2024-04-24 23:15:59, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001204112 4947 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 17, mRNA. ACCESSION NM_001204112 VERSION NM_001204112.1 GI:323362970 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4947) AUTHORS Hara,H., Takeda,T., Yamamoto,N., Furuya,K., Hirose,K., Kamiya,T. and Adachi,T. TITLE Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS JOURNAL FEBS J. 280 (14), 3313-3327 (2013) PUBMED 23648111 REFERENCE 2 (bases 1 to 4947) AUTHORS Ha Thi,H.T., Lim,H.S., Kim,J., Kim,Y.M., Kim,H.Y. and Hong,S. TITLE Transcriptional and post-translational regulation of Bim is essential for TGF-beta and TNF-alpha-induced apoptosis of gastric cancer cell JOURNAL Biochim. Biophys. Acta 1830 (6), 3584-3592 (2013) PUBMED 23500081 REFERENCE 3 (bases 1 to 4947) AUTHORS Piazza,R., Magistroni,V., Mogavero,A., Andreoni,F., Ambrogio,C., Chiarle,R., Mologni,L., Bachmann,P.S., Lock,R.B., Collini,P., Pelosi,G. and Gambacorti-Passerini,C. TITLE Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex JOURNAL Neoplasia 15 (5), 511-522 (2013) PUBMED 23633923 REFERENCE 4 (bases 1 to 4947) AUTHORS Bean,G.R., Ganesan,Y.T., Dong,Y., Takeda,S., Liu,H., Chan,P.M., Huang,Y., Chodosh,L.A., Zambetti,G.P., Hsieh,J.J. and Cheng,E.H. TITLE PUMA and BIM are required for oncogene inactivation-induced apoptosis JOURNAL Sci Signal 6 (268), RA20 (2013) PUBMED 23532334 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 4947) AUTHORS Sharma,A., Singh,K., Mazumder,S., Hill,B.T., Kalaycio,M. and Almasan,A. TITLE BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells JOURNAL Cell Death Dis 4, E628 (2013) PUBMED 23681223 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 4947) AUTHORS Ng,K.P., Hillmer,A.M., Chuah,C.T., Juan,W.C., Ko,T.K., Teo,A.S., Ariyaratne,P.N., Takahashi,N., Sawada,K., Fei,Y., Soh,S., Lee,W.H., Huang,J.W., Allen,J.C. Jr., Woo,X.Y., Nagarajan,N., Kumar,V., Thalamuthu,A., Poh,W.T., Ang,A.L., Mya,H.T., How,G.F., Yang,L.Y., Koh,L.P., Chowbay,B., Chang,C.T., Nadarajan,V.S., Chng,W.J., Than,H., Lim,L.C., Goh,Y.T., Zhang,S., Poh,D., Tan,P., Seet,J.E., Ang,M.K., Chau,N.M., Ng,Q.S., Tan,D.S., Soda,M., Isobe,K., Nothen,M.M., Wong,T.Y., Shahab,A., Ruan,X., Cacheux-Rataboul,V., Sung,W.K., Tan,E.H., Yatabe,Y., Mano,H., Soo,R.A., Chin,T.M., Lim,W.T., Ruan,Y. and Ong,S.T. TITLE A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer JOURNAL Nat. Med. 18 (4), 521-528 (2012) PUBMED 22426421 REMARK GeneRIF: the heterogeneity of tyrosine kinase inhibitors responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism-associated tyrosine kinase inhibitors resistance. Publication Status: Online-Only REFERENCE 7 (bases 1 to 4947) AUTHORS Huang,D.C., Adams,J.M. and Cory,S. TITLE The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 JOURNAL EMBO J. 17 (4), 1029-1039 (1998) PUBMED 9463381 REFERENCE 8 (bases 1 to 4947) AUTHORS O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M., Cory,S. and Huang,D.C. TITLE Bim: a novel member of the Bcl-2 family that promotes apoptosis JOURNAL EMBO J. 17 (2), 384-395 (1998) PUBMED 9430630 REFERENCE 9 (bases 1 to 4947) AUTHORS Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J. TITLE Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) JOURNAL Cell 87 (4), 619-628 (1996) PUBMED 8929531 REFERENCE 10 (bases 1 to 4947) AUTHORS Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J. TITLE BID: a novel BH3 domain-only death agonist JOURNAL Genes Dev. 10 (22), 2859-2869 (1996) PUBMED 8918887 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096670.1, AK290377.1, DQ849202.1 and AI268146.1. This sequence is a reference standard in the RefSeqGene project. Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]. Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: DQ849202.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support ERS025081, ERS025084 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 AC096670.1 78236-78307 c 73-288 AK290377.1 73-288 289-726 DQ849202.1 1-438 727-4922 AC096670.1 30794-34989 c 4923-4947 AI268146.1 1-25 c FEATURES Location/Qualifiers source 1..4947 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q13" gene 1..4947 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="BCL2-like 11 (apoptosis facilitator)" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" exon 1..275 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 67..69 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="gcc" /db_xref="dbSNP:5833391" variation 72 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:1439286" variation 75 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:3929143" misc_feature 121..123 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="upstream in-frame stop codon" variation 196 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:368164757" variation 209 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116907128" exon 276..412 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 285 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:189552070" CDS 289..531 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="isoform 17 is encoded by transcript variant 17; bcl-2 interacting protein Bim; bcl-2 interacting mediator of cell death; bcl-2-related ovarian death agonist" /codon_start=1 /product="bcl-2-like protein 11 isoform 17" /protein_id="NP_001191041.1" /db_xref="GI:323362971" /db_xref="CCDS:CCDS56131.1" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" /translation="
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMVREIEEVVV
" misc_feature 298..408 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="Bim protein N-terminus; Region: Bim_N; pfam06773" /db_xref="CDD:115431" variation 327 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112446582" variation 342 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140468882" variation 365 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:375839187" variation 382 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200974474" variation 386 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:370683853" variation 388 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:151214891" variation 390 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:150345581" exon 413..502 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" exon 503..627 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" exon 628..4940 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 630 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142125092" variation 654 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:193171782" variation 661 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:374405413" variation 668 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:185078669" variation 682 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:138706378" variation 692 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:150291943" variation 714 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:372164447" variation 718 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375598912" STS 724..866 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH99076" /db_xref="UniSTS:90012" variation 738 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:200016050" variation 739 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:202136894" variation 744 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:376786434" variation 753 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954977" variation 758 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:10199276" variation 794 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111743396" variation 805 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:7595612" variation 813 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:12996100" variation 834 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954978" variation 853 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:12989846" variation 858 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:114776970" variation 951 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115158848" variation 1022 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:367628733" variation 1025 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116174114" variation 1062 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:149549441" variation 1105 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115106683" polyA_signal 1107..1112 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 1126 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" variation 1133 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371903732" variation 1237 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:72948380" variation 1263 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:143188267" variation 1355 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:148236299" variation 1369 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:141765222" variation 1394 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:189977826" variation 1475 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954981" variation 1829 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:77565616" variation 1966 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:146204948" variation 1976 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:181241895" variation 1977 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:139230805" variation 1982 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:373964210" variation 1988 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:200499684" variation 2004..2005 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:68021656" variation 2030..2031 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aat" /db_xref="dbSNP:375483724" variation 2038 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142335632" variation 2056 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:112485457" variation 2072 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:150522049" variation 2118 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:74787552" variation 2196 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:183793167" variation 2228 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:368175038" variation 2266 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:13422314" variation 2302 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:72837819" variation 2316..2317 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ta" /db_xref="dbSNP:113512595" variation 2406 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:1051222" variation 2413 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375194820" variation 2434 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:149840577" variation 2461 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:10201912" variation 2509 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:369746614" variation 2547 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:6750142" variation 2548 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:6753785" variation 2616 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:180695314" variation 2655 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:144847549" variation 2704 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:375517063" variation 2731 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112845179" variation 2733 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111569632" variation 2786 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:118047556" variation 2910..2911 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="g" /db_xref="dbSNP:35247728" variation 3033 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:148552232" variation 3034 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:186316334" variation 3059 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954982" STS 3077..3186 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="WI-11737" /db_xref="UniSTS:72182" variation 3166 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:145582217" variation 3171 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:191863875" variation 3198 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:147688758" variation 3307..3308 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:377590041" variation 3364 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371870358" variation 3471..3472 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:370249195" variation 3477 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:182097802" variation 3482..3483 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ct" /db_xref="dbSNP:139489747" variation 3613 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:186695504" variation 3747 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:13421457" variation 3793 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:113315090" variation 3942 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142474437" variation 3962..3963 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:372197396" variation 4094 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:191596895" variation 4123 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:76256675" variation 4179..4180 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:113356382" variation 4249 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:369475391" variation 4282 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:151236568" variation 4289 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:114720778" variation 4328 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:377665630" variation 4345 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954983" variation 4370 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140452150" variation 4567 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371052885" variation 4587 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:376059878" variation 4650..4656 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aacataa" /db_xref="dbSNP:3833441" variation 4656..4662 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="tttatgt" /db_xref="dbSNP:71801447" variation 4656 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200735948" STS 4690..4812 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH91369" /db_xref="UniSTS:85445" variation 4814 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115389757" variation 4850 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954984" polyA_signal 4921..4926 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 4940 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" ORIGIN
acttcgctccgcgcagccgcctggtctgcagtttgttggagctctgcgtccagcgccgctgccgctgccgccgccgccgccgccgccgccgccgccgccgccgccgccactaccaccacttgattcttgcagccaccctgcgaaccctgccacactgcgatcgcatcatcgcggtattcggttcgctgcgttcccgccgccaccgcctcggcgccctttcttggcccttgttcccccaaatgtctgactctgactctcggactgagaaacgcaagaaaaaaagaccaaatggcaaagcaaccttctgatgtaagttctgagtgtgaccgagaaggtagacaattgcagcctgcggagaggcctccccagctcagacctggggcccctacctccctacagacagagccacaagacaggagcccagcacccatgagttgtgacaaatcaacacaaaccccaagtcctccttgccaggccttcaaccactatctcagtgcaatggttagagaaatagaggaagttgtcgtgtagttgtcatgtattcagtccacttaagggcagtggggaagcgtttgagacggagctgtggaggctgaatccttgaaggaggaggtgagagaggcacaggtatttttgaataattaccaagcagccgaagaccacccacgaatggttatcttacgactgttacgttacattgtccgcctggtgtggagaatgcattgacaggttctttgcggagccgagataccatgcagacattttgcttgttcaaaccaacaagacccagcaccgcggtctcctggtgccattattatgcagccagcggttctcttgtggagggggcaggtgacgtttcagaagacaccgagctggatgggactacctttctgttcatcaccacacagcagaatttctaatggaagtttgttgtgaatgtaaaggagggagcattctttgctttttaatatacaaaccatggttttttggagcaggattttgtgtaagaatggtgtttacatgcagtgtgttttccccctcaccttcaataaggtttttcaaaaaggaaatggaaactttttaaccaatttgtgaataacttttgtattaaaattttaagaacctacggcctattctcagaggattatgtaacccctgcagtggaaactgagccagctaacttaaaaagctgccttagtttatttttagagattacagaatttttaaacagggagacgtgtgatatactccctcccttccctactattgcctctctgacctttttaaattatttttaataccaaaagagttcttttgaaatggaactgattaaaagggcagagggtctgttgccagcctgcattgatataccagtcccatttgtaaatatttacgtacctttataaattcagttgcatctgtggcaaaatttcagactatttttgcgtctttcctcatcactttttgtgatgcaactccagtctggactcagatgcatagatttggtccagtgtattttcatgataaagtgaaattgagtcagaacaagagttaatatctgcctgtatcttgcacagttcgagcgatctgttattaactgggaagcatttggtgttggttttcattccatttcgacgagcatgttattgggaagtattctgaagaggcaatagcagtaataacaacagacttaagtgctacgcccctttgtgctgctggcttttctggttgcaggctttcccatggtcacaggatgcactgtcagcatcaggtcccagagggccaccgtgtccattacagcagagtccagctgcagcatccagctcacgccctcatgggaattggcacaggcctggggcagggcttctgatggccatttgcttggcctcctgcattttagtccaactcacagtccactagcttcactcctttaaattcactttgaaacaggcctcatcccacttccaccagcaccatagaagaataattctgggcagaagtctgttttttttcatttttccaggacagttggatattgtcaggccacttgtgaccccagccatgtagtgagggtgctctttctctgtgcctgctccttatgagtgcagtggaaggaagccacacactggtcagtcatttcagaggcagcagatgcccagggagacccaagaaagagtcaggttagggagcagtgaaagtgaggagggaagacaattctgtgaactctgtaactcttaaaatttttgaaaactccatcgttaaacaacttttaaaagaaataactaaattttcaaatgagtaagcagtgccaccaactagtgttttgcccgatagaagagccagcatgttcacgttatttaaattaggtggaaaaatctaaacatttttatcttcataatttaaaaaatatatatgtatatattgcatattcactttttcctttaggtagagatgatttcaatccaaatactcttactttaaaaaatttcctttccccaagaatctccttgggactttgacttatttttaaagctgtgttggagctcatcttgttccctgatgtgtctcgagcccattggtagggtcatacaaagcccacggttacaagcagtggtaggattgcagccgtgggcctgctggacacacacatacaccaaagatgtatttggatctgggcaccccctcccaggatccctgtactcacgtgccagtctcctgactagagcactttactctgtttcctcagccctgcagcccctgggagcacacactgggtgcagccctgggccaggcacgggaggccctgccctgtgctgcccaggggctgtgtgcaccacatgagcacatttccctctggcctggcggcctccaggctggctgtggaaacagttcctgaggaaattagagattctatgaattgtaggagtattaaagaccaggctgttggcaccagaacttaaagcgatgactggatgtctctgtactgtatgtatctggttatcaagatgcctctgtgcagaaagtatgcctcccgtgggtatacgtttttaccttttttaaaaaacatttttgtagaaaaaataattaaatcccctttttggaaacttactgcaggttttgtgccttgacaacctctccctatgtgaggtttgtaaaaagtgtcctgtgacttaacacagaaacgcaataaacacacacaaaatagtttcatgagtgattcttcagatgcccttcccaactggttagttgatcaagaattttgggggtgggggttgcggagaaatcaagtttaaaattccttctgattaaaaaaatatagtggaatacaattgtctgccgtttccccttcttaatgtatatattgtgagtatttattagattcgtaggtcatattacttatcaactgagccaaatgtctgtgtgcaattgtgtttcctttaccttgtaaaattttgtacagcataaataagtaaaaaaatcactgtttttctcaactttttcaaaatcaaggattgtaaatattgtagattctttttctgtgtgatgtgtcctactgtttcataatgctgtaacttgtagaaatattgtatatttattttctgcttatttaatgtcttaatttctgaaaagtattaacatccctgtctcccactcccctgccgtcccatgaagttaactcctgagagttgtcgggggtgactggagagctcattgcagaccacgtggtcctccagggtggctctccaccttcgggtcctggtatttccagtcaagtgggtttcaattcttgggctttgccgcccttatgatgaagtgtgtgtttgatgccagtgagaaactcagtctggcaggctacaaaattctactccaagaaatacccagcaaccttctgtttgttccaaagcaactagcttatcatgcaagcaaattttgctgactccaggctttatctttaggaaaacaaaaaaaccaaagtattatcagcaggtgggaaagatttttctattgaaaatttatccctgacaactcagcgtttagaaaagaaataaaatgtgccacttccagaggtgctgcattgcagttgttcagggctagggccaggcaggacaagtgaatgggtgggacaggtggctcctgcctaaggaccacctcaggccactaaccccttgtggacaactgtgagtagctgggttttcccccacctgctgtgcaacttcctgtgctttgaggttggactaacttgtcttcaggagctaattaactgtacagccctccccacgccccacccatacggtcactgcatttggtcagcctgcttcttcaggtcgatgccctccttctgatactccatctccttcaggggaggttggggccccactggactgggtgtcaagatgtgaaagcttatgggagctttaaggagacttcatggtggttccatgcaggtggttctgccatccctgctgatttagcctggtgcctgtgtgtgtccactcacgtacacgtggggtgggggaaacgtgtctacagatgacgctaaatcagttggggtctactctaaacagcattgtgtgtaagaagcatcctcaagctcccagttaagtaacttgactacttttatttgggaatttcagactatagaagctctcttatgttttatgtccagattctgtgaccactagttactgtatcagaactcatcaggtacccacttataaatagcactgatctggctgtatactgatccatcactaacctgttttctaggacccagcgtatgtagcatttgtattgcagtttccctggcttacttgtgttttgcactgatgaattttgacagggtaattgccactttacttgtgcaatactgctgtaaataactgcagatttttaaacaatcttttatgttaattttataaaaataaaactttcaactagttaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10018 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IDA GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA GeneID:10018 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:10018 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA GeneID:10018 -> Biological process: GO:0001782 [B cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0001783 [B cell apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0001822 [kidney development] evidence: IEA GeneID:10018 -> Biological process: GO:0002262 [myeloid cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS GeneID:10018 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA GeneID:10018 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0007420 [brain development] evidence: IEA GeneID:10018 -> Biological process: GO:0008584 [male gonad development] evidence: IEA GeneID:10018 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA GeneID:10018 -> Biological process: GO:0030879 [mammary gland development] evidence: IEA GeneID:10018 -> Biological process: GO:0032464 [positive regulation of protein homooligomerization] evidence: IDA GeneID:10018 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA GeneID:10018 -> Biological process: GO:0035148 [tube formation] evidence: IEA GeneID:10018 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA GeneID:10018 -> Biological process: GO:0043029 [T cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0043583 [ear development] evidence: IEA GeneID:10018 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: IEA GeneID:10018 -> Biological process: GO:0046620 [regulation of organ growth] evidence: IEA GeneID:10018 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0048066 [developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048070 [regulation of developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048536 [spleen development] evidence: IEA GeneID:10018 -> Biological process: GO:0048538 [thymus development] evidence: IEA GeneID:10018 -> Biological process: GO:0048563 [post-embryonic organ morphogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IGI GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IMP GeneID:10018 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:2000271 [positive regulation of fibroblast apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:10018 -> Cellular component: GO:0005874 [microtubule] evidence: IDA GeneID:10018 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA GeneID:10018 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IEA GeneID:10018 -> Cellular component: GO:0097140 [BIM-BCL-xl complex] evidence: IDA GeneID:10018 -> Cellular component: GO:0097141 [BIM-BCL-2 complex] evidence: IDA
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