2024-03-29 07:32:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001201363 1028 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens high mobility group nucleosomal binding domain 3 (HMGN3), transcript variant 4, mRNA. ACCESSION NM_001201363 VERSION NM_001201363.1 GI:318067960 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1028) AUTHORS Lei,S.F., Shen,H., Yang,T.L., Guo,Y., Dong,S.S., Xu,X.H., Deng,F.Y., Tian,Q., Liu,Y.J., Liu,Y.Z., Li,J. and Deng,H.W. TITLE Genome-wide association study identifies HMGN3 locus for spine bone size variation in Chinese JOURNAL Hum. Genet. 131 (3), 463-469 (2012) PUBMED 21947420 REMARK GeneRIF: The SNPs in the region of HMGN3 gene formed a tightly combined haplotype block in both Chinese and Caucasians. The results suggest that the genomic region containing HMGN3 gene may be associated with spine BS in Chinese. REFERENCE 2 (bases 1 to 1028) AUTHORS Ueda,T., Furusawa,T., Kurahashi,T., Tessarollo,L. and Bustin,M. TITLE The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion JOURNAL Mol. Cell. Biol. 29 (19), 5264-5276 (2009) PUBMED 19651901 REMARK GeneRIF: loss of HMGN3 impairs glucose-stimulated insulin secretion and leads to a diabetic phenotype. REFERENCE 3 (bases 1 to 1028) AUTHORS Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y., Jurisica,I. and Li,S.S. TITLE Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening JOURNAL Proteomics 7 (11), 1775-1785 (2007) PUBMED 17474147 REFERENCE 4 (bases 1 to 1028) AUTHORS Leong,P.W., Liew,K., Lim,W. and Chow,V.T. TITLE Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions JOURNAL Virology 295 (1), 147-159 (2002) PUBMED 12033773 REFERENCE 5 (bases 1 to 1028) AUTHORS West,K.L., Ito,Y., Birger,Y., Postnikov,Y., Shirakawa,H. and Bustin,M. TITLE HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins JOURNAL J. Biol. Chem. 276 (28), 25959-25969 (2001) PUBMED 11356838 REFERENCE 6 (bases 1 to 1028) AUTHORS Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D. TITLE Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor JOURNAL Mol. Endocrinol. 9 (2), 243-254 (1995) PUBMED 7776974 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355796.11, BF790582.1 and AY043282.1. Summary: Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. Transcript Variant: This variant (4) has an additional exon in the 3' coding region compared to variant 1, which causes a frame-shift. The resulting isoform (HMGN3d) is longer and has a distinct C-terminus compared to isoform HMGN3a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BF790582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-146 AL355796.11 102841-102986 c 147-677 BF790582.1 43-573 678-1028 AY043282.1 552-902 FEATURES Location/Qualifiers source 1..1028 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6q14.1" gene 1..1028 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /note="high mobility group nucleosomal binding domain 3" /db_xref="GeneID:9324" /db_xref="HGNC:12312" /db_xref="MIM:604502" exon 1..193 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(101) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="c" /db_xref="dbSNP:9361504" variation complement(160) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:376144393" CDS 179..571 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /note="isoform HMGN3d is encoded by transcript variant 4; thyroid hormone receptor interacting protein 7; high mobility group nucleosome-binding domain-containing protein 3; TR-interacting protein 7" /codon_start=1 /product="high mobility group nucleosome-binding domain-containing protein 3 isoform HMGN3d" /protein_id="NP_001188292.1" /db_xref="GI:318067961" /db_xref="GeneID:9324" /db_xref="HGNC:12312" /db_xref="MIM:604502" /translation="
MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEEIHISRSTVNVSTSRGTPPSTLSVKGQIETVRAQKTESVDNEGE
" misc_feature 182..472 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /note="HMG14 and HMG17; Region: HMG14_17; pfam01101" /db_xref="CDD:201597" exon 194..244 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(212) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:113419539" exon 245..274 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(256) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:114465555" variation complement(260) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:201661342" exon 275..325 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(301) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:140809230" variation complement(320) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="g" /db_xref="dbSNP:139595568" exon 326..439 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(363) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:61755716" variation complement(368) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:200614084" variation complement(383) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:371608885" exon 440..532 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" exon 533..1014 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /inference="alignment:Splign:1.39.8" variation complement(559) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:370315630" variation complement(562) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:182681016" variation complement(671) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:199768088" variation complement(686) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:9448657" variation complement(699) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:147596321" STS 784..989 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /standard_name="HSC2GA122" /db_xref="UniSTS:80944" variation complement(786) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="c" /replace="t" /db_xref="dbSNP:34043789" variation complement(833) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:145115667" variation complement(941) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:373201970" polyA_signal 989..994 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" variation complement(1009) /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" /replace="a" /replace="g" /db_xref="dbSNP:192168635" polyA_site 1014 /gene="HMGN3" /gene_synonym="PNAS-24; PNAS-25; TRIP7" ORIGIN
ggagcagcagggaggcgagcagagggcccccagagggagccgcggaggtgcaggtcgaagaggccgggctacgtcgtgccctgcgcgtgagcagctgcagaggcagaggcagcatccagcggcggcgccagcagttccagtccgttgctttactttttgcttcaccgacatagtcattatgccgaagagaaagtctccagagaatacagagggcaaagatggatccaaagtaactaaacaggagcccacaagacggtctgccagattgtcagcgaaacctgctccaccaaaacctgaacccaaaccaagaaaaacatctgctaagaaagaacctggagcaaagattagcagaggtgctaaagggaagaaggaggaaaagcaggaagctggaaaggaaggtactgcaccatctgaaaatggtgaaactaaagctgaagagatccacatctctcgctcaactgttaatgtctcaacctccagaggcaccccacccagcacactgtcagtaaaggggcagattgaaacagtgagagcacagaaaactgaatctgtagataacgagggagaatgaattgtcatgaaaaattggggttgattttatgtatctcttgggacaacttttaaaagctatttttaccaagtattttgtaaatgctaattttttaggactctactagttggcatacgaaaatatataaggatggacattttatcgtctcatagtcatgctttttggaaatttacatcatcctcaagtaaaataaatatcagttaaatattggaagctgtgtgtaagattgattcagcattccatgcacttgctttaaaatttagtcctgtgcatactgtggtgtttttactgtgcatatttgaatttttcatgcagtttttctagagcaataatcagtggtgcttttgtacctaggttttatgtgattttaatgaaacatggatagttgtggccacctgctgactatttgtggtttaaaataaaaggtttacttgtctgcagaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9324 -> Molecular function: GO:0031492 [nucleosomal DNA binding] evidence: IEA GeneID:9324 -> Molecular function: GO:0046966 [thyroid hormone receptor binding] evidence: NAS GeneID:9324 -> Biological process: GO:0008150 [biological_process] evidence: ND GeneID:9324 -> Biological process: GO:0016568 [chromatin modification] evidence: IEA GeneID:9324 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA GeneID:9324 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:9324 -> Biological process: GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] evidence: IEA GeneID:9324 -> Cellular component: GO:0000785 [chromatin] evidence: IEA GeneID:9324 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:9324 -> Cellular component: GO:0005634 [nucleus] evidence: NAS GeneID:9324 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:9324 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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