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2024-04-26 23:35:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199780 4235 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, beta type, 2
(PSMB2), transcript variant 3, mRNA.
ACCESSION NM_001199780
VERSION NM_001199780.1 GI:315139003
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4235)
AUTHORS Collavoli,A., Comelli,L., Cervelli,T. and Galli,A.
TITLE The over-expression of the beta2 catalytic subunit of the
proteasome decreases homologous recombination and impairs DNA
double-strand break repair in human cells
JOURNAL J. Biomed. Biotechnol. 2011, 757960 (2011)
PUBMED 21660142
REMARK GeneRIF: Results showed that the overexpression of beta2 subunit
decreased homologous recombination in human cells without altering
the cell proteasome activity and the Rad51p level.
REFERENCE 2 (bases 1 to 4235)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 3 (bases 1 to 4235)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 4 (bases 1 to 4235)
AUTHORS Conticello,S.G., Harris,R.S. and Neuberger,M.S.
TITLE The Vif protein of HIV triggers degradation of the human
antiretroviral DNA deaminase APOBEC3G
JOURNAL Curr. Biol. 13 (22), 2009-2013 (2003)
PUBMED 14614829
REFERENCE 5 (bases 1 to 4235)
AUTHORS Yu,X., Yu,Y., Liu,B., Luo,K., Kong,W., Mao,P. and Yu,X.F.
TITLE Induction of APOBEC3G ubiquitination and degradation by an HIV-1
Vif-Cul5-SCF complex
JOURNAL Science 302 (5647), 1056-1060 (2003)
PUBMED 14564014
REFERENCE 6 (bases 1 to 4235)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
REFERENCE 7 (bases 1 to 4235)
AUTHORS Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
TITLE Human proteasome subunits from 2-dimensional gels identified by
partial sequencing
JOURNAL Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994)
PUBMED 7811265
REMARK Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID:
7864893]
REFERENCE 8 (bases 1 to 4235)
AUTHORS Nothwang,H.G., Tamura,T., Tanaka,K. and Ichihara,A.
TITLE Sequence analyses and inter-species comparisons of three novel
human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine
potential proteolytic active-site residues
JOURNAL Biochim. Biophys. Acta 1219 (2), 361-368 (1994)
PUBMED 7918633
REFERENCE 9 (bases 1 to 4235)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
REFERENCE 10 (bases 1 to 4235)
AUTHORS Dawson,S.J. and White,L.A.
TITLE Treatment of Haemophilus aphrophilus endocarditis with
ciprofloxacin
JOURNAL J. Infect. 24 (3), 317-320 (1992)
PUBMED 1602151
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK310023.1, AL157951.5 and
BM664618.1.
Summary: The proteasome is a multicatalytic proteinase complex with
a highly ordered ring-shaped 20S core structure. The core structure
is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
member of the proteasome B-type family, also known as the T1B
family, that is a 20S core beta subunit. Multiple alternatively
spliced transcript variants encoding distinct isoforms have been
found for this gene. [provided by RefSeq, Dec 2010].
Transcript Variant: This variant (3) lacks two exons from the 5'
end and has an alternate 5' exon, as compared to variant 1. The
resulting isoform (3) is shorter at the N-terminus, as compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK310023.1, DA917638.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-991 AK310023.1 1-991
992-3866 AL157951.5 6371-9245
3867-4235 BM664618.1 1-369 c
FEATURES Location/Qualifiers
source 1..4235
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34.2"
gene 1..4235
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="proteasome (prosome, macropain) subunit, beta type,
2"
/db_xref="GeneID:5690"
/db_xref="HGNC:9539"
/db_xref="MIM:602175"
exon 1..102
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
misc_feature 45..47
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="upstream in-frame stop codon"
exon 103..173
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
exon 174..336
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
CDS 240..494
/gene="PSMB2"
/gene_synonym="HC7-I"
/EC_number="3.4.25.1"
/note="isoform 3 is encoded by transcript variant 3;
macropain subunit C7-I; multicatalytic endopeptidase
complex subunit C7-1; proteasome component C7-I;
proteasome subunit, beta type, 2; proteasome subunit beta
type-2; proteasome beta 2 subunit; multicatalytic
endopeptidase complex subunit C7-I"
/codon_start=1
/product="proteasome subunit beta type-2 isoform 3"
/protein_id="NP_001186709.1"
/db_xref="GI:315139004"
/db_xref="GeneID:5690"
/db_xref="HGNC:9539"
/db_xref="MIM:602175"
/translation="
MDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
"
misc_feature <240..464
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="The Ntn hydrolases (N-terminal nucleophile) are a
diverse superfamily of of enzymes that are activated
autocatalytically via an N-terminally lcated nucleophilic
amino acid. N-terminal nucleophile (NTN-) hydrolase
superfamily, which contains a...; Region: Ntn_hydrolase;
cl00467"
/db_xref="CDD:213420"
exon 337..386
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 363
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804236"
exon 387..4220
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 448
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804237"
STS 493..594
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-35307"
/db_xref="UniSTS:2779"
variation 499
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:12386"
variation 529
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:60768546"
variation 571
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:61192957"
variation 646
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:61038979"
STS 988..1090
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 1072..2591
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1072..1160
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1091..2671
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="AB049870"
/db_xref="UniSTS:480103"
STS 1091..2632
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D10S275"
/db_xref="UniSTS:147992"
STS 1517..1647
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D15S1390"
/db_xref="UniSTS:474340"
variation 1578
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132065"
variation 1602
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132067"
variation 1613
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132068"
STS 2455..2630
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
STS 2457..2627
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="G35510"
/db_xref="UniSTS:44150"
STS 3363..3506
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-74572"
/db_xref="UniSTS:30275"
STS 4068..4172
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-74576"
/db_xref="UniSTS:54319"
variation 4079
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062255"
polyA_site 4220
/gene="PSMB2"
/gene_synonym="HC7-I"
ORIGIN
agtactaaccagctatttcatagctgttgcatgaggaaagggactagagtaggattgtacccctcagtctatgctttgtttactctgagtgtacaaaagatggatatgaattgtctcccacggcagcagctaacttcacacgccgaaacctggctgactgtcttcggagtcggaccccatatcatgtgaacctcctcctggctggctatgatgagcatgaagggccagcgctgtattacatggactacctggcagccttggccaaggccccttttgcagcccacggctatggtgccttcctgactctcagtatcctcgaccgatactacacaccgactatctcacgtgagagggcagtggaactccttaggaaatgtctggaggagctccagaaacgcttcatcctgaatctgccaaccttcagtgttcgaatcattgacaaaaatggcatccatgacctggataacatttccttccccaaacagggctcctaacatcatgtcctccctcccacttgccagggaacttttttttgatgggctcctttatttttttctactcttttcaggcgcactcttgataaatggttaattcagaataaaggtgactatggatataattgagccctctggtccaggtctcagtttacctaatattacctcagaaaggatatggagggaagatgatctttttgccaggtctgacttttcttcctgctccgccctccattaacgctcagtaccctttagcagctgacggccccacgttctactccatgcttggcttcctttccaactagctctttcatatattttacttgctagtatctccattctctctaaagtagtggttctttttgcccttaaacttaaatttttaaattaattaacctgaattaataatacatgcacttaatgtaacatgcaaacagtacaaaaacatgtagtgaaaaatatttcttccagagctgggtgtggtggctcatacctgtaatcccagcactttgggaggccgaggcgggcggatcacgaggtcaagagagcgagaccatcctgaccaacatggtaaaaccccgtctctactaaaaatacaaaaattagctgggcgtggtggcacgcacccctagtcccagctactggggaggctgagacaggagaatcggtcgaacccgggaggcagaggttgcagtgagcctagatcgcgccactgtactccagcctggcaacagagtgagactccgtctcaaaaaaagaaggaaaaatgtttcttccatccctataatccagtcatctgcttcctgcttcccttcctggaggaaacttcagctactaatttcttatgttttttaagagatattctgttactgtgtaaagtatacatacatacagacacatgccccctttaaattttttagatttatttatttatttagagacagggtctcactctagcccaggctggagtgctgtggcgtaatcttggctcactgcaacctccgcctcccgggcccaagtgatcctcccatctcagcctcctgagtagctaggattacaggcgcacaccaccaatgcccagctagtttttgtgtttttcatagagacagggtctcaccatgtcattcaggttggtcttgaactcctgggctcaagcagtctgcctgccttggcttcccagtgctgggattacaggcgtgagccaccgtgcccggctaaaaagtatttttaagttctgcatattgcttatttcacttaacactatattagagattgttttatatcaatacatatagatatgcttattcttgttgacagttgcataattttccattaaattgatgtatcatgggcagttaaccagttactcgttttactcttagcataactttagggaacaatgtggatgttttgtggttaaagctattaaaacagtggttcttgaccagatgtgtgtttcagaatgttcatctcacatttccagttgctactgatgctgctggtctaggaaccacatatcaaaaccatttggtctccgactaagataaaccctactttatccaattctgtgctcctcttaatatcatatacagataggtttttgttttgtctgtgattaaatgtatcatctaagatactacctactgatcataacgttcatattaaagtattgggttaacattagatttgggtgtcttatacactatttaatacgccaatgataaatgccttacaccataagaagaaagctaatcattgagtaaatgggagaaaagagatgattcacgtcactacagttgattcaacctccaacaccaccatgaatatgcataggtttgagcttttagctagattcctgagtgtaaggcatctattttaaaagtgccacaggttggccgggtgcggtggctcatgcctgtaatcccagcactttggccgcccgccgaggcgggcggatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaaccccatctctactaaaaaaatatataacaattagccaggcgtggtggcacacgcctgtaaacccaactacttgggaggctgaggcaggagaattgcttgagcccgggagagggaggttgcagtgagccgagatcatgccactgcactccagcctggctgacagagcaagactctgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaagcgccacagatgattctgacgccctacccagtggagtgctgctactaaagcacagactatcctgctacatgattttcccatctgtacaatgactgaaatagcacctattctatgtggtagatatgagaattccatgaagtaatataggtaaacatttagttcagggcttggcatgtggtaagtgctcagtaagtgtataatgattggtaaacttgttattctgcattcaggcctcaccagggatgacatacggttctctgcctttgaatgtaagtgtccccagggcaatctcaggcaagcctgcaaacccatcctgactctcagtgtttttttgccaatctggatctctttcctgagctccaaatcaactcattcctagatagctcaccctccagatttagggacatcgaactcagtatgtctaaagctgagccttaccatctgcccctctccaaaccgcctctatgacattctgtcttagagaattagagctacctggtttcccaagtgcccaagtcagaaacccaggcatcatttatttttaataaatgttttattttggaataaatttggttttacagaaaagttgcaaagataatatggtgtccttataccccttattcagtttctgtaatgttaacatcttctatataccacagtatgtttgtcaaaactgagaaaccaacattggttggtgtattagtattactaagctccaggctttattcagattttaccagtttttccactaattttcttctgttctaggatataatccaagatacaacattgcatttagctgggcatcatttttatgccattctttatctcctgtctctacatggccaccaagttctggcatttctacatcctaaatcttttaattttattataattttttattgttgtttttcagagacagggtcttgctccatcacctaggctggagtacagtggcacgatcgtagcttactgcagtaagttcacttgaactcctgggctcaagtgaacctcttaccccagcctcccaactagctgggactagaggggtgcaccactgcacccagctaattttgtcaaaattttttgtagagacagggtctcgccatgttgcctaggctggtctcgaactcttggcctcaagtgatcctcccaccttggtctgccaaagcactgggattacagatgtgagccactgcacccagcctaatctttataaatctccatccccattactctggttcaccccctatcgtttcttagactatttaacagcctcctaacttcactctacttttaatctcttccctctccaggtctttctccatattttaaaaaactagtttcaccatccattcctctctgcccttaaaactttctggtggttttccatggcttaagagaataaagcccaattctttgatttgacatgctaggcattccataatcctctccgaacctaactccccacttcctttccctcctttacacctcataaagcctgtgttccaactaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5690 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
GeneID:5690 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5690 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5690 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5690 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5690 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
GeneID:5690 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5690 -> Biological process: GO:0014070 [response to organic cyclic compound] evidence: IEA
GeneID:5690 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5690 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5690 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5690 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5690 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5690 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001186709 -> EC 3.4.25.1
by
@meso_cacase at
DBCLS
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