GGRNA Home | Help | Advanced search

2024-03-28 18:44:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001204870            4459 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens WNT1 inducible signaling pathway protein 1 (WISP1),
            transcript variant 4, mRNA.
ACCESSION   NM_001204870
VERSION     NM_001204870.1  GI:325910844
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Liu,J.F., Hou,S.M., Tsai,C.H., Huang,C.Y., Hsu,C.J. and Tang,C.H.
  TITLE     CCN4 induces vascular cell adhesion molecule-1 expression in human
            synovial fibroblasts and promotes monocyte adhesion
  JOURNAL   Biochim. Biophys. Acta 1833 (5), 966-975 (2013)
   PUBMED   23313051
  REMARK    GeneRIF: The CCN4-induced VCAM-1 expression promoted monocyte
            adhesion to human OASFs.
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Saxena,R., Saleheen,D., Been,L.F., Garavito,M.L., Braun,T.,
            Bjonnes,A., Young,R., Ho,W.K., Rasheed,A., Frossard,P., Sim,X.,
            Hassanali,N., Radha,V., Chidambaram,M., Liju,S., Rees,S.D.,
            Ng,D.P., Wong,T.Y., Yamauchi,T., Hara,K., Tanaka,Y., Hirose,H.,
            McCarthy,M.I., Morris,A.P., Basit,A., Barnett,A.H., Katulanda,P.,
            Matthews,D., Mohan,V., Wander,G.S., Singh,J.R., Mehra,N.K.,
            Ralhan,S., Kamboh,M.I., Mulvihill,J.J., Maegawa,H., Tobe,K.,
            Maeda,S., Cho,Y.S., Tai,E.S., Kelly,M.A., Chambers,J.C.,
            Kooner,J.S., Kadowaki,T., Deloukas,P., Rader,D.J., Danesh,J. and
            Sanghera,D.K.
  CONSRTM   DIAGRAM; MuTHER; AGEN
  TITLE     Genome-wide association study identifies a novel locus contributing
            to type 2 diabetes susceptibility in Sikhs of Punjabi origin from
            India
  JOURNAL   Diabetes 62 (5), 1746-1755 (2013)
   PUBMED   23300278
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Zemans,R.L., McClendon,J., Aschner,Y., Briones,N., Young,S.K.,
            Lau,L.F., Kahn,M. and Downey,G.P.
  TITLE     Role of beta-catenin-regulated CCN matricellular proteins in
            epithelial repair after inflammatory lung injury
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 304 (6), L415-L427 (2013)
   PUBMED   23316072
  REMARK    GeneRIF: Beta-catenin-dependent expression of WISP1 and Cyr61 is
            critical for epithelial repair.
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Hennemeier,I., Humpf,H.U., Gekle,M. and Schwerdt,G.
  TITLE     The food contaminant and nephrotoxin ochratoxin A enhances Wnt1
            inducible signaling protein 1 and tumor necrosis factor-alpha
            expression in human primary proximal tubule cells
  JOURNAL   Mol Nutr Food Res 56 (9), 1375-1384 (2012)
   PUBMED   22778029
  REMARK    GeneRIF: Prolonged exposure of kidney cells to ochratoxin A,
            expectable in human kidney due to a normal diet, leads to a marked
            ERK1/2-dependent upregulation of WISP1 gene expression, which,
            accompanied by increased ERK1/2- dependent TNF-alpha expression.
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Shao,H., Cai,L., Grichnik,J.M., Livingstone,A.S., Velazquez,O.C.
            and Liu,Z.J.
  TITLE     Activation of Notch1 signaling in stromal fibroblasts inhibits
            melanoma growth by upregulating WISP-1
  JOURNAL   Oncogene 30 (42), 4316-4326 (2011)
   PUBMED   21516124
  REMARK    GeneRIF: This study shows that constitutive activation of the
            Notch1 pathway confers fibroblasts with a suppressive phenotype to
            melanoma growth, partially through WISP-1.
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Xie,D., Nakachi,K., Wang,H., Elashoff,R. and Koeffler,H.P.
  TITLE     Elevated levels of connective tissue growth factor, WISP-1, and
            CYR61 in primary breast cancers associated with more advanced
            features
  JOURNAL   Cancer Res. 61 (24), 8917-8923 (2001)
   PUBMED   11751417
  REMARK    GeneRIF: Elevated levels of connective tissue growth factor,
            WISP-1, and CYR61 in primary breast cancers associated with more
            advanced features.
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Desnoyers,L., Arnott,D. and Pennica,D.
  TITLE     WISP-1 binds to decorin and biglycan
  JOURNAL   J. Biol. Chem. 276 (50), 47599-47607 (2001)
   PUBMED   11598131
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Tanaka,S., Sugimachi,K., Saeki,H., Kinoshita,J., Ohga,T.,
            Shimada,M., Maehara,Y. and Sugimachi,K.
  TITLE     A novel variant of WISP1 lacking a Von Willebrand type C module
            overexpressed in scirrhous gastric carcinoma
  JOURNAL   Oncogene 20 (39), 5525-5532 (2001)
   PUBMED   11571650
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Xu,L., Corcoran,R.B., Welsh,J.W., Pennica,D. and Levine,A.J.
  TITLE     WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
  JOURNAL   Genes Dev. 14 (5), 585-595 (2000)
   PUBMED   10716946
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (25), 14717-14722 (1998)
   PUBMED   9843955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX476382.1, AY196486.1,
            AF192304.6 and AI347990.1.
            
            Summary: This gene encodes a member of the WNT1 inducible signaling
            pathway (WISP) protein subfamily, which belongs to the connective
            tissue growth factor (CTGF) family. WNT1 is a member of a family of
            cysteine-rich, glycosylated signaling proteins that mediate diverse
            developmental processes. The CTGF family members are characterized
            by four conserved cysteine-rich domains: insulin-like growth
            factor-binding domain, von Willebrand factor type C module,
            thrombospondin domain and C-terminal cystine knot-like domain. This
            gene may be downstream in the WNT1 signaling pathway that is
            relevant to malignant transformation. It is expressed at a high
            level in fibroblast cells, and overexpressed in colon tumors. The
            encoded protein binds to decorin and biglycan, two members of a
            family of small leucine-rich proteoglycans present in the
            extracellular matrix of connective tissue, and possibly prevents
            the inhibitory activity of decorin and biglycan in tumor cell
            proliferation. It also attenuates p53-mediated apoptosis in
            response to DNA damage through activation of the Akt kinase. It is
            83% identical to the mouse protein at the amino acid level.
            Multiple alternatively spliced transcript variants have been
            identified. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (4) lacks three internal exons in
            the coding region, as compared to variant 1. The resulting isoform
            (4) has a shorter and distinct C-terminus, as compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY196486.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BX476382.1         1-30
            31-291              AY196486.1         8-268
            292-4179            AF192304.6         65650-69537
            4180-4459           AI347990.1         1-280               c
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..4459
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="WNT1 inducible signaling pathway protein 1"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
     exon            1..175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       22
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35244636"
     STS             50..1627
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /db_xref="UniSTS:486382"
     variation       55
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116716037"
     STS             57..525
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /db_xref="UniSTS:481399"
     variation       58
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113859079"
     variation       60
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201515187"
     variation       76
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370168550"
     variation       77
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373840690"
     STS             78..496
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /db_xref="UniSTS:482064"
     misc_feature    95..97
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="upstream in-frame stop codon"
     CDS             107..475
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; Wnt-1 inducible signaling pathway protein 1;
                     WNT1 induced secreted protein 1; CCN family member 4"
                     /codon_start=1
                     /product="WNT1-inducible-signaling pathway protein 1
                     isoform 4 precursor"
                     /protein_id="NP_001191799.1"
                     /db_xref="GI:325910845"
                     /db_xref="CCDS:CCDS56556.1"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
                     /translation="
MRWFLPWTLAAVTAAAASTVLATAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN
"
     sig_peptide     107..172
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
     mat_peptide     173..472
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /product="WNT1-inducible-signaling pathway protein 1
                     isoform 4"
     misc_feature    209..457
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl00070"
                     /db_xref="CDD:200610"
     variation       128
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145302227"
     variation       130
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147864416"
     variation       134
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141541463"
     variation       135
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147047617"
     variation       140
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145240649"
     variation       144
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149172980"
     variation       155
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375956639"
     variation       174
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370536589"
     variation       175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374241755"
     exon            176..4455
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       219
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370616029"
     variation       226
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35938742"
     variation       234
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374293123"
     variation       235
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34279368"
     variation       264
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368398252"
     variation       268
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150347257"
     variation       292
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3739261"
     variation       307
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369316693"
     variation       341
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200845163"
     variation       366
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371947572"
     variation       376
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34665171"
     variation       427
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146812236"
     variation       469
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140629356"
     variation       477
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192420341"
     variation       497
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200836970"
     variation       502
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374163879"
     variation       620
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138013484"
     variation       730
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57390041"
     variation       844
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:142394577"
     variation       926
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113549310"
     variation       951
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184580529"
     variation       1068
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190313906"
     variation       1116
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142461254"
     variation       1219
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929969"
     variation       1445
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12164193"
     variation       1454
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145960909"
     variation       1460
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73362554"
     variation       1529
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182003497"
     variation       1608
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:4265166"
     variation       1659
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929970"
     variation       1728
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374010309"
     variation       1733
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4577938"
     variation       1824
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377032724"
     variation       1938
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146162433"
     variation       1993
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185849289"
     variation       2289
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188945068"
     variation       2298
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181057409"
     variation       2301
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148796937"
     variation       2522
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117072299"
     variation       2555
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977549"
     variation       2858
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73362557"
     variation       2860
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76779268"
     variation       2894
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2929971"
     variation       2901
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373530385"
     variation       2925
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142427022"
     variation       2977
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929972"
     variation       3030
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2929973"
     variation       3054
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151300566"
     variation       3202
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:16904856"
     variation       3233..3234
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36017627"
     variation       3289
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370468302"
     variation       3331
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977550"
     variation       3446
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9649971"
     variation       3448
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186406622"
     variation       3478
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904857"
     variation       3567
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191533905"
     variation       3601
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200715437"
     variation       3629
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145461011"
     variation       3770
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16904858"
     variation       3878
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114925013"
     variation       3888
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904859"
     variation       3944
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:73711826"
     variation       3946..3947
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35647766"
     variation       3951
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16904860"
     variation       3964..3967
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="ctga"
                     /db_xref="dbSNP:372155216"
     variation       3966..3969
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="gact"
                     /db_xref="dbSNP:367926394"
     variation       3990
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182511484"
     variation       4007
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186242527"
     variation       4053
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74818902"
     variation       4072
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977551"
     STS             4137..4303
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /standard_name="RH102883"
                     /db_xref="UniSTS:97217"
     STS             4151..4362
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /standard_name="RH76344"
                     /db_xref="UniSTS:92556"
     variation       4184
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147688784"
     variation       4196
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191950359"
     variation       4361
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77866098"
     polyA_signal    4433..4438
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
     polyA_site      4455
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
ORIGIN      
atatctggtgctcctgatgggccggccagtctgggcccagctcccccgagaggtggtcggatcctctgggctgctcggtcgatgcctgtgccactgacgtccaggcatgaggtggttcctgccctggacgctggcagcagtgacagcagcagccgccagcaccgtcctggccacggcagggaagaagtgtctggctgtgtaccagccagaggcatccatgaacttcacacttgcgggctgcatcagcacacgctcctatcaacccaagtactgtggagtttgcatggacaataggtgctgcatcccctacaagtctaagactatcgacgtgtccttccagtgtcctgatgggcttggcttctcccgccaggtcctatggattaatgcctgcttctgtaacctgagctgtaggaatcccaatgacatctttgctgacttggaatcctaccctgacttctcagaaattgccaactaggcaggcacaaatcttgggtcttggggactaacccaatgcctgtgaagcagtcagcccttatggccaataacttttcaccaatgagccttagttaccctgatctggacccttggcctccatttctgtctctaaccattcaaatgacgcctgatggtgctgctcaggcccatgctatgagttttctccttgatatcattcagcatctactctaaagaaaaatgcctgtctctagctgttctggactacacccaagcctgatccagcctttccaagtcactagaagtcctgctggatcttgcctaaatcccaagaaatggaatcaggtagacttttaatatcactaatttcttctttagatgccaaaccacaagactctttgggtccattcagatgaatagatggaatttggaacaatagaataatctattatttggagcctgccaagaggtactgtaatgggtaattctgacgtcagcgcaccaaaactatcctgattccaaatatgtatgcacctcaaggtcatcaaacatttgccaagtgagttgaatagttgcttaattttgatttttaatggaaagttgtatccattaacctgggcattgttgaggttaagtttctcttcacccctacactgtgaagggtacagattaggtttgtcccagtcagaaataaaatttgataaacattcctgttgatgggaaaagcccccagttaatactccagagacagggaaaggtcagcccgtttcagaaggaccaattgactctcacactgaatcagctgctgactggcagggctttgggcagttggccaggctcttccttgaatcttctcccttgtcctgcttggggttcataggaattggtaaggcctctggactggcctgtctggcccctgagagtggtgccctggaacactcctctactcttacagagccttgagagacccagctgcagaccatgccagacccactgaaatgaccaagacaggttcaggtaggggtgtgggtcaaaccaagaagtgggtgcccttggtagcagcctggggtgacctctagagctggaggctgtgggactccaggggcccccgtgttcaggacacatctattgcagagactcatttcacagcctttcgttctgctgaccaaatggccagttttctggtaggaagatggaggtttaccggttgtttagaaacagaaatagacttaataaaggtttaaagctgaagaggttgaagctaaaaggaaaaggttgttgttaatgaatatcaggctattatttattgtattaggaaaatataatatttactgttagaattcttttatttagggccttttctgtgccagacattgctctcagtgctttgcatgtattagctcactgaatcttcacgacaatgttgagaagttcccattattatttctgttcttacaaatgtgaaacggaagctcatagaggtgagaaaactcaaccagagtcacccagttggtgactgggaaagttaggattcagatcgaaattggactgtctttataacccatattttccccctgtttttagagcttccaaatgtgtcagaataggaaaacattgcaataaatggcttgattttttaatgtcatttttccctcttatagtctttctagctccttttcaaaagacgagaatatctgattttctgataatttaggtgcttaagcatccaaaatacatgggacacacaaaaatccaggaatcccctgtagcttattccctctttcccatcggaaccagctctcatcacacatttaaaagatgattctgtttacccaatgctgcatattgaatgttgtgtagttattcacagggaattctgtgcagtgtgcagagagattcctaaacgggaaaaggactgggaatacatcctccttactgtgacctccccaaaacctagtccagtgcaaggtatacagtggtgctcattaaatacttgatgaatacaggaagctgtgcatgtgttcctacttttattcgaagctctcttcttccaaagctacatgaaaatagaattttaacagtcaaaattttatattaagtgccttagcaaaagagacatttaatatttcaaagaaatgcatatgtatgtatacatatatttgtgtatgcgtatgcaagaattcttgtataaagagaattcactccatgaatgatctcttctgtaagtcagtgtgaatcatgttagattttctgagagtgaaaacacctgccatctacaaattacaaggctggataacagctcactccatttgaaattcagtggaaacccaagagctaggttcttactgaatttgcatctcaatttgggaaactgaacttagctttcaaagatcataggaagtctggttggagaaactagggattattctggcaatgggtgcaggaaggtggtcagaataacccagtcgccattggttttgagaaacggaactatcttatgcagagcccggagggcaagtctcagacccatgggttgaagccatggagaaggaaatttggatccaatgtaatgaagcgctttctaagtcagaatttccctgcaatggtgtggcctgattcaataaaaattaagaataataaatataatggaaaaaaatctccactgattgagtgtttacttggtgccaagcactatgctaagttgttcattattttatttaattgttacagcaattttgagtatgcatctttcactattttataagtggaaaagagaagtgcccccaaaaagttagagctcaaacagcagcttattctaccagcccctgctcttgcggaggcctctggaaaagacctgaatgacacctattggagaattacatctacaaggggcttcaaacagaccaaatagatcatcacctctgtggtcccttgttaactatatgttctgagacaaaggaaagctaccctaagggttagttaacctttgctgaggaaatttacattcatacttagagtgaattactcaggtgtgcttaggtgtgcaaaagggaaggagacctgaattcaccaagttaaatcttgctaaaccttatcataagcattttttgagcgcttagcatacaccaagccttgtggaaggtgctttcctgccatatctcatttaatcctcacagcaaacctatagaatatggcattatcatctgagtctcacagaagtttagtcgtgtactcaaggtcttaccagctagtgaacagcagaccaagactggaaacccaggatagtctgatacctgagccatctcttcttgtgctacgcctagttattctgtcccccaaatcaaaaggcatgacctttataagaggcgctttactgacaatagctgcaattttaactttgaaaatgattcagaattatcaaagatagtagattcgaatgacatgattgtctataatctcgctagccttgtactgtgtgtgcatagcaattacagggaagtaatctagctcctgactattatgttgaactatgtcgctgctttttacaaacttgtcttgatccaaagcagtcacaatgataaccctgcatatctgggaatcataagtcaactatgtatccctgtgtgtgtatatatatgtatgtatgtatctattttcaaactgtgatttaatatttaaatattcctactgccatttttgtgactgaaaaactacacatgaggaaacgtcttagaattttccaatagaggaaaaataacacttgggcaatctgtcatgtttcacaacagttctcatttttctcatgatttgtgtagcgtggaatgtgtttgctcaatgtgaagggttttcattgctcaatttctctgtgtaagtcttttccttaaggtaataaaccatcagcaaagtcacatactggagttggtggcttttcttgtacaggcagttgttatgagacaatgatggagcattgagcatgttcaataaatgtgcagatggtggaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8840 -> Molecular function: GO:0005520 [insulin-like growth factor binding] evidence: IEA
            GeneID:8840 -> Biological process: GO:0001558 [regulation of cell growth] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:8840 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:8840 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:8840 -> Cellular component: GO:0005615 [extracellular space] evidence: NAS
            GeneID:8840 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.