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2024-03-29 07:32:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001201363            1028 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens high mobility group nucleosomal binding domain 3
            (HMGN3), transcript variant 4, mRNA.
ACCESSION   NM_001201363
VERSION     NM_001201363.1  GI:318067960
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Lei,S.F., Shen,H., Yang,T.L., Guo,Y., Dong,S.S., Xu,X.H.,
            Deng,F.Y., Tian,Q., Liu,Y.J., Liu,Y.Z., Li,J. and Deng,H.W.
  TITLE     Genome-wide association study identifies HMGN3 locus for spine bone
            size variation in Chinese
  JOURNAL   Hum. Genet. 131 (3), 463-469 (2012)
   PUBMED   21947420
  REMARK    GeneRIF: The SNPs in the region of HMGN3 gene formed a tightly
            combined haplotype block in both Chinese and Caucasians. The
            results suggest that the genomic region containing HMGN3 gene may
            be associated with spine BS in Chinese.
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Ueda,T., Furusawa,T., Kurahashi,T., Tessarollo,L. and Bustin,M.
  TITLE     The nucleosome binding protein HMGN3 modulates the transcription
            profile of pancreatic beta cells and affects insulin secretion
  JOURNAL   Mol. Cell. Biol. 29 (19), 5264-5276 (2009)
   PUBMED   19651901
  REMARK    GeneRIF: loss of HMGN3 impairs glucose-stimulated insulin secretion
            and leads to a diabetic phenotype.
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Leong,P.W., Liew,K., Lim,W. and Chow,V.T.
  TITLE     Differential display RT-PCR analysis of enterovirus-71-infected
            rhabdomyosarcoma cells reveals mRNA expression responses of
            multiple human genes with known and novel functions
  JOURNAL   Virology 295 (1), 147-159 (2002)
   PUBMED   12033773
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   West,K.L., Ito,Y., Birger,Y., Postnikov,Y., Shirakawa,H. and
            Bustin,M.
  TITLE     HMGN3a and HMGN3b, two protein isoforms with a tissue-specific
            expression pattern, expand the cellular repertoire of
            nucleosome-binding proteins
  JOURNAL   J. Biol. Chem. 276 (28), 25959-25969 (2001)
   PUBMED   11356838
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol. Endocrinol. 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355796.11, BF790582.1 and
            AY043282.1.
            
            Summary: Thyroid hormone receptors are hormone-dependent
            transcription factors that regulate expression of a variety of
            specific target genes. The protein encoded by this gene binds
            thyroid hormone receptor beta, but only in the presence of thyroid
            hormone. The encoded protein, a member of the HMGN protein family,
            is thought to reduce the compactness of the chromatin fiber in
            nucleosomes, thereby enhancing transcription from chromatin
            templates. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (4) has an additional exon in the
            3' coding region compared to variant 1, which causes a frame-shift.
            The resulting isoform (HMGN3d) is longer and has a distinct
            C-terminus compared to isoform HMGN3a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF790582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AL355796.11        102841-102986       c
            147-677             BF790582.1         43-573
            678-1028            AY043282.1         552-902
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..1028
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="high mobility group nucleosomal binding domain 3"
                     /db_xref="GeneID:9324"
                     /db_xref="HGNC:12312"
                     /db_xref="MIM:604502"
     exon            1..193
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(101)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:9361504"
     variation       complement(160)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376144393"
     CDS             179..571
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="isoform HMGN3d is encoded by transcript variant 4;
                     thyroid hormone receptor interacting protein 7; high
                     mobility group nucleosome-binding domain-containing
                     protein 3; TR-interacting protein 7"
                     /codon_start=1
                     /product="high mobility group nucleosome-binding
                     domain-containing protein 3 isoform HMGN3d"
                     /protein_id="NP_001188292.1"
                     /db_xref="GI:318067961"
                     /db_xref="GeneID:9324"
                     /db_xref="HGNC:12312"
                     /db_xref="MIM:604502"
                     /translation="
MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEEIHISRSTVNVSTSRGTPPSTLSVKGQIETVRAQKTESVDNEGE
"
     misc_feature    182..472
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="HMG14 and HMG17; Region: HMG14_17; pfam01101"
                     /db_xref="CDD:201597"
     exon            194..244
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(212)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113419539"
     exon            245..274
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(256)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114465555"
     variation       complement(260)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201661342"
     exon            275..325
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(301)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140809230"
     variation       complement(320)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139595568"
     exon            326..439
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(363)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61755716"
     variation       complement(368)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200614084"
     variation       complement(383)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371608885"
     exon            440..532
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     exon            533..1014
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(559)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370315630"
     variation       complement(562)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182681016"
     variation       complement(671)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199768088"
     variation       complement(686)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9448657"
     variation       complement(699)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147596321"
     STS             784..989
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /standard_name="HSC2GA122"
                     /db_xref="UniSTS:80944"
     variation       complement(786)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34043789"
     variation       complement(833)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145115667"
     variation       complement(941)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373201970"
     polyA_signal    989..994
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
     variation       complement(1009)
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192168635"
     polyA_site      1014
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
ORIGIN      
ggagcagcagggaggcgagcagagggcccccagagggagccgcggaggtgcaggtcgaagaggccgggctacgtcgtgccctgcgcgtgagcagctgcagaggcagaggcagcatccagcggcggcgccagcagttccagtccgttgctttactttttgcttcaccgacatagtcattatgccgaagagaaagtctccagagaatacagagggcaaagatggatccaaagtaactaaacaggagcccacaagacggtctgccagattgtcagcgaaacctgctccaccaaaacctgaacccaaaccaagaaaaacatctgctaagaaagaacctggagcaaagattagcagaggtgctaaagggaagaaggaggaaaagcaggaagctggaaaggaaggtactgcaccatctgaaaatggtgaaactaaagctgaagagatccacatctctcgctcaactgttaatgtctcaacctccagaggcaccccacccagcacactgtcagtaaaggggcagattgaaacagtgagagcacagaaaactgaatctgtagataacgagggagaatgaattgtcatgaaaaattggggttgattttatgtatctcttgggacaacttttaaaagctatttttaccaagtattttgtaaatgctaattttttaggactctactagttggcatacgaaaatatataaggatggacattttatcgtctcatagtcatgctttttggaaatttacatcatcctcaagtaaaataaatatcagttaaatattggaagctgtgtgtaagattgattcagcattccatgcacttgctttaaaatttagtcctgtgcatactgtggtgtttttactgtgcatatttgaatttttcatgcagtttttctagagcaataatcagtggtgcttttgtacctaggttttatgtgattttaatgaaacatggatagttgtggccacctgctgactatttgtggtttaaaataaaaggtttacttgtctgcagaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9324 -> Molecular function: GO:0031492 [nucleosomal DNA binding] evidence: IEA
            GeneID:9324 -> Molecular function: GO:0046966 [thyroid hormone receptor binding] evidence: NAS
            GeneID:9324 -> Biological process: GO:0008150 [biological_process] evidence: ND
            GeneID:9324 -> Biological process: GO:0016568 [chromatin modification] evidence: IEA
            GeneID:9324 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:9324 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:9324 -> Biological process: GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] evidence: IEA
            GeneID:9324 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
            GeneID:9324 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:9324 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:9324 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:9324 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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