2024-05-08 22:53:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001204107 5033 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 12, mRNA. ACCESSION NM_001204107 VERSION NM_001204107.1 GI:323362960 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5033) AUTHORS Hara,H., Takeda,T., Yamamoto,N., Furuya,K., Hirose,K., Kamiya,T. and Adachi,T. TITLE Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS JOURNAL FEBS J. 280 (14), 3313-3327 (2013) PUBMED 23648111 REFERENCE 2 (bases 1 to 5033) AUTHORS Ha Thi,H.T., Lim,H.S., Kim,J., Kim,Y.M., Kim,H.Y. and Hong,S. TITLE Transcriptional and post-translational regulation of Bim is essential for TGF-beta and TNF-alpha-induced apoptosis of gastric cancer cell JOURNAL Biochim. Biophys. Acta 1830 (6), 3584-3592 (2013) PUBMED 23500081 REFERENCE 3 (bases 1 to 5033) AUTHORS Piazza,R., Magistroni,V., Mogavero,A., Andreoni,F., Ambrogio,C., Chiarle,R., Mologni,L., Bachmann,P.S., Lock,R.B., Collini,P., Pelosi,G. and Gambacorti-Passerini,C. TITLE Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex JOURNAL Neoplasia 15 (5), 511-522 (2013) PUBMED 23633923 REFERENCE 4 (bases 1 to 5033) AUTHORS Bean,G.R., Ganesan,Y.T., Dong,Y., Takeda,S., Liu,H., Chan,P.M., Huang,Y., Chodosh,L.A., Zambetti,G.P., Hsieh,J.J. and Cheng,E.H. TITLE PUMA and BIM are required for oncogene inactivation-induced apoptosis JOURNAL Sci Signal 6 (268), RA20 (2013) PUBMED 23532334 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 5033) AUTHORS Sharma,A., Singh,K., Mazumder,S., Hill,B.T., Kalaycio,M. and Almasan,A. TITLE BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells JOURNAL Cell Death Dis 4, E628 (2013) PUBMED 23681223 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 5033) AUTHORS Ng,K.P., Hillmer,A.M., Chuah,C.T., Juan,W.C., Ko,T.K., Teo,A.S., Ariyaratne,P.N., Takahashi,N., Sawada,K., Fei,Y., Soh,S., Lee,W.H., Huang,J.W., Allen,J.C. Jr., Woo,X.Y., Nagarajan,N., Kumar,V., Thalamuthu,A., Poh,W.T., Ang,A.L., Mya,H.T., How,G.F., Yang,L.Y., Koh,L.P., Chowbay,B., Chang,C.T., Nadarajan,V.S., Chng,W.J., Than,H., Lim,L.C., Goh,Y.T., Zhang,S., Poh,D., Tan,P., Seet,J.E., Ang,M.K., Chau,N.M., Ng,Q.S., Tan,D.S., Soda,M., Isobe,K., Nothen,M.M., Wong,T.Y., Shahab,A., Ruan,X., Cacheux-Rataboul,V., Sung,W.K., Tan,E.H., Yatabe,Y., Mano,H., Soo,R.A., Chin,T.M., Lim,W.T., Ruan,Y. and Ong,S.T. TITLE A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer JOURNAL Nat. Med. 18 (4), 521-528 (2012) PUBMED 22426421 REMARK GeneRIF: the heterogeneity of tyrosine kinase inhibitors responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism-associated tyrosine kinase inhibitors resistance. Publication Status: Online-Only REFERENCE 7 (bases 1 to 5033) AUTHORS Huang,D.C., Adams,J.M. and Cory,S. TITLE The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 JOURNAL EMBO J. 17 (4), 1029-1039 (1998) PUBMED 9463381 REFERENCE 8 (bases 1 to 5033) AUTHORS O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M., Cory,S. and Huang,D.C. TITLE Bim: a novel member of the Bcl-2 family that promotes apoptosis JOURNAL EMBO J. 17 (2), 384-395 (1998) PUBMED 9430630 REFERENCE 9 (bases 1 to 5033) AUTHORS Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J. TITLE Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) JOURNAL Cell 87 (4), 619-628 (1996) PUBMED 8929531 REFERENCE 10 (bases 1 to 5033) AUTHORS Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J. TITLE BID: a novel BH3 domain-only death agonist JOURNAL Genes Dev. 10 (22), 2859-2869 (1996) PUBMED 8918887 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096670.1, AK290377.1, AY423442.1 and AI268146.1. This sequence is a reference standard in the RefSeqGene project. Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]. Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AY423442.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support ERS025083, ERS025084 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 AC096670.1 78236-78307 c 73-288 AK290377.1 73-288 289-482 AY423442.1 1-194 483-483 AC096670.1 49107-49107 c 484-812 AY423442.1 196-524 813-5008 AC096670.1 30794-34989 c 5009-5033 AI268146.1 1-25 c FEATURES Location/Qualifiers source 1..5033 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q13" gene 1..5033 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="BCL2-like 11 (apoptosis facilitator)" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" exon 1..275 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 67..69 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="gcc" /db_xref="dbSNP:5833391" variation 72 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:1439286" variation 75 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:3929143" misc_feature 121..123 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="upstream in-frame stop codon" variation 196 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:368164757" variation 209 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116907128" exon 276..412 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 285 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:189552070" CDS 289..546 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="isoform 12 is encoded by transcript variant 12; bcl-2 interacting protein Bim; bcl-2 interacting mediator of cell death; bcl-2-related ovarian death agonist" /codon_start=1 /product="bcl-2-like protein 11 isoform 12" /protein_id="NP_001191036.1" /db_xref="GI:323362961" /db_xref="CCDS:CCDS56132.1" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" /translation="
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRLAKLLASST
" misc_feature 298..408 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="Bim protein N-terminus; Region: Bim_N; pfam06773" /db_xref="CDD:115431" misc_feature 412..>498 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="Bcl-x interacting; Region: Bclx_interact; pfam08945" /db_xref="CDD:149879" variation 327 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112446582" variation 342 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140468882" variation 365 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:375839187" variation 382 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200974474" variation 386 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:370683853" variation 388 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:151214891" variation 390 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:150345581" exon 413..516 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 443 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:114585494" variation 446 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:141962978" variation 462 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:143377281" variation 474..475 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="c" /db_xref="dbSNP:35807932" variation 475 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:146318804" variation 478 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:370016302" variation 479 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:373945451" variation 483 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:724710" variation 498 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:142641143" variation 506 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:376024148" exon 517..588 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 520 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:377424906" variation 535 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:114858291" variation 571 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:140646021" variation 578 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:190520877" exon 589..713 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" exon 714..5026 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 716 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142125092" variation 740 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:193171782" variation 747 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:374405413" variation 754 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:185078669" variation 768 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:138706378" variation 778 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:150291943" variation 800 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:372164447" variation 804 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375598912" STS 810..952 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH99076" /db_xref="UniSTS:90012" variation 824 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:200016050" variation 825 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:202136894" variation 830 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:376786434" variation 839 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954977" variation 844 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:10199276" variation 880 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111743396" variation 891 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:7595612" variation 899 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:12996100" variation 920 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954978" variation 939 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:12989846" variation 944 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:114776970" variation 1037 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115158848" variation 1108 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:367628733" variation 1111 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116174114" variation 1148 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:149549441" variation 1191 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115106683" polyA_signal 1193..1198 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 1212 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" variation 1219 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371903732" variation 1323 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:72948380" variation 1349 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:143188267" variation 1441 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:148236299" variation 1455 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:141765222" variation 1480 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:189977826" variation 1561 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954981" variation 1915 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:77565616" variation 2052 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:146204948" variation 2062 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:181241895" variation 2063 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:139230805" variation 2068 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:373964210" variation 2074 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:200499684" variation 2090..2091 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:68021656" variation 2116..2117 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aat" /db_xref="dbSNP:375483724" variation 2124 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142335632" variation 2142 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:112485457" variation 2158 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:150522049" variation 2204 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:74787552" variation 2282 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:183793167" variation 2314 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:368175038" variation 2352 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:13422314" variation 2388 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:72837819" variation 2402..2403 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ta" /db_xref="dbSNP:113512595" variation 2492 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:1051222" variation 2499 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375194820" variation 2520 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:149840577" variation 2547 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:10201912" variation 2595 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:369746614" variation 2633 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:6750142" variation 2634 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:6753785" variation 2702 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:180695314" variation 2741 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:144847549" variation 2790 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:375517063" variation 2817 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112845179" variation 2819 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111569632" variation 2872 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:118047556" variation 2996..2997 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="g" /db_xref="dbSNP:35247728" variation 3119 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:148552232" variation 3120 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:186316334" variation 3145 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954982" STS 3163..3272 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="WI-11737" /db_xref="UniSTS:72182" variation 3252 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:145582217" variation 3257 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:191863875" variation 3284 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:147688758" variation 3393..3394 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:377590041" variation 3450 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371870358" variation 3557..3558 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:370249195" variation 3563 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:182097802" variation 3568..3569 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ct" /db_xref="dbSNP:139489747" variation 3699 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:186695504" variation 3833 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:13421457" variation 3879 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:113315090" variation 4028 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142474437" variation 4048..4049 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:372197396" variation 4180 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:191596895" variation 4209 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:76256675" variation 4265..4266 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:113356382" variation 4335 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:369475391" variation 4368 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:151236568" variation 4375 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:114720778" variation 4414 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:377665630" variation 4431 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954983" variation 4456 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140452150" variation 4653 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371052885" variation 4673 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:376059878" variation 4736..4742 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aacataa" /db_xref="dbSNP:3833441" variation 4742..4748 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="tttatgt" /db_xref="dbSNP:71801447" variation 4742 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200735948" STS 4776..4898 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH91369" /db_xref="UniSTS:85445" variation 4900 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115389757" variation 4936 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954984" polyA_signal 5007..5012 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 5026 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" ORIGIN
acttcgctccgcgcagccgcctggtctgcagtttgttggagctctgcgtccagcgccgctgccgctgccgccgccgccgccgccgccgccgccgccgccgccgccgccactaccaccacttgattcttgcagccaccctgcgaaccctgccacactgcgatcgcatcatcgcggtattcggttcgctgcgttcccgccgccaccgcctcggcgccctttcttggcccttgttcccccaaatgtctgactctgactctcggactgagaaacgcaagaaaaaaagaccaaatggcaaagcaaccttctgatgtaagttctgagtgtgaccgagaaggtagacaattgcagcctgcggagaggcctccccagctcagacctggggcccctacctccctacagacagagccacaagcttccatgaggcaggctgaacctgcagatatgcgcccagagatatggatcgcccaagagttgcggcgtattggagacgagtttaacgcttactatgcaaggaggctggcaaaactcctggcatcctccacctgacataaaccagttcacagaacattccagcctagatctgaaatgttagagaaatagaggaagttgtcgtgtagttgtcatgtattcagtccacttaagggcagtggggaagcgtttgagacggagctgtggaggctgaatccttgaaggaggaggtgagagaggcacaggtatttttgaataattaccaagcagccgaagaccacccacgaatggttatcttacgactgttacgttacattgtccgcctggtgtggagaatgcattgacaggttctttgcggagccgagataccatgcagacattttgcttgttcaaaccaacaagacccagcaccgcggtctcctggtgccattattatgcagccagcggttctcttgtggagggggcaggtgacgtttcagaagacaccgagctggatgggactacctttctgttcatcaccacacagcagaatttctaatggaagtttgttgtgaatgtaaaggagggagcattctttgctttttaatatacaaaccatggttttttggagcaggattttgtgtaagaatggtgtttacatgcagtgtgttttccccctcaccttcaataaggtttttcaaaaaggaaatggaaactttttaaccaatttgtgaataacttttgtattaaaattttaagaacctacggcctattctcagaggattatgtaacccctgcagtggaaactgagccagctaacttaaaaagctgccttagtttatttttagagattacagaatttttaaacagggagacgtgtgatatactccctcccttccctactattgcctctctgacctttttaaattatttttaataccaaaagagttcttttgaaatggaactgattaaaagggcagagggtctgttgccagcctgcattgatataccagtcccatttgtaaatatttacgtacctttataaattcagttgcatctgtggcaaaatttcagactatttttgcgtctttcctcatcactttttgtgatgcaactccagtctggactcagatgcatagatttggtccagtgtattttcatgataaagtgaaattgagtcagaacaagagttaatatctgcctgtatcttgcacagttcgagcgatctgttattaactgggaagcatttggtgttggttttcattccatttcgacgagcatgttattgggaagtattctgaagaggcaatagcagtaataacaacagacttaagtgctacgcccctttgtgctgctggcttttctggttgcaggctttcccatggtcacaggatgcactgtcagcatcaggtcccagagggccaccgtgtccattacagcagagtccagctgcagcatccagctcacgccctcatgggaattggcacaggcctggggcagggcttctgatggccatttgcttggcctcctgcattttagtccaactcacagtccactagcttcactcctttaaattcactttgaaacaggcctcatcccacttccaccagcaccatagaagaataattctgggcagaagtctgttttttttcatttttccaggacagttggatattgtcaggccacttgtgaccccagccatgtagtgagggtgctctttctctgtgcctgctccttatgagtgcagtggaaggaagccacacactggtcagtcatttcagaggcagcagatgcccagggagacccaagaaagagtcaggttagggagcagtgaaagtgaggagggaagacaattctgtgaactctgtaactcttaaaatttttgaaaactccatcgttaaacaacttttaaaagaaataactaaattttcaaatgagtaagcagtgccaccaactagtgttttgcccgatagaagagccagcatgttcacgttatttaaattaggtggaaaaatctaaacatttttatcttcataatttaaaaaatatatatgtatatattgcatattcactttttcctttaggtagagatgatttcaatccaaatactcttactttaaaaaatttcctttccccaagaatctccttgggactttgacttatttttaaagctgtgttggagctcatcttgttccctgatgtgtctcgagcccattggtagggtcatacaaagcccacggttacaagcagtggtaggattgcagccgtgggcctgctggacacacacatacaccaaagatgtatttggatctgggcaccccctcccaggatccctgtactcacgtgccagtctcctgactagagcactttactctgtttcctcagccctgcagcccctgggagcacacactgggtgcagccctgggccaggcacgggaggccctgccctgtgctgcccaggggctgtgtgcaccacatgagcacatttccctctggcctggcggcctccaggctggctgtggaaacagttcctgaggaaattagagattctatgaattgtaggagtattaaagaccaggctgttggcaccagaacttaaagcgatgactggatgtctctgtactgtatgtatctggttatcaagatgcctctgtgcagaaagtatgcctcccgtgggtatacgtttttaccttttttaaaaaacatttttgtagaaaaaataattaaatcccctttttggaaacttactgcaggttttgtgccttgacaacctctccctatgtgaggtttgtaaaaagtgtcctgtgacttaacacagaaacgcaataaacacacacaaaatagtttcatgagtgattcttcagatgcccttcccaactggttagttgatcaagaattttgggggtgggggttgcggagaaatcaagtttaaaattccttctgattaaaaaaatatagtggaatacaattgtctgccgtttccccttcttaatgtatatattgtgagtatttattagattcgtaggtcatattacttatcaactgagccaaatgtctgtgtgcaattgtgtttcctttaccttgtaaaattttgtacagcataaataagtaaaaaaatcactgtttttctcaactttttcaaaatcaaggattgtaaatattgtagattctttttctgtgtgatgtgtcctactgtttcataatgctgtaacttgtagaaatattgtatatttattttctgcttatttaatgtcttaatttctgaaaagtattaacatccctgtctcccactcccctgccgtcccatgaagttaactcctgagagttgtcgggggtgactggagagctcattgcagaccacgtggtcctccagggtggctctccaccttcgggtcctggtatttccagtcaagtgggtttcaattcttgggctttgccgcccttatgatgaagtgtgtgtttgatgccagtgagaaactcagtctggcaggctacaaaattctactccaagaaatacccagcaaccttctgtttgttccaaagcaactagcttatcatgcaagcaaattttgctgactccaggctttatctttaggaaaacaaaaaaaccaaagtattatcagcaggtgggaaagatttttctattgaaaatttatccctgacaactcagcgtttagaaaagaaataaaatgtgccacttccagaggtgctgcattgcagttgttcagggctagggccaggcaggacaagtgaatgggtgggacaggtggctcctgcctaaggaccacctcaggccactaaccccttgtggacaactgtgagtagctgggttttcccccacctgctgtgcaacttcctgtgctttgaggttggactaacttgtcttcaggagctaattaactgtacagccctccccacgccccacccatacggtcactgcatttggtcagcctgcttcttcaggtcgatgccctccttctgatactccatctccttcaggggaggttggggccccactggactgggtgtcaagatgtgaaagcttatgggagctttaaggagacttcatggtggttccatgcaggtggttctgccatccctgctgatttagcctggtgcctgtgtgtgtccactcacgtacacgtggggtgggggaaacgtgtctacagatgacgctaaatcagttggggtctactctaaacagcattgtgtgtaagaagcatcctcaagctcccagttaagtaacttgactacttttatttgggaatttcagactatagaagctctcttatgttttatgtccagattctgtgaccactagttactgtatcagaactcatcaggtacccacttataaatagcactgatctggctgtatactgatccatcactaacctgttttctaggacccagcgtatgtagcatttgtattgcagtttccctggcttacttgtgttttgcactgatgaattttgacagggtaattgccactttacttgtgcaatactgctgtaaataactgcagatttttaaacaatcttttatgttaattttataaaaataaaactttcaactagttaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10018 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IDA GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA GeneID:10018 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:10018 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA GeneID:10018 -> Biological process: GO:0001782 [B cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0001783 [B cell apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0001822 [kidney development] evidence: IEA GeneID:10018 -> Biological process: GO:0002262 [myeloid cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS GeneID:10018 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA GeneID:10018 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0007420 [brain development] evidence: IEA GeneID:10018 -> Biological process: GO:0008584 [male gonad development] evidence: IEA GeneID:10018 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA GeneID:10018 -> Biological process: GO:0030879 [mammary gland development] evidence: IEA GeneID:10018 -> Biological process: GO:0032464 [positive regulation of protein homooligomerization] evidence: IDA GeneID:10018 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA GeneID:10018 -> Biological process: GO:0035148 [tube formation] evidence: IEA GeneID:10018 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA GeneID:10018 -> Biological process: GO:0043029 [T cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0043583 [ear development] evidence: IEA GeneID:10018 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: IEA GeneID:10018 -> Biological process: GO:0046620 [regulation of organ growth] evidence: IEA GeneID:10018 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0048066 [developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048070 [regulation of developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048536 [spleen development] evidence: IEA GeneID:10018 -> Biological process: GO:0048538 [thymus development] evidence: IEA GeneID:10018 -> Biological process: GO:0048563 [post-embryonic organ morphogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IGI GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IMP GeneID:10018 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:2000271 [positive regulation of fibroblast apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:10018 -> Cellular component: GO:0005874 [microtubule] evidence: IDA GeneID:10018 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA GeneID:10018 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IEA GeneID:10018 -> Cellular component: GO:0097140 [BIM-BCL-xl complex] evidence: IDA GeneID:10018 -> Cellular component: GO:0097141 [BIM-BCL-2 complex] evidence: IDA
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