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2019-03-25 14:28:55, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001199954            2123 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens actin, gamma 1 (ACTG1), transcript variant 1, mRNA.
ACCESSION   NM_001199954
VERSION     NM_001199954.1  GI:316659408
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Baranwal,S., Naydenov,N.G., Harris,G., Dugina,V., Morgan,K.G.,
            Chaponnier,C. and Ivanov,A.I.
  TITLE     Nonredundant roles of cytoplasmic beta- and gamma-actin isoforms in
            regulation of epithelial apical junctions
  JOURNAL   Mol. Biol. Cell 23 (18), 3542-3553 (2012)
   PUBMED   22855531
  REMARK    GeneRIF: Data indicate beta-cytoplasmic (beta-CYA) and
            gamma-cytoplasmic (gamma-CYA) actins differential localization and
            dynamics at epithelial junctions.
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Xiang,Y., Zheng,K., Ju,H., Wang,S., Pei,Y., Ding,W., Chen,Z.,
            Wang,Q., Qiu,X., Zhong,M., Zeng,F., Ren,Z., Qian,C., Liu,G.,
            Kitazato,K. and Wang,Y.
  TITLE     Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells
            affect herpes simplex virus 1 infection and replication
  JOURNAL   J. Virol. 86 (16), 8440-8451 (2012)
   PUBMED   22623803
  REMARK    GeneRIF: These results showed the biphasic F-actin dynamics in
            herpes simplex virus 1 neuronal infection and confirmed the
            association of F-actin with the changes in the expression and
            activity of cofilin 1.
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Riviere,J.B., van Bon,B.W., Hoischen,A., Kholmanskikh,S.S.,
            O'Roak,B.J., Gilissen,C., Gijsen,S., Sullivan,C.T., Christian,S.L.,
            Abdul-Rahman,O.A., Atkin,J.F., Chassaing,N., Drouin-Garraud,V.,
            Fry,A.E., Fryns,J.P., Gripp,K.W., Kempers,M., Kleefstra,T.,
            Mancini,G.M., Nowaczyk,M.J., van Ravenswaaij-Arts,C.M.,
            Roscioli,T., Marble,M., Rosenfeld,J.A., Siu,V.M., de Vries,B.B.,
            Shendure,J., Verloes,A., Veltman,J.A., Brunner,H.G., Ross,M.E.,
            Pilz,D.T. and Dobyns,W.B.
  TITLE     De novo mutations in the actin genes ACTB and ACTG1 cause
            Baraitser-Winter syndrome
  JOURNAL   Nat. Genet. 44 (4), 440-444 (2012)
   PUBMED   22366783
  REMARK    GeneRIF: identified de novo missense changes in the cytoplasmic
            actin-encoding genes ACTB and ACTG1 in one and two probands,
            respectively; suggest that Baraitser-Winter syndrome is the
            predominant phenotype associated with mutation of these two genes
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Shum,M.S., Pasquier,E., Po'uha,S.T., O'Neill,G.M., Chaponnier,C.,
            Gunning,P.W. and Kavallaris,M.
  TITLE     gamma-Actin regulates cell migration and modulates the ROCK
            signaling pathway
  JOURNAL   FASEB J. 25 (12), 4423-4433 (2011)
   PUBMED   21908715
  REMARK    GeneRIF: knockdown of gamma-actin significantly reduced speed of
            motility and severely affected the cell's ability to explore, which
            was, in part, due to a loss of cell polarity
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Kiuchi,T., Nagai,T., Ohashi,K. and Mizuno,K.
  TITLE     Measurements of spatiotemporal changes in G-actin concentration
            reveal its effect on stimulus-induced actin assembly and
            lamellipodium extension
  JOURNAL   J. Cell Biol. 193 (2), 365-380 (2011)
   PUBMED   21502360
  REMARK    GeneRIF: Cytoplasmic G-actin concentration is a critical parameter
            for determining the extent of stimulus-induced G-actin assembly and
            cell extension.
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Rodriguez Del Castillo,A., Vitale,M.L. and Trifaro,J.M.
  TITLE     Ca2+ and pH determine the interaction of chromaffin cell scinderin
            with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate
            and its cellular distribution during nicotinic-receptor stimulation
            and protein kinase C activation
  JOURNAL   J. Cell Biol. 119 (4), 797-810 (1992)
   PUBMED   1331119
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J. Infect. 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Erba,H.P., Eddy,R., Shows,T., Kedes,L. and Gunning,P.
  TITLE     Structure, chromosome location, and expression of the human
            gamma-actin gene: differential evolution, location, and expression
            of the cytoskeletal beta- and gamma-actin genes
  JOURNAL   Mol. Cell. Biol. 8 (4), 1775-1789 (1988)
   PUBMED   2837653
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Vandekerckhove,J., Schering,B., Barmann,M. and Aktories,K.
  TITLE     Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in
            arginine 177
  JOURNAL   J. Biol. Chem. 263 (2), 696-700 (1988)
   PUBMED   3335520
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Chou,C.C., Davis,R.C., Fuller,M.L., Slovin,J.P., Wong,A.,
            Wright,J., Kania,S., Shaked,R., Gatti,R.A. and Salser,W.A.
  TITLE     Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and
            amino acid substitutions that may be cancer related
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (9), 2575-2579 (1987)
   PUBMED   3472224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455954.1, AC139149.6 and
            BC063495.1.
            
            Summary: Actins are highly conserved proteins that are involved in
            various types of cell motility, and maintenance of the
            cytoskeleton. In vertebrates, three main groups of actin isoforms,
            alpha, beta and gamma have been identified. The alpha actins are
            found in muscle tissues and are a major constituent of the
            contractile apparatus. The beta and gamma actins co-exist in most
            cell types as components of the cytoskeleton, and as mediators of
            internal cell motility. Actin, gamma 1, encoded by this gene, is a
            cytoplasmic actin found in non-muscle cells. Mutations in this gene
            are associated with DFNA20/26, a subtype of autosomal dominant
            non-syndromic sensorineural progressive hearing loss. Alternative
            splicing results in multiple transcript variants.[provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC007442.2, BC000292.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                DB455954.1         9-94
            87-252              AC139149.6         18642-18807
            253-381             AC139149.6         19062-19190
            382-621             AC139149.6         19280-19519
            622-1060            AC139149.6         19796-20234
            1061-1242           AC139149.6         20314-20495
            1243-2076           AC139149.6         20589-21422
            2077-2123           BC063495.1         1810-1856
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25"
     gene            1..2123
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="actin, gamma 1"
                     /db_xref="GeneID:71"
                     /db_xref="HGNC:144"
                     /db_xref="MIM:102560"
     exon            1..252
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       85
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7503278"
     variation       101
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139403"
     variation       109..110
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549207"
     variation       113..114
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549240"
     variation       117..118
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549198"
     variation       223..224
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17435367"
     exon            253..381
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     CDS             259..1386
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="cytoskeletal gamma-actin"
                     /codon_start=1
                     /product="actin, cytoplasmic 2"
                     /protein_id="NP_001186883.1"
                     /db_xref="GI:316659409"
                     /db_xref="CCDS:CCDS11782.1"
                     /db_xref="GeneID:71"
                     /db_xref="HGNC:144"
                     /db_xref="MIM:102560"
                     /translation="
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
"
     misc_feature    262..264
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylglutamate, in Actin, cytoplasmic 2,
                     N-terminally processed, partial; propagated from
                     UniProtKB/Swiss-Prot (P63261.1); acetylation site"
     misc_feature    265..1383
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="Actin; Region: Actin; pfam00022"
                     /db_xref="CDD:200935"
     misc_feature    280..801
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="Nucleotide-Binding Domain of the sugar
                     kinase/HSP70/actin superfamily; Region:
                     NBD_sugar-kinase_HSP70_actin; cd00012"
                     /db_xref="CDD:212657"
     misc_feature    order(289..300,304..306,310..312,667..669,718..729)
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="nucleotide binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:212657"
     misc_feature    475..477
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Tele-methylhistidine; propagated from
                     UniProtKB/Swiss-Prot (P63261.1); methylation site"
     variation       263
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549194"
     STS             266..465
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC116333P1"
                     /db_xref="UniSTS:270310"
     STS             291..443
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC97568P1"
                     /db_xref="UniSTS:273653"
     variation       300
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549195"
     variation       304
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549241"
     variation       336
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549228"
     variation       339
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549230"
     variation       345
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549232"
     STS             346..465
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC116333P2"
                     /db_xref="UniSTS:270311"
     variation       346
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549243"
     variation       353
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549231"
     variation       357
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549238"
     variation       363
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549193"
     variation       371
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549244"
     variation       377
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549236"
     variation       378
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549174"
     exon            382..621
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       384
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549197"
     STS             397..1067
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="Acat1"
                     /db_xref="UniSTS:546573"
     STS             397..896
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC85795P4"
                     /db_xref="UniSTS:273493"
     variation       399
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549215"
     variation       400
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549214"
     variation       419
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549216"
     STS             421..1329
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC108612P1"
                     /db_xref="UniSTS:270141"
     STS             424..801
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC201106P1"
                     /db_xref="UniSTS:271883"
     variation       434
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11549199"
     variation       435
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549220"
     variation       447
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549245"
     variation       457
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549224"
     variation       460
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11549233"
     variation       479
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549185"
     STS             484..943
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC137757P2"
                     /db_xref="UniSTS:270854"
     STS             487..840
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC23952P1"
                     /db_xref="UniSTS:272216"
     STS             496..859
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC129447P1"
                     /db_xref="UniSTS:270591"
     STS             505..942
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC109653P1"
                     /db_xref="UniSTS:270174"
     variation       528
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549209"
     variation       556
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549188"
     variation       558
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549239"
     variation       562
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549229"
     variation       563
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549172"
     variation       581
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549181"
     variation       593
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549176"
     exon            622..1060
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     STS             624..941
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC115141P1"
                     /db_xref="UniSTS:270285"
     STS             625..1119
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC224995P1"
                     /db_xref="UniSTS:272113"
     STS             627..944
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC99880P2"
                     /db_xref="UniSTS:273691"
     STS             627..893
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC152551P1"
                     /db_xref="UniSTS:271229"
     STS             629..985
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC85361P1"
                     /db_xref="UniSTS:273471"
     variation       636
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549201"
     STS             640..893
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC275467P1"
                     /db_xref="UniSTS:272382"
     variation       651
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11150794"
     variation       657
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230158"
     variation       671
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549180"
     variation       681
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549226"
     variation       688
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549196"
     variation       707
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549175"
     variation       714
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549208"
     variation       723
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549227"
     variation       729
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549222"
     variation       737
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549206"
     STS             740..1204
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC117780P1"
                     /db_xref="UniSTS:270340"
     variation       771..772
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549192"
     variation       773
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549177"
     STS             776..1381
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC109669P1"
                     /db_xref="UniSTS:270176"
     STS             782..940
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC133768P1"
                     /db_xref="UniSTS:270660"
     STS             847..1342
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC138261P1"
                     /db_xref="UniSTS:270864"
     variation       869
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549225"
     variation       874..875
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549212"
     STS             886..1252
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="Acta1"
                     /db_xref="UniSTS:478947"
     variation       918
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549205"
     variation       948
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549213"
     variation       959
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549179"
     STS             964..1202
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC101699P1"
                     /db_xref="UniSTS:270062"
     variation       972
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549173"
     variation       980..981
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549235"
     variation       987
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230159"
     variation       994
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549178"
     variation       1010
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549202"
     variation       1031
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549191"
     exon            1061..1242
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     STS             1108..1329
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC20960P1"
                     /db_xref="UniSTS:272003"
     variation       1134
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549211"
     variation       1157
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549204"
     variation       1176
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139405"
     STS             1181..1339
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="PMC305873P2"
                     /db_xref="UniSTS:272568"
     variation       1188
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1135989"
     STS             1196..1325
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="fb23d02.x1"
                     /db_xref="UniSTS:190320"
     variation       1212
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3211110"
     variation       1227
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549187"
     exon            1243..2105
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       1249
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549200"
     variation       1272
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139807"
     variation       1284
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139406"
     variation       1298
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549186"
     variation       1386
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549223"
     STS             1519..1868
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="G06574"
                     /db_xref="UniSTS:50845"
     variation       1636
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3369"
     variation       1700
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549182"
     variation       1723
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1063817"
     variation       1725
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549183"
     variation       1746
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1140892"
     variation       1756
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139408"
     variation       1781
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549221"
     variation       1868
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1140383"
     STS             1903..2097
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="SHGC-8015"
                     /db_xref="UniSTS:52694"
     variation       1911
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139409"
     variation       1912
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139410"
     variation       1941
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549203"
     STS             1984..2051
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /standard_name="D17S1646E"
                     /db_xref="UniSTS:147512"
     variation       1986
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7502276"
     variation       2003
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139414"
ORIGIN      
gcgcgccgccgggccgcgcgggcgcgccgcttccgcttaaataacggcgggggaggccgcggtcggtctcagtcgccgctgccagctctcgcactctgttcttccgccgctccgccgtcgcgtttctctgccggtgagcgccccgccccggggcctgagctggacgtcgcaggcctgcgccccccgaccccggctggccccgcttccagctgccgaggcctcgtcgcgccttccccgggaacaaaaggcggggtcgcaatggaagaagagatcgccgcgctggtcattgacaatggctccggcatgtgcaaagctggttttgctggggacgacgctccccgagccgtgtttccttccatcgtcgggcgccccagacaccagggcgtcatggtgggcatgggccagaaggactcctacgtgggcgacgaggcccagagcaagcgtggcatcctgaccctgaagtaccccattgagcatggcatcgtcaccaactgggacgacatggagaagatctggcaccacaccttctacaacgagctgcgcgtggccccggaggagcacccagtgctgctgaccgaggcccccctgaaccccaaggccaacagagagaagatgactcagattatgtttgagaccttcaacaccccggccatgtacgtggccatccaggccgtgctgtccctctacgcctctgggcgcaccactggcattgtcatggactctggagacggggtcacccacacggtgcccatctacgagggctacgccctcccccacgccatcctgcgtctggacctggctggccgggacctgaccgactacctcatgaagatcctcactgagcgaggctacagcttcaccaccacggccgagcgggaaatcgtgcgcgacatcaaggagaagctgtgctacgtcgccctggacttcgagcaggagatggccaccgccgcatcctcctcttctctggagaagagctacgagctgcccgatggccaggtcatcaccattggcaatgagcggttccggtgtccggaggcgctgttccagccttccttcctgggtatggaatcttgcggcatccacgagaccaccttcaactccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacggtgctgtcgggcggcaccaccatgtacccgggcattgccgacaggatgcagaaggagatcaccgccctggcgcccagcaccatgaagatcaagatcatcgcacccccagagcgcaagtactcggtgtggatcggtggctccatcctggcctcactgtccaccttccagcagatgtggattagcaagcaggagtacgacgagtcgggcccctccatcgtccaccgcaaatgcttctaaacggactcagcagatgcgtagcatttgctgcatgggttaattgagaatagaaatttgcccctggcaaatgcacacacctcatgctagcctcacgaaactggaataagccttcgaaaagaaattgtccttgaagcttgtatctgatatcagcactggattgtagaacttgttgctgattttgaccttgtattgaagttaactgttccccttggtatttgtttaataccctgtacatatctttgagttcaacctttagtacgtgtggcttggtcacttcgtggctaaggtaagaacgtgcttgtggaagacaagtctgtggcttggtgagtctgtgtggccagcagcctctgatctgtgcagggtattaacgtgtcagggctgagtgttctgggatttctctagaggctggcaagaaccagttgttttgtcttgcgggtctgtcagggttggaaagtccaagccgtaggacccagtttcctttcttagctgatgtctttggccagaacaccgtgggctgttacttgctttgagttggaagcggtttgcatttacgcctgtaaatgtattcattcttaatttatgtaaggttttttttgtacgcaattctcgattctttgaagagatgacaacaaattttggttttctactgttatgtgagaacattaggccccagcaacacgtcattgtgtaaggaaaaataaaagtgctgccgtaaccaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:71 -> Molecular function: GO:0005200 [structural constituent of cytoskeleton] evidence: IC
            GeneID:71 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:71 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:71 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:71 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:71 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:71 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
            GeneID:71 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:71 -> Biological process: GO:0034332 [adherens junction organization] evidence: TAS
            GeneID:71 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:71 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:71 -> Biological process: GO:0045214 [sarcomere organization] evidence: IEA
            GeneID:71 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:71 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:71 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS
            GeneID:71 -> Cellular component: GO:0030016 [myofibril] evidence: IEA
            GeneID:71 -> Cellular component: GO:0031941 [filamentous actin] evidence: IEA
            GeneID:71 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA

by @meso_cacase at DBCLS
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