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2024-03-28 17:19:41, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001204397            3482 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant
            4, mRNA.
ACCESSION   NM_001204397
VERSION     NM_001204397.1  GI:324710991
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Zhang,J.X., Tong,Z.T., Yang,L., Wang,F., Chai,H.P., Zhang,F.,
            Xie,M.R., Zhang,A.L., Wu,L.M., Hong,H., Yin,L., Wang,H., Wang,H.Y.
            and Zhao,Y.
  TITLE     PITX2: a promising predictive biomarker of patients' prognosis and
            chemoradioresistance in esophageal squamous cell carcinoma
  JOURNAL   Int. J. Cancer 132 (11), 2567-2577 (2013)
   PUBMED   23132660
  REMARK    GeneRIF: High expression of PITX2 was associated with
            chemoradioresistance in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Zhang,Z., Gutierrez,D., Li,X., Bidlack,F., Cao,H., Wang,J.,
            Andrade,K., Margolis,H.C. and Amendt,B.A.
  TITLE     The LIM homeodomain transcription factor LHX6: a transcriptional
            repressor that interacts with pituitary homeobox 2 (PITX2) to
            regulate odontogenesis
  JOURNAL   J. Biol. Chem. 288 (4), 2485-2500 (2013)
   PUBMED   23229549
  REMARK    GeneRIF: LHX6 is a transcriptional repressor that interacts with
            pituitary homeobox 2 (PITX2) to regulate odontogenesis
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Bevan,S., Traylor,M., Adib-Samii,P., Malik,R., Paul,N.L.,
            Jackson,C., Farrall,M., Rothwell,P.M., Sudlow,C., Dichgans,M. and
            Markus,H.S.
  TITLE     Genetic heritability of ischemic stroke and the contribution of
            previously reported candidate gene and genomewide associations
  JOURNAL   Stroke 43 (12), 3161-3167 (2012)
   PUBMED   23042660
  REMARK    GeneRIF: 3 loci from related cardiovascular genomewide studies were
            significant: PHACTR1 in large-vessel disease (P=2.63e(-6)), PITX2
            in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic
            stroke (P=5.50e(-7)).
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC,
            Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls
            MA, Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL,
            Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A,
            Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M,
            Chen WM, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R,
            Norrving B, Higgins P, Benn M, Sale M, Kuhlenbaumer G, Doney AS,
            Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN,
            Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI,
            Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard
            BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Pare G, Berger K,
            Thorleifsson G, Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke
            R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P,
            Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia
            JF, Stefansson K, Dichgans M and Markus HS.
  CONSRTM   Australian Stroke Genetics Collaborative, Wellcome Trust Case
            Control Consortium 2 (WTCCC2); International Stroke Genetics
            Consortium
  TITLE     Genetic risk factors for ischaemic stroke and its subtypes (the
            METASTROKE collaboration): a meta-analysis of genome-wide
            association studies
  JOURNAL   Lancet Neurol 11 (11), 951-962 (2012)
   PUBMED   23041239
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Li,Q., Pan,H., Guan,L., Su,D. and Ma,X.
  TITLE     CITED2 mutation links congenital heart defects to dysregulation of
            the cardiac gene VEGF and PITX2C expression
  JOURNAL   Biochem. Biophys. Res. Commun. 423 (4), 895-899 (2012)
   PUBMED   22735262
  REMARK    GeneRIF: CITED2 variants decreased its ability to mediate the
            expression of vascular endothelial growth factor (VEGF) and the
            expression of the paired-like homeodomain transcription factor
            2-gamma (PITX2C), both of which are closely related to cardiac
            development.
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Pellegrini-Bouiller,I., Manrique,C., Gunz,G., Grino,M.,
            Zamora,A.J., Figarella-Branger,D., Grisoli,F., Jaquet,P. and
            Enjalbert,A.
  TITLE     Expression of the members of the Ptx family of transcription
            factors in human pituitary adenomas
  JOURNAL   J. Clin. Endocrinol. Metab. 84 (6), 2212-2220 (1999)
   PUBMED   10372733
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Amendt,B.A., Sutherland,L.B., Semina,E.V. and Russo,A.F.
  TITLE     The molecular basis of Rieger syndrome. Analysis of Pitx2
            homeodomain protein activities
  JOURNAL   J. Biol. Chem. 273 (32), 20066-20072 (1998)
   PUBMED   9685346
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Arakawa,H., Nakamura,T., Zhadanov,A.B., Fidanza,V., Yano,T.,
            Bullrich,F., Shimizu,M., Blechman,J., Mazo,A., Canaani,E. and
            Croce,C.M.
  TITLE     Identification and characterization of the ARP1 gene, a target for
            the human acute leukemia ALL1 gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (8), 4573-4578 (1998)
   PUBMED   9539779
REFERENCE   9  (bases 1 to 3482)
  AUTHORS   Alward,W.L., Semina,E.V., Kalenak,J.W., Heon,E., Sheth,B.P.,
            Stone,E.M. and Murray,J.C.
  TITLE     Autosomal dominant iris hypoplasia is caused by a mutation in the
            Rieger syndrome (RIEG/PITX2) gene
  JOURNAL   Am. J. Ophthalmol. 125 (1), 98-100 (1998)
   PUBMED   9437321
REFERENCE   10 (bases 1 to 3482)
  AUTHORS   Semina,E.V., Reiter,R., Leysens,N.J., Alward,W.L., Small,K.W.,
            Datson,N.A., Siegel-Bartelt,J., Bierke-Nelson,D., Bitoun,P.,
            Zabel,B.U., Carey,J.C. and Murray,J.C.
  TITLE     Cloning and characterization of a novel bicoid-related homeobox
            transcription factor gene, RIEG, involved in Rieger syndrome
  JOURNAL   Nat. Genet. 14 (4), 392-399 (1996)
   PUBMED   8944018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP372081.1, AK127829.1,
            BX380370.2, U69961.1 and BC106010.1.
            
            Summary: This gene encodes a member of the RIEG/PITX homeobox
            family, which is in the bicoid class of homeodomain proteins. The
            encoded protein acts as a transcription factor and regulates
            procollagen lysyl hydroxylase gene expression. This protein plays a
            role in the terminal differentiation of somatotroph and lactotroph
            cell phenotypes, is involved in the development of the eye, tooth
            and abdominal organs, and acts as a transcriptional regulator
            involved in basal and hormone-regulated activity of prolactin.
            Mutations in this gene are associated with Axenfeld-Rieger
            syndrome, iridogoniodysgenesis syndrome, and sporadic cases of
            Peters anomaly. A similar protein in other vertebrates is involved
            in the determination of left-right asymmetry during development.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) has an additional exon in the
            5' UTR, as compared to variant 2. Variants 2, 4 and 5 encode the
            same isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127829.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025088 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BP372081.1         1-162
            163-428             AK127829.1         1-266
            429-543             BX380370.2         313-427
            544-1104            AK127829.1         382-942
            1105-1579           U69961.1           98-572
            1580-3476           AK127829.1         1418-3314
            3477-3482           BC106010.1         1741-1746
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..3482
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="paired-like homeodomain 2"
                     /db_xref="GeneID:5308"
                     /db_xref="HGNC:9005"
                     /db_xref="MIM:601542"
     exon            1..205
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     exon            206..1579
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     variation       549
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739191"
     variation       553
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739192"
     variation       607
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739193"
     variation       610
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739194"
     variation       1105
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739200"
     variation       1570
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2739203"
     exon            1580..1813
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     exon            1814..1869
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1815..1817
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="upstream in-frame stop codon"
     CDS             1824..2777
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="isoform b is encoded by transcript variant 4;
                     paired-like homeodomain transcription factor 2; rieg
                     bicoid-related homeobox transcription factor 1;
                     all1-responsive gene 1; solurshin; pituitary homeobox 2;
                     homeobox protein PITX2; ALL1-responsive protein ARP1"
                     /codon_start=1
                     /product="pituitary homeobox 2 isoform b"
                     /protein_id="NP_001191326.1"
                     /db_xref="GI:324710992"
                     /db_xref="CCDS:CCDS3692.1"
                     /db_xref="GeneID:5308"
                     /db_xref="HGNC:9005"
                     /db_xref="MIM:601542"
                     /translation="
METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
"
     misc_feature    2079..2255
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(2079..2093,2097..2099,2148..2150,2166..2168,
                     2205..2207,2211..2216,2223..2228,2232..2240,2244..2249)
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(2085..2087,2094..2096,2214..2216,2223..2228,
                     2235..2237)
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    2643..2699
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /note="OAR domain; Region: OAR; pfam03826"
                     /db_xref="CDD:146451"
     misc_feature    2658..2699
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99697.2);
                     Region: OAR"
     misc_feature    2676..2690
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99697.2);
                     Region: Nuclear localization signal (Potential)"
     variation       1860
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1131942"
     exon            1870..2007
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     exon            2008..2213
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     variation       2118
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1051887"
     exon            2214..3479
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /inference="alignment:Splign:1.39.8"
     variation       2708
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1051888"
     variation       2726
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2739199"
     variation       2801
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1051889"
     STS             3235..3366
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /standard_name="D4S3305"
                     /db_xref="UniSTS:47798"
     STS             3235..3362
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /standard_name="SHGC-50188"
                     /db_xref="UniSTS:81619"
     variation       3334
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739201"
     variation       3336
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2739202"
     polyA_site      3479
                     /gene="PITX2"
                     /gene_synonym="ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2;
                     Otlx2; PTX2; RGS; RIEG; RIEG1; RS"
ORIGIN      
gcagtctgtgtaagttttcatatctctgagtgtgtgcacacagtggagagggtggagcctgccatcctcaaatctgaaaagattgagagatttcagagggcccagatgtgccaaaggtcagagggatcaatatacaggccctaccacggaaaggcggggaaaaggttcgaatagaaaactgctgcagaagggaagccactgagaggagcaaatgtggacttgagggaaactctctcccccacccccacttctatcccgtgcaatttaataccatcctcgccaggaaccttaacctcgtcattttaaaaaatgagatatccgtgacccagggtgaacttgttgaatgtaggtacagcagaggaaattctagactctatgagcgtctgagccttgtccagtgcaaacccttcgtgaacactgggtcagtgcgtggccgtgcccacctgtgcgccgacactctcagcatgcctggtccacccgccttgacctcgggcgcggtgtcccagctaagctgggcccagcgtcccggccttccccagctgacaagcctagctcgttcgctcccggctgtggccctcccaccctctcccactagctcactccattcttctagatttctcttcactcatcctctcccatccccaccgcgcccacctccactcccgccctctaccggtctctcactttcctccctccgcagtccctctttgctgtgacctctttcctcaactctgcaggcctgaaagaaggtcacacacgcacgctcacacccacactccacacgcctcgtcccaaacaaccccatgaacattgtcctttgttccgtctcttgggccactttccctgtcgcttcctcccagcccgtcctgatttgctccccaaaagtacgtttctgtctccccgctgccctggcgctccccctttgatttattagggctgccgggttggcgcagattgctttttcttctcttccatcccatcctcccttctggtcctcctttccacagtgggagtccgtgctcctgctcctcggttggctcctaagtgccccgccaggtcccctctcctttcgctctcccggctccggctcccgactcttcggcccgctggcatctgcttccctcccctgcctcgtttctcgtcgcccctgctcgctccccccggcgctcgcccgggcgctgtgctcgctcctggatcgccagccgcgcagccgggctcggccggccgcccgcgcgccactgtgcagtggagtttggtggaatctctgctgacgtcacgtcactccccacacggagtaggagcagagggaagagagagggatgagagggagggagaggagagagagtgcgagaccgagcgagaaagctggagaggagcagaaagaaactgccagtggcggctagatttcggaggccccagtgcacccgtggactccttcggaacttggcaccctcaggagccctgcagtcctctcaggcccggctttcgggcgcttgccgtgcagccggaggctcggctcgctggaaatcgccccgggaagcagtgggacgcggagacagcagctctctcccggtagccgaatcactaaatctggagccgccaaactgctacttctgggcccacgggcccacaaggatcgaatcggcagagtccccgcccgcgttctcgctagcgggtgggggaaccgcctggccgtccccaccctggatccccacgccacagcgccgggcagcccctcctgtaggcagcgaccttggccagaggctccccagggcccagctcccttcaggagaggccgagacgcagggaaacgataacggggaatggagaccaactgccgcaaactggtgtcggcgtgtgtgcaattaggcgtgcagccggcggccgttgaatgtctcttctccaaagactccgaaatcaaaaaggtcgagttcacggactctcctgagagccgaaaagaggcagccagcagcaagttcttcccgcggcagcatcctggcgccaatgagaaagataaaagccagcaggggaagaatgaggacgtgggcgccgaggacccgtctaagaagaagcggcaaaggcggcagcggactcactttaccagccagcagctccaggagctggaggccactttccagaggaaccgctacccggacatgtccacacgcgaagaaatcgctgtgtggaccaaccttacggaagcccgagtccgggtttggttcaagaatcgtcgggccaaatggagaaagagggagcgcaaccagcaggccgagctatgcaagaatggcttcgggccgcagttcaatgggctcatgcagccctacgacgacatgtacccaggctattcctacaacaactgggccgccaagggccttacatccgcctccctatccaccaagagcttccccttcttcaactctatgaacgtcaaccccctgtcatcacagagcatgttttccccacccaactctatctcgtccatgagcatgtcgtccagcatggtgccctcagcagtgacaggcgtcccgggctccagtctcaacagcctgaataacttgaacaacctgagtagcccgtcgctgaattccgcggtgccgacgcctgcctgtccttacgcgccgccgactcctccgtatgtttatagggacacgtgtaactcgagcctggccagcctgagactgaaagcaaagcagcactccagcttcggctacgccagcgtgcagaacccggcctccaacctgagtgcttgccagtatgcagtggaccggcccgtgtgagccgcacccacagcgccgggatcctaggaccttgccggatggggcaactccgcccttgaaagactgggaattatgctagaaggtcgtgggcactaaagaaagggagagaaagagaagctatatagagaaaaggaaaccactgaatcaaagagagagctcctttgatttcaaagggatgtcctcagtgtctgacatctttcactacaagtatttctaacagttgcaaggacacatacacaaacaaatgtttgactggatatgacattttaacattactataagcttgttattttttaagtttagcattgttaacatttaaatgactgaaaggatgtatatatatcgaaatgtcaaattaattttataaaagcagttgttagtaatatcacaacagtgtttttaaaggttaggctttaaaataaagcatgttatacagaagcgattaggatttttcgcttgcgagcaagggagtgtatatactaaatgccacactgtatgtttctaacatattattattattataaaaaatgtgtgaatatcagttttagaatagtttctctggtggatgcaatgatgtttctgaaactgctatgtacaacctaccctgtgtataacatttcgtacaatattattgttttacttttcagcaaatatgaaacaaatgtgttttatttcatgggagtaaaatatactgcatacaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5308 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IDA
            GeneID:5308 -> Molecular function: GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] evidence: IEA
            GeneID:5308 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:5308 -> Molecular function: GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] evidence: IDA
            GeneID:5308 -> Molecular function: GO:0001085 [RNA polymerase II transcription factor binding] evidence: IPI
            GeneID:5308 -> Molecular function: GO:0001102 [RNA polymerase II activating transcription factor binding] evidence: IPI
            GeneID:5308 -> Molecular function: GO:0001105 [RNA polymerase II transcription coactivator activity] evidence: IDA
            GeneID:5308 -> Molecular function: GO:0001191 [RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription] evidence: IDA
            GeneID:5308 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5308 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5308 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5308 -> Molecular function: GO:0031490 [chromatin DNA binding] evidence: IEA
            GeneID:5308 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:5308 -> Molecular function: GO:0043021 [ribonucleoprotein complex binding] evidence: IC
            GeneID:5308 -> Molecular function: GO:0051219 [phosphoprotein binding] evidence: IPI
            GeneID:5308 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5308 -> Biological process: GO:0001569 [patterning of blood vessels] evidence: IEA
            GeneID:5308 -> Biological process: GO:0001570 [vasculogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0001764 [neuron migration] evidence: IEA
            GeneID:5308 -> Biological process: GO:0002074 [extraocular skeletal muscle development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0003171 [atrioventricular valve development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0003253 [cardiac neural crest cell migration involved in outflow tract morphogenesis] evidence: ISS
            GeneID:5308 -> Biological process: GO:0003350 [pulmonary myocardium development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:5308 -> Biological process: GO:0007368 [determination of left/right symmetry] evidence: ISS
            GeneID:5308 -> Biological process: GO:0007520 [myoblast fusion] evidence: IEA
            GeneID:5308 -> Biological process: GO:0008584 [male gonad development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0008585 [female gonad development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0009725 [response to hormone stimulus] evidence: IEA
            GeneID:5308 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:5308 -> Biological process: GO:0021763 [subthalamic nucleus development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0021855 [hypothalamus cell migration] evidence: IEA
            GeneID:5308 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IEA
            GeneID:5308 -> Biological process: GO:0031076 [embryonic camera-type eye development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0033189 [response to vitamin A] evidence: IEA
            GeneID:5308 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0035315 [hair cell differentiation] evidence: IC
            GeneID:5308 -> Biological process: GO:0035886 [vascular smooth muscle cell differentiation] evidence: IEA
            GeneID:5308 -> Biological process: GO:0035993 [deltoid tuberosity development] evidence: IMP
            GeneID:5308 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA
            GeneID:5308 -> Biological process: GO:0042476 [odontogenesis] evidence: IMP
            GeneID:5308 -> Biological process: GO:0043010 [camera-type eye development] evidence: IMP
            GeneID:5308 -> Biological process: GO:0043388 [positive regulation of DNA binding] evidence: IEA
            GeneID:5308 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5308 -> Biological process: GO:0048536 [spleen development] evidence: ISS
            GeneID:5308 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0055009 [atrial cardiac muscle tissue morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0055015 [ventricular cardiac muscle cell development] evidence: IEA
            GeneID:5308 -> Biological process: GO:0060126 [somatotropin secreting cell differentiation] evidence: TAS
            GeneID:5308 -> Biological process: GO:0060127 [prolactin secreting cell differentiation] evidence: TAS
            GeneID:5308 -> Biological process: GO:0060412 [ventricular septum morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0060460 [left lung morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0060577 [pulmonary vein morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0060578 [superior vena cava morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0061031 [endodermal digestive tract morphogenesis] evidence: IEA
            GeneID:5308 -> Biological process: GO:0061072 [iris morphogenesis] evidence: IMP
            GeneID:5308 -> Biological process: GO:0061325 [cell proliferation involved in outflow tract morphogenesis] evidence: ISS
            GeneID:5308 -> Biological process: GO:0070986 [left/right axis specification] evidence: ISS
            GeneID:5308 -> Biological process: GO:2000288 [positive regulation of myoblast proliferation] evidence: IEA
            GeneID:5308 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5308 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
            GeneID:5308 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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