xref="dbSNP:36118987" variation 3511 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:184563970" variation 3568 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:190199472" variation 3624 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:76228049" variation 3665 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:35866749" variation 3840 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:182385280" variation 3922 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="g" /db_xref="dbSNP:187376240" variation 4206 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="c" /replace="t" /db_xref="dbSNP:138231001" variation 4216 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="c" /db_xref="dbSNP:189383231" variation 4260 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="a" /replace="t" /db_xref="dbSNP:180939735" polyA_signal 4322..4327 /gene="BAG4" /gene_synonym="BAG-4; SODD" variation 4340 /gene="BAG4" /gene_synonym="BAG-4; SODD" /replace="g" /replace="t" /db_xref="dbSNP:142725480" polyA_site 4356 /gene="BAG4" /gene_synonym="BAG-4; SODD" ORIGIN
aggtaagaggaaactccattggataaatggcgaggaaacgtatactccctcttaaggaacacggtgtcttccttcgtctccgggttcccgagaccccagagtcactgacctccgtccctcagctttcggggttcggcagcagaaggggcgggcccgggcctgggattggctggcgtcgtccgacccccttcgctgctctccattcgcaatcgcccgcgggcgcctgcgcgatgggtcggccgtggggagcggggcgggaagcgcttcagggcagcggatcccatgtcggccctgaggcgctcgggctacggccccagtgacggtccgtcctacggccgctactacgggcctgggggtggagatgtgccggtacacccacctccacccttatatcctcttcgccctgaacctccccagcctcccatttcctggcgggtgcgcgggggcggcccggcggagaccacctggctgggagaaggcggaggaggcgatggctactatccctcgggaggcgcctggccagagcctggtcgagccggaggaagccaccagagtttgaattcttatacaaatggagcgtatggtccaacataccccccaggccctggggcaaatactgcctcatactcaggggcttattatgcacctggttatactcagaccagttactccacagaagttccaagtacttaccgttcatctggcaacagcccaactccagtctctcgttggatctatccccagcaggactgtcagactgaagcaccccctcttagggggcaggttccaggatatccgccttcacagaaccctggaatgaccctgccccattatccttatggagatggtaatcgtagtgttccacaatcaggaccgactgtacgaccacaagaagatgcgtgggcttctcctggtgcttatggaatgggtggccgttatccctggccttcatcagcgccctcagcaccacccggcaatctctacatgactgaaagtacttcaccatggcctagcagtggctctccccagtcacccccttcacccccagtccagcagcccaaggattcttcatacccctatagccaatcagatcaaagcatgaaccggcacaactttccttgcagtgtccatcagtacgaatcctcggggacagtgaacaatgatgattcagatcttttggattcccaagtccagtatagtgctgagcctcagctgtatggtaatgccaccagtgaccatcccaacaatcaagatcaaagtagcagtcttcctgaagaatgtgtaccttcagatgaaagtactcctccgagtattaaaaaaatcatacatgtgctggagaaggtccagtatcttgaacaagaagtagaagaatttgtaggaaaaaagacagacaaagcatactggcttctggaagaaatgctaaccaaggaacttttggaactggattcagttgaaactgggggccaggactctgtacggcaggccagaaaagaggctgtttgtaagattcaggccatactggaaaaattagaaaaaaaaggattatgaaaggatttagaacaaagtggaagcctgttactaacttgaccaaagaacacttgatttggttaattaccctctttttgaaatgcctgttgatgacaagaagcaatacattccagctttcctttgattttatacttgaaaaactggcaaaggaatggaagaatattttagtcatgagttgttttcagttttcagacgaatgaatgtaataggaaactatggagttaccaatattgccaagtagactcactccttaaaaaatttatggatatctacaagctgcttcttaccagcaggagggaaacacacttcacacaacaggcttatcagaaacctaccagatgaaactggatataatctgagacaaacaggatgtgtttttttaaacatctggatatcttgtcacatttttgtacattgtgactgctttcaacatatacttcatgtgtaattatagcttagactttagccttcttggacttctgttttgttttgttatttgcagtttacaaatatagtattattctctacttcttggtacattttgtagtaatatgtttaatataattattcaagagactatattgacagccagatagtatggcagttctgaaaaaatttatatcttttcaccacttgaatatactgcaatgtgtagtgagtaaattgtctccctttttctatagatcattaggttagagtttttttcttcttttttttttttttttttttttaccacttctgctgttcatggtagtagtggaaggtaaatttggaaatggcattgacataaaatgaaaatgtttacggacacttttcttttttgcttttttattgtatttggataaagatccacttaaaagttatctgttttttcctgttttttttttttttccccaaagtgtagttatgttttcactattgctgcttctatagagggcattgtgatagagagttacagatgaaacattaaatgccacagtgagtagaaataattactacaaaaagtaataaatatgattacttggtaatatcattctccatctaaaatactagtttcacctgtgagcagatttcagctcagtttatagttaaaaacaatgagggtaaaatgggattcatgctcagggaatgaatcagccatagttagagtgggaaattattattttcttcatttaaaggtagattttatgtttatttccctaaattgcataagataaaattgtctgtttaataaaaagacatttattaccattattaacagtcattttagagccaaatttaagaaaaggatattgaaagggtctttattggccttgtttgggtaactctatgctgttagatagaagagacttaggtaaataactttttatgtctgaggtgagtacacaatattggttcttggaaaaatagctgtttcttcataagatacccaagtgataattttttttcccctagactgtcaggcctatgagtaaatactaaatctattagctgtccccactcataaaccaaaccaaaccaatacaaacagatgaggagaggaaatgtagtaaaaatactggctgggtcttatgattgggatgagtgattttataagataatatggtgataattttattctaggattttatttttggcctaatataggaatgtttaaaaaaggcttttctatgaaaattagaaatttatacttgaaattaaaagtctagaagggggaggaccttaaagctaagctaccagtaagacaatgaataattcagaagagaacactattcttttactgactgagtgcccaagatgccaatttccatgaagtcttgatttatatatatgtacacatgttatgcacatacatgtttgttttctaacagttattttttaagcttttgagataattttagacttacagaagagttgtaaaagtagtagagttcttgtatactctgcacccaccttgcccttatgttaacatcttacgtaacaatagaacatttgtcaaaattaagaaattaaccttgatataatactaactaaagtagaaagtttaaaaagtagagattttagtcttttcactaatgtccttttactgttccaagacccagccttgcatttagctatcatgcctacgtcctgtcttccagtctgtgacagtgtatcataacaggggatacctgatgttgtaatgtatttctggtgttgttaaccttgatcactatgctaaggtggtgtctgctaggattcgctactgtaaacttactgtgttttccttgtaattattgaatatttgctggagatacccggagactatgcaaatgtcccgtttctgcttaaacttttgctcattttactatccattggcagatcttgcttgtggcagttactactgtggtgttctaatggtgattttctatttctctcaatccttctacatttattattggaattcttctgtaaggaagagttgtcagttctggatttatatttttaactataataagatattcaggataagtatagatttagaacttaaagatgttaaatcatgttaaaattattccaaataccaatatcaaagaaaactaagttggtaatctatctcagaaaatatatgaacttaagaaggaaaatagtatttatgatttgtagaattggttcaacttttgacttaatactgactttggactgaattcaaagttttcttgaaatttcacatctggactttttaaagtgtctacatttatattactttggggatcattttgtcaaagtcttgaataaagttacccagtcctggcatgataaacacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9530 -> Molecular function: GO:0005057 [receptor signaling protein activity] evidence: TAS GeneID:9530 -> Molecular function: GO:0051087 [chaperone binding] evidence: IEA GeneID:9530 -> Biological process: GO:0006457 [protein folding] evidence: TAS GeneID:9530 -> Biological process: GO:0010763 [positive regulation of fibroblast migration] evidence: IEA GeneID:9530 -> Biological process: GO:0030838 [positive regulation of actin filament polymerization] evidence: IEA GeneID:9530 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IEA GeneID:9530 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:9530 -> Biological process: GO:0045785 [positive regulation of cell adhesion] evidence: IEA GeneID:9530 -> Biological process: GO:0051496 [positive regulation of stress fiber assembly] evidence: IEA GeneID:9530 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA GeneID:9530 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IDA GeneID:9530 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA GeneID:9530 -> Biological process: GO:0072659 [protein localization to plasma membrane] evidence: IEA GeneID:9530 -> Biological process: GO:0097178 [ruffle assembly] evidence: IEA GeneID:9530 -> Biological process: GO:2001145 [negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] evidence: IEA GeneID:9530 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:9530 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:9530 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:9530 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:9530 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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